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Conserved domains on  [gi|195147564|ref|XP_002014749|]
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cytosolic Fe-S cluster assembly factor NUBP1 homolog [Drosophila persimilis]

Protein Classification

Mrp/NBP35 family ATP-binding protein( domain architecture ID 10566257)

Mrp (multiple resistance and pH adaptation)/NBP35 (nucleotide-binding protein 35) family ATP-binding protein is an iron-sulfur (FeS) cluster protein that functions as a scaffold to assemble nascent FeS clusters for transfer to FeS-requiring enzymes

CATH:  3.40.50.300
Gene Ontology:  GO:0046872|GO:0005524|GO:0051536|GO:0140663|GO:0016226|GO:0016887
PubMed:  8921898

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 53-307 4.56e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


:

Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 352.14  E-value: 4.56e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564   53 DVKHKLLILSGKGGVGKSTVTTLLTRYLARsyPDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDdNVCLMS 132
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALAR--LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAH-GIKVMS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  133 IGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSapdsvhAIIVTTPQEVALL 212
Cdd:pfam10609  78 IGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDEQLTLAQLLPLTG------AVIVTTPQDVALL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  213 DVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAGEDI--TS 290
Cdd:pfam10609 152 DVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIF--GKGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFvlAD 229

                         250
                  ....*....|....*..
gi 195147564  291 VKNPTTEALEGICSKIM 307
Cdd:pfam10609 230 PDSPAAKAFLKIADKVA 246
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 53-307 4.56e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 352.14  E-value: 4.56e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564   53 DVKHKLLILSGKGGVGKSTVTTLLTRYLARsyPDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDdNVCLMS 132
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALAR--LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAH-GIKVMS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  133 IGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSapdsvhAIIVTTPQEVALL 212
Cdd:pfam10609  78 IGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDEQLTLAQLLPLTG------AVIVTTPQDVALL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  213 DVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAGEDI--TS 290
Cdd:pfam10609 152 DVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIF--GKGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFvlAD 229

                         250
                  ....*....|....*..
gi 195147564  291 VKNPTTEALEGICSKIM 307
Cdd:pfam10609 230 PDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 56-280 1.28e-106

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 309.43  E-value: 1.28e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  56 HKLLILSGKGGVGKSTVTTLLTRYLARSypDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDdNVCLMSIGF 135
Cdd:cd02037    1 HIIAVLSGKGGVGKSTVAVNLALALAKK--GYKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVG-GIKVMSIGF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 136 LLGSvDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSapdsvhAIIVTTPQEVALLDVR 215
Cdd:cd02037   78 LLPE-DDAVIWRGPMKSGAIKQFLKDVDWGELDYLIIDLPPGTGDEHLSLVQLIPIDG------AVVVTTPQEVSLIDVR 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195147564 216 KEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAK 280
Cdd:cd02037  151 KAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIF--GKGGGEKLAEELGVPFLGKIPLDPELAK 213
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
51-308 8.90e-106

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 312.91  E-value: 8.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  51 LKDVKHKLLILSGKGGVGKSTVTTLLTRYLARS-YPdsnFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDDNVC 129
Cdd:NF041136   1 LSRIKHKILVMSGKGGVGKSTVAANLAVALARRgYK---VGLLDVDIHGPSIPKLLGLEGKRLGSEDEGILPVEYSDNLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 130 LMSIGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDsapdsvHAIIVTTPQEV 209
Cdd:NF041136  78 VMSIGFLLENRDDAVIWRGPVKMGVIKQFLSDVEWGDLDYLIIDSPPGTGDEPLSVAQLIPDA------GAVIVTTPQEL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 210 ALLDVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAG--ED 287
Cdd:NF041136 152 ALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIF--KSGGGEKLAEEMGVPFLGRIPIDPEIVEAGDAGrpFV 229

                        250       260
                 ....*....|....*....|.
gi 195147564 288 ITSVKNPTTEALEGICSKIMS 308
Cdd:NF041136 230 LDYAWSPAAKALEKIVDPILE 250
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
49-297 2.33e-42

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 149.81  E-value: 2.33e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  49 AALKDVKHKLLILSGKGGVGKSTVTTLLTryLARSYPDSNFGVLDIDICGPSQPRLMGALGEN-VHQSGSGWSPV---GI 124
Cdd:PRK11670 101 PGVNGVKNIIAVSSGKGGVGKSSTAVNLA--LALAAEGAKVGILDADIYGPSIPTMLGAEDQRpTSPDGTHMAPImahGL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 125 DDNvclmSIGFLLGSvDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSylkddSAPdSVHAIIVT 204
Cdd:PRK11670 179 ATN----SIGYLVTD-DNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQ-----NIP-VTGAVVVT 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 205 TPQEVALLDVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDA 284
Cdd:PRK11670 248 TPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIF--GTGGAEKLAEKYHTQLLGQMPLHISLREDLDR 325

