|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
343-1175 |
0e+00 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 567.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 343 PVPNSYESLEGGGYQDLAAPPAGVPSKQAPPFGYNYPTMHPgyqQSPAPRPDSSPAHGGYNPsgyQPYSQPFPSlnelss 422
Cdd:COG5028 45 PYTTPPLQQQSRRQIDQAATAMHNTGANNPAPSVMSPAFQS---QQKFSSPYGGSMADGTAP---KPTNPLVPV------ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 423 algglsgvpELEMETLRPLNLLQErnilPPKQASPPEPNLSSDLRKVNCSPDTFRCTLTNIPQTQALLNKARLPLGLLLH 502
Cdd:COG5028 113 ---------DLFEDQPPPISDLFL----PPPPIVPPLTTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 503 PFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPDEFmYNPVTRS--YGEPHKRPEVQN 575
Cdd:COG5028 180 PFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 576 STVEFIASSDYMLRPPQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPG-DTRTRIGFVTFDSTIHFYNLQEGLSQ 654
Cdd:COG5028 259 GVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 655 pQMLVVSDIEDVFIP-THDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLMCPTGGRVSVFQTQLPT 733
Cdd:COG5028 339 -QMLIVSDLDEPFLPfPSGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPN 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 734 LGAGLLQSREDPNLRsstktvqHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHhI 813
Cdd:COG5028 418 MGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-A 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 814 HNTAQRQKLQRDLQRYLSRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLANVNPDSGFAVQMSIEESLAdTSLAC 893
Cdd:COG5028 490 TRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVY 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 894 FQAALLYTSSKGKRRIRVHTLCLPVVSQLSEVFAGADIQAITCLLANMAIDRSVSSSLSDARDALVNAVVDCLSAYRAN- 972
Cdd:COG5028 569 FQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKEl 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 973 -GSNIqPSGLIAPAALRLFPLYVLALLKQKALRTGtSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRIDNMTEQGALHL 1051
Cdd:COG5028 649 vKSNT-STQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPD 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1052 NDSVV-PQPplLQLTAEKLTREGAFLMDCGSVMYLWVGKCCNEMFIRDVLGFPNYASLPSSMTEIPELQTTYSERTRAFI 1130
Cdd:COG5028 727 EGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNII 804
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 326673253 1131 SWLLE---SRTFHPAFhVVKDDAPA-KSSFFQHLVEDRTESAFSYYEFL 1175
Cdd:COG5028 805 GELRSvndDSTLPLVL-VRGGGDPSlRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
591-834 |
6.19e-127 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 388.94 E-value: 6.19e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 591 PQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPGD-TRTRIGFVTFDSTIHFYNLQEGLSQPQMLVVSDIEDVFIP 669
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 670 THDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLMCPTGGRVSVFQTQLPTLGAGLLQSREDPNLRS 749
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 750 STKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHiHNTAQRQKLQRDLQRY 829
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFNF-SAPNDVEKLVNELARY 239
|
....*
gi 326673253 830 LSRKI 834
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
591-830 |
1.69e-106 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 334.22 E-value: 1.69e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 591 PQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPGDTRTRIGFVTFDSTIHFYNLQEGLSQPQMLVVSDIEDVFIPT 670
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 671 HDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLM--CPTGGRVSVFQTQLPTLGA-GLLQSREDPNL 747
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 748 RSSTKTVQHLAPATD-FYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHIHntaQRQKLQRDL 826
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 326673253 827 QRYL 830
Cdd:pfam04811 238 QRYF 241
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
556-1184 |
1.51e-36 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 151.00 E-value: 1.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 556 MYNPVTRSYGEPHKRPEVQNSTVEFIASSDYMLrppqPAVYLFVLDVSHNAVesgYLNVfCQSLLDNLD------KLPgd 629
Cdd:PTZ00395 919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI---YNNI-TYTILEGIRyavqnvKCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 630 tRTRIGFVTFDSTIHFYNLQEGLSQP-------------QMLVVSDIEDVFIPTH-DSLLVNLKESKELVKDLLNALPGM 695
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 696 FSQTRETQSALGPALQAAYKLMCPTGG--RVSVFQTQLPTLGAGLLQSREDPNLRSSTKTVQHLapatdFYKKLALDCSG 773
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 774 QQIGVDLFLLSSQYSDLA--SLACVSKYSAGSVFYYPSFhhIHNTAQRQKLQRDLQRYLSRKIGFEAVMRIRCTKGLSIH 851
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF--LWQKDYKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVK 1220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 852 TF---HGNF-FVRSTDLLSLANVNPDSGFAVQMSIEESLADTSLACFQAALLYTSSKGKRRIRVHTLCLPVVSQLSEVFA 927
Cdd:PTZ00395 1221 KLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFR 1300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 928 GADIQAitclLANMAIDRSVSSSLSDarDALVNAVVDCLSA----YRANGSNIQPSG-LIAPAALRLFPLYVLALLKQKA 1002
Cdd:PTZ00395 1301 YTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPLFTSSLLKHNV 1374
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1003 lrTGTSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRID---NMTEQGALHLNDSVVPqPPLLQLTAEKLTREGAFLMDC 1079
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIHikgKTNEIDSMDVDDDLFI-PKTIPSSAEKIYSNGIYLLDA 1451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1080 GSVMYLWVGKCCNEMFIRDVLGfpnyaSLPSSMT--EIPELQTTYSERTRAFISWLleSRTFHPAFHVVKDDAPAKSSFF 1157
Cdd:PTZ00395 1452 CTHFYLYFGFHSDANFAKEIVG-----DIPTEKNahELNLTDTPNAQKVQRIIKNL--SRIHHFNKYVPLVMVAPKSNEE 1524
|
650 660 670
....*....|....*....|....*....|.
