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Conserved domains on  [gi|124801080|ref|XP_001349607|]
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ATP-dependent RNA helicase UAP56 [Plasmodium falciparum 3D7]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13028696)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 55-282 7.15e-127

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 366.29  E-value: 7.15e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  55 GGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnnd 134
Cdd:cd17950    2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQ----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKeDNIPHIIIGTPGRILALIREK 214
Cdd:cd17950   71 ---------VSVLVICHTRELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLK-NKCPHIVVGTPGRILALVREK 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 215 YLITDKIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd17950  141 KLKLSHVKHFVLDECDKMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 293-422 6.94e-53

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 173.85  E-value: 6.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 293 LLQHYVKLQEKDKTRKLI-EILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRI 371
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124801080 372 LVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFV 422
Cdd:cd18787   81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
 
Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 55-282 7.15e-127

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 366.29  E-value: 7.15e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  55 GGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnnd 134
Cdd:cd17950    2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQ----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKeDNIPHIIIGTPGRILALIREK 214
Cdd:cd17950   71 ---------VSVLVICHTRELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLK-NKCPHIVVGTPGRILALVREK 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 215 YLITDKIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd17950  141 KLKLSHVKHFVLDECDKMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
57-426 1.45e-124

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 368.32  E-value: 1.45e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENqdmqdtkemnndnn 136
Cdd:COG0513    4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRP-------------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:COG0513   70 -----RAPQALILAPTRELALQVAEELRKLAKYL-GLRVATVYGGVSIGRQIRALKRG--VDIVVATPGRLLDLIERGAL 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLeklDM--RSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKlKLHGLL 294
Cdd:COG0513  142 DLSGVETLVLDEADRML---DMgfIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENA-TAETIE 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 295 QHYVKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVS 374
Cdd:COG0513  218 QRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVA 297

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124801080 375 TDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQE 426
Cdd:COG0513  298 TDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDE 349
PTZ00424 PTZ00424
helicase 45; Provisional
 57-449 1.10e-76

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 244.74  E-value: 1.10e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnn 136
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNA------------- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGRILALIREKYL 216
Cdd:PTZ00424  97 -------CQALILAPTRELAQQIQKVVLALGDYLK-VRCHACVGGTVVRDDINKLKAGV--HMVVGTPGRVYDMIDKRHL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEaKLKLHGLLQH 296
Cdd:PTZ00424 167 RVDDLKLFILDEADEMLSR-GFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKD-ELTLEGIRQF 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 297 YVKLQEKD-KTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVST 375
Cdd:PTZ00424 245 YVAVEKEEwKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITT 324

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 376 DLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSqEDTLALNEVQTRFEVAISEMPNKI 449
Cdd:PTZ00424 325 DLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTP-DDIEQLKEIERHYNTQIEEMPMEV 397
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 293-422 6.94e-53

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 173.85  E-value: 6.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 293 LLQHYVKLQEKDKTRKLI-EILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRI 371
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124801080 372 LVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFV 422
Cdd:cd18787   81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 79-269 7.15e-40

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 140.84  E-value: 7.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   79 SEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngdnkfVRCLGLAHTRELAYQ 158
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNG--------------------PQALVLAPTRELAEQ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  159 IKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEdniPHIIIGTPGRILALIREKYLItDKIQHFVLDECDKCLEKlDM 238
Cdd:pfam00270  61 IYEELKKLGKGL-GLKVASLLGGDSRKEQLEKLKG---PDILVGTPGRLLDLLQERKLL-KNLKLLVLDEAHRLLDM-GF 134

                         170       180       190
                  ....*....|....*....|....*....|.
gi 124801080  239 RSDVQKIFISTPLKKQVMFFSATMAKEMRDV 269
Cdd:pfam00270 135 GPDLEEILRRLPKKRQILLLSATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
70-280 3.17e-36

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 132.23  E-value: 3.17e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080    70 ISESGFEHPSEVQQETIPAAITGT-DILCQAKSGMGKTAVFVLSILQQLDTNenqdmqdtkemnndnnnngdnKFVRCLG 148
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRG---------------------KGGRVLV 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   149 LAHTRELAYQIKNEFDRFSKYLKNVRCeVVYGGISMNKHIKLFKEDNiPHIIIGTPGRILALIREKYLITDKIQHFVLDE 228
Cdd:smart00487  60 LVPTRELAEQWAEELKKLGPSLGLKVV-GLYGGDSKREQLRKLESGK-TDILVTTPGRLLDLLENDKLSLSNVDLVILDE 137

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 124801080   229 CDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:smart00487 138 AHRLLDG-GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFI 188
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 304-413 9.62e-33

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 120.01  E-value: 9.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  304 DKTRKLIEILDALEFNQVIIFVKSVtRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGID 383
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTK-KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 124801080  384 IERVNIVINYDMPENSDSYLHRVGRAGRFG 413
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
333-413 4.72e-28

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 106.14  E-value: 4.72e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   333 TLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRF 412
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81


                   .
gi 124801080   413 G 413
Cdd:smart00490  82 G 82
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
298-425 2.41e-15

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 77.87  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 298 VKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDL 377
Cdd:COG0514  210 VPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIA 289

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124801080 378 FGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQ 425
Cdd:COG0514  290 FGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPE 337
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 347-421 1.42e-09

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 60.11  E-value: 1.42e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 347 AIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTF 421
Cdd:PRK11057 265 AYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLF 339
 
Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 55-282 7.15e-127

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 366.29  E-value: 7.15e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  55 GGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnnd 134
Cdd:cd17950    2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQ----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKeDNIPHIIIGTPGRILALIREK 214
Cdd:cd17950   71 ---------VSVLVICHTRELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLK-NKCPHIVVGTPGRILALVREK 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 215 YLITDKIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd17950  141 KLKLSHVKHFVLDECDKMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
57-426 1.45e-124

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 368.32  E-value: 1.45e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENqdmqdtkemnndnn 136
Cdd:COG0513    4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRP-------------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:COG0513   70 -----RAPQALILAPTRELALQVAEELRKLAKYL-GLRVATVYGGVSIGRQIRALKRG--VDIVVATPGRLLDLIERGAL 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLeklDM--RSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKlKLHGLL 294
Cdd:COG0513  142 DLSGVETLVLDEADRML---DMgfIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENA-TAETIE 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 295 QHYVKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVS 374
Cdd:COG0513  218 QRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVA 297

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124801080 375 TDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQE 426
Cdd:COG0513  298 TDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDE 349
PTZ00424 PTZ00424
helicase 45; Provisional
 57-449 1.10e-76

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 244.74  E-value: 1.10e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnn 136
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNA------------- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGRILALIREKYL 216
Cdd:PTZ00424  97 -------CQALILAPTRELAQQIQKVVLALGDYLK-VRCHACVGGTVVRDDINKLKAGV--HMVVGTPGRVYDMIDKRHL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEaKLKLHGLLQH 296
Cdd:PTZ00424 167 RVDDLKLFILDEADEMLSR-GFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKD-ELTLEGIRQF 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 297 YVKLQEKD-KTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVST 375
Cdd:PTZ00424 245 YVAVEKEEwKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITT 324

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 376 DLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSqEDTLALNEVQTRFEVAISEMPNKI 449
Cdd:PTZ00424 325 DLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTP-DDIEQLKEIERHYNTQIEEMPMEV 397
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 66-280 2.44e-70