                        250
                 ....*....|...
gi 195147564 285 GEDiTSVKNPTTE 297
Cdd:PRK11670 326 GTP-TVVSRPESE 337
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 45-235 1.20e-25

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 103.34  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  45 ALVAAALKDVKHKLLILSGKGGVGKSTVTTLLTRYLARSypDSNFGVLDIDICGPSQPRLMGALGE----NVHQSGSGWS 120
Cdd:COG0489   82 LLLLLLLRLLLEVIAVTSGKGGEGKSTVAANLALALAQS--GKRVLLIDADLRGPSLHRMLGLENRpglsDVLAGEASLE 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 121 ----PVGIDdNVCLMSIGFLLGSVDDAIiwrgpkKNGMIRQFLSE---------VDwgnldlllldTPPGTSDEHLSVVS 187
Cdd:COG0489  160 dviqPTEVE-GLDVLPAGPLPPNPSELL------ASKRLKQLLEElrgrydyviID----------TPPGLGVADATLLA 222

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 195147564 188 YLKDdsapdsvHAIIVTTPQEVALLDVRKEINFCKKQQIPIVGVIENM 235
Cdd:COG0489  223 SLVD-------GVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNM 263
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 53-307 4.56e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 352.14  E-value: 4.56e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564   53 DVKHKLLILSGKGGVGKSTVTTLLTRYLARsyPDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDdNVCLMS 132
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALAR--LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAH-GIKVMS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  133 IGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSapdsvhAIIVTTPQEVALL 212
Cdd:pfam10609  78 IGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDEQLTLAQLLPLTG------AVIVTTPQDVALL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  213 DVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAGEDI--TS 290
Cdd:pfam10609 152 DVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIF--GKGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFvlAD 229

                         250
                  ....*....|....*..
gi 195147564  291 VKNPTTEALEGICSKIM 307
Cdd:pfam10609 230 PDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 56-280 1.28e-106

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 309.43  E-value: 1.28e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  56 HKLLILSGKGGVGKSTVTTLLTRYLARSypDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDdNVCLMSIGF 135
Cdd:cd02037    1 HIIAVLSGKGGVGKSTVAVNLALALAKK--GYKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVG-GIKVMSIGF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 136 LLGSvDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSapdsvhAIIVTTPQEVALLDVR 215
Cdd:cd02037   78 LLPE-DDAVIWRGPMKSGAIKQFLKDVDWGELDYLIIDLPPGTGDEHLSLVQLIPIDG------AVVVTTPQEVSLIDVR 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195147564 216 KEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAK 280
Cdd:cd02037  151 KAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIF--GKGGGEKLAEELGVPFLGKIPLDPELAK 213
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
51-308 8.90e-106

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 312.91  E-value: 8.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  51 LKDVKHKLLILSGKGGVGKSTVTTLLTRYLARS-YPdsnFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDDNVC 129
Cdd:NF041136   1 LSRIKHKILVMSGKGGVGKSTVAANLAVALARRgYK---VGLLDVDIHGPSIPKLLGLEGKRLGSEDEGILPVEYSDNLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 130 LMSIGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDsapdsvHAIIVTTPQEV 209
Cdd:NF041136  78 VMSIGFLLENRDDAVIWRGPVKMGVIKQFLSDVEWGDLDYLIIDSPPGTGDEPLSVAQLIPDA------GAVIVTTPQEL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 210 ALLDVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAG--ED 287
Cdd:NF041136 152 ALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIF--KSGGGEKLAEEMGVPFLGRIPIDPEIVEAGDAGrpFV 229

                        250       260
                 ....*....|....*....|.
gi 195147564 288 ITSVKNPTTEALEGICSKIMS 308
Cdd:NF041136 230 LDYAWSPAAKALEKIVDPILE 250
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
49-297 2.33e-42

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 149.81  E-value: 2.33e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  49 AALKDVKHKLLILSGKGGVGKSTVTTLLTryLARSYPDSNFGVLDIDICGPSQPRLMGALGEN-VHQSGSGWSPV---GI 124
Cdd:PRK11670 101 PGVNGVKNIIAVSSGKGGVGKSSTAVNLA--LALAAEGAKVGILDADIYGPSIPTMLGAEDQRpTSPDGTHMAPImahGL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 125 DDNvclmSIGFLLGSvDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSylkddSAPdSVHAIIVT 204
Cdd:PRK11670 179 ATN----SIGYLVTD-DNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQ-----NIP-VTGAVVVT 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 205 TPQEVALLDVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFpaKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDA 284
Cdd:PRK11670 248 TPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIF--GTGGAEKLAEKYHTQLLGQMPLHISLREDLDR 325

                        250
                 ....*....|...
gi 195147564 285 GEDiTSVKNPTTE 297
Cdd:PRK11670 326 GTP-TVVSRPESE 337
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 45-235 1.20e-25

