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Conserved domains on  [gi|156843900|ref|XP_001645015|]
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uncharacterized protein Kpol_1072p27 [Vanderwaltozyma polyspora DSM 70294]

Protein Classification

POC3_POC4 domain-containing protein( domain architecture ID 10564532)

POC3_POC4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POC3_POC4 pfam10448
20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S ...
 1-142 5.15e-34

20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (POC3 and POC4) have been solved, and they closely resemble those of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them.


:

Pssm-ID: 402192  Cd Length: 136  Bit Score: 115.61  E-value: 5.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156843900    1 MSVQTFSKTLEPSGSISGkLLDVSVTIPVDLSNNKIPITVTIGSKEGGINAGENDTgndinnlKLLCYYYSISRRSDKND 80
Cdd:pfam10448   1 MIVRTIQKTLESLSGSFT-SLDVEVAIHAIHYSNKIPISIRINGEMDTTFESSSSG-------LLINYVYAISVSDKLSD 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156843900   81 VVSTVLLDTSIDSVRDT-TRQLSTLLCKKYRHPCYVAWSSDASN-TNDMFDQISIIKTCVQYIH 142
Cdd:pfam10448  73 VVVVVLLGTSSDMKIDIvARQIARLLVKKYNPPCYVTISSKWWRgTLDQASDFEKLMFVLECIK 136
 
Name Accession Description Interval E-value
POC3_POC4 pfam10448
20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S ...
 1-142 5.15e-34

20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (POC3 and POC4) have been solved, and they closely resemble those of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them.


Pssm-ID: 402192  Cd Length: 136  Bit Score: 115.61  E-value: 5.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156843900    1 MSVQTFSKTLEPSGSISGkLLDVSVTIPVDLSNNKIPITVTIGSKEGGINAGENDTgndinnlKLLCYYYSISRRSDKND 80
Cdd:pfam10448   1 MIVRTIQKTLESLSGSFT-SLDVEVAIHAIHYSNKIPISIRINGEMDTTFESSSSG-------LLINYVYAISVSDKLSD 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156843900   81 VVSTVLLDTSIDSVRDT-TRQLSTLLCKKYRHPCYVAWSSDASN-TNDMFDQISIIKTCVQYIH 142
Cdd:pfam10448  73 VVVVVLLGTSSDMKIDIvARQIARLLVKKYNPPCYVTISSKWWRgTLDQASDFEKLMFVLECIK 136
 
Name Accession Description Interval E-value
POC3_POC4 pfam10448
20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S ...
 1-142 5.15e-34

20S proteasome chaperone assembly proteins 3 and 4; This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (POC3 and POC4) have been solved, and they closely resemble those of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them.


Pssm-ID: 402192  Cd Length: 136  Bit Score: 115.61  E-value: 5.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156843900    1 MSVQTFSKTLEPSGSISGkLLDVSVTIPVDLSNNKIPITVTIGSKEGGINAGENDTgndinnlKLLCYYYSISRRSDKND 80
Cdd:pfam10448   1 MIVRTIQKTLESLSGSFT-SLDVEVAIHAIHYSNKIPISIRINGEMDTTFESSSSG-------LLINYVYAISVSDKLSD 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156843900   81 VVSTVLLDTSIDSVRDT-TRQLSTLLCKKYRHPCYVAWSSDASN-TNDMFDQISIIKTCVQYIH 142
Cdd:pfam10448  73 VVVVVLLGTSSDMKIDIvARQIARLLVKKYNPPCYVTISSKWWRgTLDQASDFEKLMFVLECIK 136
PAC4 pfam16093
Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes ...
 69-116 1.62e-04

Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.


Pssm-ID: 465017  Cd Length: 72  Bit Score: 37.93  E-value: 1.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 156843900   69 YYSISRRSDKNDVVSTVLLDTSidSVRDTTRQLSTLLCKKYRHPCYVA 116
Cdd:pfam16093  24 AVAMPTRYNSTPPLSTTLLGDP--SSDDFSTRLAQRLARRTGKQVYVS 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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