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Conserved domains on  [gi|149254044|ref|XP_001476078|]
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PRAME family member 8 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
195-401 4.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 195 LEILNVFHPEHIEEFELNTEWNVFN--LARFAPCLGQMRNLRKLLLAplyknvfkiANRtgdredkcVKEFVSIFSKFNC 272
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGnqLTDLPEELANLTNLKELDLS---------NNQ--------LTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 273 LQHLSMQG--VHFLTDHMSQvfrclMTPLESLSITHYQISqsDLDSfsccqSLFQLKHLemkgmvlQVLDV--MPLRGLL 348
Cdd:COG4886  161 LKSLDLSNnqLTDLPEELGN-----LTNLKELDLSNNQIT--DLPE-----PLGNLTNL-------EELDLsgNQLTDLP 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149254044 349 EKVA--KTLETLNLQGCKLKDsqlnalLPSFIRCSQLTKINLYNNDFS-MPILKDL 401
Cdd:COG4886  222 EPLAnlTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTdLPPLANL 271
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-401 4.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 195 LEILNVFHPEHIEEFELNTEWNVFN--LARFAPCLGQMRNLRKLLLAplyknvfkiANRtgdredkcVKEFVSIFSKFNC 272
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGnqLTDLPEELANLTNLKELDLS---------NNQ--------LTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 273 LQHLSMQG--VHFLTDHMSQvfrclMTPLESLSITHYQISqsDLDSfsccqSLFQLKHLemkgmvlQVLDV--MPLRGLL 348
Cdd:COG4886  161 LKSLDLSNnqLTDLPEELGN-----LTNLKELDLSNNQIT--DLPE-----PLGNLTNL-------EELDLsgNQLTDLP 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149254044 349 EKVA--KTLETLNLQGCKLKDsqlnalLPSFIRCSQLTKINLYNNDFS-MPILKDL 401
Cdd:COG4886  222 EPLAnlTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTdLPPLANL 271
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-401 4.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 195 LEILNVFHPEHIEEFELNTEWNVFN--LARFAPCLGQMRNLRKLLLAplyknvfkiANRtgdredkcVKEFVSIFSKFNC 272
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGnqLTDLPEELANLTNLKELDLS---------NNQ--------LTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149254044 273 LQHLSMQG--VHFLTDHMSQvfrclMTPLESLSITHYQISqsDLDSfsccqSLFQLKHLemkgmvlQVLDV--MPLRGLL 348
Cdd:COG4886  161 LKSLDLSNnqLTDLPEELGN-----LTNLKELDLSNNQIT--DLPE-----PLGNLTNL-------EELDLsgNQLTDLP 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149254044 349 EKVA--KTLETLNLQGCKLKDsqlnalLPSFIRCSQLTKINLYNNDFS-MPILKDL 401
Cdd:COG4886  222 EPLAnlTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTdLPPLANL 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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