gi 326673253 1158 QHL----VEDRTESAFSYYEFLLHVQQQMSK 1184
Cdd:PTZ00395 1525 EHLislcVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
17-463 |
3.70e-12 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 70.95 E-value: 3.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 17 SMSSAQNG---GGAATVPCQNGPG-QAYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDYSGNYYQNSSGPSL 92
Cdd:pfam03154 158 SDSSAQQQilqTQPPVLQAQSGAAsPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 93 YPAAPGSqtaahpystsnaPVPSLQQAAPYAMPAGYYGQPYSQPS-HGQTHAQPQQMQ--PSLVPassgnnlgAPLyPIV 169
Cdd:pfam03154 238 HPQRLPS------------PHPPLQPMTQPPPPSQVSPQPLPQPSlHGQMPPMPHSLQtgPSHMQ--------HPV-PPQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 170 SYPSAPGSSQYGTLRSSQTGIGQPPVSTV-MPPPPTQSSLQQYSQGKGATPTP-AHPGYGAPPLSQTPtvngqsnavqqh 247
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQSQLQSQQPPREQPLPPAPlSMPHIKPPPTTPIP------------ 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 248 ydqNLVNPMGH----HYSGAPPTSTGPNTERTPSGTPGASV--HSSPGHHQGLLYAdrgvnnavssaagdhsssssdhee 321
Cdd:pfam03154 365 ---QLPNPQSHkhppHLSGPSPFQMNSNLPPPPALKPLSSLstHHPPSAHPPPLQL------------------------ 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 322 edeedeeaggdssstttgsaspVPNSyeslegggyQDLAAPPAGVP----SKQAPPFGYNYPT---MHPGYQQSPAPR-- 392
Cdd:pfam03154 418 ----------------------MPQS---------QQLPPPPAQPPvltqSQSLPPPAASHPPtsgLHQVPSQSPFPQhp 466
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 326673253 393 --PDSSPAHggYNPSGYQPYSQP-FPSLNELSSALGGLSG-VPELEMETLRPLNLLQERNILPPKQASPPEPNLS 463
Cdd:pfam03154 467 fvPGGPPPI--TPPSGPPTSTSSaMPGIQPPSSASVSSSGpVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
27-289 |
1.70e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 27 AATVPCQNGPGQAYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAgkiPVSGTDYSGNYYQNSSGPSLYPAAPGSQTAAHPY 106
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP---AVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 107 STSNA----PVPSLQQAAPyAMPAGYYgQPYSQPSH-----GQTHAQPQQMQPSLVPAssgnnlgAPLYPIVSYPSAPG- 176
Cdd:PHA03247 2821 AASPAgplpPPTSAQPTAP-PPPPGPP-PPSLPLGGsvapgGDVRRRPPSRSPAAKPA-------APARPPVRRLARPAv 2891
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 177 SSQYGTLRSSQTGIGQPPVSTVMPPPPTQSSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVNGQSNAVQQHYDQNLVnPM 256
Cdd:PHA03247 2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV-PG 2970
|
250 260 270
....*....|....*....|....*....|...