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 103.34  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  45 ALVAAALKDVKHKLLILSGKGGVGKSTVTTLLTRYLARSypDSNFGVLDIDICGPSQPRLMGALGE----NVHQSGSGWS 120
Cdd:COG0489   82 LLLLLLLRLLLEVIAVTSGKGGEGKSTVAANLALALAQS--GKRVLLIDADLRGPSLHRMLGLENRpglsDVLAGEASLE 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 121 ----PVGIDdNVCLMSIGFLLGSVDDAIiwrgpkKNGMIRQFLSE---------VDwgnldlllldTPPGTSDEHLSVVS 187
Cdd:COG0489  160 dviqPTEVE-GLDVLPAGPLPPNPSELL------ASKRLKQLLEElrgrydyviID----------TPPGLGVADATLLA 222

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 195147564 188 YLKDdsapdsvHAIIVTTPQEVALLDVRKEINFCKKQQIPIVGVIENM 235
Cdd:COG0489  223 SLVD-------GVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNM 263
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 58-281 2.57e-10

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 59.28  E-value: 2.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564   58 LLILSGKGGVGKSTVTTLLTRYLARsypdSNFGVLDIDiCGPSQPRLMGALGENVHQS----------GSGW------SP 121
Cdd:pfam01656   1 IAIAGTKGGVGKTTLAANLARALAR----RGLRVLLID-LDPQSNNSSVEGLEGDIAPalqalaeglkGRVNldpillKE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  122 VGIDDNVCLMSIGFLLGsvDDAIIWRGPKKNGMIRQFLSE---------VDwgnldlllldTPPGTSDehlsvvSYLKDD 192
Cdd:pfam01656  76 KSDEGGLDLIPGNIDLE--KFEKELLGPRKEERLREALEAlkedydyviID----------GAPGLGE------LLRNAL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564  193 SAPDSVhaIIVTTPQEVALLDVRKEINFCKK-------QQIPIVGVIENMSGFRCGHCGHSSEIFPAKTGgaaamcaeme 265
Cdd:pfam01656 138 IAADYV--IIPLEPEVILVEDAKRLGGVIAAlvggyalLGLKIIGVVLNKVDGDNHGKLLKEALEELLRG---------- 205

                         250
                  ....*....|....*.
gi 195147564  266 VPLLGSLPLDPAIAKA 281
Cdd:pfam01656 206 LPVLGVIPRDEAVAEA 221
CooC COG3640
CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, ...
 59-95 2.50e-06

CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442857 [Multi-domain]  Cd Length: 249  Bit Score: 47.85  E-value: 2.50e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 195147564  59 LILSGKGGVGKSTVTTLLTRYLARsypdSNFGVLDID 95
Cdd:COG3640    3 IAVAGKGGVGKTTLSALLARYLAE----KGKPVLAVD 35
CooC1 cd02034
accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in ...
 62-90 1.47e-04

accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.


Pssm-ID: 349754 [Multi-domain]  Cd Length: 249  Bit Score: 42.30  E-value: 1.47e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 195147564  62 SGKGGVGKSTVTTLLTRYLARSY---------PDSNFG 90
Cdd:cd02034    6 AGKGGVGKTTIAALLIRYLAKKGgkvlavdadPNSNLA 43
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 174-310 2.57e-04

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 41.41  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195147564 174 TPPGTSDEHLSVVSylkddsAPDSVhaIIVTTPQEVALLDVRKEINFCKKQQ-IPIVGVIENMSgfrcghcgHSSEIFPA 252
Cdd:COG0455  101 TGAGISDSVLLFLA------AADEV--VVVTTPEPTSITDAYALLKLLRRRLgVRRAGVVVNRV--------RSEAEARD 164

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195147564 253 KTGGAAAMCAE---MEVPLLGSLPLDPAIAKACDAGE--DITSVKNPTTEALEGICSKIMSSF 310
Cdd:COG0455  165 VFERLEQVAERflgVRLRVLGVIPEDPAVREAVRRGRplVLAAPDSPAARAIRELAARLAGWP 227
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 56-97 1.07e-03

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 38.29  E-value: 1.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 195147564  56 HKLLILSGKGGVGKSTVTTLLTRYLARsypdSNFGVLDIDIC 97
Cdd:cd02042    1 KVIAVANQKGGVGKTTLAVNLAAALAL----RGKRVLLIDLD 38
TraL cd05386
transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI ...
 59-95 1.88e-03

transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI superfamily which contains a ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion. The specific function of TraL protein is unknown.


Pssm-ID: 349771  Cd Length: 155  Bit Score: 38.09  E-value: 1.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 195147564  59 LILSGKGGVGKSTVTTLLTRYLARSypDSNFGVLDID 95
Cdd:cd05386    4 FVLQGKGGVGKSVIASLLAQYLIDK--GQPVSCIDTD 38
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 57-82 9.28e-03

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 9.28e-03
                         10        20
                 ....*....|....*....|....*.
gi 195147564  57 KLLILSGKGGVGKSTVTTLLTRYLAR 82
Cdd:cd01983    2 VIAVTGGKGGVGKTTLAAALAVALAA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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