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Conserved domains on  [gi|1430654123|ref|WP_113854575|]
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transcription elongation factor GreB [Sutterella wadsworthensis]

Protein Classification

transcription elongation factor GreB( domain architecture ID 11479724)

transcription elongation factor GreB induces cleavage of the nascent transcript to allow the resumption of elongation from the new 3' terminus; releases sequences of up to 9 nucleotides in length

Gene Symbol:  greB
Gene Ontology:  GO:0003677|GO:0070063|GO:0006354
PubMed:  17917675|31103420

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
greB PRK01885
transcription elongation factor GreB; Reviewed
 16-178 7.22e-84

transcription elongation factor GreB; Reviewed


:

Pssm-ID: 179345 [Multi-domain]  Cd Length: 157  Bit Score: 244.37  E-value: 7.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  16 PNTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAA 95
Cdd:PRK01885    1 AMKTNYITREGYARLKQELDYLWREERPEVTQKVSWAASLGDRSENADYIYGKKRLREIDRRVRFLTKRLENLKVVDYSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  96 hPETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILE 175
Cdd:PRK01885   81 -QQEGKVFFGAWVEIENEDGEEKRFRIVGPDEIDGRKGYISIDSPMARALLKKEVGDEVTVNT------PAGEAEWYVNE 153


                  ...
gi 1430654123 176 VTY 178
Cdd:PRK01885  154 IEY 156
 
Name Accession Description Interval E-value
greB PRK01885
transcription elongation factor GreB; Reviewed
 16-178 7.22e-84

transcription elongation factor GreB; Reviewed


Pssm-ID: 179345 [Multi-domain]  Cd Length: 157  Bit Score: 244.37  E-value: 7.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  16 PNTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAA 95
Cdd:PRK01885    1 AMKTNYITREGYARLKQELDYLWREERPEVTQKVSWAASLGDRSENADYIYGKKRLREIDRRVRFLTKRLENLKVVDYSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  96 hPETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILE 175
Cdd:PRK01885   81 -QQEGKVFFGAWVEIENEDGEEKRFRIVGPDEIDGRKGYISIDSPMARALLKKEVGDEVTVNT------PAGEAEWYVNE 153


                  ...
gi 1430654123 176 VTY 178
Cdd:PRK01885  154 IEY 156
GreA COG0782
Transcription elongation factor, GreA/GreB family [Transcription];
16-177 2.37e-61

Transcription elongation factor, GreA/GreB family [Transcription];


Pssm-ID: 440545 [Multi-domain]  Cd Length: 156  Bit Score: 187.26  E-value: 2.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  16 PNTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAA 95
Cdd:COG0782     1 MMKKNYLTPEGYEKLKAELEELKTVERPEIAEAIAEARAEGDLSENAEYDAAKEEQGFIEGRIRELEKRLANAEVIDPSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  96 HPeTDQVFFGATVLYCN-QRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEIL 174
Cdd:COG0782    81 LD-TDKVFFGATVTLEDlEDGEEETYTIVGPDEADPKKGKISIESPLGRALLGKKVGDEVEVTT------PGGEREYEIL 153


                  ...
gi 1430654123 175 EVT 177
Cdd:COG0782   154 EIE 156
greB TIGR01461
transcription elongation factor GreB; The GreA and GreB transcription elongation factors ...
 18-178 7.22e-58

transcription elongation factor GreB; The GreA and GreB transcription elongation factors enable to continuation of RNA transcription past template-encoded arresting sites. Among the Proteobacteria, distinct clades of GreA and GreB are found. GreB differs functionally in that it releases larger oligonucleotides. This model describes proteobacterial GreB. [Transcription, Transcription factors]


Pssm-ID: 130528 [Multi-domain]  Cd Length: 156  Bit Score: 178.53  E-value: 7.22e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  18 TKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAAHp 97
Cdd:TIGR01461   1 KTPLITPEGYEKLKQELNYLWREERPEVTQKVTWAASLGDRSENADYQYGKKRLREIDRRVRFLTKRLENLKVVDYSPQ- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  98 ETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILEVT 177
Cdd:TIGR01461  80 QEGKVFFGAWVELENDDGVTHRFRIVGYDEIDGRKNYISIDSPLARALLKKEVGDEVVVNT------PAGEASWYVNAIE 153


                  .
gi 1430654123 178 Y 178
Cdd:TIGR01461 154 Y 154
GreA_GreB_N pfam03449
Transcription elongation factor, N-terminal; This domain adopts a long alpha-hairpin structure.
 20-90 3.22e-27

Transcription elongation factor, N-terminal; This domain adopts a long alpha-hairpin structure.


