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Conserved domains on  [gi|363750674|ref|XP_003645554|]
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Hypothetical protein Ecym_3244 [Eremothecium cymbalariae DBVPG#7215]

Protein Classification

Vps39_1 and Vps39_2 domain-containing protein( domain architecture ID 10563857)

Vps39_1 and Vps39_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 596-704 9.78e-37

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


:

Pssm-ID: 371008  Cd Length: 108  Bit Score: 133.91  E-value: 9.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   596 IDTVLFQIYVHYNKTLVGPLIRVQNNCDFKTVEESLKSNQMFQELIDFYYNKAEHDKALQLLTHLSDYvDKNFTAQKVHE 675
Cdd:pfam10366    1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADE-TTGDETDSTLK 79

                           90       100
                   ....*....|....*....|....*....
gi 363750674   676 EIKNLVIDYLRKLPAQYLESIFEYTDWLL 704
Cdd:pfam10366   80 GPKETIIQYLQKLGPSDLDLILEYSDWVL 108
Vps39_2 super family cl11034
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 892-1004 3.33e-16

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


The actual alignment was detected with superfamily member pfam10367:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 75.37  E-value: 3.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   892 FLIENGSKLDPISLFEKLPPDIPINNLKDFLSRRIKNSSMKKNQSRIKSNLLRVNLIECTYKSSRLSSDFVIINDDSKCY 971
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESVCA 82

                           90       100       110
                   ....*....|....*....|....*....|...
gi 363750674   972 VCHKylNIGTsewlSLFKIGDHNVVAHYNCGRS 1004
Cdd:pfam10367   83 VCHK--RLGE----SVFVVYPNGVVVHYGCFRR 109
 
Name Accession Description Interval E-value
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 596-704 9.78e-37

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 133.91  E-value: 9.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   596 IDTVLFQIYVHYNKTLVGPLIRVQNNCDFKTVEESLKSNQMFQELIDFYYNKAEHDKALQLLTHLSDYvDKNFTAQKVHE 675
Cdd:pfam10366    1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADE-TTGDETDSTLK 79

                           90       100
                   ....*....|....*....|....*....
gi 363750674   676 EIKNLVIDYLRKLPAQYLESIFEYTDWLL 704
Cdd:pfam10366   80 GPKETIIQYLQKLGPSDLDLILEYSDWVL 108
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 892-1004 3.33e-16

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 75.37  E-value: 3.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   892 FLIENGSKLDPISLFEKLPPDIPINNLKDFLSRRIKNSSMKKNQSRIKSNLLRVNLIECTYKSSRLSSDFVIINDDSKCY 971
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESVCA 82

                           90       100       110
                   ....*....|....*....|....*....|...
gi 363750674   972 VCHKylNIGTsewlSLFKIGDHNVVAHYNCGRS 1004
Cdd:pfam10367   83 VCHK--RLGE----SVFVVYPNGVVVHYGCFRR 109
 
Name Accession Description Interval E-value
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 596-704 9.78e-37

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 133.91  E-value: 9.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   596 IDTVLFQIYVHYNKTLVGPLIRVQNNCDFKTVEESLKSNQMFQELIDFYYNKAEHDKALQLLTHLSDYvDKNFTAQKVHE 675
Cdd:pfam10366    1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADE-TTGDETDSTLK 79

                           90       100
                   ....*....|....*....|....*....
gi 363750674   676 EIKNLVIDYLRKLPAQYLESIFEYTDWLL 704
Cdd:pfam10366   80 GPKETIIQYLQKLGPSDLDLILEYSDWVL 108
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 892-1004 3.33e-16

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 75.37  E-value: 3.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363750674   892 FLIENGSKLDPISLFEKLPPDIPINNLKDFLSRRIKNSSMKKNQSRIKSNLLRVNLIECTYKSSRLSSDFVIINDDSKCY 971
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESVCA 82

                           90       100       110
                   ....*....|....*....|....*....|...
gi 363750674   972 VCHKylNIGTsewlSLFKIGDHNVVAHYNCGRS 1004
Cdd:pfam10367   83 VCHK--RLGE----SVFVVYPNGVVVHYGCFRR 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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