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Conserved domains on  [gi|1444972167|ref|WP_115588229|]
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molybdenum cofactor biosynthesis protein MoaE [Aliarcobacter skirrowii]

Protein Classification

molybdopterin synthase catalytic subunit( domain architecture ID 10091526)

molybdopterin synthase catalytic subunit is the catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin

CATH:  3.90.1170.40
EC:  2.8.1.12
Gene Ontology:  GO:0006777|GO:0030366|GO:1990140
PubMed:  35744859
SCOP:  4001136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 21-131 2.74e-36

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


:

Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 121.08  E-value: 2.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  21 SWYEKYKNLNYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIA 95
Cdd:cd00756     5 ELLAALRDPEAGAVVTFVGTVRDHDEgkgVEALEYEAYPPMAEKELEEIAEEARERWGLlrVAIIHRVGRLPPGEAIVLV 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1444972167  96 GVCSPQRRVALELIDEFVEDFKKNAPIWKYDLRDNK 131
Cdd:cd00756    85 AVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 21-131 2.74e-36

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 121.08  E-value: 2.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  21 SWYEKYKNLNYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIA 95
Cdd:cd00756     5 ELLAALRDPEAGAVVTFVGTVRDHDEgkgVEALEYEAYPPMAEKELEEIAEEARERWGLlrVAIIHRVGRLPPGEAIVLV 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1444972167  96 GVCSPQRRVALELIDEFVEDFKKNAPIWKYDLRDNK 131
Cdd:cd00756    85 AVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 13-141 2.34e-27

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 99.10  E-value: 2.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  13 LNIEKIHNSWYEKykNLNYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVK 87
Cdd:COG0314    11 FDLAAELAALRAS--DPEAGAVVTFVGTVRDHNDgrrVTALEYEAYPPMAEKELAEIAEEAAERWGLldVAVIHRVGRLE 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1444972167  88 NHESSYIAGVCSPQRRVALELIDEFVEDFKKNAPIWKYDLRDNKRIYAKDRSQK 141
Cdd:COG0314    89 PGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSSD 142
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 32-135 4.39e-12

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 58.93  E-value: 4.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  32 GAFITFVGIVRDEngIDG-----LSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIAGVCSPQRRV 104
Cdd:PLN02390    5 GAIATFSGTTRDT--FEGktvleLRYEAYVPMALRELRKICDEARSRWSLhkIAVAHRLGPVPVGETSVFVAVSSVHRAD 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1444972167 105 ALELIDEFVEDFKKNAPIWKydlrdnKRIYA 135
Cdd:PLN02390   83 ALDACKFLIDELKASVPIWK------KEVYD 107
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 30-111 1.87e-07

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 46.68  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  30 NYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIAGVCSPQRRV 104
Cdd:pfam02391  19 EAGAVVTFVGTVRDHFDgkkVTALEYEAYPPMAEKELAEIAEEARERWPLldVAIVHRVGRLPVGEAIVLVAVSSPHRAE 98

                          90
                  ....*....|.
gi 1444972167 105 ALE----LIDE 111
Cdd:pfam02391  99 AFEaceyLIDE 109
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 21-131 2.74e-36

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 121.08  E-value: 2.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  21 SWYEKYKNLNYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIA 95
Cdd:cd00756     5 ELLAALRDPEAGAVVTFVGTVRDHDEgkgVEALEYEAYPPMAEKELEEIAEEARERWGLlrVAIIHRVGRLPPGEAIVLV 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1444972167  96 GVCSPQRRVALELIDEFVEDFKKNAPIWKYDLRDNK 131
Cdd:cd00756    85 AVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 13-141 2.34e-27

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 99.10  E-value: 2.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  13 LNIEKIHNSWYEKykNLNYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVK 87
Cdd:COG0314    11 FDLAAELAALRAS--DPEAGAVVTFVGTVRDHNDgrrVTALEYEAYPPMAEKELAEIAEEAAERWGLldVAVIHRVGRLE 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1444972167  88 NHESSYIAGVCSPQRRVALELIDEFVEDFKKNAPIWKYDLRDNKRIYAKDRSQK 141
Cdd:COG0314    89 PGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSSD 142
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 32-135 4.39e-12

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 58.93  E-value: 4.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  32 GAFITFVGIVRDEngIDG-----LSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIAGVCSPQRRV 104
Cdd:PLN02390    5 GAIATFSGTTRDT--FEGktvleLRYEAYVPMALRELRKICDEARSRWSLhkIAVAHRLGPVPVGETSVFVAVSSVHRAD 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1444972167 105 ALELIDEFVEDFKKNAPIWKydlrdnKRIYA 135
Cdd:PLN02390   83 ALDACKFLIDELKASVPIWK------KEVYD 107
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 30-111 1.87e-07

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 46.68  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  30 NYGAFITFVGIVRDENG---IDGLSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHESSYIAGVCSPQRRV 104
Cdd:pfam02391  19 EAGAVVTFVGTVRDHFDgkkVTALEYEAYPPMAEKELAEIAEEARERWPLldVAIVHRVGRLPVGEAIVLVAVSSPHRAE 98

                          90
                  ....*....|.
gi 1444972167 105 ALE----LIDE 111
Cdd:pfam02391  99 AFEaceyLIDE 109
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 32-124 1.69e-04

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 39.98  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444972167  32 GAFITFVGIVRDENGIDG-----LSFDIYEPILKKWFASWQEKAKTKDAI--VFLAHSLGDVKNHES-SYIAgVCSPQRR 103
Cdd:PRK14493  160 GAIATFTGRVRAKEDADDepteyLEFEKYDGVADERMAAIREELKQRDGVfeVLLHHRTGVIEAGEDiVFVV-VLAGHRQ 238

                          90       100
                  ....*....|....*....|.
gi 1444972167 104 VALELIDEFVEDFKKNAPIWK 124
Cdd:PRK14493  239 EAFRAVSDGIDRLKDEVPIFK 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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