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Conserved domains on  [gi|2024386781|ref|XP_004948582|]
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protein TANC2 isoform X1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1099-1298 9.66e-55

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1099 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1178
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1179 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1258
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024386781 1259 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 929-1224 4.49e-20

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  929 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 1002
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1003 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 1073
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1074 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1153
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1154 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1224
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1334-1448 4.86e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1565-1864 9.47e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 9.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1565 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1627
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1628 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1704
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1705 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1782
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1783 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1862
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024386781 1863 VG 1864
Cdd:pfam05109  710 SG 711
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1099-1298 9.66e-55

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1099 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1178
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1179 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1258
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024386781 1259 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1177-1263 3.96e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1177 LMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1256
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024386781 1257 FLVDHGA 1263
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 929-1224 4.49e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  929 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 1002
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1003 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 1073
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1074 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1153
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1154 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1224
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1082-1302 8.47e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.09  E-value: 8.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1082 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGH- 1152
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1153 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVEFLLAQGASISLMDKEGLTALswACL--------------- 1215
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1216 -KG----------------HL-------AVVRALVENGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1269
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2024386781 1270 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1302
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
969-1047 4.39e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.39e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024386781  969 GYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1047
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1334-1448 4.86e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1107-1228 2.76e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVV--------------PLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1172
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1173 GRTPLMMAASEGHLGTV----EFLLAQGASISLM------DKEGLTALSWACLKGHLAVVRALVEN 1228
Cdd:cd22192    169 GNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1565-1864 9.47e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 9.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1565 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1627
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1628 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1704
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1705 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1782
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1783 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1862
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024386781 1863 VG 1864
Cdd:pfam05109  710 SG 711
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1581-1738 2.32e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1581 PSPPHTSPAHQGSSyRFSPPPVgSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvyrsQSGSPVRYQQEPSAVSPLPGRPK 1660
Cdd:PHA03247  2871 PAAKPAAPARPPVR-RLARPAV-SRSTESFALPPDQPERPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQ 2940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1661 SPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSSA---------VHSSTVIPTGAYSQVAHSMASKYQAAAG 1731
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPP 3020


                   ....*..
gi 2024386781 1732 EMGVNQS 1738
Cdd:PHA03247  3021 PVSLKQT 3027
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1089-1266 3.46e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.92  E-value: 3.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1089 KDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQgaavaqpNRRGVV--PLFSAVRQGHWQIVDLLLTHGADV 1166
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1167 nmADKQGRTPLMMAASeghlgTVEFllaqgasislmdKEGLTALSWACLKGHLAVVRALVENGAA------------TDH 1234
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024386781 1235 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1266
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1335-1450 6.46e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 6.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1335 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1414
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024386781 1415 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1450
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1409-1451 1.41e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024386781 1409 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1238-1266 1.46e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.46e-04
                            10        20
                    ....*....|....*....|....*....
gi 2024386781  1238 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1266
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1388-1439 2.24e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024386781 1388 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1439
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1408-1441 5.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2024386781  1408 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1099-1298 9.66e-55

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1099 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1178
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1179 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1258
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024386781 1259 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1107-1298 1.76e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 189.78  E-value: 1.76e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1186
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1187 GTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1266
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024386781 1267 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:COG0666    247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
956-1276 2.79e-49

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 177.84  E-value: 2.79e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  956 LNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG 1035
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1036 HLEVVKFLIQcdwsmAGqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeeverAQINSFDSlWGETALTAAA 1115
Cdd:COG0666     99 DLEIVKLLLE-----AG--------------------------------------------ADVNARDK-DGETPLHLAA 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1116 GRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQ 1195
Cdd:COG0666    129 YNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1196 GASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1275
Cdd:COG0666    209 GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288