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 221.16  E-value: 2.44e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngDNKFVR 145
Cdd:cd00268    1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKK----------------KGRGPQ 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGISMNKHIKLFKedNIPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd00268   65 ALVLAPTRELAMQIAEVARKLGKG-TGLKVAAIYGGAPIKKQIEALK--KGPDIVVGTPGRLLDLIERGKLDLSNVKYLV 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 226 LDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd00268  142 LDEADRMLD-MGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 57-422 5.58e-68

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 223.28  E-value: 5.58e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenQDMQDTKEmnndnn 136
Cdd:PRK11192   3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHL-----LDFPRRKS------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnKFVRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGRILALIREKYL 216
Cdd:PRK11192  72 -----GPPRILILTPTRELAMQVADQARELAKHTH-LDIATITGGVAYMNHAEVFSENQ--DIVVATPGRLLQYIKEENF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKcleKLDM--RSDVQKIFISTPLKKQVMFFSATMAKE-MRDVCKKFLQNPVEIfiDDEA----KLK 289
Cdd:PRK11192 144 DCRAVETLILDEADR---MLDMgfAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEV--EAEPsrreRKK 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 290 LHgllQHYVKLQEKD-KTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFE 368
Cdd:PRK11192 219 IH---QWYYRADDLEhKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGR 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 124801080 369 NRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFV 422
Cdd:PRK11192 296 VNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 57-447 3.89e-67

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 225.88  E-value: 3.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNenqdmqdtkemnndnn 136
Cdd:PRK11634   8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPE---------------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdNKFVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:PRK11634  72 ----LKAPQILVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQG--PQIVVGTPGRLLDHLKRGTL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLeKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKLKlHGLLQH 296
Cdd:PRK11634 146 DLSKLSGLVLDEADEML-RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTR-PDISQS 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 297 YVKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTD 376
Cdd:PRK11634 224 YWTVWGMRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATD 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124801080 377 LFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQEDTLALN-EVQTRFEVAISEMPN 447
Cdd:PRK11634 304 VAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNiERTMKLTIPEVELPN 375
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 62-426 4.14e-63

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 211.20  E-value: 4.14e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTnenqdmqdtkemnndnnnngdn 141
Cdd:PRK11776  11 LPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDV---------------------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 142 KFVRC--LGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITD 219
Cdd:PRK11776  69 KRFRVqaLVLCPTRELADQVAKEIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHG--AHIIVGTPGRILDHLRKGTLDLD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 220 KIQHFVLDECDKcleKLDM--RSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEaklklHGLL--- 294
Cdd:PRK11776 147 ALNTLVLDEADR---MLDMgfQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVEST-----HDLPaie 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 295 QHYVKLQEKDKTRKLIEILDALEFNQVIIF--VKSVTRAITldKLLTECNFPSIAIHGGLEQQERieryDK-FKKFENR- 370
Cdd:PRK11776 219 QRFYEVSPDERLPALQRLLLHHQPESCVVFcnTKKECQEVA--DALNAQGFSALALHGDLEQRDR----DQvLVRFANRs 292

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 371 --ILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQE 426
Cdd:PRK11776 293 csVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEE 350
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 57-429 4.32e-63

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 211.21  E-value: 4.32e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQdtkemnndnn 136
Cdd:PRK10590   3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKG---------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdNKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKhiKLFKEDNIPHIIIGTPGRILALIREKYL 216
Cdd:PRK10590  73 ----RRPVRALILTPTRELAAQIGENVRDYSKYL-NIRSLVVFGGVSINP--QMMKLRGGVDVLVATPGRLLDLEHQNAV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKcleKLDMR--SDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI--DDEAKLKLHG 292
Cdd:PRK10590 146 KLDQVEILVLDEADR---MLDMGfiHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVarRNTASEQVTQ 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 293 LLqHYVklqekDKTRKLiEILDAL----EFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFE 368
Cdd:PRK10590 223 HV-HFV-----DKKRKR-ELLSQMigkgNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGD 295

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124801080 369 NRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQEDTL 429
Cdd:PRK10590 296 IRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKL 356
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 56-446 2.55e-59

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 201.68  E-value: 2.55e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  56 GFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKEmnndn 135
Cdd:PRK01297  88 RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGE----- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 136 nnngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLK-NVRCEVvyGGISMNKHIKLFkEDNIPHIIIGTPGRILALIREK 214
Cdd:PRK01297 163 --------PRALIIAPTRELVVQIAKDAAALTKYTGlNVMTFV--GGMDFDKQLKQL-EARFCDILVATPGRLLDFNQRG 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 215 YLITDKIQHFVLDECDKCLeklDMR--SDVQKIFISTPLK--KQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKLKl 290
Cdd:PRK01297 232 EVHLDMVEVMVLDEADRML---DMGfiPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVAS- 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 291 HGLLQHYVKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENR 370
Cdd:PRK01297 308 DTVEQHVYAVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIR 387

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124801080 371 ILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFvSSQEDTLALNEVQTRFEVAIS-EMP 446
Cdd:PRK01297 388 VLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF-AGEDDAFQLPEIEELLGRKIScEMP 463
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 293-422 6.94e-53

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 173.85  E-value: 6.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 293 LLQHYVKLQEKDKTRKLI-EILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRI 371
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124801080 372 LVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFV 422
Cdd:cd18787   81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
PTZ00110 PTZ00110
helicase; Provisional
 56-430 2.65e-52

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 184.59  E-value: 2.65e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  56 GFKDFFLKpellrAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKemnndn 135
Cdd:PTZ00110 136 SFPDYILK-----SLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGDGP------ 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 136 nnngdnkfvRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISmnKHIKLFKEDNIPHIIIGTPGRILALIREKY 215
Cdd:PTZ00110 205 ---------IVLVLAPTRELAEQIREQCNKFGASSK-IRNTVAYGGVP--KRGQIYALRRGVEILIACPGRLIDFLESNV 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 216 LITDKIQHFVLDECDKcleKLDMRSDVQ--KIFISTPLKKQVMFFSATMAKEM----RDVCKkflQNPVEIFIDDEAKLK 289
Cdd:PTZ00110 273 TNLRRVTYLVLDEADR---MLDMGFEPQirKIVSQIRPDRQTLMWSATWPKEVqslaRDLCK---EEPVHVNVGSLDLTA 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 290 LHGLLQHYVKLQEKDKTRKLIEILDAL--EFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKF 367
Cdd:PTZ00110 347 CHNIKQEVFVVEEHEKRGKLKMLLQRImrDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTG 426

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 368 ENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQEDTLA 430
Cdd:PTZ00110 427 KSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLA 489
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 59-281 5.90e-51

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 171.35  E-value: 5.90e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  59 DFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnn 138
Cdd:cd17939    1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRE--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 139 gdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLIT 218
Cdd:cd17939   66 -----TQALVLAPTRELAQQIQKVVKALGDYM-GVKVHACIGGTSVREDRRKLQYG--PHIVVGTPGRVFDMLQRRSLRT 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 219 DKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIF 281
Cdd:cd17939  138 DKIKMFVLDEADEMLSR-GFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 57-280 2.05e-50

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 169.79  E-value: 2.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnn 136
Cdd:cd17940    1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDV------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:cd17940   68 -------IQALILVPTRELALQTSQVCKELGKHMG-VKVMVTTGGTSLRDDIMRLYQT--VHVLVGTPGRILDLAKKGVA 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 217 ITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17940  138 DLSHCKTLVLDEADKLLSQ-DFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 57-280 1.86e-47

