NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|124802753|ref|XP_001347584|]
View 

RNA methyltransferase, putative [Plasmodium falciparum 3D7]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 13031065)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047|GO:0003723|GO:0032259|GO:0006396
PubMed:  11763972|17338813|30457841|18029778|8265370
SCOP:  3001122

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 53-195 1.10e-69

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349969  Cd Length: 140  Bit Score: 210.92  E-value: 1.10e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  53 TYVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKkeINFFGNMGTYDYITIEYFDNIYELKEYLTKHDILLYACEISV 132
Cdd:cd18096    1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVHLVGRRK--FNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIVP 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 133 NALSITTNPYeHKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTASLNVSVSCAIILQNF 195
Cdd:cd18096   79 GAEPIETHPF-PGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGSGTASLNVSVAASIVLHHF 140
 
Name Accession Description Interval E-value
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 53-195 1.10e-69

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 210.92  E-value: 1.10e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  53 TYVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKkeINFFGNMGTYDYITIEYFDNIYELKEYLTKHDILLYACEISV 132
Cdd:cd18096    1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVHLVGRRK--FNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIVP 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 133 NALSITTNPYeHKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTASLNVSVSCAIILQNF 195
Cdd:cd18096   79 GAEPIETHPF-PGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGSGTASLNVSVAASIVLHHF 140
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 54-192 1.81e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 131.11  E-value: 1.81e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753   54 YVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKEINFF----GNMGTYDYITIEYFDNIYELKEYLTKHDILLYACe 129
Cdd:pfam00588   3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPkairASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753  130 iSVNALSITTNPYEhKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:pfam00588  82 -SLGGKSLYEIDFP-KKVALVFGNEGTGLSNEVLELCDRLVRIPMSGD-VESLNVAVAAAIAL 141
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 65-192 1.36e-21

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 90.64  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVGKRKKEINffGN-----MGTYDYITIEYFDNIYELKEYLTKHDILLYACeisvnALSITT 139
Cdd:COG0566  128 NLGAILRSAAAFGVDGVILPKRRADPYN--PKvvrasAGALFHVPVARVTNLADALEELKEAGFWVVGT-----DLDGEA 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124802753 140 NPYE---HKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGkGTASLNVSVSCAIIL 192
Cdd:COG0566  201 SLYEvdlPGPVALVLGNEGKGLSRLVLEACDELVRIPMAG-GVESLNVAVAAAILL 255
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 39-192 8.68e-13

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 65.83  E-value: 8.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753   39 INDKLKKDSYEKIKTYVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKEIN---FFGNMGTYDYITIEYFDNIYELK 115
Cdd:TIGR00186  77 LNDLYKTAKSKKQPFLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNstvVKTSSGAVEYVPLARVTNLSRTI 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  116 EYLTKHDILLYACEISVNALSittnpYEHKDT---AFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:TIGR00186 157 TKLKESGFWTVGTDLDAQDTL-----YQVKLTkplALVVGNEGEGVSRLIKENCDFLIKIPMAGK-VDSLNVSVAAGILL 230
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 62-192 9.63e-11

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 60.01  E-value: 9.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  62 KKKNVGCIVRSCVAFNVHKIFIVGKrKKEINFFGN--MGTYDYITIEYFDNIYELKEYLTKHDILLYACEISVNALSITT 139
Cdd:PRK11081  29 KPHNVSAIIRTADAVGVHEVHAVWP-GSRMRTMGStaAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDTAVDFRE 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124802753 140 NPYEhKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:PRK11081 108 IDYT-RPTCILMGQEKTGISQEALALADQDIIIPMIGM-VQSLNVSVASALIL 158
 
Name Accession Description Interval E-value
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 53-195 1.10e-69

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 210.92  E-value: 1.10e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  53 TYVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKkeINFFGNMGTYDYITIEYFDNIYELKEYLTKHDILLYACEISV 132
Cdd:cd18096    1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVHLVGRRK--FNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIVP 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 133 NALSITTNPYeHKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTASLNVSVSCAIILQNF 195
Cdd:cd18096   79 GAEPIETHPF-PGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGSGTASLNVSVAASIVLHHF 140
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 54-192 1.81e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 131.11  E-value: 1.81e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753   54 YVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKEINFF----GNMGTYDYITIEYFDNIYELKEYLTKHDILLYACe 129
Cdd:pfam00588   3 VVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPkairASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753  130 iSVNALSITTNPYEhKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:pfam00588  82 -SLGGKSLYEIDFP-KKVALVFGNEGTGLSNEVLELCDRLVRIPMSGD-VESLNVAVAAAIAL 141
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 54-195 4.25e-31

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 112.32  E-value: 4.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  54 YVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVG--------KRKKeinffGNMGTYDYITIEYFDNIYELKEYLTKHDILL 125
Cdd:cd18082    1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYLVGptadifdpKAKR-----TSRGTHFSVPYERVDNFEEYLKSLKEEGYPL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124802753 126 YACEISVNALSIT-TNPYEHKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIILQNF 195
Cdd:cd18082   76 IGLELTDGSIPLSeFKFKKPKKIALIFGNERSGLSPELLALCDYTVHIPMSGK-NSSLNVSVATGIALYEF 145
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 55-193 1.16e-25

