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Conserved domains on  [gi|124513482|ref|XP_001350097|]
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tryptophan--tRNA ligase [Plasmodium falciparum 3D7]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 232-621 0e+00

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member PLN02486:

Pssm-ID: 469580  Cd Length: 383  Bit Score: 518.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 232 VTPWDVNINNEEGINYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGP 311
Cdd:PLN02486   3 VTPWEVSAKDGGKIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGRGP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 312 SSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFnQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEY-AG 390
Cdd:PLN02486  83 SSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLW-KNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYvGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 391 YLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLG--KNIPCLVPQGIDQDPYFRLSRDIAV 468
Cdd:PLN02486 162 AFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGgkDKLRCLIPCAIDQDPYFRMTRDVAP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 469 KMALHKPVVVHSVFMPGLQGvnskmsstkkkkdDNGKSNSTfdHNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREK 548
Cdd:PLN02486 242 RLGYYKPALIESRFFPALQG-------------ESGKMSAS--DPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHREL 306

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124513482 549 GGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDP 621
Cdd:PLN02486 307 GANLEVDIPWKYLNFFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAV 379
 
Name Accession Description Interval E-value
PLN02486 PLN02486
aminoacyl-tRNA ligase
 232-621 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 518.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 232 VTPWDVNINNEEGINYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGP 311
Cdd:PLN02486   3 VTPWEVSAKDGGKIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGRGP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 312 SSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFnQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEY-AG 390
Cdd:PLN02486  83 SSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLW-KNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYvGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 391 YLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLG--KNIPCLVPQGIDQDPYFRLSRDIAV 468
Cdd:PLN02486 162 AFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGgkDKLRCLIPCAIDQDPYFRMTRDVAP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 469 KMALHKPVVVHSVFMPGLQGvnskmsstkkkkdDNGKSNSTfdHNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREK 548
Cdd:PLN02486 242 RLGYYKPALIESRFFPALQG-------------ESGKMSAS--DPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHREL 306

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124513482 549 GGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDP 621
Cdd:PLN02486 307 GANLEVDIPWKYLNFFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAV 379
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 303-631 3.58e-83

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 264.58  E-value: 3.58e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  303 FYIYTGRGPSSlSMHLGHLIPFYFCKYLQEaFNVPLVIQLSDDEKYLFNQNySLEYINTLTNENVKDIISVGLNPELTFI 382
Cdd:TIGR00233   3 FRVLTGIQPSG-KMHLGHYLGAIQTKWLQQ-FGVELFICIADLHAITVKQT-DPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  383 FKNTEYAGYlYPTVLSIHKKTTLNQSMNVFGFNHSD-----NIGKISYPSFQIAPCFSQCFPnflgknipcLVPQGIDQD 457
Cdd:TIGR00233  80 FLQSDYPEH-YELAWLLSCQVTFGELKRMTQFKDKSqaenvPIGLLSYPVLQAADILLYQAD---------LVPVGIDQD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  458 PYFRLSRDIAVKMA------LHKPVVVHSVFMPGLQGVnskmsstkkkkDDNGKSNStfdHNNSVIFLTDTPEQIKNKIN 531
Cdd:TIGR00233 150 QHLELTRDLAERFNkkfknfFPKPESLISKFFPRLMGL-----------SGKKMSKS---DPNSAIFLTDTPKQIKKKIR 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  532 KYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLT 611
Cdd:TIGR00233 216 KAATDGGRVTLFEHREKPGVPNLLVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIA 295

                         330       340
                  ....*....|....*....|
gi 124513482  612 DEEISYFFDPNKPSLQKFKN 631
Cdd:TIGR00233 296 EEILDKILEPGAKKARETAN 315
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 304-599 1.02e-78