                   .
gi 2024386781 1276 L 1276
Cdd:COG0666    289 L 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
924-1243 6.80e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 167.82  E-value: 6.80e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  924 ALASLRNLYTPNIKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGF 1003
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1004 LSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwsmAGqqqgvfkkshaiqqaliaaasmgyteivsyl 1083
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-----AG------------------------------- 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1084 ldlpekdeeeverAQINSFDSlWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHG 1163
Cdd:COG0666    144 -------------ADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1164 ADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPL 1243
Cdd:COG0666    210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1177-1263 3.96e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1177 LMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1256
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024386781 1257 FLVDHGA 1263
Cdd:pfam12796   79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1144-1230 1.29e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.25  E-value: 1.29e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1144 LFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGAsiSLMDKEGLTALSWACLKGHLAVVR 1223
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024386781 1224 ALVENGA 1230
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 929-1224 4.49e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  929 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 1002
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1003 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 1073
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1074 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1153
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1154 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1224
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1082-1302 8.47e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.09  E-value: 8.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1082 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGH- 1152
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1153 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVEFLLAQGASISLMDKEGLTALswACL--------------- 1215
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1216 -KG----------------HL-------AVVRALVENGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1269
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2024386781 1270 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1302
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1111-1203 9.50e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 9.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1111 LTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHgADVNMADkQGRTPLMMAASEGHLGTVE 1190
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2024386781 1191 FLLAQGASISLMD 1203
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1108-1329 1.33e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 90.82  E-value: 1.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1108 ETALTAAAGRGKLDVCRLLLEQGAavaQPN---RRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEG 1184
Cdd:PHA02875     3 QVALCDAILFGELDIARRLLDIGI---NPNfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1185 HLGTVEFLLAQGASIS-LMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1263
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024386781 1264 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI------GCQTLpsrprgpATWAMATSKPDIMIILLSK 1329
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfgknGCVAA-------LCYAIENNKIDIVRLFIKR 224
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 989-1279 3.15e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 86.56  E-value: 3.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  989 ESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwsmagqqQGVfkkshaiqqal 1068
Cdd:PHA02874    33 DETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID---------NGV----------- 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1069 iaaasmgyteiVSYLLDLPEKDEEEVER-----AQINSFDSLwGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVP 1143
Cdd:PHA02874    93 -----------DTSILPIPCIEKDMIKTildcgIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1144 LFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVvr 1223
Cdd:PHA02874   161 IHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-- 238

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024386781 1224 ALVENGAATDHADKNGRTPLDLAAFYG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1279
Cdd:PHA02874   239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1119-1298 7.52e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 85.49  E-value: 7.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1119 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQ-----IVDLLLTHGADVNMADKQGRTPLMMAASE--GHLGTVEF 1191
Cdd:PHA03100    47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEY 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1192 LLAQGASISLMDKEGLTALSWA--CLKGHLAVVRALVENGA----------------ATDHADKNGRTPLDLAAFYGDAE 1253
Cdd:PHA03100   127 LLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVdinaknrvnyllsygvPINIKDVYGFTPLHYAVYNNNPE 206

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2024386781 1254 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:PHA03100   207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1109-1292 1.23e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.02  E-value: 1.23e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1109 TALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGAD----------------------- 1165
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1166 VNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDL 1245
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2024386781 1246 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVgCRNTSVVVTLL 1292
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLI 242
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1005-1238 2.63e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1005 SIVVLLCKKRAKVDHLDKNGQCALVHAALRGH-----LEVVKFLIQcdwsmAGQQQGVFKKSHAIQQALIAAASMGYTEI 1079
Cdd:PHA03100    49 DVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLE-----YGANVNAPDNNGITPLLYAISKKSNSYSI 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1080 VSYLLDLpekdeeeveRAQINSFDSlWGETALTAAA--GRGKLDVCRLLLEQGAAVAQPNRrgvvplfsavrqghwqiVD 1157
Cdd:PHA03100   124 VEYLLDN---------GANVNIKNS-DGENLLHLYLesNKIDLKILKLLIDKGVDINAKNR-----------------VN 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1158 LLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADK 1237
Cdd:PHA03100   177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256


                   .
gi 2024386781 1238 N 1238
Cdd:PHA03100   257 T 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 936-1298 3.16e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 84.73  E-value: 3.16e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  936 IKVSRLLILGGANVNYRtEVLNNAPILCVQSHlGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRA 1015
Cdd:PHA02876   158 LLIAEMLLEGGADVNAK-DIYCITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1016 KVDHLDkngqCALVHAALRGHLEVVKFLIQCDWSMagQQQGVFKKSHAIQQALIAAASmgytEIVSYLLdlpekdeeevE 1095
Cdd:PHA02876   236 NINKND----LSLLKAIRNEDLETSLLLYDAGFSV--NSIDDCKNTPLHHASQAPSLS----RLVPKLL----------E 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1096 RAQINSFDSLWGETALTAAAGRG-KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQ-IVDLLLTHGADVNMADKQG 1173
Cdd:PHA02876   296 RGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCD 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1174 RTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWA-CLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYG-D 1251
Cdd:PHA02876   376 KTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcK 455