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 98.69  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  55 VVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKeinFFGN----MGTYDYITIEYFDNIYELKEYLTKHDILLYACEI 130
Cdd:cd18092   19 VVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNK---FKKNrgvaMGADKWLDVHRHDSTEECLAALKEQGYRIVATSL 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 131 SVNALSITTNPYEHKdTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIILQ 193
Cdd:cd18092   96 SPDAVPLDELDYTRP-TALVFGNEKDGVSEEALAAADERVYIPMYGF-VESLNVSVAAAIILY 156
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 65-192 1.46e-24

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 95.14  E-value: 1.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVGKRKKEINffGNM-----GTYDYITIEYFDNIYELKEYLTKHDILLYACEISvNALSITT 139
Cdd:cd18103   13 NLGAIIRSAEAFGVDGVIIPKRRSAPLT--PTVakasaGALEHLPIARVTNLARALEELKEAGFWIYGADGE-AEKSLYD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124802753 140 NPYEHKdTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:cd18103   90 VDLTGP-LALVLGSEGKGLRRLVLKNCDFLVKIPMAGK-VDSLNVSVAAGIIL 140
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 65-192 8.41e-24

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 93.26  E-value: 8.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVgkrKKEINFFGN------MGTYDYITIEYFDNIYELKEYLTKHDILLYAceISVNALSIT 138
Cdd:cd18095   13 NLGTIIRTAAAFGVDGVILS---KGTVDPYNPkvvrasMGALFRLPIIRVDDLEELLEELKEAGYKVVA--ADLDGGSSL 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 124802753 139 TNPYEHKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:cd18095   88 YDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGG-VESLNVAVAAAILL 140
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 54-192 1.42e-23

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 92.63  E-value: 1.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  54 YVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVG--------KRKKEinffgNMGTYDYITIEYFDNIYELKEYLTKHDILL 125
Cdd:cd18097    2 VVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGytptpphpKVAKT-----ALGAEESVPWEHFEDTLEAVRALKARGYTI 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124802753 126 YACEISVNALSITTNPYEhKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTaSLNVSVSCAIIL 192
Cdd:cd18097   77 IALETTENSVPLHEARLP-RPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKN-SLNVAVAAAVAL 141
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 65-192 1.36e-21

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 90.64  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVGKRKKEINffGN-----MGTYDYITIEYFDNIYELKEYLTKHDILLYACeisvnALSITT 139
Cdd:COG0566  128 NLGAILRSAAAFGVDGVILPKRRADPYN--PKvvrasAGALFHVPVARVTNLADALEELKEAGFWVVGT-----DLDGEA 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124802753 140 NPYE---HKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGkGTASLNVSVSCAIIL 192
Cdd:COG0566  201 SLYEvdlPGPVALVLGNEGKGLSRLVLEACDELVRIPMAG-GVESLNVAVAAAILL 255
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 65-195 2.22e-16

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 74.09  E-value: 2.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVGKRKKEINffGNM-----GTYDYITIEYFDNIYELKEYLTKHDILLYA--CEISVNALSI 137
Cdd:cd18105   13 NLGAILRSAYFLGVDGVVVSSKNSAPLS--PVVskasaGALELMPIYSVDNLASFLKSSKENGWKVVGtsAPPSASSDKK 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124802753 138 TTNPYE------HKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTA----SLNVSVSCAIILQNF 195
Cdd:cd18105   91 TIPANElselllEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAENpgvdSLNVSVAAGILLHSL 158
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 65-195 5.87e-15

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 69.88  E-value: 5.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIvgkRKKEINFFG------NMGTYDYITIEYFDNIYELKEYltKHDILLYACeiSVNALSIT 138
Cdd:cd18109   13 NLGTIIRTADWFGIRQIIC---SPDTVDPYNpkvvqaSMGSIFRVQIHYTDLPALLAEL--KKAFPVYGA--DLDGENLY 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124802753 139 TNPYEHKdTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKGTASLNVSVSCAIILQNF 195
Cdd:cd18109   86 EFTLPEK-GILVMGNEGHGISPEVLKLLTHRLTIPRYGKGAESLNVAVATAILLSEF 141
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 57-192 3.36e-14

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 67.67  E-value: 3.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  57 IYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKE-------INFFGNMGTYDYITIEyfdniyELKEYLTkHDILLYACE 129
Cdd:cd18098    5 IENPKTPKNVGTLWRAAGCLGASFVFTIGARYKRrkqstdtSKAWRHIPLFHYDDLE------DLAEPLP-FGAVLVAVE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124802753 130 ISVNALSITTnpYEHKDTAF-LFGNEGTGIHDNVLKICDKIIYIPqygkGTASLNVSVSCAIIL 192
Cdd:cd18098   78 LTEGATPLPD--FKHPDRAVyLLGPEDGGLPQEVLARCHHVVYLP----TRGSLNVAVAGSIVL 135
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 39-192 8.68e-13