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 250.96  E-value: 1.02e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 304 YIYTGRGPSSlSMHLGHLIP-FYFCKYLQEAfNVPLVIQLSDDEKYLFNQnYSLEYINTLTNENVKDIISVGLNPELTFI 382
Cdd:cd00806    1 RVLSGIQPSG-SLHLGHYLGaFRFWVWLQEA-GYELFFFIADLHALTVKQ-LDPEELRQNTRENAKDYLACGLDPEKSTI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 383 FKNTEYAGyLYPTVLSIHKKTTLNQSMNVFGFN------HSDNIGKISYPSFQIAPCFSqcfPNFlgknipCLVPQGIDQ 456
Cdd:cd00806   78 FFQSDVPE-HYELAWLLSCVVTFGELERMTGFKdksaqgESVNIGLLTYPVLQAADILL---YKA------CLVPVGIDQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 457 DPYFRLSRDIAVKM------ALHKPVVVHSV--FMPGLQGVnskmsstkkkkddNGK-SNStfdHNNSVIFLTDTPEQIK 527
Cdd:cd00806  148 DPHLELTRDIARRFnklygeIFPKPAALLSKgaFLPGLQGP-------------SKKmSKS---DPNNAIFLTDSPKEIK 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124513482 528 NKINKYAFSGGGTtiqEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTEL 599
Cdd:cd00806  212 KKIMKAATDGGRT---EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEIDEYRSGGLGYGECKKLLAEAIQEF 280
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 305-614 1.55e-16

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 81.25  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 305 IYTGRGPSSlSMHLGHLI----PFYFckyLQEAFNvpLVIQLSDDEKYLFNQNYSLeyINTLTNENVKDIISVGLNPELT 380
Cdd:COG0180    6 VLSGIQPTG-RLHLGNYLgalkNWVE---LQDEYE--CFFFIADLHALTTPQDPEE--LRENTREVAADYLAAGLDPEKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 381 FIFKN------TEYAGYLyptvLSIhkkTTLNQSMNVFGF------NHSDNI--GKISYPSFQIAPcfsqcfpnflgknI 446
Cdd:COG0180   78 TIFVQsdvpehAELAWLL----SCL---TPLGELERMPQFkdksakNGKENVnaGLLTYPVLMAAD-------------I 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 447 ----PCLVPQGIDQDPYFRLSRDIAVKM-ALHKPVVV--------HSVFMPGLQGvnskmsstkkkkddNGK-SNStfdh 512
Cdd:COG0180  138 llykADLVPVGEDQKQHLELTRDIARRFnHRYGEVFPepealipeEGARIPGLDG--------------RKKmSKS---- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 513 NNSVIFLTDTPEQIKNKINKyAFSGGGTtiqEHREKGGNLDKDISYQYLRyLLEDDNKLNEIGEKYKKGEMLSGEIKKIL 592
Cdd:COG0180  200 YGNTINLLDDPKEIRKKIKS-AVTDSER---LRYDDPGKPEVCNLFTIYS-AFSGKEEVEELEAEYRAGGIGYGDLKKAL 274

                        330       340
                 ....*....|....*....|..
gi 124513482 593 IDVLTELVLKHQEKKKSLTDEE 614
Cdd:COG0180  275 AEAVVEFLAPIRERRAELLADP 296
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
305-619 4.56e-12

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 67.30  E-value: 4.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  305 IYTGRGPSSlSMHLGHLIPFYFCKYLQEAFNVPLVIqLSDDEKYLFNQNYS----LEYINTLTNENVKDIISVGLNPELT 380
Cdd:pfam00579   8 VYSGIDPTG-PLHLGYLVPLMKLRQFQQAGHEVFFL-IGDLHAIIGDPSKSperkLLSRETVLENAIKAQLACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  381 FIFKNTEYAGYL-YPTVLS-IHKKTTLNQsMNVFG-----FNHSDNI--GKISYPSFQIAPCFsqcfpnFLGKNIpclVP 451
Cdd:pfam00579  86 EIVNNSDWLEHLeLAWLLRdLGKHFSLNR-MLQFKdvkkrLEQGPGIslGEFTYPLLQAYDIL------LLKADL---QP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  452 QGIDQDPYFRLSRDIA---VKMALHKPVVVHSVFMPGLQGVNSKmsstkkkkddnGKSnstfdHNNSVIFLTDTPEQIKN 528
Cdd:pfam00579 156 GGSDQWGNIELGRDLArrfNKKIFKKPVGLTNPLLTGLDGGKKM-----------SKS-----AGNSAIFLDDDPESVYK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  529 KInKYAFSGGgttiqehrekggnlDKDISYqYLRYLLEDDNKLNEIGEKYkKGEMLSGEIKKILIDVLTELVlkHQEKKK 608
Cdd:pfam00579 220 KI-QKAYTDP--------------DREVRK-DLKLFTFLSNEEIEILEAE-LGKSPYREAEELLAREVTGLV--HGGDLK 280

