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Conserved domains on  [gi|124506177|ref|XP_001351686|]
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AKAP-like protein [Plasmodium falciparum 3D7]

Protein Classification

AKAP7-like phosphoesterase domain-containing protein( domain architecture ID 1908047)

AKAP7-like phosphoesterase domain-containing protein with similarities to the domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7 (also known as AKAP18), which belongs to the 2H RNA-phosphoesterase family and contains two conserved His-x-Thr motifs which may bind AMP and CMP. May act as a phosphoesterase or as an AMP sensor

CATH:  3.90.1140.10
PubMed:  27102985|27487922|18082768

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS super family cl44428
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 46-265 6.19e-30

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


The actual alignment was detected with superfamily member pfam10469:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 111.59  E-value: 6.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177   46 PNYFICIPIKNDNICNELINIQKHVLVKYDELKDCI-IERNKFHISLLILHIKKN-QIELSKEAFNEAMEKIKKNMHNEK 123
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDeEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177  124 IC--FEKLDTF-----RNDVLYLSLKEDSN-KYIINIINHLIDSFSKRGIKIIFNNKkpakeilsnnnkkelnknsndlq 195
Cdd:pfam10469  81 LSlrFKGLETFnddpsAVRVLYAKVEEDDHsPKLQELADRIIRRFQEAGLLVKENNS----------------------- 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124506177  196 HITPHLTLMKNSYMKKMYMNKKPQILP-FFYTDYDLTNLLKEQIDIQKIQFLEMDmDTSTSYYKIVSEFNL 265
Cdd:pfam10469 138 RVKLHMTLMNTRYRKKKYAKSKESFDArEILDEFKDFDFGTQKVSELHLCSMGSS-DESDGFYHVEASVKL 207
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 46-265 6.19e-30

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 111.59  E-value: 6.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177   46 PNYFICIPIKNDNICNELINIQKHVLVKYDELKDCI-IERNKFHISLLILHIKKN-QIELSKEAFNEAMEKIKKNMHNEK 123
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDeEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177  124 IC--FEKLDTF-----RNDVLYLSLKEDSN-KYIINIINHLIDSFSKRGIKIIFNNKkpakeilsnnnkkelnknsndlq 195
Cdd:pfam10469  81 LSlrFKGLETFnddpsAVRVLYAKVEEDDHsPKLQELADRIIRRFQEAGLLVKENNS----------------------- 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124506177  196 HITPHLTLMKNSYMKKMYMNKKPQILP-FFYTDYDLTNLLKEQIDIQKIQFLEMDmDTSTSYYKIVSEFNL 265
Cdd:pfam10469 138 RVKLHMTLMNTRYRKKKYAKSKESFDArEILDEFKDFDFGTQKVSELHLCSMGSS-DESDGFYHVEASVKL 207
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 46-265 6.19e-30

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 111.59  E-value: 6.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177   46 PNYFICIPIKNDNICNELINIQKHVLVKYDELKDCI-IERNKFHISLLILHIKKN-QIELSKEAFNEAMEKIKKNMHNEK 123
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDeEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124506177  124 IC--FEKLDTF-----RNDVLYLSLKEDSN-KYIINIINHLIDSFSKRGIKIIFNNKkpakeilsnnnkkelnknsndlq 195
Cdd:pfam10469  81 LSlrFKGLETFnddpsAVRVLYAKVEEDDHsPKLQELADRIIRRFQEAGLLVKENNS----------------------- 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124506177  196 HITPHLTLMKNSYMKKMYMNKKPQILP-FFYTDYDLTNLLKEQIDIQKIQFLEMDmDTSTSYYKIVSEFNL 265
Cdd:pfam10469 138 RVKLHMTLMNTRYRKKKYAKSKESFDArEILDEFKDFDFGTQKVSELHLCSMGSS-DESDGFYHVEASVKL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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