gi 326673253 257 GHHYSGAPPTSTGPNTERTPSGTPGASVHSSPG 289
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
39-257 |
1.80e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 45.51 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 39 AYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDYSGNYYqnSSGPSLYPAAPGSQTAAHPYSTSNAPVPSLQQ 118
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTT--GSVVVAASGSAGSGTGTTAASSTAATSSTTST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 119 AAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPIVSYPSAPGSSQYGTLRSSQTGIGQPPVSTV 198
Cdd:COG3469 79 TATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTET 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 326673253 199 MPPPPTQ--------SSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVNGQSNAVQQH----YDQNLVNPMG 257
Cdd:COG3469 159 ATGGTTTtsttttttSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHvlvgYWHNFDNGSG 229
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
106-233 |
2.45e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.10 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 106 YSTSNAPVPSLQQAAPyaMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPiVSYPsaPGSSQYGTLRS 185
Cdd:TIGR01628 375 FMQLQPRMRQLPMGSP--MGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRP-NGLA--PMNAVRAPSRN 449
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 326673253 186 SQTGIGQPPVSTVMPPPPTQSslQQYSQGKGATPTPAHPGYGAPPLSQ 233
Cdd:TIGR01628 450 AQNAAQKPPMQPVMYPPNYQS--LPLSQDLPQPQSTASQGGQNKKLAQ 495
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
343-1175 |
0e+00 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 567.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 343 PVPNSYESLEGGGYQDLAAPPAGVPSKQAPPFGYNYPTMHPgyqQSPAPRPDSSPAHGGYNPsgyQPYSQPFPSlnelss 422
Cdd:COG5028 45 PYTTPPLQQQSRRQIDQAATAMHNTGANNPAPSVMSPAFQS---QQKFSSPYGGSMADGTAP---KPTNPLVPV------ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 423 algglsgvpELEMETLRPLNLLQErnilPPKQASPPEPNLSSDLRKVNCSPDTFRCTLTNIPQTQALLNKARLPLGLLLH 502
Cdd:COG5028 113 ---------DLFEDQPPPISDLFL----PPPPIVPPLTTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 503 PFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPDEFmYNPVTRS--YGEPHKRPEVQN 575
Cdd:COG5028 180 PFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 576 STVEFIASSDYMLRPPQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPG-DTRTRIGFVTFDSTIHFYNLQEGLSQ 654
Cdd:COG5028 259 GVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 655 pQMLVVSDIEDVFIP-THDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLMCPTGGRVSVFQTQLPT 733
Cdd:COG5028 339 -QMLIVSDLDEPFLPfPSGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPN 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 734 LGAGLLQSREDPNLRsstktvqHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHhI 813
Cdd:COG5028 418 MGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-A 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 814 HNTAQRQKLQRDLQRYLSRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLANVNPDSGFAVQMSIEESLAdTSLAC 893
Cdd:COG5028 490 TRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVY 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 894 FQAALLYTSSKGKRRIRVHTLCLPVVSQLSEVFAGADIQAITCLLANMAIDRSVSSSLSDARDALVNAVVDCLSAYRAN- 972
Cdd:COG5028 569 FQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKEl 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 973 -GSNIqPSGLIAPAALRLFPLYVLALLKQKALRTGtSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRIDNMTEQGALHL 1051
Cdd:COG5028 649 vKSNT-STQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPD 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1052 NDSVV-PQPplLQLTAEKLTREGAFLMDCGSVMYLWVGKCCNEMFIRDVLGFPNYASLPSSMTEIPELQTTYSERTRAFI 1130
Cdd:COG5028 727 EGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNII 804
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 326673253 1131 SWLLE---SRTFHPAFhVVKDDAPA-KSSFFQHLVEDRTESAFSYYEFL 1175
Cdd:COG5028 805 GELRSvndDSTLPLVL-VRGGGDPSlRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
591-834 |
6.19e-127 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 388.94 E-value: 6.19e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 591 PQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPGD-TRTRIGFVTFDSTIHFYNLQEGLSQPQMLVVSDIEDVFIP 669
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 670 THDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLMCPTGGRVSVFQTQLPTLGAGLLQSREDPNLRS 749
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 750 STKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHiHNTAQRQKLQRDLQRY 829
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFNF-SAPNDVEKLVNELARY 239
|
....*
gi 326673253 830 LSRKI 834
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
591-830 |
1.69e-106 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 334.22 E-value: 1.69e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 591 PQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPGDTRTRIGFVTFDSTIHFYNLQEGLSQPQMLVVSDIEDVFIPT 670
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 671 HDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLM--CPTGGRVSVFQTQLPTLGA-GLLQSREDPNL 747
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 748 RSSTKTVQHLAPATD-FYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHIHntaQRQKLQRDL 826
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 326673253 827 QRYL 830
Cdd:pfam04811 238 QRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
591-828 |
3.40e-104 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 328.05 E-value: 3.40e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 591 PQPAVYLFVLDVSHNAVESGYLNVFCQSLLDNLDKLPGDTRTRIGFVTFDSTIHFYNLQEGLSQPQMLVVSDIEDVFIPT 670
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 671 HDSLLVNLKESKELVKDLLNALPGMFSQ--TRETQSALGPALQAAYKLM--CPTGGRVSVFQTQLPTLGAGLLQSREDPN 746
Cdd:cd01468 81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLkgTFAGGRIIVFQGGLPTVGPGKLKSREDKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 747 LRSSTKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHIHNTaqrQKLQRDL 826
Cdd:cd01468 161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDG---SKFKQDL 237
|
..