                         330
                  ....*....|.
gi 124513482  609 SLTDEEISYFF 619
Cdd:pfam00579 281 KAAAEAVNKLL 291
 
Name Accession Description Interval E-value
PLN02486 PLN02486
aminoacyl-tRNA ligase
 232-621 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 518.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 232 VTPWDVNINNEEGINYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGP 311
Cdd:PLN02486   3 VTPWEVSAKDGGKIDYDKLVDKFGCQRLDPSLIDRVERLTGRPAHPFLRRGVFFAHRDLEEILDAYEKGEKFYLYTGRGP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 312 SSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFnQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEY-AG 390
Cdd:PLN02486  83 SSEALHLGHLIPFMFTKYLQDAFKVPLVIQLTDDEKFLW-KNLSVEESQRLARENAKDIIACGFDVERTFIFSDFDYvGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 391 YLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLG--KNIPCLVPQGIDQDPYFRLSRDIAV 468
Cdd:PLN02486 162 AFYKNMVKIAKCVTLNQVRGIFGFSGEDNIGKISFPAVQAAPSFPSSFPHLFGgkDKLRCLIPCAIDQDPYFRMTRDVAP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 469 KMALHKPVVVHSVFMPGLQGvnskmsstkkkkdDNGKSNSTfdHNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREK 548
Cdd:PLN02486 242 RLGYYKPALIESRFFPALQG-------------ESGKMSAS--DPNSAIYVTDTPKEIKNKINKYAFSGGQDTVEEHREL 306

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124513482 549 GGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDP 621
Cdd:PLN02486 307 GANLEVDIPWKYLNFFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAAVTDEMVDAFMAV 379
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 232-613 3.82e-118

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 356.10  E-value: 3.82e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 232 VTPWDVninnEEGINYNKLIKEFGCSKITENhIKRIEKLtnskaHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGP 311
Cdd:PRK12285   6 VTPWEV----SGIVDYDKLFEEFGIEPFTEV-LPELPEP-----HPLMRRGIIFGHRDYDKILEAYRNGKPFAVYTGFMP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 312 SSLsMHLGHLIPFYFCKYLQEaFNVPLVIQLSDDEKYLFNqNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAgY 391
Cdd:PRK12285  76 SGP-MHIGHKMVFDELKWHQE-FGANVYIPIADDEAYAAR-GLSWEETREWAYEYILDLIALGFDPDKTEIYFQSENI-K 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 392 LYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFsqcFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKM- 470
Cdd:PRK12285 152 VYDLAFELAKKVNFSELKAIYGFTGETNIGHIFYPATQAADIL---HPQLEEGPKPTLVPVGIDQDPHIRLTRDIAERLh 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 471 ---ALHKPVVVHSVFMPGLQGvnskmsstkkkkddnGKSNSTFDhnNSVIFLTDTPEQIKNKINKyAFSGGGTTIQEHRE 547
Cdd:PRK12285 229 ggyGFIKPSSTYHKFMPGLTG---------------GKMSSSKP--ESAIYLTDDPETVKKKIMK-ALTGGRATLEEQRK 290

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124513482 548 KGGNLDKDISYQYLRYLL-EDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDE 613
Cdd:PRK12285 291 LGGEPDECVVYELLLYHLeEDDKELKEIYEECRSGELLCGECKKEAAEKIAEFLKEHQEKREEAREI 357
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 303-631 3.58e-83

