|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
346-585 |
1.46e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
:
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.46e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 418
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 419 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 493
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 494 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 564
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024366446 565 -----------------NHTHLTTYGVVQLFDQPHPRR 585
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| WD40 super family |
cl29593 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1635-1935 |
4.94e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
The actual alignment was detected with superfamily member cd00200:
Pssm-ID: 475233 [Multi-domain] Cd Length: 289 Bit Score: 110.12 E-value: 4.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1792
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1869
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024366446 1870 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
346-585 |
1.46e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.46e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 418
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 419 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 493
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 494 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 564
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024366446 565 -----------------NHTHLTTYGVVQLFDQPHPRR 585
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
346-585 |
4.02e-83 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 274.49 E-value: 4.02e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV--------DFTTKNGkFRDLRKsKFRLnKGDKQLDFTYEMTKQ 417
Cdd:smart01026 3 KWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 418 AfvaggssGEQLHVPHHI-SDVLSDITYYVYTARRTP---------------KSVLCCHVRSQWEPNeYPASMERMQswt 481
Cdd:smart01026 80 L-------EDPDIPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDVK--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 482 pdECIPEFYTDPSIFRSIHP----------DMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGK 550
Cdd:smart01026 149 --ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGK 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2024366446 551 DAVKEKNVCLHLVD-----------------NHTHLTTYGVV--QLFDQPHPRR 585
Cdd:smart01026 227 EAVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
346-585 |
1.67e-48 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 174.97 E-value: 1.67e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV-DFTTKN------GKFRDLRKSKFRLNKG-DKQLDFTYEMTkq 417
Cdd:pfam02138 2 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 418 afvaggssgEQLHVPHHISdvlsdiTYYVytarrTPKSVLCCHVR------SQWE--------PNEYPASMERmqSW--- 480
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRlepfttLHIElqggkfdhPDRLFHSIEE--AWrsa 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 481 ---TPD--ECIPEFYTDPSIFRSIH----------PDMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFG 544
Cdd:pfam02138 138 snsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENLHEWIDLIFG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 545 YKLQGKDAVKEKNVCLHL-----VDNH------------THLTTYGVV--QLFDQPHPRR 585
Cdd:pfam02138 218 YKQRGEEAVEALNVFHPLtyegsVDLDsikdpverdaieAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1635-1935 |
4.94e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.12 E-value: 4.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1792
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1869
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024366446 1870 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1635-1935 |
1.11e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.68 E-value: 1.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsaDGT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFDEldSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1792
Cdd:COG2319 144 VRLWDLATGKLLRTLTG--HSGAVTSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1869
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNsvAF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024366446 1870 DLYGNEVVTGTVANKIGVYSmlessalpVSTTKL--SSENFRGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWD--------LATGKLlrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1635-1669 |
2.32e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 48.88 E-value: 2.32e-07
10 20 30
....*....|....*....|....*....|....*
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1669
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1635-1669 |
1.11e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.11e-06
10 20 30
....*....|....*....|....*....|....*
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1669
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
346-585 |
1.46e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.46e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVVDFTT-------KNGKFRDLRKSKFRLNKGDKQLDFTYEMTKQA 418
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 419 FvaggsSGEQLHVPHHISDVLSDITYYVYTARRTP--KSVLCCHVRS-QWEPNEYPASMERMQS--WTPDECIPEFYTDP 493
Cdd:cd06071 83 D-----SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDAaDRLFNSIPSSWRSASEnpSDVKELIPEFYYLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 494 SIFRSIHPD---------MPDLDVPSWCSSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGKDAVKEKNVCLHLVD 564
Cdd:cd06071 158 EFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLTY 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 2024366446 565 -----------------NHTHLTTYGVVQLFDQPHPRR 585
Cdd:cd06071 238 egsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
346-585 |
4.02e-83 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 274.49 E-value: 4.02e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV--------DFTTKNGkFRDLRKsKFRLnKGDKQLDFTYEMTKQ 417
Cdd:smart01026 3 KWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 418 AfvaggssGEQLHVPHHI-SDVLSDITYYVYTARRTP---------------KSVLCCHVRSQWEPNeYPASMERMQswt 481
Cdd:smart01026 80 L-------EDPDIPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDVK--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 482 pdECIPEFYTDPSIFRSIHP----------DMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFGYKLQGK 550
Cdd:smart01026 149 --ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGK 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2024366446 551 DAVKEKNVCLHLVD-----------------NHTHLTTYGVV--QLFDQPHPRR 585
Cdd:smart01026 227 EAVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
346-585 |
1.67e-48 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 174.97 E-value: 1.67e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 346 QWVHGRVSNFDYLMHLNSLAGRRMGDPNYHPVLPWVV-DFTTKN------GKFRDLRKSKFRLNKG-DKQLDFTYEMTkq 417
Cdd:pfam02138 2 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 418 afvaggssgEQLHVPHHISdvlsdiTYYVytarrTPKSVLCCHVR------SQWE--------PNEYPASMERmqSW--- 480
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRlepfttLHIElqggkfdhPDRLFHSIEE--AWrsa 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 481 ---TPD--ECIPEFYTDPSIFRSIH----------PDMPDLDVPSWC-SSYEEFIEVHRMLLESREVSQDLHHWIDLTFG 544
Cdd:pfam02138 138 snsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENLHEWIDLIFG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 545 YKLQGKDAVKEKNVCLHL-----VDNH------------THLTTYGVV--QLFDQPHPRR 585
Cdd:pfam02138 218 YKQRGEEAVEALNVFHPLtyegsVDLDsikdpverdaieAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1635-1935 |
4.94e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.12 E-value: 4.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTSEvpprFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL----RTLKGHTGPVRDVAASADGTYLASGssDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlagGVNAGlIRCLAVSPNG 1792
Cdd:cd00200 75 IRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR---GHTDW-VNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKA-AEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1869
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024366446 1870 DLYGNEVVTGTVANKIGVYSMLesSALPVSTtkLSSENfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLR--TGECVQT--LSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1631-1889 |
1.09e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 109.35 E-value: 1.09e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1631 HQIKLQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdGTSEVppRFTYSEHKKSVFYVSQLEASQHVVSC- 1709
Cdd:cd00200 40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGEC--VRTLTGHTSYVSSVAFSPDGRILSSSs 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1710 -DGTVHIWDQFTGKLIRTFDelDSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRLaggvNAGLIRCLAV 1788
Cdd:cd00200 113 rDKTIKVWDVETGKCLTTLR--GHTDWVNSV-AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----HTGEVNSVAF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1789 SPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKAAEGNVLISSSS-DHSMTVWKELEQKPLHHYKSASEPIH 1867
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVT 265
|
250 260
....*....|....*....|....
