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Conserved domains on  [gi|124512556|ref|XP_001349411|]
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histone-arginine methyltransferase CARM1, putative [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
516-679 6.48e-20

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 89.71  E-value: 6.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 516 HRTMILDKCRTQCYYDFINKNkeIFENKIVLDIGCGSSIISLFCSDY-AKVVVGIDNAEKILEKAKKITEINKAkniylf 594
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGL------ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 595 kgkleDHNIYVDEKNEIyylnkDLDIETfeksnnvklkilKFDIIISEWMGYFLFYECMINTILYARDKYLKENGYIFPN 674
Cdd:COG4076   84 -----SDRITVINADAT-----DLDLPE------------KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPE 141


                 ....*
gi 124512556 675 KIYLY 679
Cdd:COG4076  142 RITNA 146
zf-C4H2 super family cl24228
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 363-467 2.76e-03

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


The actual alignment was detected with superfamily member pfam10146:

Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 40.05  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556  363 KNYtgNKIEESILIEKFVQSsqsdhEEINNLHKKINSMEQIIKHLMNEIIKRDMTKKKKNESIHVMKNDSshNTNKHEYN 442
Cdd:pfam10146  34 KEY--KKEMELLLQEKMAHV-----EELRLIHADINKMEKVIKEAEEERNRVLEGAVRLHEEYIPLKLEI--DRMRRELL 104

                          90       100
                  ....*....|....*....|....*
gi 124512556  443 NvlCCKQNSIHDTYEKEIQTDNIEQ 467
Cdd:pfam10146 105 G--LEELPLLHEEEEDLIQTTIFEK 127
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
516-679 6.48e-20

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 89.71  E-value: 6.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 516 HRTMILDKCRTQCYYDFINKNkeIFENKIVLDIGCGSSIISLFCSDY-AKVVVGIDNAEKILEKAKKITEINKAkniylf 594
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGL------ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 595 kgkleDHNIYVDEKNEIyylnkDLDIETfeksnnvklkilKFDIIISEWMGYFLFYECMINTILYARDKYLKENGYIFPN 674
Cdd:COG4076   84 -----SDRITVINADAT-----DLDLPE------------KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPE 141


                 ....*
gi 124512556 675 KIYLY 679
Cdd:COG4076  142 RITNA 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 545-672 1.62e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 545 VLDIGCGSSIISL-FCSDYAKVVVGIDNAEKILEKAKKITEINKAKNIYLFKGKLEDHNIYVDEkneiyylnkdldietf 623
Cdd:cd02440    2 VLDLGCGTGALALaLASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADE---------------- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124512556 624 eksnnvklkilKFDIIISEWMGYFLF--YECMINTILyardKYLKENGYIF 672
Cdd:cd02440   66 -----------SFDVIISDPPLHHLVedLARFLEEAR----RLLKPGGVLV 101
PRK14968 PRK14968
putative methyltransferase; Provisional
 541-590 1.75e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.35  E-value: 1.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124512556 541 ENKIVLDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKKITEINKAKN 590
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRN 72
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 545-581 3.16e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.62  E-value: 3.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124512556  545 VLDIGCGSSIISLFCSDYAKV-VVGIDNAEKILEKAKK 581
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGArVTGVDLSPEMLERARE 38
zf-C4H2 pfam10146
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 363-467 2.76e-03

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 40.05  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556  363 KNYtgNKIEESILIEKFVQSsqsdhEEINNLHKKINSMEQIIKHLMNEIIKRDMTKKKKNESIHVMKNDSshNTNKHEYN 442
Cdd:pfam10146  34 KEY--KKEMELLLQEKMAHV-----EELRLIHADINKMEKVIKEAEEERNRVLEGAVRLHEEYIPLKLEI--DRMRRELL 104

                          90       100
                  ....*....|....*....|....*
gi 124512556  443 NvlCCKQNSIHDTYEKEIQTDNIEQ 467
Cdd:pfam10146 105 G--LEELPLLHEEEEDLIQTTIFEK 127
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
516-679 6.48e-20

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 89.71  E-value: 6.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 516 HRTMILDKCRTQCYYDFINKNkeIFENKIVLDIGCGSSIISLFCSDY-AKVVVGIDNAEKILEKAKKITEINKAkniylf 594
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGL------ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 595 kgkleDHNIYVDEKNEIyylnkDLDIETfeksnnvklkilKFDIIISEWMGYFLFYECMINTILYARDKYLKENGYIFPN 674
Cdd:COG4076   84 -----SDRITVINADAT-----DLDLPE------------KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPE 141


                 ....*
gi 124512556 675 KIYLY 679
Cdd:COG4076  142 RITNA 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 545-672 1.62e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 545 VLDIGCGSSIISL-FCSDYAKVVVGIDNAEKILEKAKKITEINKAKNIYLFKGKLEDHNIYVDEkneiyylnkdldietf 623
Cdd:cd02440    2 VLDLGCGTGALALaLASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADE---------------- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124512556 624 eksnnvklkilKFDIIISEWMGYFLF--YECMINTILyardKYLKENGYIF 672
Cdd:cd02440   66 -----------SFDVIISDPPLHHLVedLARFLEEAR----RLLKPGGVLV 101
PRK14968 PRK14968
putative methyltransferase; Provisional
 541-590 1.75e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.35  E-value: 1.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124512556 541 ENKIVLDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKKITEINKAKN 590
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRN 72
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 545-581 3.16e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.62  E-value: 3.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124512556  545 VLDIGCGSSIISLFCSDYAKV-VVGIDNAEKILEKAKK 581
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGArVTGVDLSPEMLERARE 38
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 546-581 1.02e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.19  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124512556  546 LDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKK 581
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELARE 36
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 539-641 2.15e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.71  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556  539 IFENKIVLDIGCGSSIISLFCSDYA---KVVVGIDNAEKILEKAKKITEINKAKNIYLFKGkledhniyvdekneiyyln 615
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQG------------------- 61

                          90       100
                  ....*....|....*....|....*.
gi 124512556  616 kdlDIETFEKSnnvkLKILKFDIIIS 641
Cdd:pfam13847  62 ---DIEELPEL----LEDDKFDVVIS 80
zf-C4H2 pfam10146
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 363-467 2.76e-03

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 40.05  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556  363 KNYtgNKIEESILIEKFVQSsqsdhEEINNLHKKINSMEQIIKHLMNEIIKRDMTKKKKNESIHVMKNDSshNTNKHEYN 442
Cdd:pfam10146  34 KEY--KKEMELLLQEKMAHV-----EELRLIHADINKMEKVIKEAEEERNRVLEGAVRLHEEYIPLKLEI--DRMRRELL 104

                          90       100
                  ....*....|....*....|....*
gi 124512556  443 NvlCCKQNSIHDTYEKEIQTDNIEQ 467
Cdd:pfam10146 105 G--LEELPLLHEEEEDLIQTTIFEK 127
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 545-600 3.23e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 38.46  E-value: 3.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124512556 545 VLDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKKITEinkAKNIYLFKGKLED 600
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAA---ELNVDFVQGDLED 80
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 541-600 5.43e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 40.16  E-value: 5.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512556 541 ENKIVLDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKKITEINKAKNIYLFKGKLED 600
Cdd:COG2265  233 GGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEE 292
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 541-581 7.33e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 38.05  E-value: 7.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 124512556 541 ENKIVLDIGCGSSIISLFCSDYAKVVVGIDNAEKILEKAKK 581
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARE 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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