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 264.58  E-value: 3.58e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  303 FYIYTGRGPSSlSMHLGHLIPFYFCKYLQEaFNVPLVIQLSDDEKYLFNQNySLEYINTLTNENVKDIISVGLNPELTFI 382
Cdd:TIGR00233   3 FRVLTGIQPSG-KMHLGHYLGAIQTKWLQQ-FGVELFICIADLHAITVKQT-DPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  383 FKNTEYAGYlYPTVLSIHKKTTLNQSMNVFGFNHSD-----NIGKISYPSFQIAPCFSQCFPnflgknipcLVPQGIDQD 457
Cdd:TIGR00233  80 FLQSDYPEH-YELAWLLSCQVTFGELKRMTQFKDKSqaenvPIGLLSYPVLQAADILLYQAD---------LVPVGIDQD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  458 PYFRLSRDIAVKMA------LHKPVVVHSVFMPGLQGVnskmsstkkkkDDNGKSNStfdHNNSVIFLTDTPEQIKNKIN 531
Cdd:TIGR00233 150 QHLELTRDLAERFNkkfknfFPKPESLISKFFPRLMGL-----------SGKKMSKS---DPNSAIFLTDTPKQIKKKIR 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  532 KYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLT 611
Cdd:TIGR00233 216 KAATDGGRVTLFEHREKPGVPNLLVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIA 295

                         330       340
                  ....*....|....*....|
gi 124513482  612 DEEISYFFDPNKPSLQKFKN 631
Cdd:TIGR00233 296 EEILDKILEPGAKKARETAN 315
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 304-599 1.02e-78

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 250.96  E-value: 1.02e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 304 YIYTGRGPSSlSMHLGHLIP-FYFCKYLQEAfNVPLVIQLSDDEKYLFNQnYSLEYINTLTNENVKDIISVGLNPELTFI 382
Cdd:cd00806    1 RVLSGIQPSG-SLHLGHYLGaFRFWVWLQEA-GYELFFFIADLHALTVKQ-LDPEELRQNTRENAKDYLACGLDPEKSTI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 383 FKNTEYAGyLYPTVLSIHKKTTLNQSMNVFGFN------HSDNIGKISYPSFQIAPCFSqcfPNFlgknipCLVPQGIDQ 456
Cdd:cd00806   78 FFQSDVPE-HYELAWLLSCVVTFGELERMTGFKdksaqgESVNIGLLTYPVLQAADILL---YKA------CLVPVGIDQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 457 DPYFRLSRDIAVKM------ALHKPVVVHSV--FMPGLQGVnskmsstkkkkddNGK-SNStfdHNNSVIFLTDTPEQIK 527
Cdd:cd00806  148 DPHLELTRDIARRFnklygeIFPKPAALLSKgaFLPGLQGP-------------SKKmSKS---DPNNAIFLTDSPKEIK 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124513482 528 NKINKYAFSGGGTtiqEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTEL 599
Cdd:cd00806  212 KKIMKAATDGGRT---EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEIDEYRSGGLGYGECKKLLAEAIQEF 280
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 306-535 1.14e-16

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 81.45  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 306 YTGRGPSSLsMHLGHLIPFYFCKYLQEA-FNVplVIQLSDDEKYLfNQNYSLEYINTLTNENVKDIISVGLNPELT-FIF 383
Cdd:PRK08560  34 YIGFEPSGK-IHLGHLLTMNKLADLQKAgFKV--TVLLADWHAYL-NDKGDLEEIRKVAEYNKKVFEALGLDPDKTeFVL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 384 -----KNTEYAGylypTVLSIHKKTTLNQ---SMNVFGfNHSDN--IGKISYPSFQIAPCFSqcfpnfLGKNIPClvpQG 453
Cdd:PRK08560 110 gsefqLDKEYWL----LVLKLAKNTTLARarrSMTIMG-RRMEEpdVSKLVYPLMQVADIFY------LDVDIAV---GG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 454 IDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLQGVNskmsstkkkkddnGK-SNSTfdhNNSVIFLTDTPEQIKNKINK 532
Cdd:PRK08560 176 MDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGG-------------IKmSKSK---PGSAIFVHDSPEEIRRKIKK 239


                 ...
gi 124513482 533 yAF 535
Cdd:PRK08560 240 -AY 241
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 305-614 1.55e-16