gi 326673253 827 QR 828
Cdd:cd01468 238 QR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
556-1184 |
1.51e-36 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 151.00 E-value: 1.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 556 MYNPVTRSYGEPHKRPEVQNSTVEFIASSDYMLrppqPAVYLFVLDVSHNAVesgYLNVfCQSLLDNLD------KLPgd 629
Cdd:PTZ00395 919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI---YNNI-TYTILEGIRyavqnvKCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 630 tRTRIGFVTFDSTIHFYNLQEGLSQP-------------QMLVVSDIEDVFIPTH-DSLLVNLKESKELVKDLLNALPGM 695
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 696 FSQTRETQSALGPALQAAYKLMCPTGG--RVSVFQTQLPTLGAGLLQSREDPNLRSSTKTVQHLapatdFYKKLALDCSG 773
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 774 QQIGVDLFLLSSQYSDLA--SLACVSKYSAGSVFYYPSFhhIHNTAQRQKLQRDLQRYLSRKIGFEAVMRIRCTKGLSIH 851
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF--LWQKDYKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVK 1220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 852 TF---HGNF-FVRSTDLLSLANVNPDSGFAVQMSIEESLADTSLACFQAALLYTSSKGKRRIRVHTLCLPVVSQLSEVFA 927
Cdd:PTZ00395 1221 KLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFR 1300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 928 GADIQAitclLANMAIDRSVSSSLSDarDALVNAVVDCLSA----YRANGSNIQPSG-LIAPAALRLFPLYVLALLKQKA 1002
Cdd:PTZ00395 1301 YTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPLFTSSLLKHNV 1374
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1003 lrTGTSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRID---NMTEQGALHLNDSVVPqPPLLQLTAEKLTREGAFLMDC 1079
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIHikgKTNEIDSMDVDDDLFI-PKTIPSSAEKIYSNGIYLLDA 1451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 1080 GSVMYLWVGKCCNEMFIRDVLGfpnyaSLPSSMT--EIPELQTTYSERTRAFISWLleSRTFHPAFHVVKDDAPAKSSFF 1157
Cdd:PTZ00395 1452 CTHFYLYFGFHSDANFAKEIVG-----DIPTEKNahELNLTDTPNAQKVQRIIKNL--SRIHHFNKYVPLVMVAPKSNEE 1524
|
650 660 670
....*....|....*....|....*....|.
gi 326673253 1158 QHL----VEDRTESAFSYYEFLLHVQQQMSK 1184
Cdd:PTZ00395 1525 EHLislcVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
930-1031 |
1.69e-35 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 130.32 E-value: 1.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 930 DIQAITCLLANMAIDRSVSSSLSDARDALVNAVVDCLSAYRAN-GSNIQPSGLIAPAALRLFPLYVLALLKQKALRTGTS 1008
Cdd:pfam04815 1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYcASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
|
90 100
....*....|....*....|...
gi 326673253 1009 TRLDERVFSMCEFKSQPLHQIMR 1031
Cdd:pfam04815 81 SPSDERAYARHLLLSLPVEELLL 103
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
835-919 |
3.81e-33 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 123.03 E-value: 3.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 835 GFEAVMRIRCTKGLSIHTFHGNFFVRS-TDLLSLANVNPDSGFAVQMSIEESLADTSLACFQAALLYTSSKGKRRIRVHT 913
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 326673253 914 LCLPVV 919
Cdd:pfam08033 81 VALPVT 86
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
474-1089 |
5.84e-23 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 105.73 E-value: 5.84e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 474 DTFRCTLTNIPQTQALLNKARLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfLDQRR--WKCNLCYRVNDV 551
Cdd:COG5047 10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 552 PDEfmYNPVTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVESGYLNVFCQSLLDNLDKLPGDt 630
Cdd:COG5047 89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPE- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 631 rTRIGFVTFDSTIHF----------------------YNLQE--GLSQPQMLVVSDIEDVFI----------PTHDSLLV 676
Cdd:COG5047 156 -ALVGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGFESKISGIgqfassrfllPTQQCEFK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 677 NLKESKELVKDLLNALPGmFSQTRETQSALGPA---LQAAYKLMcptGGRVSVFQTQLPTLGAGLLQSRE--DPnLRS-- 749
Cdd:COG5047 235 LLNILEQLQPDPWPVPAG-KRPLRCTGSALNIAsslLEQCFPNA---GCHIVLFAGGPCTVGPGTVVSTElkEP-MRShh 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 750 --STKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFhhihntaQRQKLQRDLQ 827
Cdd:COG5047 310 diESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSF-------TTSIFKQSFQ 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 828 RYLSR------KIGFEAVMRIRCTKGLSIHTFHGN---------------FFVRSTDLLSLANVNPDSGFAVQMSIEESL 886
Cdd:COG5047 383 RIFNRdsegylKMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGA 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 887 ADTS-----LACFQAALLYTSSKGKRRIRVHTLCLPVVSQLSEVFAGA-DIQAITCLLANMAIDRSVSSSLSDARDALVN 960
Cdd:COG5047 463 ASGSaqrpaEAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKINRSfDQEAAAVFMARIAAFKAETEDIIDVFRWIDR 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 961 AVVDCLSAYrANGSNIQPSGLIAPAALRLFPLYVLALLKQKALRTGtSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRI 1040
Cdd:COG5047 543 NLIRLCQKF-ADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVF-NNSPDETAFYRHMLNNADVNDSLIMIQPTLQSY 620
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 326673253 1041 dNMTEQGALHLNDSVVPQPPLLQLTAEKLTregaFLMDCGSVMYLWVGK 1089
Cdd:COG5047 621 -SFEKGGVPVLLDSVSVKPDVILLLDTFFH----ILIFHGSYIAQWRNA 664
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
518-554 |
8.01e-16 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 72.09 E-value: 8.01e-16
10 20 30
....*....|....*....|....*....|....*...