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 162.23  E-value: 1.86e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNenqdmqdtkemnndnn 136
Cdd:cd18046    1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTS---------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdNKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:cd18046   65 ----LKATQALVLAPTRELAQQIQKVVMALGDYM-GIKCHACIGGTSVRDDAQKLQAG--PHIVVGTPGRVFDMINRRYL 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 217 ITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd18046  138 RTDYIKMFVLDEADEMLSR-GFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 57-429 1.06e-46

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 168.81  E-value: 1.06e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKEMNndnn 136
Cdd:PLN00206 123 FSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRNPL---- 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfvrCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKhiKLFKEDNIPHIIIGTPGRILALIREKYL 216
Cdd:PLN00206 199 ---------AMVLTPTRELCVQVEDQAKVLGKGLP-FKTALVVGGDAMPQ--QLYRIQQGVELIVGTPGRLIDLLSKHDI 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDkCLEKLDMRSDVQKIF--ISTPlkkQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKLKlHGLL 294
Cdd:PLN00206 267 ELDNVSVLVLDEVD-CMLERGFRDQVMQIFqaLSQP---QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPN-KAVK 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 295 QHYVKLQEKDKTRKLIEILDALEFNQ--VIIFVKS------VTRAITldkllTECNFPSIAIHGGLEQQERIERYDKFKK 366
Cdd:PLN00206 342 QLAIWVETKQKKQKLFDILKSKQHFKppAVVFVSSrlgadlLANAIT-----VVTGLKALSIHGEKSMKERREVMKSFLV 416

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 367 FENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQEDTL 429
Cdd:PLN00206 417 GEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNL 479
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 66-280 3.21e-46

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 158.58  E-value: 3.21e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngdnkfVR 145
Cdd:cd17943    1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRH--------------------PQ 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEdniPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd17943   61 VLILAPTREIAVQIHDVFKKIGKKLEGLKCEVFIGGTPVKEDKKKLKG---CHIAVGTPGRIKQLIELGALNVSHVRLFV 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 226 LDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17943  138 LDEADKLMEG-SFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 57-281 2.71e-44

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 153.92  E-value: 2.71e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenqdMQDTKEmnndnn 136
Cdd:cd17955    1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL-------SEDPYG------ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFkeDNIPHIIIGTPGRILALIR---- 212
Cdd:cd17955   68 -------IFALVLTPTRELAYQIAEQFRALGAPL-GLRCCVIVGGMDMVKQALEL--SKRPHIVVATPGRLADHLRssdd 137

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 213 -EKYLitDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIF 281
Cdd:cd17955  138 tTKVL--SRVKFLVLDEADRLLTG-SFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 57-280 6.02e-44

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 152.86  E-value: 6.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenqdMQDTKEMNndnn 136
Cdd:cd17954    2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL-------LENPQRFF---- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfvrCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKH-IKLFKEdniPHIIIGTPGRIL-ALIREK 214
Cdd:cd17954   71 ---------ALVLAPTRELAQQISEQFEALGSSI-GLKSAVLVGGMDMMAQaIALAKK---PHVIVATPGRLVdHLENTK 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124801080 215 YLITDKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17954  138 GFSLKSLKFLVMDEADRLLN-MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 57-446 6.02e-42

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 156.65  E-value: 6.02e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNE---NQDMQDTkemnn 133
Cdd:PRK04537  11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPalaDRKPEDP----- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 134 dnnnngdnkfvRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIRE 213
Cdd:PRK04537  86 -----------RALILAPTRELAIQIHKDAVKFGADL-GLRFALVYGGVDYDKQRELLQQG--VDVIIATPGRLIDYVKQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 214 KYLITDKIQHF-VLDECDKCLEkLDMRSDVQKIFISTPLK--KQVMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAkLKL 290
Cdd:PRK04537 152 HKVVSLHACEIcVLDEADRMFD-LGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETET-ITA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 291 HGLLQHYVKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENR 370
Cdd:PRK04537 230 ARVRQRIYFPADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLE 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124801080 371 ILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFvSSQEDTLALNEVQTRFEVAISEMP 446
Cdd:PRK04537 310 ILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF-ACERYAMSLPDIEAYIEQKIPVEP 384
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 57-421 6.48e-42

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 153.59  E-value: 6.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKEmnndnn 136
Cdd:PRK04837  10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVNQ------ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkfVRCLGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGISMNKHIKLFkeDNIPHIIIGTPGRILALIREKYL 216
Cdd:PRK04837  84 -------PRALIMAPTRELAVQIHADAEPLAQA-TGLKLGLAYGGDGYDKQLKVL--ESGVDILIGTTGRLIDYAKQNHI 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 217 ITDKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQ--VMFFSATMAKEMRDVCKKFLQNPVEIFIDDEAKLKlhgll 294
Cdd:PRK04837 154 NLGAIQVVVLDEADRMFD-LGFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTG----- 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 295 qHYVKlQE------KDKTRKLIEILDALEFNQVIIFV------KSVTRAITLDK----LLTecnfpsiaihGGLEQQERI 358
Cdd:PRK04837 228 -HRIK-EElfypsnEEKMRLLQTLIEEEWPDRAIIFAntkhrcEEIWGHLAADGhrvgLLT----------GDVAQKKRL 295

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 359 ERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTF 421
Cdd:PRK04837 296 RILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 79-269 7.15e-40

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 140.84  E-value: 7.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   79 SEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngdnkfVRCLGLAHTRELAYQ 158
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNG--------------------PQALVLAPTRELAEQ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  159 IKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEdniPHIIIGTPGRILALIREKYLItDKIQHFVLDECDKCLEKlDM 238
Cdd:pfam00270  61 IYEELKKLGKGL-GLKVASLLGGDSRKEQLEKLKG---PDILVGTPGRLLDLLQERKLL-KNLKLLVLDEAHRLLDM-GF 134

                         170       180       190
                  ....*....|....*....|....*....|.
gi 124801080  239 RSDVQKIFISTPLKKQVMFFSATMAKEMRDV 269
Cdd:pfam00270 135 GPDLEEILRRLPKKRQILLLSATLPRNLEDL 165
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 62-283 3.41e-38

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 138.10  E-value: 3.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAI-TGTDILCQAKSGMGKTAVFVLSILQQ-LDTNENQDMQDtkemnndnnnng 139
Cdd:cd17964    1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSlLNTKPAGRRSG------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 140 dnkfVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEDNiPHIIIGTPGRILALIREKYLITD 219
Cdd:cd17964   69 ----VSALIISPTRELALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRGR-PDILVATPGRLIDHLENPGVAKA 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124801080 220 --KIQHFVLDECDKClekLDM--RSDVQKIFISTPLKK----QVMFFSATMAKEMRDVCKKFLQNPVEiFID 283
Cdd:cd17964  144 ftDLDYLVLDEADRL---LDMgfRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTLKKDYK-FID 211
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 62-280 2.37e-37

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 135.01  E-value: 2.37e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAITGTD--ILCQAKSGMGKTAVFVLSILQQLDTNEnqdmqdtkemnndnnnng 139
Cdd:cd17963    1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPenLIAQSQSGTGKTAAFVLAMLSRVDPTL------------------ 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 140 dnKFVRCLGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGISMNKHiKLFKEdnipHIIIGTPGRILALIREKYLITD 219
Cdd:cd17963   63 --KSPQALCLAPTRELARQIGEVVEKMGKF-TGVKVALAVPGNDVPRG-KKITA----QIVIGTPGTVLDWLKKRQLDLK 134

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124801080 220 KIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17963  135 KIKILVLDEADVMLDTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 62-278 3.39e-37