gi 2024366446 1868 --AFDLYGNEVVTGTVANKIGVYS 1889
Cdd:cd00200 266 slAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1635-1935 |
1.11e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.68 E-value: 1.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsaDGT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFDEldSKAPITAVtTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1792
Cdd:COG2319 144 VRLWDLATGKLLRTLTG--HSGAVTSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH--AF 1869
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNsvAF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024366446 1870 DLYGNEVVTGTVANKIGVYSmlessalpVSTTKL--SSENFRGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWD--------LATGKLlrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1635-1879 |
3.01e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.44 E-value: 3.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTsevpPRFTYSEHKKSVFYVsqleA----SQHVVSC- 1709
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATGK----LLRTLTGHTGAVRSV----AfspdGKLLASGs 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1710 -DGTVHIWDQFTGKLIRTFDelDSKAPITAVTtMPPPYHSISVASADSVLRFIDhRKPGlQHEFRLAGGVNAglIRCLAV 1788
Cdd:COG2319 224 aDGTVRLWDLATGKLLRTLT--GHSGSVRSVA-FSPDGRLLASGSADGTVRLWD-LATG-ELLRTLTGHSGG--VNSVAF 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1789 SPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH 1867
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
|
250
....*....|....
gi 2024366446 1868 --AFDLYGNEVVTG 1879
Cdd:COG2319 377 svAFSPDGRTLASG 390
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1635-1848 |
1.50e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLynygdgtSEVPPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-------ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGsaDGT 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFDelDSKAPITAVttmpppyhSIS-------VASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRC 1785
Cdd:COG2319 270 VRLWDLATGELLRTLT--GHSGGVNSV--------AFSpdgkllaSGSDDGTVRLWDLATGKLLRTLT----GHTGAVRS 335
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024366446 1786 LAVSPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVW 1848
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1635-1811 |
2.68e-11 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 68.01 E-value: 2.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWplyNYGDGTsevpPRFTYSEHKKSVFYVSQLEASQHVVSC--DGT 1712
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGE----LLRTLTGHSGGVNSVAFSPDGKLLASGsdDGT 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1713 VHIWDQFTGKLIRTFDelDSKAPITAVTTMPPPyHSISVASADSVLRFIDHRKPGLQHEFRlaggVNAGLIRCLAVSPNG 1792
Cdd:COG2319 312 VRLWDLATGKLLRTLT--GHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLT----GHTGAVTSVAFSPDG 384
|
170
....*....|....*....
gi 2024366446 1793 RSVMAGFSSGFIVLLDTRT 1811
Cdd:COG2319 385 RTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1710-1935 |
1.00e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 63.01 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1710 DGTVHIWDQFTGKLIRTFdeLDSKAPITAVTTMPPPYHSISvASADSVLRFIDHRKPGLQHEFRLAGGVnaglIRCLAVS 1789
Cdd:COG2319 57 DLTLLLLDAAAGALLATL--LGHTAAVLSVAFSPDGRLLAS-ASADGTVRLWDLATGLLLRTLTGHTGA----VRSVAFS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024366446 1790 PNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIK-AAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIH- 1867
Cdd:COG2319 130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRs 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024366446 1868 -AFDLYGNEVVTGTVANKIGVYSMleSSALPVSTTKLSSenfrGTLTSLAVLPMKCHLLLGSDNGVIRL 1935
Cdd:COG2319 210 vAFSPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRL 272
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1635-1669 |
2.32e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 48.88 E-value: 2.32e-07
10 20 30
....*....|....*....|....*....|....*
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1669
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1635-1669 |
1.11e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.11e-06
10 20 30
....*....|....*....|....*....|....*
gi 2024366446 1635 LQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLW 1669
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1749-1825 |
4.73e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 41.11 E-value: 4.73e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024366446 1749 ISVASADSVLRFidHRKPGlQHEFRLAGGVNAGLIRCLAVSPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDI 1825
Cdd:pfam12894 10 IALATEDGELLL--HRLNW-QRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
|
|
| |