gi 326673253 518 IVRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPDE 554
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
477-846 |
2.52e-15 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 81.14 E-value: 2.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 477 RCTLTNIPQTQALLNKARLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFlDQRRWKCNLCYRVNDVPde 554
Cdd:PLN00162 13 RMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHFP-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 555 fmynpvtRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVESGYLNvfcQSLLDNLDKLPGD 629
Cdd:PLN00162 89 -------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALLPEN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 630 trTRIGFVTFDSTIHFYNL------------------------QEGLS----QPQMLVVSDIEDVFIPTH-DSLLVNLKE 680
Cdd:PLN00162 158 --ALVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLPASE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 681 SK--------ELVKDLLNALPGMFSQtRETqsalGPALQAAYKLM--C-P-TGGRVSVFQTQLPTLGAGLLQSRE--DPn 746
Cdd:PLN00162 236 CEftlnsaleELQKDPWPVPPGHRPA-RCT----GAALSVAAGLLgaCvPgTGARIMAFVGGPCTEGPGAIVSKDlsEP- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 747 LRS----STKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLSSQYSDLASLACVSKYSAGSVFYYPSFHHihnTAQRQKL 822
Cdd:PLN00162 310 IRShkdlDKDAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGH---SVFKDSL 386
|
410 420
....*....|....*....|....*...
gi 326673253 823 QRDLQR----YLsrKIGFEAVMRIRCTK 846
Cdd:PLN00162 387 RRVFERdgegSL--GLSFNGTFEVNCSK 412
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
17-463 |
3.70e-12 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 70.95 E-value: 3.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 17 SMSSAQNG---GGAATVPCQNGPG-QAYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDYSGNYYQNSSGPSL 92
Cdd:pfam03154 158 SDSSAQQQilqTQPPVLQAQSGAAsPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 93 YPAAPGSqtaahpystsnaPVPSLQQAAPYAMPAGYYGQPYSQPS-HGQTHAQPQQMQ--PSLVPassgnnlgAPLyPIV 169
Cdd:pfam03154 238 HPQRLPS------------PHPPLQPMTQPPPPSQVSPQPLPQPSlHGQMPPMPHSLQtgPSHMQ--------HPV-PPQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 170 SYPSAPGSSQYGTLRSSQTGIGQPPVSTV-MPPPPTQSSLQQYSQGKGATPTP-AHPGYGAPPLSQTPtvngqsnavqqh 247
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQSQLQSQQPPREQPLPPAPlSMPHIKPPPTTPIP------------ 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 248 ydqNLVNPMGH----HYSGAPPTSTGPNTERTPSGTPGASV--HSSPGHHQGLLYAdrgvnnavssaagdhsssssdhee 321
Cdd:pfam03154 365 ---QLPNPQSHkhppHLSGPSPFQMNSNLPPPPALKPLSSLstHHPPSAHPPPLQL------------------------ 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 322 edeedeeaggdssstttgsaspVPNSyeslegggyQDLAAPPAGVP----SKQAPPFGYNYPT---MHPGYQQSPAPR-- 392
Cdd:pfam03154 418 ----------------------MPQS---------QQLPPPPAQPPvltqSQSLPPPAASHPPtsgLHQVPSQSPFPQhp 466
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 326673253 393 --PDSSPAHggYNPSGYQPYSQP-FPSLNELSSALGGLSG-VPELEMETLRPLNLLQERNILPPKQASPPEPNLS 463
Cdd:pfam03154 467 fvPGGPPPI--TPPSGPPTSTSSaMPGIQPPSSASVSSSGpVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
1055-1130 |
1.40e-07 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 50.00 E-value: 1.40e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 326673253 1055 VVPQPPLLQLTAEKLTREGAFLMDCGSVMYLWVGKccNEMFIRDVLGFPNYASLPSSM-TEIPELQT-TYSERTRAFI 1130
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGK--GSSLLEKLFAALLAAQLDDDErFPLPEVIRvPQGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
27-289 |
1.70e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 27 AATVPCQNGPGQAYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAgkiPVSGTDYSGNYYQNSSGPSLYPAAPGSQTAAHPY 106
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP---AVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 107 STSNA----PVPSLQQAAPyAMPAGYYgQPYSQPSH-----GQTHAQPQQMQPSLVPAssgnnlgAPLYPIVSYPSAPG- 176
Cdd:PHA03247 2821 AASPAgplpPPTSAQPTAP-PPPPGPP-PPSLPLGGsvapgGDVRRRPPSRSPAAKPA-------APARPPVRRLARPAv 2891
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 177 SSQYGTLRSSQTGIGQPPVSTVMPPPPTQSSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVNGQSNAVQQHYDQNLVnPM 256
Cdd:PHA03247 2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV-PG 2970
|
250 260 270
....*....|....*....|....*....|...