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 81.25  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 305 IYTGRGPSSlSMHLGHLI----PFYFckyLQEAFNvpLVIQLSDDEKYLFNQNYSLeyINTLTNENVKDIISVGLNPELT 380
Cdd:COG0180    6 VLSGIQPTG-RLHLGNYLgalkNWVE---LQDEYE--CFFFIADLHALTTPQDPEE--LRENTREVAADYLAAGLDPEKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 381 FIFKN------TEYAGYLyptvLSIhkkTTLNQSMNVFGF------NHSDNI--GKISYPSFQIAPcfsqcfpnflgknI 446
Cdd:COG0180   78 TIFVQsdvpehAELAWLL----SCL---TPLGELERMPQFkdksakNGKENVnaGLLTYPVLMAAD-------------I 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 447 ----PCLVPQGIDQDPYFRLSRDIAVKM-ALHKPVVV--------HSVFMPGLQGvnskmsstkkkkddNGK-SNStfdh 512
Cdd:COG0180  138 llykADLVPVGEDQKQHLELTRDIARRFnHRYGEVFPepealipeEGARIPGLDG--------------RKKmSKS---- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 513 NNSVIFLTDTPEQIKNKINKyAFSGGGTtiqEHREKGGNLDKDISYQYLRyLLEDDNKLNEIGEKYKKGEMLSGEIKKIL 592
Cdd:COG0180  200 YGNTINLLDDPKEIRKKIKS-AVTDSER---LRYDDPGKPEVCNLFTIYS-AFSGKEEVEELEAEYRAGGIGYGDLKKAL 274

                        330       340
                 ....*....|....*....|..
gi 124513482 593 IDVLTELVLKHQEKKKSLTDEE 614
Cdd:COG0180  275 AEAVVEFLAPIRERRAELLADP 296
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
305-619 4.56e-12

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 67.30  E-value: 4.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  305 IYTGRGPSSlSMHLGHLIPFYFCKYLQEAFNVPLVIqLSDDEKYLFNQNYS----LEYINTLTNENVKDIISVGLNPELT 380
Cdd:pfam00579   8 VYSGIDPTG-PLHLGYLVPLMKLRQFQQAGHEVFFL-IGDLHAIIGDPSKSperkLLSRETVLENAIKAQLACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  381 FIFKNTEYAGYL-YPTVLS-IHKKTTLNQsMNVFG-----FNHSDNI--GKISYPSFQIAPCFsqcfpnFLGKNIpclVP 451
Cdd:pfam00579  86 EIVNNSDWLEHLeLAWLLRdLGKHFSLNR-MLQFKdvkkrLEQGPGIslGEFTYPLLQAYDIL------LLKADL---QP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  452 QGIDQDPYFRLSRDIA---VKMALHKPVVVHSVFMPGLQGVNSKmsstkkkkddnGKSnstfdHNNSVIFLTDTPEQIKN 528
Cdd:pfam00579 156 GGSDQWGNIELGRDLArrfNKKIFKKPVGLTNPLLTGLDGGKKM-----------SKS-----AGNSAIFLDDDPESVYK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482  529 KInKYAFSGGgttiqehrekggnlDKDISYqYLRYLLEDDNKLNEIGEKYkKGEMLSGEIKKILIDVLTELVlkHQEKKK 608
Cdd:pfam00579 220 KI-QKAYTDP--------------DREVRK-DLKLFTFLSNEEIEILEAE-LGKSPYREAEELLAREVTGLV--HGGDLK 280

                         330
                  ....*....|.
gi 124513482  609 SLTDEEISYFF 619
Cdd:pfam00579 281 KAAAEAVNKLL 291
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 305-599 6.86e-08