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 135.02  E-value: 3.39e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDmqdtkemnndnnnnGDN 141
Cdd:cd17961    1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES--------------GEE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 142 KFVRCLGLAHTRELAYQIKNEFDRFSKYL-KNVRCEVVYGGISMNKHIKLFKEdnIPHIIIGTPGRILALIREKYLI-TD 219
Cdd:cd17961   67 QGTRALILVPTRELAQQVSKVLEQLTAYCrKDVRVVNLSASSSDSVQRALLAE--KPDIVVSTPARLLSHLESGSLLlLS 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 220 KIQHFVLDECDKCL----EkldmrSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPV 278
Cdd:cd17961  145 TLKYLVIDEADLVLsygyE-----EDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 66-281 4.93e-37

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 134.30  E-value: 4.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngdNKFVR 145
Cdd:cd17947    1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKK-----------------KAATR 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLIT-DKIQHF 224
Cdd:cd17947   64 VLVLVPTRELAMQCFSVLQQLAQF-TDITFALAVGGLSLKAQEAALRAR--PDIVIATPGRLIDHLRNSPSFDlDSIEIL 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124801080 225 VLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIF 281
Cdd:cd17947  141 VLDEADRMLE-EGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 57-278 1.01e-36

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 133.60  E-value: 1.01e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQqldtnenqdmqdtkemnndnn 136
Cdd:cd17938    1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ--------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkFVRCLGLAHTRELAYQIKNEFDRFSKYLKN--VRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGRILALIREK 214
Cdd:cd17938   60 ------IVVALILEPSRELAEQTYNCIENFKKYLDNpkLRVALLIGGVKAREQLKRLESGV--DIVVGTPGRLEDLIKTG 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124801080 215 YLITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTP------LKKQVMFFSATM-AKEMRDVCKKFLQNPV 278
Cdd:cd17938  132 KLDLSSVRFFVLDEADRLLSQ-GNLETINRIYNRIPkitsdgKRLQVIVCSATLhSFEVKKLADKIMHFPT 201
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 57-280 1.42e-36

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 133.36  E-value: 1.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNenqdmqdtkemnndnn 136
Cdd:cd18045    1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQ---------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdNKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKlfKEDNIPHIIIGTPGRILALIREKYL 216
Cdd:cd18045   65 ----VRETQALILSPTRELAVQIQKVLLALGDYM-NVQCHACIGGTSVGDDIR--KLDYGQHIVSGTPGRVFDMIRRRSL 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 217 ITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd18045  138 RTRHIKMLVLDEADEMLNK-GFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
DEXDc smart00487
DEAD-like helicases superfamily;
70-280 3.17e-36

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 132.23  E-value: 3.17e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080    70 ISESGFEHPSEVQQETIPAAITGT-DILCQAKSGMGKTAVFVLSILQQLDTNenqdmqdtkemnndnnnngdnKFVRCLG 148
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRG---------------------KGGRVLV 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   149 LAHTRELAYQIKNEFDRFSKYLKNVRCeVVYGGISMNKHIKLFKEDNiPHIIIGTPGRILALIREKYLITDKIQHFVLDE 228
Cdd:smart00487  60 LVPTRELAEQWAEELKKLGPSLGLKVV-GLYGGDSKREQLRKLESGK-TDILVTTPGRLLDLLENDKLSLSNVDLVILDE 137

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 124801080   229 CDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:smart00487 138 AHRLLDG-GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFI 188
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 55-280 5.91e-36

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 131.66  E-value: 5.91e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  55 GGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnnd 134
Cdd:cd17959    1 GGFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPT----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngdnKFVRCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREK 214
Cdd:cd17959   70 -------VGARALILSPTRELALQTLKVTKELGKFT-DLRTALLVGGDSLEEQFEALASN--PDIIIATPGRLLHLLVEM 139

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124801080 215 YLITDKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17959  140 NLKLSSVEYVVFDEADRLFE-MGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 66-280 1.98e-34

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 127.69  E-value: 1.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdTNENQDMQDTKemnndnnnngdnkfVR 145
Cdd:cd17960    1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL-LKRKANLKKGQ--------------VG 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRF-SKYLKNVRCEVVYGGISMNKHIKLFKEDNiPHIIIGTPGRILALIREKYLITDK--IQ 222
Cdd:cd17960   66 ALIISPTRELATQIYEVLQSFlEHHLPKLKCQLLIGGTNVEEDVKKFKRNG-PNILVGTPGRLEELLSRKADKVKVksLE 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 223 HFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17960  145 VLVLDEADRLLD-LGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 66-280 4.18e-34

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 127.44  E-value: 4.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKEMNndnnnngdnkfvR 145
Cdd:cd17945    1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGP------------Y 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKhiKLFKEDNIPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd17945   69 ALILAPTRELAQQIEEETQKFAKPL-GIRVVSIVGGHSIEE--QAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVV 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124801080 226 LDECDKcleKLDM--RSDVQKI--------------------FISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17945  146 LDEADR---MIDMgfEPQVTKIldampvsnkkpdteeaeklaASGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 66-282 5.87e-34

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 126.16  E-value: 5.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQdmqdtkemnndnnnngdnKFVR 145
Cdd:cd17957    1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKK------------------KGLR 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGismNKHIKLFKEDNIPH--IIIGTPGRILALIREKYLITDKIQH 223
Cdd:cd17957   63 ALILAPTRELASQIYRELLKLSKG-TGLRIVLLSKS---LEAKAKDGPKSITKydILVSTPLRLVFLLKQGPIDLSSVEY 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 224 FVLDECDKCLEKLdMRSDVQKIF-ISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd17957  139 LVLDEADKLFEPG-FREQTDEILaACTNPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 57-282 6.33e-34

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 126.83  E-value: 6.33e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdTNENQDMQDTKEMNNdnn 136
Cdd:cd17967    2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKL-LEDGPPSVGRGRRKA--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nngdnkFVRCLGLAHTRELAYQIKNEFDRFSkYLKNVRCEVVYGGISMNKHIKlfKEDNIPHIIIGTPGRILALIrEKYL 216
Cdd:cd17967   78 ------YPSALILAPTRELAIQIYEEARKFS-YRSGVRSVVVYGGADVVHQQL--QLLRGCDILVATPGRLVDFI-ERGR 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124801080 217 IT-DKIQHFVLDECDKcleKLDM--RSDVQKIFISTPL----KKQVMFFSATMAKEMRDVCKKFLQNpvEIFI 282
Cdd:cd17967  148 ISlSSIKFLVLDEADR---MLDMgfEPQIRKIVEHPDMppkgERQTLMFSATFPREIQRLAADFLKN--YIFL 215
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 304-413 9.62e-33

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 120.01  E-value: 9.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  304 DKTRKLIEILDALEFNQVIIFVKSVtRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGID 383
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTK-KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 124801080  384 IERVNIVINYDMPENSDSYLHRVGRAGRFG 413
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 67-282 9.53e-32

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 120.09  E-value: 9.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  67 LRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNenqdmQDTKEMNndnnnngdnkfVRC 146
Cdd:cd17941    2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRE-----RWTPEDG-----------LGA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 147 LGLAHTRELAYQIKNEFDRFSKYlKNVRCEVVYGGISMNKHIKLFKEDNIphiIIGTPGRILALIREK-YLITDKIQHFV 225
Cdd:cd17941   66 LIISPTRELAMQIFEVLRKVGKY-HSFSAGLIIGGKDVKEEKERINRMNI---LVCTPGRLLQHMDETpGFDTSNLQMLV 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124801080 226 LDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd17941  142 LDEADRILD-MGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 66-280 1.85e-31