Pssm-ID: 460920 [Multi-domain]  Cd Length: 71  Bit Score: 97.83  E-value: 3.22e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1430654123  20 NYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEV 90
Cdd:pfam03449   1 IPLTREGYEKLKEELEHLKTVERPEIAEAIAEAREHGDLSENAEYDAAKEEQAFIEARIRELEDKLANAEV 71
ASKHA_NBD_CmcH_N cd24102
N-terminal nucleotide-binding domain (NBD) of 3'-hydroxymethylcephem-O-carbamoyltransferase ...
 23-86 4.44e-03

N-terminal nucleotide-binding domain (NBD) of 3'-hydroxymethylcephem-O-carbamoyltransferase (CmcH) and similar proteins; CmcH (EC 2.1.3.7), also called 3'-hydroxymethylcephem-O-CASE (CCT), has 3-hydroxymethylcephem carbamoyltransferase activity. It catalyzes the carbamoylation reaction in the cephamycin (antibiotic) biosynthesis. Members of this family consist of two domains. The model corresponds to the N-terminal Kae1-like domain.


Pssm-ID: 466952 [Multi-domain]  Cd Length: 316  Bit Score: 36.92  E-value: 4.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1430654123  23 TPACYRRLLderEHLVNVerPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIE 86
Cdd:cd24102    39 TVSDVLDAL---ERLNDV--PDVLCLSGWWPGDHLIGSPTGAGYHGLEKEIIVEKSRFLGKTVK 97
 
Name Accession Description Interval E-value
greB PRK01885
transcription elongation factor GreB; Reviewed
 16-178 7.22e-84

transcription elongation factor GreB; Reviewed


Pssm-ID: 179345 [Multi-domain]  Cd Length: 157  Bit Score: 244.37  E-value: 7.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  16 PNTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAA 95
Cdd:PRK01885    1 AMKTNYITREGYARLKQELDYLWREERPEVTQKVSWAASLGDRSENADYIYGKKRLREIDRRVRFLTKRLENLKVVDYSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  96 hPETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILE 175
Cdd:PRK01885   81 -QQEGKVFFGAWVEIENEDGEEKRFRIVGPDEIDGRKGYISIDSPMARALLKKEVGDEVTVNT------PAGEAEWYVNE 153


                  ...
gi 1430654123 176 VTY 178
Cdd:PRK01885  154 IEY 156
GreA COG0782
Transcription elongation factor, GreA/GreB family [Transcription];
16-177 2.37e-61

Transcription elongation factor, GreA/GreB family [Transcription];


Pssm-ID: 440545 [Multi-domain]  Cd Length: 156  Bit Score: 187.26  E-value: 2.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  16 PNTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAA 95
Cdd:COG0782     1 MMKKNYLTPEGYEKLKAELEELKTVERPEIAEAIAEARAEGDLSENAEYDAAKEEQGFIEGRIRELEKRLANAEVIDPSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  96 HPeTDQVFFGATVLYCN-QRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEIL 174
Cdd:COG0782    81 LD-TDKVFFGATVTLEDlEDGEEETYTIVGPDEADPKKGKISIESPLGRALLGKKVGDEVEVTT------PGGEREYEIL 153


                  ...
gi 1430654123 175 EVT 177
Cdd:COG0782   154 EIE 156
greB TIGR01461
transcription elongation factor GreB; The GreA and GreB transcription elongation factors ...
 18-178 7.22e-58

transcription elongation factor GreB; The GreA and GreB transcription elongation factors enable to continuation of RNA transcription past template-encoded arresting sites. Among the Proteobacteria, distinct clades of GreA and GreB are found. GreB differs functionally in that it releases larger oligonucleotides. This model describes proteobacterial GreB. [Transcription, Transcription factors]


Pssm-ID: 130528 [Multi-domain]  Cd Length: 156  Bit Score: 178.53  E-value: 7.22e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  18 TKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAAHp 97
Cdd:TIGR01461   1 KTPLITPEGYEKLKQELNYLWREERPEVTQKVTWAASLGDRSENADYQYGKKRLREIDRRVRFLTKRLENLKVVDYSPQ- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  98 ETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILEVT 177
Cdd:TIGR01461  80 QEGKVFFGAWVELENDDGVTHRFRIVGYDEIDGRKNYISIDSPLARALLKKEVGDEVVVNT------PAGEASWYVNAIE 153