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 54.15  E-value: 6.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 305 IYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIqLSDDEKYLFNQNYSLEYINTLTNE----NVKDI------ISVG 374
Cdd:cd00805    3 VYIGFDPTAPSLHLGHLVPLMKLRDFQQAGHEVIVL-IGDATAMIGDPSGKSEERKLLDLElireNAKYYkkqlkaILDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 375 LNPELTFIFKNTEYAGYLYP-TVLSIHKKTTLNQS------MNVFGFNHSDNIGKISYPSFQIAPCFsqcfpnFLGKNIp 447
Cdd:cd00805   82 IPPEKAKFVNNSDWLLSLYTlDFLRLGKHFTVNRMlrrdavKVRLEEEEGISFSEFIYPLLQAYDFV------YLDVDL- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 448 clvpQ--GIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLQGVNSkmsstkkkkddnGKSnstfDHNNSVIFLTDTPEQ 525
Cdd:cd00805  155 ----QlgGSDQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDGGKM------------SKS----EGNAIWDPVLDSPYD 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124513482 526 IKNKINKyAFsgggttiqehrekggnlDKDIsYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTEL 599
Cdd:cd00805  215 VYQKIRN-AF-----------------DPDV-LEFLKLFTFLDYEEIEELEEEHAEGPLPRDAKKALAEELTKL 269
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 449-599 1.90e-05

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 47.16  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 449 LVPQGIDQDPYFRLSRDIAVKM--ALHKPVVVHSVFM-------PGLQGvnskmsstkkkkddNGK-SNSTfdhNNSvIF 518
Cdd:PRK12282 145 LVPVGDDQLPMIEQTREIVRRFnsLYGTDVLVEPEALlpeagrlPGLDG--------------KAKmSKSL---GNA-IY 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 519 LTDTPEQIKNKINK-YafsgggtTIQEH--REKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDV 595
Cdd:PRK12282 207 LSDDADTIKKKVMSmY-------TDPNHirVEDPGKVEGNVVFTYLDAFDPDKAEVAELKAHYQRGGLGDVKCKRYLEEV 279


                 ....
gi 124513482 596 LTEL 599
Cdd:PRK12282 280 LQEL 283
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 449-614 2.89e-05

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 46.62  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 449 LVPQGIDQDPYFRLSRDIAVKM-ALHKPV-VVHSVFMP-------GLqgvnskmsstkkkkDDNGK--SNSTfDHNNSVI 517
Cdd:PRK00927 141 LVPVGEDQKQHLELTRDIARRFnNLYGEVfPVPEPLIPkvgarvmGL--------------DGPTKkmSKSD-PNDNNTI 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 518 FLTDTPEQIKNKINKyAF--SGGGTTIQEHREKggnlDKDIS--YQYLRYLLEDDnkLNEIGEKYKKGEMLSGEIKKILI 593
Cdd:PRK00927 206 NLLDDPKTIAKKIKK-AVtdSERLREIRYDLPN----KPEVSnlLTIYSALSGES--IEELEAEYEAGGKGYGDFKKDLA 278

                        170       180
                 ....*....|....*....|.
gi 124513482 594 DVLTELVLKHQEKKKSLTDEE 614
Cdd:PRK00927 279 EAVVEFLAPIRERYEELLADP 299
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 396-532 2.37e-03

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 40.83  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 396 VLSIHKKTTLN------QSMnvfGFNHSDN--IGKISYPSFQIAPCFsqcfpnFLGKNIPCLvpqGIDQDPYFRLSRDIA 467
Cdd:PTZ00126 164 VMDIARSFNITrikrcsQIM---GRSEGDEqpCAQILYPCMQCADIF------YLKADICQL---GMDQRKVNMLAREYC 231

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124513482 468 -VKMALHKPVVVHSVFMPGL-QGvnskmsstkkkKDDNGKSNStfdhnNSVIFLTDTPEQIKNKINK 532
Cdd:PTZ00126 232 dKKKIKKKPIILSHHMLPGLlEG-----------QEKMSKSDP-----NSAIFMEDSEEDVNRKIKK 282
PRK13354 PRK13354
tyrosyl-tRNA synthetase; Provisional
 281-340 7.63e-03

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 237360 [Multi-domain]  Cd Length: 410  Bit Score: 39.11  E-value: 7.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124513482 281 RGIFFSHRDLDFLLNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVI 340
Cdd:PRK13354  12 RGAINQETDEEKLRKSLKEGKPLTLYLGFDPTAPSLHIGHLVPLMKLKRFQDAGHRPVIL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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