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 119.44  E-value: 1.85e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenqdmQDTKEMNNDNNNNGdnkfvr 145
Cdd:cd17952    1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHI--------MDQRELEKGEGPIA------ 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 cLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd17952   67 -VIVAPTRELAQQIYLEAKKFGKAY-NLRVVAVYGGGSKWEQAKALQEG--AEIVVATPGRLIDMVKKKATNLQRVTYLV 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 226 LDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17952  143 LDEADRMFD-MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 66-280 3.14e-29

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 113.03  E-value: 3.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILqqldtnenqdmqdtkemnndnnnngdnkfVR 145
Cdd:cd17962    1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI-----------------------------IR 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLG---------LAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYL 216
Cdd:cd17962   52 CLTehrnpsaliLTPTRELAVQIEDQAKELMKGLPPMKTALLVGGLPLPPQLYRLQQG--VKVIIATPGRLLDILKQSSV 129

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 217 ITDKIQHFVLDECDkCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17962  130 ELDNIKIVVVDEAD-TMLKMGFQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 66-290 5.48e-29

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 113.87  E-value: 5.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAIT-GTDILCQAKSGMGKTAVFVLSILQQLdTNENQDMQDTKEmnndnnnngdNKFV 144
Cdd:cd17946    1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERL-LSQKSSNGVGGK----------QKPL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 145 RCLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITDKIQH- 223
Cdd:cd17946   70 RALILTPTRELAVQVKDHLKAIAKYT-NIKIASIVGGLAVQKQERLLKKR--PEIVVATPGRLWELIQEGNEHLANLKSl 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 224 --FVLDECDKCLEK---LDMRSDVQKIFISTPLKK---QVMFFSATMAKEMrDVCKKFLQNPVEIFIDDEAKLKL 290
Cdd:cd17946  147 rfLVLDEADRMLEKghfAELEKILELLNKDRAGKKrkrQTFVFSATLTLDH-QLPLKLNSKKKKKKKEKKQKLEL 220
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 62-282 9.08e-29

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 113.91  E-value: 9.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTN--ENQDMQDTKEmnndnnnng 139
Cdd:cd18052   50 LCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEglTASSFSEVQE--------- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 140 dnkfVRCLGLAHTRELAYQIKNEFDRFSkYLKNVRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGRILALIREKYLITD 219
Cdd:cd18052  121 ----PQALIVAPTRELANQIFLEARKFS-YGTCIRPVVVYGGVSVGHQIRQIEKGC--HILVATPGRLLDFIGRGKISLS 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124801080 220 KIQHFVLDECDKcleKLDM--RSDVQKI--FISTPLK--KQVMFFSATMAKEMRDVCKKFLqNPVEIFI 282
Cdd:cd18052  194 KLKYLILDEADR---MLDMgfGPEIRKLvsEPGMPSKedRQTLMFSATFPEEIQRLAAEFL-KEDYLFL 258
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 62-280 1.33e-28

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 112.47  E-value: 1.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenQDMQDTKEMNNDNNnngdn 141
Cdd:cd17953   19 LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHI-----KDQRPVKPGEGPIG----- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 142 kfvrcLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDNipHIIIGTPGR---ILALIREKYLIT 218
Cdd:cd17953   89 -----LIMAPTRELALQIYVECKKFSKAL-GLRVVCVYGGSGISEQIAELKRGA--EIVVCTPGRmidILTANNGRVTNL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124801080 219 DKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17953  161 RRVTYVVLDEADRMFD-MGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
HELICc smart00490
helicase superfamily c-terminal domain;
333-413 4.72e-28

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 106.14  E-value: 4.72e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080   333 TLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRF 412
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81


                   .
gi 124801080   413 G 413
Cdd:smart00490  82 G 82
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 53-276 5.35e-26

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 105.89  E-value: 5.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  53 HTGGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQdtkeMN 132
Cdd:cd18051   19 HIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGESL----PS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 133 NDNNNNGDNKFVRCLGLAHTRELAYQIKNEFDRFSkYLKNVRCEVVYGGISMNKHIKLFkeDNIPHIIIGTPGRILALIR 212
Cdd:cd18051   95 ESGYYGRRKQYPLALVLAPTRELASQIYDEARKFA-YRSRVRPCVVYGGADIGQQMRDL--ERGCHLLVATPGRLVDMLE 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 213 EKYLITDKIQHFVLDECDKcleKLDM------RSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQN 276
Cdd:cd18051  172 RGKIGLDYCKYLVLDEADR---MLDMgfepqiRRIVEQDTMPPTGERQTLMFSATFPKEIQMLARDFLDN 238
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 66-280 1.06e-25

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 103.60  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKemnndnnnngdnkfvR 145
Cdd:cd17966    1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGDGP---------------I 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd17966   66 VLVLAPTRELAQQIQQEANKFGGSS-RLRNTCVYGGAPKGPQIRDLRRG--VEICIATPGRLIDFLDQGKTNLRRVTYLV 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124801080 226 LDECDKcleKLDM--RSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17966  143 LDEADR---MLDMgfEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 66-281 4.62e-23

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 96.38  E-value: 4.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQdtkemnndnnnnGDNKFVr 145
Cdd:cd17958    1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQ------------RNGPGV- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 cLGLAHTRELAYQIKNEfdrFSKYL-KNVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITDKIQHF 224
Cdd:cd17958   68 -LVLTPTRELALQIEAE---CSKYSyKGLKSVCVYGGGNRNEQIEDLSKG--VDIIIATPGRLNDLQMNNVINLKSITYL 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124801080 225 VLDECDKcleKLDMRSDVQ--KIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIF 281
Cdd:cd17958  142 VLDEADR---MLDMGFEPQirKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 57-277 1.64e-22

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 95.47  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITG--TDILCQAKSGMGKTAVFVLSILQQLDTNEnqdmqdtkemnnd 134
Cdd:cd18048   20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALK------------- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngdnKFVRCLGLAHTRELAYQIKNEFDRFSKYLKNVrcEVVYG--GISMNKHIKLFKEdniphIIIGTPGRILALIR 212
Cdd:cd18048   87 -------LYPQCLCLSPTFELALQTGKVVEEMGKFCVGI--QVIYAirGNRPGKGTDIEAQ-----IVIGTPGTVLDWCF 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124801080 213 EKYLIT-DKIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNP 277
Cdd:cd18048  153 KLRLIDvTNISVFVLDEADVMINVQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 66-280 6.79e-22

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 93.17  E-value: 6.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLS-ILQQLDtnenqdmQDTKemnndnnnngdNKFV 144
Cdd:cd17951    1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALE-------QEKK-----------LPFI 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 145 RCLG-----LAHTRELAYQIKNEFDRFSKYLK-----NVRCEVVYGGISMNKHIKLFKedNIPHIIIGTPGRILALIREK 214
Cdd:cd17951   63 KGEGpygliVCPSRELARQTHEVIEYYCKALQeggypQLRCLLCIGGMSVKEQLEVIR--KGVHIVVATPGRLMDMLNKK 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124801080 215 YLITDKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17951  141 KINLDICRYLCLDEADRMID-MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 67-283 1.42e-21

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 92.04  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  67 LRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKemnndnnnngdnkfvrC 146
Cdd:cd17942    2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTG----------------V 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 147 LGLAHTRELAYQIkneFDRFSKYLKN--VRCEVVYGGIsmNKHIKLFKEDNIPHIIIGTPGRIL-ALIREKYLITDKIQH 223
Cdd:cd17942   66 IIISPTRELALQI---YGVAKELLKYhsQTFGIVIGGA--NRKAEAEKLGKGVNILVATPGRLLdHLQNTKGFLYKNLQC 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 224 FVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPvEIFID 283
Cdd:cd17942  141 LIIDEADRILE-IGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK-PLYVG 198
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 57-277 1.70e-21