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 65.83  E-value: 8.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753   39 INDKLKKDSYEKIKTYVVIYNIGKKKNVGCIVRSCVAFNVHKIFIVGKRKKEIN---FFGNMGTYDYITIEYFDNIYELK 115
Cdd:TIGR00186  77 LNDLYKTAKSKKQPFLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNstvVKTSSGAVEYVPLARVTNLSRTI 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  116 EYLTKHDILLYACEISVNALSittnpYEHKDT---AFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:TIGR00186 157 TKLKESGFWTVGTDLDAQDTL-----YQVKLTkplALVVGNEGEGVSRLIKENCDFLIKIPMAGK-VDSLNVSVAAGILL 230
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 65-192 1.64e-12

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 63.24  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVhKIFIVG-----------KRkkeinffGNMGTYDYITIEYFDNIYELKEYLTKHDILLyaceISVN 133
Cdd:cd18094   12 NTGNIARTCAATGA-RLHLIEplgfslddkrlKR-------AGLDYWDHVDLTVHDSWEAFLEALPPGRLFL----FTTK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 134 AlsiTTNPYEHK---DTAFLFGNEGTGIHDNVLKIC-DKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:cd18094   80 G---TKPYTDFDfkpGDYLVFGRESTGLPEEILDAFpDRRLRIPMRPK-VRSLNLSNSVAIVL 138
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 60-192 1.98e-12

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 62.93  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  60 IGKKKNVGCIVRSCVAFNVHKIFIVGKRKKEINFFGN--MGTYDYITIEYfDNIYELKEYLTK---HDILLYACEISVNA 134
Cdd:cd18091    8 IDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKAlsVSAEKWLPIEE-VKPEDLLPYLKEkkqEGYTIVGLEQTANS 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124802753 135 LSITTNPYEHKdTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:cd18091   87 VSLHDFQFPKK-TVLVLGNEKEGIPAELLSLLDVCVEIPQLGV-IRSLNVHVSGAIAI 142
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 62-192 9.63e-11

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 60.01  E-value: 9.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  62 KKKNVGCIVRSCVAFNVHKIFIVGKrKKEINFFGN--MGTYDYITIEYFDNIYELKEYLTKHDILLYACEISVNALSITT 139
Cdd:PRK11081  29 KPHNVSAIIRTADAVGVHEVHAVWP-GSRMRTMGStaAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDTAVDFRE 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124802753 140 NPYEhKDTAFLFGNEGTGIHDNVLKICDKIIYIPQYGKgTASLNVSVSCAIIL 192
Cdd:PRK11081 108 IDYT-RPTCILMGQEKTGISQEALALADQDIIIPMIGM-VQSLNVSVASALIL 158
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 65-192 1.95e-08

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 51.96  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNV--HkifIVG-----------KRKkeinffGnMGTYDYITIEYFDNIYELKEYLTKHDILLyaceIS 131
Cdd:COG0219   14 NTGNIIRLCAATGArlH---LIEplgfslddkklKRA------G-LDYWELVDLTVHDSWEAFLEALPGGRLFL----FT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124802753 132 VNA-LSITTNPYEHKDtAFLFGNEGTGIHDNVLKI-CDKIIYIPQYGkGTASLNVSVSCAIIL 192
Cdd:COG0219   80 TKGtKPYTDVDYQPGD-VLLFGRETAGLPEEVLAApADQRLRIPMRP-GVRSLNLSNAVAIVL 140
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 65-192 8.36e-06

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 44.41  E-value: 8.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  65 NVGCIVRSCVAFNVHKIFIVGKRKKEIN---FFGNMGTYDYI-TIEYFDNiyeLKEYLtkHDI-LLYAC----------- 128
Cdd:cd18093   13 NIGAVARAMKNFGLSDLRLVNPRCDDPEeaaRALASGAEDVLeNAKVYDT---LEEAL--ADCdLVVATtarprglrrpl 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124802753 129 EISVNALSITTNPYEHKDTAFLFGNEGTGIHDNVLKICDKIIYIP---QYGkgtaSLNVSVSCAIIL 192
Cdd:cd18093   88 LTPRELAELLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTIPtnpEYP----SLNLAQAVAIVL 150
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 55-192 1.79e-03

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 37.62  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124802753  55 VVIYNIGKKKNVGCIVRSCVAFNVHKIfIVGK------RKKEINffGNMGTYDYITIEYFDNIYELKEYLTKHDILLYAc 128
Cdd:cd18106    3 VICDNIRDPGNLGSILRSAAAAGCSKV-LLTKgcvdpwEPKVLR--AGAGAHFRLPIYGNLSWDDIPNYLPDDSKVFLA- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124802753 129 EISVNALSITTNPYEHKDTAFLFGNEGTGIHDNVLKICD----KIIYIPqYGKGTASLNVSVSCAIIL 192
Cdd:cd18106   79 DNNLPVQPYDSIDYCSGPIVLVIGGETHGVSPEAYKLAHstggSRVHIP-LANGVDSLNSAVAASILL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH