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Conserved domains on  [gi|339236205|ref|XP_003379657|]
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conserved hypothetical protein [Trichinella spiralis]

Protein Classification

Get4 family protein( domain architecture ID 8915)

Get4 family protein is a DUF410 domain-containing protein similar to Saccharomyces cerevisiae Golgi to ER traffic protein 4 that may play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane

CATH:  1.25.40.10
Gene Ontology:  GO:0045048|GO:0016192|GO:0006620

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GET4 super family cl04440
Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts ...
 45-194 8.61e-16

Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.


The actual alignment was detected with superfamily member pfam04190:

Pssm-ID: 461217  Cd Length: 251  Bit Score: 74.14  E-value: 8.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236205   45 QRKFSSLLPILYESVGKFSEKGQNLIAEDMAGLYVAALKASKSPINCSVISNLKSIFQwmILNCKSESQERFLSQILGWS 124
Cdd:pfam04190   1 QKKYDEAIDLLYSGALSLLKAGQYGSGADLALLLLEVYEKAGIPVDEESKDRLIELLS--LFPPEEPTRKKFIKKAIKWS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 339236205  125 LEVSpEYPRGHPDLHRMYVEVYHGAGNFHSSIFHIMLIDDGQYI--GKYLAECYSKyAFPSELDIFITQFIL 194
Cdd:pfam04190  79 AKFG-EYPFGDPELHHVIGSLLWEEGDYYLAERHLLLGTDDSAEllADMLVEWYKE-GYPSEADLFIARAVL 148
 
Name Accession Description Interval E-value
GET4 pfam04190
Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts ...
 45-194 8.61e-16

Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.


Pssm-ID: 461217  Cd Length: 251  Bit Score: 74.14  E-value: 8.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236205   45 QRKFSSLLPILYESVGKFSEKGQNLIAEDMAGLYVAALKASKSPINCSVISNLKSIFQwmILNCKSESQERFLSQILGWS 124
Cdd:pfam04190   1 QKKYDEAIDLLYSGALSLLKAGQYGSGADLALLLLEVYEKAGIPVDEESKDRLIELLS--LFPPEEPTRKKFIKKAIKWS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 339236205  125 LEVSpEYPRGHPDLHRMYVEVYHGAGNFHSSIFHIMLIDDGQYI--GKYLAECYSKyAFPSELDIFITQFIL 194
Cdd:pfam04190  79 AKFG-EYPFGDPELHHVIGSLLWEEGDYYLAERHLLLGTDDSAEllADMLVEWYKE-GYPSEADLFIARAVL 148
 
Name Accession Description Interval E-value
GET4 pfam04190
Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts ...
 45-194 8.61e-16

Golgi to ER traffic protein 4; In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.


Pssm-ID: 461217  Cd Length: 251  Bit Score: 74.14  E-value: 8.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339236205   45 QRKFSSLLPILYESVGKFSEKGQNLIAEDMAGLYVAALKASKSPINCSVISNLKSIFQwmILNCKSESQERFLSQILGWS 124
Cdd:pfam04190   1 QKKYDEAIDLLYSGALSLLKAGQYGSGADLALLLLEVYEKAGIPVDEESKDRLIELLS--LFPPEEPTRKKFIKKAIKWS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 339236205  125 LEVSpEYPRGHPDLHRMYVEVYHGAGNFHSSIFHIMLIDDGQYI--GKYLAECYSKyAFPSELDIFITQFIL 194
Cdd:pfam04190  79 AKFG-EYPFGDPELHHVIGSLLWEEGDYYLAERHLLLGTDDSAEllADMLVEWYKE-GYPSEADLFIARAVL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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