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 92.09  E-value: 1.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISESGFEHPSEVQQETIPAAITG--TDILCQAKSGMGKTAVFVLSILQQLDTnenqdmqdtkemnnd 134
Cdd:cd18047    3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEP--------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 135 nnnngDNKFVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISMNKHIKLFKEdniphIIIGTPGRILA-LIRE 213
Cdd:cd18047   68 -----ANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQ-----IVIGTPGTVLDwCSKL 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 214 KYLITDKIQHFVLDECDKCLEKLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNP 277
Cdd:cd18047  138 KFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 81-279 2.90e-21

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 91.45  E-value: 2.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  81 VQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtneNQDMQDTKEmnndnnnngdNKFVRCLGLAHTRELAYQIK 160
Cdd:cd17944   16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKL----QEDQQPRKR----------GRAPKVLVLAPTRELANQVT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 161 NEFDRFSKYLkNVRCevVYGGISMNKHIKLFKeDNIpHIIIGTPGRILALIREKYLITDKIQHFVLDECDKCLEkLDMRS 240
Cdd:cd17944   82 KDFKDITRKL-SVAC--FYGGTPYQQQIFAIR-NGI-DILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLD-MGFAE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 124801080 241 DVQKIfISTPLKK------QVMFFSATMAKEMRDVCKKFLQNPVE 279
Cdd:cd17944  156 QVEEI-LSVSYKKdsednpQTLLFSATCPDWVYNVAKKYMKSQYE 199
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 66-296 4.08e-19

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 85.88  E-value: 4.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLdtnenqdmQDTKEMNNDNNNNgdnkfVR 145
Cdd:cd17948    1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRL--------LRYKLLAEGPFNA-----PR 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYLkNVRCEVVYGGISMnKHIKLFkEDNIPHIIIGTPGRILALIREKYLITDKIQHFV 225
Cdd:cd17948   68 GLVITPSRELAEQIGSVAQSLTEGL-GLKVKVITGGRTK-RQIRNP-HFEEVDILVATPGALSKLLTSRIYSLEQLRHLV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 226 LDECDKCLEK--LDMrsdVQKIFISTPLKK-------------QVMFFSATMAKEMRDVCKKFLQ-NPVEIFIDDeaklK 289
Cdd:cd17948  145 LDEADTLLDDsfNEK---LSHFLRRFPLASrrsentdgldpgtQLVLVSATMPSGVGEVLSKVIDvDSIETVTSD----K 217


                 ....*..
gi 124801080 290 LHGLLQH 296
Cdd:cd17948  218 LHRLMPH 224
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 71-280 1.59e-18

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 83.79  E-value: 1.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  71 SESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENqdmqdtkemnndnnnngdnKFVR----- 145
Cdd:cd17949    7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEP-------------------RVDRsdgtl 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVYGGISmNKHIK--LFKEDNiphIIIGTPGRILALIRE-KYLITDKIQ 222
Cdd:cd17949   68 ALVLVPTRELALQIYEVLEKLLKPFHWIVPGYLIGGEK-RKSEKarLRKGVN---ILIATPGRLLDHLKNtQSFDVSNLR 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 223 HFVLDECDKCLE------------KLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEI 280
Cdd:cd17949  144 WLVLDEADRLLDmgfekditkileLLDDKRSKAGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 45-282 1.49e-17

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 82.37  E-value: 1.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  45 MRGSYATVHTGGFKDFFLKPELLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQD 124
Cdd:cd18050   52 IRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 125 MQDTKemnndnnnngdnkfvRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISMNKHIKLFKEDniPHIIIGTP 204
Cdd:cd18050  132 RGDGP---------------ICLVLAPTRELAQQVQQVADDYGKSSR-LKSTCIYGGAPKGPQIRDLERG--VEICIATP 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 205 GRILALIREKYLITDKIQHFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd18050  194 GRLIDFLEAGKTNLRRCTYLVLDEADRMLD-MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 66-282 5.73e-17

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 80.05  E-value: 5.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGTDILCQAKSGMGKTAVFVLSILQQLDTNENQDMQDTKemnndnnnngdnkfvR 145
Cdd:cd18049   35 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGP---------------I 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 146 CLGLAHTRELAYQIKN---EFDRFSKylknVRCEVVYGGISMNKHIKLFKEDniPHIIIGTPGRILALIREKYLITDKIQ 222
Cdd:cd18049  100 CLVLAPTRELAQQVQQvaaEYGRACR----LKSTCIYGGAPKGPQIRDLERG--VEICIATPGRLIDFLEAGKTNLRRCT 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 223 HFVLDECDKCLEkLDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDVCKKFLQNPVEIFI 282
Cdd:cd18049  174 YLVLDEADRMLD-MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
298-425 2.41e-15

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 77.87  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 298 VKLQEKDKTRKLIEILDALEFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDL 377
Cdd:COG0514  210 VPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIA 289

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124801080 378 FGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVSSQ 425
Cdd:COG0514  290 FGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPE 337
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 66-262 2.47e-14

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 72.28  E-value: 2.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  66 LLRAISESGFEHPSEVQQETIPAAITGT---------DILCQAKSGMGKTAVFVLSILQQLDTnenqdmqdtkemnndnn 136
Cdd:cd17956    1 LLKNLQNNGITSAFPVQAAVIPWLLPSSkstppyrpgDLCVSAPTGSGKTLAYVLPIVQALSK----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 137 nnGDNKFVRCLGLAHTRELAYQIKNEFDRFSKYLKNVRCEVVyGGISMNKHIKLFKEDNIPH------IIIGTPGRILAL 210
Cdd:cd17956   64 --RVVPRLRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLS-GQKSFKKEQKLLLVDTSGRylsrvdILVATPGRLVDH 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124801080 211 IREKYLIT-DKIQHFVLDECDKCL--------EKLDM------RSDVQKIFISTPLKKQV-----MFFSATM 262
Cdd:cd17956  141 LNSTPGFTlKHLRFLVIDEADRLLnqsfqdwlETVMKalgrptAPDLGSFGDANLLERSVrplqkLLFSATL 212
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 297-413 1.43e-12

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 64.54  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 297 YVKLQEKDKTRKLIEILDAL---EFNQ-VIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRIL 372
Cdd:cd18794    5 FYSVRPKDKKDEKLDLLKRIkveHLGGsGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVI 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 124801080 373 VSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFG 413
Cdd:cd18794   85 VATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDG 125
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
145-409 3.34e-12

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 68.51  E-value: 3.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 145 RCLGLAHTRELAYQIKNEFDRFskylknVRCEVVYGGismnkhiklfKEDNIPHIIIGTPGRILALIREKYLiTDKIQHF 224
Cdd:COG1061  129 RVLVLVPRRELLEQWAEELRRF------LGDPLAGGG----------KKDSDAPITVATYQSLARRAHLDEL-GDRFGLV 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 225 VLDEC--------DKCLEKLDM-----------RSDVQKIFISTpLKKQVMFFSATMAKEMRDVCK-KFLQNPVEIFIDD 284
Cdd:COG1061  192 IIDEAhhagapsyRRILEAFPAayrlgltatpfRSDGREILLFL-FDGIVYEYSLKEAIEDGYLAPpEYYGIRVDLTDER 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 285 EAKLKLHGLLQHYVKLQEKDKTRKLIEILDAL-EFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDK 363
Cdd:COG1061  271 AEYDALSERLREALAADAERKDKILRELLREHpDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEA 350