                  .
gi 1430654123 178 Y 178
Cdd:TIGR01461 154 Y 154
greA PRK00226
transcription elongation factor GreA; Reviewed
 17-178 2.73e-38

transcription elongation factor GreA; Reviewed


Pssm-ID: 234693 [Multi-domain]  Cd Length: 157  Bit Score: 128.69  E-value: 2.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  17 NTKNYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAAH 96
Cdd:PRK00226    2 MKKIPMTQEGYEKLEEELEELKTVERPEIIEAIAEAREHGDLSENAEYHAAKEEQGFIEGRIRELEDKLSNAEVIDPSKL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  97 PeTDQVFFGATV-LYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILE 175
Cdd:PRK00226   82 S-GGKVKFGSTVtLKDLDTDEEETYQIVGSDEADPKQGKISIESPIARALIGKKVGDTVEVTT------PGGEYEYEILS 154


                  ...
gi 1430654123 176 VTY 178
Cdd:PRK00226  155 VEY 157
greA TIGR01462
transcription elongation factor GreA; The GreA and GreB transcription elongation factors ...
 21-177 9.87e-33

transcription elongation factor GreA; The GreA and GreB transcription elongation factors enable to continuation of RNA transcription past template-encoded arresting sites. Among the Proteobacteria, distinct clades of GreA and GreB are found. GreA differs functionally in that it releases smaller oligonucleotides. Because members of the family outside the Proteobacteria resemble GreA more closely than GreB, the GreB clade (TIGR01461) forms a plausible outgroup and the remainder of the GreA/B family, included in this model, is designated GreA. In the Chlamydias and some spirochetes, the region described by this model is found as the C-terminal region of a much larger protein. [Transcription, Transcription factors]


Pssm-ID: 273638 [Multi-domain]  Cd Length: 151  Bit Score: 114.25  E-value: 9.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  21 YMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPAAHpETD 100
Cdd:TIGR01462   1 PLTQEGYEKLKEELEYLKTVKRPEISEEIAEAREHGDLSENAEYHAAKEEQGFNEGRIAELEDLLANAQVIDDSKL-STD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1430654123 101 QVFFGATV-LYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILEVT 177
Cdd:TIGR01462  80 VVGFGSTVtIKDLDTGEEETYTIVGSWEADPKEGKISIDSPLGKALIGKKVGDSVEVQT------PKGEKEYEILKIE 151
GreA_GreB_N pfam03449
Transcription elongation factor, N-terminal; This domain adopts a long alpha-hairpin structure.
 20-90 3.22e-27

Transcription elongation factor, N-terminal; This domain adopts a long alpha-hairpin structure.


Pssm-ID: 460920 [Multi-domain]  Cd Length: 71  Bit Score: 97.83  E-value: 3.22e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1430654123  20 NYMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEV 90
Cdd:pfam03449   1 IPLTREGYEKLKEELEHLKTVERPEIAEAIAEAREHGDLSENAEYDAAKEEQAFIEARIRELEDKLANAEV 71
GreA_GreB pfam01272
Transcription elongation factor, GreA/GreB, C-term; This domain has an FKBP-like fold.
 99-178 8.73e-19

Transcription elongation factor, GreA/GreB, C-term; This domain has an FKBP-like fold.


Pssm-ID: 426171 [Multi-domain]  Cd Length: 77  Bit Score: 76.40  E-value: 8.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  99 TDQVFFGATVLYCNQR-GEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTpatsthPAGVDTLEILEVT 177
Cdd:pfam01272   3 ADVVTFGSTVTLEDLDtGEEETYTIVGPDEADPSKGKISVLSPLGKALLGKKVGDTVEVTA------PGGKIKYEILKIE 76


                  .
gi 1430654123 178 Y 178
Cdd:pfam01272  77 Y 77
PRK14720 PRK14720
transcription elongation factor GreA;
28-164 1.06e-15

transcription elongation factor GreA;


Pssm-ID: 184804 [Multi-domain]  Cd Length: 906  Bit Score: 74.04  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  28 RRLLD----EREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIESAEVVDPaAHPETDQVF 103
Cdd:PRK14720  754 RRALNkkkkELEHLKDVEMPENSKDIGEAQELGDLRENAEYKAAKEKQQQLQAALKRLEAEIDSAKILDL-TDVKTSKVG 832

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1430654123 104 FGATV-LYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTPATSTH 164
Cdd:PRK14720  833 FGTKVkLKNEDTGEEESYSILGPWESDPEEGIISYQSPLGKSLLGKKEGDSLEFVINDTETR 894
PRK06342 PRK06342
transcription elongation factor GreA;
76-176 6.48e-14

transcription elongation factor GreA;


Pssm-ID: 180535 [Multi-domain]  Cd Length: 160  Bit Score: 65.89  E-value: 6.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  76 RRIRFLNKRIESAEVVDPAAHPETdqVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVk 155
Cdd:PRK06342   71 RDLRYLAARRRTAQLMPDPASTDV--VAFGSTVTFSRDDGRVQTYRIVGEDEADPKAGSISYVSPVARALMGKAVGDVV- 147