gi 326673253 257 GHHYSGAPPTSTGPNTERTPSGTPGASVHSSPG 289
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
35-464 |
3.22e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.86 E-value: 3.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 35 GPGQAYPAMYPPSSYYSSAPPTGY------PTMTGH----SAPPAGKIPVSGTDYSGNyyqnSSGPSLYPAAPGSQTAAH 104
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPaprpsePAVTSRarrpDAPPQSARPRAPVDDRGD----PRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 105 PYSTSNAPVPSlQQAAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSgnnlgaplypivSYPSAPGSSQYGTLR 184
Cdd:PHA03247 2626 PPPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS------------SPPQRPRRRAARPTV 2692
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 185 SSQTGIGQPPVstvmPPPPTQSSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVNGQSNAVqqhydqnlVNPMGHHYSGAP 264
Cdd:PHA03247 2693 GSLTSLADPPP----PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP--------ATPGGPARPARP 2760
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 265 PTSTGPNTERTPSGTPGASVHSSPGHHQGLLYADRGVNNAVSSAAGDHSSSSSDHEEEDEEDEEAGGDSSSTTTGSASPV 344
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 345 PNS-----YESLEG----GGYQDLAAPPAGVPSKQA------------------------PPFGYNYPTmHPGYQQSPAP 391
Cdd:PHA03247 2841 PPPgppppSLPLGGsvapGGDVRRRPPSRSPAAKPAaparppvrrlarpavsrstesfalPPDQPERPP-QPQAPPPPQP 2919
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 326673253 392 RPDSSPAHGGYNPSGYQPYSQPFPSLNELSSALGGLSG-VPELEMETLRPLNLLQERNILPPKQASPPEPNLSS 464
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGaVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST 2993
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
59-237 |
1.02e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 50.08 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 59 PTMTGHSAPPAGKIPVSGTDYSGNYYQNSSGPSLYPAAPGSQTAAHPYSTSNAPVPSLQQAAPYAMPA--GYYGQP-YSQ 135
Cdd:PRK10263 309 PLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPApeGYPQQSqYAQ 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 136 PS--HGQTHAQPQQMQPSLVPASSGNNLGAPLYpiVSYPSAPGSSQYGTLRSSQTGIGQP----PVSTVMPPPPTQSSLQ 209
Cdd:PRK10263 389 PAvqYNEPLQQPVQPQQPYYAPAAEQPAQQPYY--APAPEQPAQQPYYAPAPEQPVAGNAwqaeEQQSTFAPQSTYQTEQ 466
|
170 180
....*....|....*....|....*...
gi 326673253 210 QYSQgkgatPTPAHPGYGAPPLSQTPTV 237
Cdd:PRK10263 467 TYQQ-----PAAQEPLYQQPQPVEQQPV 489
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
28-224 |
2.47e-05 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 48.90 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 28 ATVPCQNGPGQAY---PAMYPPSSYYSSAPPTGYPTMtGHSAPPAGKIPVSG-TDYSGNYYQNSSGPSL-YPAAPGSQTA 102
Cdd:PHA03377 739 APPPSHQAPYSGHeepQAQQAPYPGYWEPRPPQAPYL-GYQEPQAQGVQVSSyPGYAGPWGLRAQHPRYrHSWAYWSQYP 817
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 103 AHPYstsnaPVPSLQQAAPYAMP--AGYygqpysqPSHGQTH-AQPQQMQPSLVPASsgnnLGAPLYPIVSYPSAPGSSQ 179
Cdd:PHA03377 818 GHGH-----PQGPWAPRPPHLPPqwDGS-------AGHGQDQvSQFPHLQSETGPPR----LQLSQVPQLPYSQTLVSSS 881
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 326673253 180 YGTLRSSQTGIGQPPVSTVMPPPPTQsslQQYSQGKGAT-PTPAHP 224
Cdd:PHA03377 882 APSWSSPQPRAPIRPIPTRFPPPPMP---LQDSMAVGCDsSGTACP 924
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
73-293 |
1.58e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 46.18 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 73 PVSGTDYSGNYYQNSSGPSLYPAAPGSQTAAHPYST------SNAPVPSLQ------------QAAPYAMPAgyygQPYS 134
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykEPEPIPDLQvdaslwgvapkkAAAPAPAPQ----PAAQ 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 135 QPSHGQT----------------HAQPQQMQPSLVPASSGnnlgAPLYPIVSYPSAPGSSQYGTLRSSQTGIGQPPVSTV 198
Cdd:pfam09770 183 PASLPAPsrkmmsleeveaamraQAKKPAQQPAPAPAQPP----AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 199 MPPPPTQSSLQQYSQGKGATPtpahpgygaPPLSQTPTVNGQSNAVQQHYDQNLVNPmghhysGAPPTSTGPNTERTPSG 278