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 124801080 364 FKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRA 409
Cdd:COG1061  351 FRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRG 396
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
 305-409 1.15e-10

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 59.53  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEILDAlEFNQV-----IIFVKSVTRAITLDKLLTE--CNFPSIAIH-------------GGLEQQERIERYDKF 364
Cdd:cd18802    8 KLQKLIEILRE-YFPKTpdfrgIIFVERRATAVVLSRLLKEhpSTLAFIRCGfligrgnssqrkrSLMTQRKQKETLDKF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 124801080 365 KKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRA 409
Cdd:cd18802   87 RDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRA 131
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 371-422 2.52e-10

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 56.56  E-value: 2.52e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124801080 371 ILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTK-GLAVTFV 422
Cdd:cd18785   25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDeGEVILFV 77
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 92-261 7.77e-10

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 57.03  E-value: 7.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  92 GTDILCQAKSGMGKTAVFVLSILQQLDTNEnqdmqdtkemnndnnnngdnKFVrcLGLAHTRELAYQIKNEFDRFSKylK 171
Cdd:cd00046    1 GENVLITAPTGSGKTLAALLAALLLLLKKG--------------------KKV--LVLVPTKALALQTAERLRELFG--P 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 172 NVRCEVVYGGISMnKHIKLFKEDNIPhIIIGTPGRIL-ALIREKYLITDKIQHFVLDECDKCLEKLD-MRSDVQKIFIST 249
Cdd:cd00046   57 GIRVAVLVGGSSA-EEREKNKLGDAD-IIIATPDMLLnLLLREDRLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAG 134

                        170
                 ....*....|..
gi 124801080 250 PLKKQVMFFSAT 261
Cdd:cd00046  135 LKNAQVILLSAT 146
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 347-421 1.42e-09

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 60.11  E-value: 1.42e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124801080 347 AIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTF 421
Cdd:PRK11057 265 AYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLF 339
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 305-415 1.80e-09

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 55.56  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEILDALEFNQ--VIIFVKSVTraiTLDKL---LTECNFPSIAIHGGLEQQERIERYDKFKKFEN--RILVSTDL 377
Cdd:cd18793   12 KLEALLELLEELREPGekVLIFSQFTD---TLDILeeaLRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKA 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124801080 378 FGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTK 415
Cdd:cd18793   89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQK 126
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
305-415 6.98e-09

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 58.20  E-value: 6.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEILD-ALEFN---QVIIFVKSVTRAITLDKLLTECNFPSIAIHG--------GLEQQERIERYDKFKKFENRIL 372
Cdd:COG1111  336 KLSKLREILKeQLGTNpdsRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaskegdkGLTQKEQIEILERFRAGEFNVL 415

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 124801080 373 VSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTK 415
Cdd:COG1111  416 VATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREG 458
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 306-411 1.14e-07

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 51.11  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 306 TRKLIEILDALEFNQ-VIIFVKSVTRA-ITLDKLLTEC--NFPS--IAIHGGL---EQQERIEryDKFKKFENRILVST- 375
Cdd:cd18796   25 ADAYAEVIFLLERHKsTLVFTNTRSQAeRLAQRLRELCpdRVPPdfIALHHGSlsrELREEVE--AALKRGDLKVVVATs 102

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 124801080 376 --DLfgrGIDIERVNIVINYDMPENSDSYLHRVGRAGR 411
Cdd:cd18796  103 slEL---GIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 305-413 1.40e-07

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 54.08  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEILDAL--EFNQVIIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFEN--RILVSTDLFGR 380
Cdd:COG0553  534 KLEALLELLEELlaEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKAGGE 613

                         90       100       110
                 ....*....|....*....|....*....|...
gi 124801080 381 GIDIERVNIVINYDMPENSDSYLHRVGRAGRFG 413
Cdd:COG0553  614 GLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIG 646
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 57-280 1.44e-07

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 52.38  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  57 FKDFFLKPELLRAISE---------SGFEHPSEVQQETIPAaITGTDI-----------------LCQAKSGMGKTAVFV 110
Cdd:cd17965    1 FDQLKLLPSVREAIIKeilkgsnktDEEIKPSPIQTLAIKK-LLKTLMrkvtkqtsneepklevfLLAAETGSGKTLAYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 111 LSILQQLdtnENQDMQDTKEMNNDNNNNGDNKFVRCLGLAHTRELAYQIKNEFDRFSKYLKnVRCEVVYGGISmNKHIKL 190
Cdd:cd17965   80 APLLDYL---KRQEQEPFEEAEEEYESAKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVK-LGIKTFSSGFG-PSYQRL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 191 FKEDNIP-HIIIGTPGRILALIREKYLITDKIQHFVLDECDKCLEKlDMRSDVQKIFISTPLKKQVMFFSATMAKEMRDV 269
Cdd:cd17965  155 QLAFKGRiDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDR-SFLQDTTSIIKRAPKLKHLILCSATIPKEFDKT 233

                        250
                 ....*....|.
gi 124801080 270 CKKFLQNPVEI 280
Cdd:cd17965  234 LRKLFPDVVRI 244
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
62-433 2.09e-07

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 53.36  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  62 LKPELLRAISESGFEHPSEVQQETIPAAI-TGTDILCQAKSGMGKTAVFVLSILQQLDTNEnqdmqdtkemnndnnnngd 140
Cdd:COG1204    7 PLEKVIEFLKERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALLNGG------------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 141 nkfvRCLGLAHTRELAYQIKNEFDR-FSKYlkNVRCEVVYGGISMNkhIKLFKEDNIphiIIGTPGRILALIREKYLITD 219
Cdd:COG1204   68 ----KALYIVPLRALASEKYREFKRdFEEL--GIKVGVSTGDYDSD--DEWLGRYDI---LVATPEKLDSLLRNGPSWLR 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 220 KIQHFVLDEcdkclekldmrsdVQKI---------------FISTPLKKQVMFFSATMakemrdvckkflQNPVEI---- 280
Cdd:COG1204  137 DVDLVVVDE-------------AHLIddesrgptlevllarLRRLNPEAQIVALSATI------------GNAEEIaewl 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 281 ----FIDDEAKLKLH-GLLQHYVkLQEKDKTRKLIE-----ILDALEFN-QVIIFVKSVTRAIT--------LDKLLTEC 341
Cdd:COG1204  192 daelVKSDWRPVPLNeGVLYDGV-LRFDDGSRRSKDptlalALDLLEEGgQVLVFVSSRRDAESlakkladeLKRRLTPE 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 342 NFPSIAI-----------------------------HGGLEQQER--IERYdkFKKFENRILVSTD-------LFGRGID 383
Cdd:COG1204  271 EREELEElaeellevseethtnekladclekgvafhHAGLPSELRrlVEDA--FREGLIKVLVATPtlaagvnLPARRVI 348

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124801080 384 IERVNIVINYDMPeNSDsYLHRVGRAGR--FGTKGLAVTFVSSQEDTLALNE 433
Cdd:COG1204  349 IRDTKRGGMVPIP-VLE-FKQMAGRAGRpgYDPYGEAILVAKSSDEADELFE 398
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 351-411 1.08e-06

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 48.12  E-value: 1.08e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124801080 351 GLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAGR 411
Cdd:cd18801   73 GMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
PRK13766 PRK13766
Hef nuclease; Provisional
 305-429 1.08e-06

