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Conserved domains on  [gi|302883622|ref|XP_003040710|]
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uncharacterized protein NECHADRAFT_37469, partial [Fusarium vanettenii 77-13-4]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1010199)

DEAD/DEAH box containing ATP-dependent helicase family protein may catalyze the unwinding of DNA or RNA

CATH:  3.40.50.300|1.20.1320.20
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0005524|GO:0004386|GO:0003676
PubMed:  20206133
SCOP:  3002019

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 1-104 1.37e-12

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18037:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 183  Bit Score: 65.73  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   1 WQEKWLLIIDEVSMLGARTLYVVNEQLRKLRGRAQDFGGIPIVLfCGDFHQFRPVQERSillpstailwdEEKSFKAEQR 80
Cdd:cd18037   91 WRKCDVLIIDEISMLDADLFDKLDRVAREVRGSDKPFGGIQLIL-CGDFLQLPPVTKNS-----------ERQAFFFRGD 158

                         90       100
                 ....*....|....*....|....*
gi 302883622  81 YQHDRAHALWNK-FTTVVMLDEQVR 104
Cdd:cd18037  159 QQFCFEAKSWERcIFLTVELTKVFR 183
RecD super family cl33920
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 6-237 1.14e-07

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0507:

Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 53.83  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   6 LLIIDEVSMLGARTLYVVNEQLRKLRGRaqdfggipiVLFCGDFHQFRPVQERSILlpstailwdeeksfkaeqryqHDR 85
Cdd:COG0507  221 LLVVDEASMVDTRLMAALLEALPRAGAR---------LILVGDPDQLPSVGAGAVL---------------------RDL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622  86 AHALWnkfTTVVMLDEQVRAASDPQLRRLLTRVRHG---------------VQDRSDMDMLNRTCYGENRRIPWESGLTV 150
Cdd:COG0507  271 IESGT---VPVVELTEVYRQADDSRIIELAHAIREGdapealnaryadvvfVEAEDAEEAAEAIVELYADRPAGGEDIQV 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622 151 VTPLNRNRWNLNveaslcfQKAQQSRLRIFVSEHRWKDGEPTEeeavmmlsqgddsavpvpaifmFVPGMPVVVNKNTHQ 230
Cdd:COG0507  348 LAPTNAGVDALN-------QAIREALNPAGELERELAEDGELE----------------------LYVGDRVMFTRNDYD 398


                 ....*..
gi 302883622 231 gLKLVNG 237
Cdd:COG0507  399 -LGVFNG 404
 
Name Accession Description Interval E-value
DEXSc_Pif1_like cd18037
DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like ...
 1-104 1.37e-12

DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like helicases involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. The members of Pif1 helicase subfamily studied so far all appear to contribute to telomere maintenance. Pif1 is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350795 [Multi-domain]  Cd Length: 183  Bit Score: 65.73  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   1 WQEKWLLIIDEVSMLGARTLYVVNEQLRKLRGRAQDFGGIPIVLfCGDFHQFRPVQERSillpstailwdEEKSFKAEQR 80
Cdd:cd18037   91 WRKCDVLIIDEISMLDADLFDKLDRVAREVRGSDKPFGGIQLIL-CGDFLQLPPVTKNS-----------ERQAFFFRGD 158

                         90       100
                 ....*....|....*....|....*
gi 302883622  81 YQHDRAHALWNK-FTTVVMLDEQVR 104
Cdd:cd18037  159 QQFCFEAKSWERcIFLTVELTKVFR 183
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 6-237 1.14e-07

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 53.83  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   6 LLIIDEVSMLGARTLYVVNEQLRKLRGRaqdfggipiVLFCGDFHQFRPVQERSILlpstailwdeeksfkaeqryqHDR 85
Cdd:COG0507  221 LLVVDEASMVDTRLMAALLEALPRAGAR---------LILVGDPDQLPSVGAGAVL---------------------RDL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622  86 AHALWnkfTTVVMLDEQVRAASDPQLRRLLTRVRHG---------------VQDRSDMDMLNRTCYGENRRIPWESGLTV 150
Cdd:COG0507  271 IESGT---VPVVELTEVYRQADDSRIIELAHAIREGdapealnaryadvvfVEAEDAEEAAEAIVELYADRPAGGEDIQV 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622 151 VTPLNRNRWNLNveaslcfQKAQQSRLRIFVSEHRWKDGEPTEeeavmmlsqgddsavpvpaifmFVPGMPVVVNKNTHQ 230
Cdd:COG0507  348 LAPTNAGVDALN-------QAIREALNPAGELERELAEDGELE----------------------LYVGDRVMFTRNDYD 398


                 ....*..
gi 302883622 231 gLKLVNG 237
Cdd:COG0507  399 -LGVFNG 404
PIF1 pfam05970
PIF1-like helicase; This family includes homologs of the PIF1 helicase, which inhibits ...
 1-55 2.26e-05

PIF1-like helicase; This family includes homologs of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated. This family includes a large number of largely uncharacterized plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.