Cdd:pfam09770 259 QGHPVTILQRPQSPQPDPAQP---------SIQPQAQQFHQQPPPVPVQPTQILQNP------NRLSAARVGYPQNPQPG 323
|
250
....*....|....*
gi 326673253 279 TPGAsvHSSPGHHQG 293
Cdd:pfam09770 324 VQPA--PAHQAHRQQ 336
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
39-257 |
1.80e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 45.51 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 39 AYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDYSGNYYqnSSGPSLYPAAPGSQTAAHPYSTSNAPVPSLQQ 118
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTT--GSVVVAASGSAGSGTGTTAASSTAATSSTTST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 119 AAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPIVSYPSAPGSSQYGTLRSSQTGIGQPPVSTV 198
Cdd:COG3469 79 TATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTET 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 326673253 199 MPPPPTQ--------SSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVNGQSNAVQQH----YDQNLVNPMG 257
Cdd:COG3469 159 ATGGTTTtsttttttSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHvlvgYWHNFDNGSG 229
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
25-235 |
1.85e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 45.75 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 25 GGAATVPCQNGP--GQAYPAMYPPSSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDYSGNYYQNSSGPSLYPAAPGSQTA 102
Cdd:PRK07764 579 GGDWQVEAVVGPapGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVA 658
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 103 AHPYSTSNAPVPSLQQAAPyamPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASsgnnlgaplypivsyPSAPGSSQYGT 182
Cdd:PRK07764 659 VPDASDGGDGWPAKAGGAA---PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP---------------PAGQADDPAAQ 720
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 326673253 183 LRSSQTGIGQPPVST--VMPPPPTQSSLQQYSQGKGATPTPAHPGYGAPPLSQTP 235
Cdd:PRK07764 721 PPQAAQGASAPSPAAddPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
2-233 |
2.37e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 2 STQGYGNPQSAV-NNYSMSSAQNGGGAATVPCQNGPG--QAYPAMYPPSSYYSSAPPTGYPTMTgHSAP----------- 67
Cdd:PRK10263 329 ATQSWAAPVEPVtQTPPVASVDVPPAQPTVAWQPVPGpqTGEPVIAPAPEGYPQQSQYAQPAVQ-YNEPlqqpvqpqqpy 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 68 --PAGKIPVSGTDYSGNYYQNSSGPSLYPA----APGSQTAAHPYSTSNAPVPSLQQAAPYAMPAG---YYGQPYSQPSH 138
Cdd:PRK10263 408 yaPAAEQPAQQPYYAPAPEQPAQQPYYAPApeqpVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAqepLYQQPQPVEQQ 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 139 GQTHAQP--QQMQPSLVP-----------ASSGNNLGAPLYPIVSYPSAPGSSQYGTLRSSQTGIgqPPVSTVMPPPPTQ 205
Cdd:PRK10263 488 PVVEPEPvvEETKPARPPlyyfeeveekrAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAAV--PPVEAAAAVSPLA 565
|
250 260 270
....*....|....*....|....*....|..
gi 326673253 206 SSLQQYSQGKGATPTPAHPGY----GAPPLSQ 233
Cdd:PRK10263 566 SGVKKATLATGAAATVAAPVFslanSGGPRPQ 597
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
20-265 |
1.08e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 43.30 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 20 SAQNGGGAATVPCQNG-PGQAYPAMYPPSSYYSSAPPTGYPtmtGHSAPPAGKIPVSGTDysgnyyqnSSGPSLYPAAPG 98
Cdd:PRK07003 366 GAPGGGVPARVAGAVPaPGARAAAAVGASAVPAVTAVTGAA---GAALAPKAAAAAAATR--------AEAPPAAPAPPA 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 99 SQTAAHPYSTSNAPVPSLQ--QAAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPIVSYPSAPG 176
Cdd:PRK07003 435 TADRGDDAADGDAPVPAKAnaRASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPA 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 177 SSQygtlRSSQTGIGQPPVSTVMPPPPTQSSLQQYSQG----------------------KGATPTPAHPGYGAP----- 229
Cdd:PRK07003 515 AAS----REDAPAAAAPPAPEARPPTPAAAAPAARAGGaaaaldvlrnagmrvssdrgarAAAAAKPAAAPAAAPkpaap 590
|
250 260 270
....*....|....*....|....*....|....*..