                          90       100
                  ....*....|....*....|.
gi 1430654123 156 lptpatsthPAGVDTLEILEV 176
Cdd:PRK06342  148 ---------SVGGQELEIIAI 159
PRK05753 PRK05753
nucleoside diphosphate kinase regulator; Provisional
 81-181 8.84e-09

nucleoside diphosphate kinase regulator; Provisional


Pssm-ID: 180236 [Multi-domain]  Cd Length: 137  Bit Score: 51.49  E-value: 8.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  81 LNKRIESAEVVDPAAHPEtDQVFFGATVLYCN-QRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKLPTP 159
Cdd:PRK05753   35 LNAELDRAQVVPPAEMPA-DVVTMNSRVRFRDlSSGEERVRTLVYPADADDSEGQLSVLAPVGAALLGLSVGQSIDWPLP 113

                          90       100
                  ....*....|....*....|..
gi 1430654123 160 ATSTHpagvdTLEILEVTYTDQ 181
Cdd:PRK05753  114 GGKET-----HLEVLEVEYQPE 130
PRK06330 PRK06330
transcript cleavage factor/unknown domain fusion protein; Validated
 8-156 2.09e-06

transcript cleavage factor/unknown domain fusion protein; Validated


Pssm-ID: 235780 [Multi-domain]  Cd Length: 718  Bit Score: 47.05  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123   8 EVKLPGLPPNTKN------YMTPACYRRLLDEREHLVNVERPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFL 81
Cdd:PRK06330  549 EVVQPSLKKGTSEveeeilWTTSESFTRMKNKLQSLVGKEMVENAKEIEDARALGDLRENSEYKFALEKRARLQEEIRVL 628

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1430654123  82 NKRIESAEVVDPAAhPETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWISPIARVFLRRHEGDEVKL 156
Cdd:PRK06330  629 SEEINRARILTKDD-VFTDKVGVGCKVVLEDDQGDKVCYTILGPWDADPDNKILSLKSKLAQEMLGKKVGDSVQF 702
PRK05892 PRK05892
nucleoside diphosphate kinase regulator; Provisional
 7-177 2.59e-06

nucleoside diphosphate kinase regulator; Provisional


Pssm-ID: 180307 [Multi-domain]  Cd Length: 158  Bit Score: 45.15  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123   7 EEVKLPGLPPNTKNYMTpACYRRLLDEREHL-VNVERPDVVnvvawaasnGDRSENGDYLYGKKRLREIDRRIRFLNKRI 85
Cdd:PRK05892    1 MKVKSKGLAPAARDHLE-AELARLRARRDRLaVEVNDRGMI---------GDHGDQAEAIQRADELARLDDRINELDRRL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430654123  86 ESAevvdPAAHPETDQVFFGATVLYCNQRGEERKIRIVGIDEADAEHGDVSWI---SPIARVFLRRHEGDEVKLPTpats 162
Cdd:PRK05892   71 RTG----PTPWSGSETLPGGTEVTLRFPDGEVETMHVISVVEETPVGREAETLtadSPLGQALAGHQAGDTVTYST---- 142

                         170
                  ....*....|....*
gi 1430654123 163 thPAGVDTLEILEVT 177
Cdd:PRK05892  143 --PQGPAQVELLAVK 155
ASKHA_NBD_CmcH_N cd24102
N-terminal nucleotide-binding domain (NBD) of 3'-hydroxymethylcephem-O-carbamoyltransferase ...
 23-86 4.44e-03

N-terminal nucleotide-binding domain (NBD) of 3'-hydroxymethylcephem-O-carbamoyltransferase (CmcH) and similar proteins; CmcH (EC 2.1.3.7), also called 3'-hydroxymethylcephem-O-CASE (CCT), has 3-hydroxymethylcephem carbamoyltransferase activity. It catalyzes the carbamoylation reaction in the cephamycin (antibiotic) biosynthesis. Members of this family consist of two domains. The model corresponds to the N-terminal Kae1-like domain.


Pssm-ID: 466952 [Multi-domain]  Cd Length: 316  Bit Score: 36.92  E-value: 4.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1430654123  23 TPACYRRLLderEHLVNVerPDVVNVVAWAASNGDRSENGDYLYGKKRLREIDRRIRFLNKRIE 86
Cdd:cd24102    39 TVSDVLDAL---ERLNDV--PDVLCLSGWWPGDHLIGSPTGAGYHGLEKEIIVEKSRFLGKTVK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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