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Conserved domains on  [gi|296005426|ref|XP_002809035|]
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conserved Plasmodium protein, unknown function [Plasmodium falciparum 3D7]

Protein Classification

FAST_1 superfamily-containing protein( domain architecture ID 18382)

FAST_1 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAST_1 super family cl06005
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 1215-1264 3.68e-03

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


The actual alignment was detected with superfamily member pfam06743:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 37.85  E-value: 3.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 296005426  1215 ILCVLAYLNIKNDEYPYFFNKILNVFRHNIKKLNKSiLLVNVLWSLCLIE 1264
Cdd:pfam06743    4 LLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPE-LLLDLVWSLCVLG 52
 
Name Accession Description Interval E-value
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 1215-1264 3.68e-03

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 37.85  E-value: 3.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 296005426  1215 ILCVLAYLNIKNDEYPYFFNKILNVFRHNIKKLNKSiLLVNVLWSLCLIE 1264
Cdd:pfam06743    4 LLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPE-LLLDLVWSLCVLG 52
 
Name Accession Description Interval E-value
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 1215-1264 3.68e-03

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 37.85  E-value: 3.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 296005426  1215 ILCVLAYLNIKNDEYPYFFNKILNVFRHNIKKLNKSiLLVNVLWSLCLIE 1264
Cdd:pfam06743    4 LLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPE-LLLDLVWSLCVLG 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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