gi 326673253 230 -PLSQTPTVNGQSNAVQQHYDQNLVNPMGHHYSGAPP 265
Cdd:PRK07003 591 rVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
25-287 |
1.26e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 43.13 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 25 GGAATVPCQNGPGQAYPamyPPSSYYSSAPPTGYPT-MTGHSAPPAGKIPVSGTDYSGNYYQNSSGPSLYPAapGSQTAA 103
Cdd:PHA03378 680 GANTMLPIQWAPGTMQP---PPRAPTPMRPPAAPPGrAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA--AAPGRA 754
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 104 HPYSTSNAPVPSlqqaapyamPAGYYGQPYSQPShGQTHAQPQQmQPSLVPASSGNNLGAPLYPIVSYPSAPGssQYGTL 183
Cdd:PHA03378 755 RPPAAAPGRARP---------PAAAPGAPTPQPP-PQAPPAPQQ-RPRGAPTPQPPPQAGPTSMQLMPRAAPG--QQGPT 821
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 184 RSSQTGIGQPPVSTVMPPPPTQSSLQQYsqgKGATPTPAhPGYGA-----------PPLSQTPTVNGQSNAV-------- 244
Cdd:PHA03378 822 KQILRQLLTGGVKRGRPSLKKPAALERQ---AAAGPTPS-PGSGTsdkivqapvfyPPVLQPIQVMRQLGSVraaaastv 897
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 326673253 245 -----QQHYDQNLVNPMghHYSGAPPTSTGPNTERTPSGTP-GASVHSS 287
Cdd:PHA03378 898 tqaptEYTGERRGVGPM--HPTDIPPSKRAKTDAYVESQPPhGGQSHSF 944
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
90-224 |
2.26e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 42.33 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 90 PSLYPAAPGSQTAAHPYSTSNAPVPSLQQAAPYAMPA-GYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPi 168
Cdd:pfam09770 215 APAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQqPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPP- 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 169 vsyPSAPGSSQY----GTLRSSQTGIGQPPVSTVmPPPPTQSSLQQYSQGKGATPTPAHP 224
Cdd:pfam09770 294 ---PVPVQPTQIlqnpNRLSAARVGYPQNPQPGV-QPAPAHQAHRQQGSFGRQAPIITHP 349
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
106-233 |
2.45e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.10 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 106 YSTSNAPVPSLQQAAPyaMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAPLYPiVSYPsaPGSSQYGTLRS 185
Cdd:TIGR01628 375 FMQLQPRMRQLPMGSP--MGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRP-NGLA--PMNAVRAPSRN 449
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 326673253 186 SQTGIGQPPVSTVMPPPPTQSslQQYSQGKGATPTPAHPGYGAPPLSQ 233
Cdd:TIGR01628 450 AQNAAQKPPMQPVMYPPNYQS--LPLSQDLPQPQSTASQGGQNKKLAQ 495
|
|
| gelsolin_S3_like |
cd11292 |
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ... |
1035-1092 |
2.99e-03 |
|
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.
Pssm-ID: 200448 Cd Length: 98 Bit Score: 38.38 E-value: 2.99e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 326673253 1035 PDLYRIDNMTEQGALHLndsvVPQPPLLQltaEKLTREGAFLMDCGSVMYLWVGKCCN 1092
Cdd:cd11292 4 KKLYKVSDASGKLKLTE----VAEGSLNQ---EMLDSEDCYILDCGSEIFVWVGKGAS 54
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
7-204 |
3.02e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 7 GNPQSAVNNYSMSSAQNGGGAATVPCQNGPGQAYPAMYPP-SSYYSSAPPTGYPTMTGHSAPPAGKIPVSGTDysgnyyq 85
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAaPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD------- 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 86 nSSGPSLYPAAPGSQTAAhpySTSNAPVPSLQQAAPYAMPAGYyGQPYSQPSHGQTHAQPQQMQPSLVPASSGNN----L 161
Cdd:PRK07764 668 -GWPAKAGGAAPAAPPPA---PAPAAPAAPAGAAPAQPAPAPA-ATPPAGQADDPAAQPPQAAQGASAPSPAADDpvplP 742
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 326673253 162 GAPLYPIVSYPSAPGSSQYGTLRSSQTGIGQPPVSTVMPPPPT 204
Cdd:PRK07764 743 PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
22-238 |
3.54e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 22 QNGGGAATVPCQNGP-GQAYPAMYPPSSyySSAPPTGYPTMTGHSAPPAGKIPVSGtdysgnyyqnsSGPSLYPAAPGSQ 100
Cdd:PRK12323 367 QSGGGAGPATAAAAPvAQPAPAAAAPAA--AAPAPAAPPAAPAAAPAAAAAARAVA-----------AAPARRSPAPEAL 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326673253 101 TAAHPYSTSNAPVPSLQQAAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSGNNLGAP--------LYPIVSYP 172
Cdd:PRK12323 434 AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpweelppeFASPAPAQ 513
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 326673253 173 SAPGSSQYGTLRSSQTGIGQPPVS-TVMPPPPTQSSLQQYSQGKGATPTPAHPGYGAPPLSQTPTVN 238
Cdd:PRK12323 514 PDAAPAGWVAESIPDPATADPDDAfETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGD 580
|
|
| |
