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Conserved domains on  [gi|2067747166|ref|WP_218257686|]
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MULTISPECIES: zeta toxin family protein [Enterococcus]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1000205)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 26-212 1.46e-47

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member pfam06414:

Pssm-ID: 475120  Cd Length: 192  Bit Score: 157.14  E-value: 1.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  26 GKKAVESPTAFLLGGQPGSGKTSLRSAILEE--TQGNVIVIDNDTFKQQHPNFDELAKLYEKDVVKHVTPYSNRMTEAII 103
Cdd:pfam06414   4 KTTSQERPKAILLGGQPGAGKTELARALLDElgRQGNVVRIDPDDFRELHPHYRELQAADPKTASEYTQPDASRWVEKLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166 104 SRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMYADdpmtARATPKQAHDIVVK 183
Cdd:pfam06414  84 QHAIENGYNIILEGTLRSPDVAKKIARALKAAGYRVEVAAVAAPPELSWLGVLDRYEEEVAE----GRYVPKEHHDEAFN 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 2067747166 184 NLPTNLETLHKTGLFSDIRLYNREG-VKLY 212
Cdd:pfam06414 160 GLRESLRALERRKLLDRVRIKDRDGkNVLY 189
 
Name Accession Description Interval E-value
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 26-212 1.46e-47

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 157.14  E-value: 1.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  26 GKKAVESPTAFLLGGQPGSGKTSLRSAILEE--TQGNVIVIDNDTFKQQHPNFDELAKLYEKDVVKHVTPYSNRMTEAII 103
Cdd:pfam06414   4 KTTSQERPKAILLGGQPGAGKTELARALLDElgRQGNVVRIDPDDFRELHPHYRELQAADPKTASEYTQPDASRWVEKLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166 104 SRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMYADdpmtARATPKQAHDIVVK 183
Cdd:pfam06414  84 QHAIENGYNIILEGTLRSPDVAKKIARALKAAGYRVEVAAVAAPPELSWLGVLDRYEEEVAE----GRYVPKEHHDEAFN 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 2067747166 184 NLPTNLETLHKTGLFSDIRLYNREG-VKLY 212
Cdd:pfam06414 160 GLRESLRALERRKLLDRVRIKDRDGkNVLY 189
COG4185 COG4185
Predicted ABC-type ATPase or kinase [General function prediction only];
31-158 9.67e-07

Predicted ABC-type ATPase or kinase [General function prediction only];


Pssm-ID: 443339  Cd Length: 197  Bit Score: 48.35  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  31 ESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELAKLYEkdvvkhvtpySNRMTEAIISRLSDQG 110
Cdd:COG4185     2 AMPRLYIIAGPNGAGKSTFARTILPEELGGLEFVNADLIARGLSPFNPETAAYE----------AGRLALERREELLAAG 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2067747166 111 YNLVIEGT--GRTtdvPIQTATMLQAKGYETKMYVMAV--PKINsylgtIER 158
Cdd:COG4185    72 RSFAFETTlsGPS---KLDLIREAKAAGYRVRLIFVGLdsPELA-----IAR 115
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 30-64 1.32e-03

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 38.62  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2067747166  30 VESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVI 64
Cdd:cd19530    27 IDLPTGVLLYGPPGCGKTLLAKAVANESGANFISV 61
 
Name Accession Description Interval E-value
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 26-212 1.46e-47

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 157.14  E-value: 1.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  26 GKKAVESPTAFLLGGQPGSGKTSLRSAILEE--TQGNVIVIDNDTFKQQHPNFDELAKLYEKDVVKHVTPYSNRMTEAII 103
Cdd:pfam06414   4 KTTSQERPKAILLGGQPGAGKTELARALLDElgRQGNVVRIDPDDFRELHPHYRELQAADPKTASEYTQPDASRWVEKLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166 104 SRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMYADdpmtARATPKQAHDIVVK 183
Cdd:pfam06414  84 QHAIENGYNIILEGTLRSPDVAKKIARALKAAGYRVEVAAVAAPPELSWLGVLDRYEEEVAE----GRYVPKEHHDEAFN 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 2067747166 184 NLPTNLETLHKTGLFSDIRLYNREG-VKLY 212
Cdd:pfam06414 160 GLRESLRALERRKLLDRVRIKDRDGkNVLY 189
COG4185 COG4185
Predicted ABC-type ATPase or kinase [General function prediction only];
31-158 9.67e-07

Predicted ABC-type ATPase or kinase [General function prediction only];


Pssm-ID: 443339  Cd Length: 197  Bit Score: 48.35  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  31 ESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELAKLYEkdvvkhvtpySNRMTEAIISRLSDQG 110
Cdd:COG4185     2 AMPRLYIIAGPNGAGKSTFARTILPEELGGLEFVNADLIARGLSPFNPETAAYE----------AGRLALERREELLAAG 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2067747166 111 YNLVIEGT--GRTtdvPIQTATMLQAKGYETKMYVMAV--PKINsylgtIER 158
Cdd:COG4185    72 RSFAFETTlsGPS---KLDLIREAKAAGYRVRLIFVGLdsPELA-----IAR 115
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 30-64 1.32e-03

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 38.62  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2067747166  30 VESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVI 64
Cdd:cd19530    27 IDLPTGVLLYGPPGCGKTLLAKAVANESGANFISV 61
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 31-169 3.32e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.78  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067747166  31 ESPTAFLLGGQPGSGKTSLRSAI---LEETQGNVIVIDNDTFKQQHPNFDELAKLYEkDVVKHVtpysnrmTEAIISRLS 107
Cdd:COG4088     2 DSPMLLILTGPPGSGKTTFAKALaqrLYAEGIAVALLHSDDFRRFLVNESFPKETYE-EVVEDV-------RTTTADNAL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2067747166 108 DQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKInsylgTIERYETMYADDPMT 169
Cdd:COG4088    74 DNGYSVIVDGTFYYRSWQRDFRNLAKHKAPIHIIYLKAPLET-----ALRRNRERGEPIPER 130
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 27-64 8.25e-03

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 36.32  E-value: 8.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2067747166  27 KKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVI 64
Cdd:cd19529    21 RLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISV 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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