Pssm-ID: 428699 [Multi-domain]  Cd Length: 361  Bit Score: 46.22  E-value: 2.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302883622    1 WQEKWLLIIDEVSMLGARTLYVVNEQLRKLRGRAQD--FGGIPIVlFCGDFHQFRPV 55
Cdd:pfam05970  99 LEKTSLIVWDEAPMTHRHCFEALDRTLRDILSETDDkpFGGKTVV-LGGDFRQILPV 154
 
Name Accession Description Interval E-value
DEXSc_Pif1_like cd18037
DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like ...
 1-104 1.37e-12

DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like helicases involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. The members of Pif1 helicase subfamily studied so far all appear to contribute to telomere maintenance. Pif1 is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350795 [Multi-domain]  Cd Length: 183  Bit Score: 65.73  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   1 WQEKWLLIIDEVSMLGARTLYVVNEQLRKLRGRAQDFGGIPIVLfCGDFHQFRPVQERSillpstailwdEEKSFKAEQR 80
Cdd:cd18037   91 WRKCDVLIIDEISMLDADLFDKLDRVAREVRGSDKPFGGIQLIL-CGDFLQLPPVTKNS-----------ERQAFFFRGD 158

                         90       100
                 ....*....|....*....|....*
gi 302883622  81 YQHDRAHALWNK-FTTVVMLDEQVR 104
Cdd:cd18037  159 QQFCFEAKSWERcIFLTVELTKVFR 183
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 6-237 1.14e-07

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 53.83  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622   6 LLIIDEVSMLGARTLYVVNEQLRKLRGRaqdfggipiVLFCGDFHQFRPVQERSILlpstailwdeeksfkaeqryqHDR 85
Cdd:COG0507  221 LLVVDEASMVDTRLMAALLEALPRAGAR---------LILVGDPDQLPSVGAGAVL---------------------RDL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622  86 AHALWnkfTTVVMLDEQVRAASDPQLRRLLTRVRHG---------------VQDRSDMDMLNRTCYGENRRIPWESGLTV 150
Cdd:COG0507  271 IESGT---VPVVELTEVYRQADDSRIIELAHAIREGdapealnaryadvvfVEAEDAEEAAEAIVELYADRPAGGEDIQV 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302883622 151 VTPLNRNRWNLNveaslcfQKAQQSRLRIFVSEHRWKDGEPTEeeavmmlsqgddsavpvpaifmFVPGMPVVVNKNTHQ 230
Cdd:COG0507  348 LAPTNAGVDALN-------QAIREALNPAGELERELAEDGELE----------------------LYVGDRVMFTRNDYD 398


                 ....*..
gi 302883622 231 gLKLVNG 237
Cdd:COG0507  399 -LGVFNG 404
PIF1 pfam05970
PIF1-like helicase; This family includes homologs of the PIF1 helicase, which inhibits ...
 1-55 2.26e-05

PIF1-like helicase; This family includes homologs of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated. This family includes a large number of largely uncharacterized plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.


Pssm-ID: 428699 [Multi-domain]  Cd Length: 361  Bit Score: 46.22  E-value: 2.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302883622    1 WQEKWLLIIDEVSMLGARTLYVVNEQLRKLRGRAQD--FGGIPIVlFCGDFHQFRPV 55
Cdd:pfam05970  99 LEKTSLIVWDEAPMTHRHCFEALDRTLRDILSETDDkpFGGKTVV-LGGDFRQILPV 154
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 6-55 1.71e-04

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 41.77  E-value: 1.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 302883622   6 LLIIDEVSMLGARTLYVVneqLRKLRGRAQdfggipiVLFCGDFHQFRPV 55
Cdd:cd17933   92 LLIVDEASMVDTRLMAAL---LSAIPAGAR-------LILVGDPDQLPSV 131
AAA_30 pfam13604
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 6-56 7.61e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.


Pssm-ID: 433343 [Multi-domain]  Cd Length: 191  Bit Score: 40.24  E-value: 7.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 302883622    6 LLIIDEVSMLGARtlyvvneQLRKLRGRAQDFGGipIVLFCGDFHQFRPVQ 56
Cdd:pfam13604  91 LLIVDEAGMVGTR-------QMARLLKLAEDAGA--RVILVGDPRQLPSVE 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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