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 51.03  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEIL-DALEFNQ---VIIFVKSVTRAITLDKLLTECNFPSIAIHG--------GLEQQERIERYDKFKKFENRIL 372
Cdd:PRK13766 348 KLEKLREIVkEQLGKNPdsrIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGqaskdgdkGMSQKEQIEILDKFRAGEFNVL 427

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124801080 373 VSTDLFGRGIDIERVNIVINYD-MPENSDSyLHRVGRAGRfGTKGLAVTFVSsqEDTL 429
Cdd:PRK13766 428 VSTSVAEEGLDIPSVDLVIFYEpVPSEIRS-IQRKGRTGR-QEEGRVVVLIA--KGTR 481
SF2_C_Hrq cd18797
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ...
 320-419 5.04e-06

C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350184 [Multi-domain]  Cd Length: 146  Bit Score: 46.10  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 320 QVIIFVKS-----VTRAITLDKLLTECNFPS-IAIH-GGLEQQER--IERydKFKKFENRILVSTDLFGRGIDIERVNIV 390
Cdd:cd18797   37 KTIVFCRSrklaeLLLRYLKARLVEEGPLASkVASYrAGYLAEDRreIEA--ELFNGELLGVVATNALELGIDIGGLDAV 114

                         90       100
                 ....*....|....*....|....*....
gi 124801080 391 INYDMPENSDSYLHRVGRAGRFGTKGLAV 419
Cdd:cd18797  115 VLAGYPGSLASLWQQAGRAGRRGKDSLVI 143
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 320-429 1.10e-05

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 47.91  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 320 QVIIFVKS-----VTRAITLDKLLTECNFPSIAIH-GGLEQQER--IERydKFKKFENRILVST---DLfgrGIDIERVN 388
Cdd:COG1205  290 RTLVFTRSrrgaeLLARYARRALREPDLADRVAAYrAGYLPEERreIER--GLRSGELLGVVSTnalEL---GIDIGGLD 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 124801080 389 IVINYDMPENSDSYLHRVGRAGRFGTKGLAVtFVSSqEDTL 429
Cdd:COG1205  365 AVVLAGYPGTRASFWQQAGRAGRRGQDSLVV-LVAG-DDPL 403
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 305-423 1.18e-05

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 47.97  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  305 KTRKLIEILDAL----EFNQV-IIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQERIERYDKFKKFENRILVSTDLFG 379
Cdd:PLN03137  662 KTKKCLEDIDKFikenHFDECgIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFG 741

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 124801080  380 RGIDIERVNIVINYDMPENSDSYLHRVGRAGRFGTKGLAVTFVS 423
Cdd:PLN03137  742 MGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYS 785
SF2_C_EcoAI-like cd18799
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ...
 322-391 1.34e-05

C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350186 [Multi-domain]  Cd Length: 116  Bit Score: 44.09  E-value: 1.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124801080 322 IIFVKSVTRAITLDKLLTECNFPSIAIHGGLEQQER----IERyDKFKKFENRILVSTDLFGRGIDIERVNIVI 391
Cdd:cd18799   10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgdeaLIL-LFFGELKPPILVTVDLLTTGVDIPEVDNVV 82
Cas3_I cd09639
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ...
 255-415 3.37e-05

CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I


Pssm-ID: 187770 [Multi-domain]  Cd Length: 353  Bit Score: 45.88  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 255 VMFFSATMAKEMrdvcKKFLQNpVEIFIDDEAKLKLHGLLQHYVKLQEKD--KTRKLIEILDAL-EFNQVIIFVKSVTRA 331
Cdd:cd09639  157 ILLMSATLPKFL----KEYAEK-IGYVEENEPLDLKPNERAPFIKIESDKvgEISSLERLLEFIkKGGSVAIIVNTVDRA 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 332 ITLDKLLTECN--FPSIAIHGGLEQQERIERYDK----FKKFENRILVSTDLFGRGIDIErVNIVINYDMPenSDSYLHR 405
Cdd:cd09639  232 QEFYQQLKEKGpeEEIMLIHSRFTEKDRAKKEAEllleFKKSEKFVIVATQVIEASLDIS-VDVMITELAP--IDSLIQR 308

                        170
                 ....*....|
gi 124801080 406 VGRAGRFGTK 415
Cdd:cd09639  309 LGRLHRYGEK 318
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 99-228 4.08e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 44.17  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080  99 AKSGMGKTAVFVLSILQQLDTNENqdmqdtkemnndnnnngdnkfvRCLGLAHTRELAYQIKNEF-DRFSKYLKNVrcEV 177
Cdd:cd17921   24 APTSSGKTLIAELAILRALATSGG----------------------KAVYIAPTRALVNQKEADLrERFGPLGKNV--GL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124801080 178 VYGGISMNKhiklfKEDNIPHIIIGTPGRILALIR-EKYLITDKIQHFVLDE 228
Cdd:cd17921   80 LTGDPSVNK-----LLLAEADILVATPEKLDLLLRnGGERLIQDVRLVVVDE 126
PRK09751 PRK09751
putative ATP-dependent helicase Lhr; Provisional
 349-410 1.50e-04

putative ATP-dependent helicase Lhr; Provisional


Pssm-ID: 137505 [Multi-domain]  Cd Length: 1490  Bit Score: 44.53  E-value: 1.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124801080  349 HGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVNIVINYDMPENSDSYLHRVGRAG 410
Cdd:PRK09751  308 HGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAG 369
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
 305-391 2.76e-04

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 41.08  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 305 KTRKLIEILDALE-FNQVIIFVKSVTRAITLDKLLtecNFPsiAIHGGLEQQERIERYDKFKKFENRILVSTDLFGRGID 383
Cdd:cd18789   35 KLRALEELLKRHEqGDKIIVFTDNVEALYRYAKRL---LKP--FITGETPQSEREEILQNFREGEYNTLVVSKVGDEGID 109


                 ....*...
gi 124801080 384 IERVNIVI 391
Cdd:cd18789  110 LPEANVAI 117
SF2_C_TRCF cd18810
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ...
 345-444 4.60e-04

C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350197 [Multi-domain]  Cd Length: 151  Bit Score: 40.40  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 345 SIAI-HGGLEQQERIERYDKFKKFENRILVSTDLFGRGIDIERVN--IVINYDMPENSDSYLHRvGRAGRFGTKGLAVTF 421
Cdd:cd18810   53 RIAIaHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANtiIIERADKFGLAQLYQLR-GRVGRSKERAYAYFL 131

                         90       100
                 ....*....|....*....|...
gi 124801080 422 VSSQEdtlALNEVQTRFEVAISE 444
Cdd:cd18810  132 YPDQK---KLTEDALKRLEAIQE 151
ComFA COG4098
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ...
 287-411 8.30e-04

Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];


Pssm-ID: 443274 [Multi-domain]  Cd Length: 451  Bit Score: 41.78  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124801080 287 KLKLHGLLQHyvKLQEKDKTRKLIEILDAL--EFNQVIIFVKSVTRAITLDKLLTEcNFPSIAIHG-GLEQQERIERYDK 363
Cdd:COG4098  288 KFKWLGNWKK--RLRRGKLPRKLLKWLKKRlkEGRQLLIFVPTIELLEQLVALLQK-LFPEERIAGvHAEDPERKEKVQA 364

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124801080 364 FKKFENRILVSTDLFGRGIDIERVN-IVINYDmpensdsylHRV----------GRAGR 411
Cdd:COG4098  365 FRDGEIPILVTTTILERGVTFPNVDvAVLGAD---------HPVfteaalvqiaGRVGR 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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