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 2024386781 1252 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRntSVVVTLLKKGAKI 1298
Cdd:PHA02876   456 LDVIEMLLDNGADVNAINIQNQYPLLIALEYH--GIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
969-1047 4.39e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.39e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024386781  969 GYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1047
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1075-1170 2.06e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 2.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1075 GYTEIVSYLLDlpekdeeevERAQINSFDSlWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNrrGVVPLFSAVRQGHWQ 1154
Cdd:pfam12796    8 GNLELVKLLLE---------NGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2024386781 1155 IVDLLLTHGADVNMAD 1170
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1141-1298 2.58e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 74.61  E-value: 2.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1141 VVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLM------------------ 1202
Cdd:PHA02874    36 TTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILpipciekdmiktildcgi 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1203 -----DKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD 1277
Cdd:PHA02874   116 dvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                          170       180
                   ....*....|....*....|.
gi 2024386781 1278 RAVGCRNTSVVVTLLKKGAKI 1298
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHI 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1334-1448 4.86e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1075-1296 8.54e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 8.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1075 GYTEIVSYLLDLpekdeeeveraQIN-SFDSLWGETALTAAAGRGKLDVCRLLLEQGAA--VAQPNRRGvvPLFSAVRQG 1151
Cdd:PHA02875    13 GELDIARRLLDI-----------GINpNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIpdVKYPDIES--ELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1152 HWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGA 1230
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1231 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAmieHVDYSGMRP----LDRAVGCRNTSVVVTLLKKGA 1296
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA---NIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGA 226
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1334-1448 3.02e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 3.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPDD-------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Ank_2 pfam12796
Ankyrin repeats (3 copies);
995-1131 6.70e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 6.70e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  995 LGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIqcdwsmagqqqgvfkkshaiqqaliaaasm 1074
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL------------------------------ 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024386781 1075 gyteivsylldlpekdeeevERAQINSFDSlwGETALTAAAGRGKLDVCRLLLEQGA 1131
Cdd:pfam12796   51 --------------------EHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1120-1269 7.36e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 7.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1120 LDVCRLLLEQGAAVAQPNRRGVVPLFSAV--RQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGT--------- 1188
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidk 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1189 ---------VEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1259
Cdd:PHA03100   166 gvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245

                          170
                   ....*....|
gi 2024386781 1260 DHGAMIEHVD 1269
Cdd:PHA03100   246 NNGPSIKTII 255
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1154-1280 9.44e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 9.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1154 QIVDLLLTHGADVNMADK-QGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAAT 1232
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1233 DHADKNGRTPLDLAAFY---------------------------------GDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1279
Cdd:PHA02878   228 DARDKCGNTPLHISVGYckdydilklllehgvdvnaksyilgltalhssiKSERKLKLLLEYGADINSLNSYKLTPLSSA 307


                   .
gi 2024386781 1280 V 1280
Cdd:PHA02878   308 V 308
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1120-1303 9.82e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.28  E-value: 9.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1120 LDVCRLLLEQGAAVAQPNRRGvvPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASI 1199
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNMAS--NLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNV 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1200 SLMDKEGLTALSWACLKGHLAVVRALVENGAATD-HAdknGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1278
Cdd:PLN03192   585 HIRDANGNTALWNAISAKHHKIFRILYHFASISDpHA---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                          170       180
                   ....*....|....*....|....*
gi 2024386781 1279 AVGCRNTSVVVTLLKKGAKIGCQTL 1303
Cdd:PLN03192   662 AMAEDHVDMVRLLIMNGADVDKANT 686
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1334-1441 1.48e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.06  E-value: 1.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG4783     45 GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR 111

                           90       100
                   ....*....|....*....|....*...
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:COG4783    112 LARAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1337-1443 1.80e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 62.11  E-value: 1.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1337 FYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFaTKALELKPKSYEAYYARAR 1416
Cdd:COG3063      2 YLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAE 67

                           90       100
                   ....*....|....*....|....*..
gi 2024386781 1417 AKRSSRQFAAALEDLNEAIKLCPNNRE 1443
Cdd:COG3063     68 LLLELGDYDEALAYLERALELDPSALR 94
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1334-1450 1.85e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.25  E-value: 1.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG3914    119 GNLLLALGRLEEALAALRRALALNPDF-------------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNN 185

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1450
Cdd:COG3914    186 LGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
Ank_4 pfam13637
Ankyrin repeats (many copies);
1206-1259 2.07e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.75  E-value: 2.07e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024386781 1206 GLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1259
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1327-1448 3.27e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.90  E-value: 3.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1327 LSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1406
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024386781 1407 SYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRL 112
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1337-1448 5.76e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.71  E-value: 5.76e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1337 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARAR 1416
Cdd:COG3914     88 LQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2024386781 1417 AKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG3914    155 ALRRLGRLEEAIAALRRALELDPDNAEALNNL 186
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1330-1451 1.28e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.37  E-value: 1.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1330 LMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1409
Cdd:COG2956     79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD-------------AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024386781 1410 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:COG2956    146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 937-1269 2.59e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 2.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  937 KVSRLLILGGANvnyrTEVLnnaPILCVQShlgytEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAK 1016
Cdd:PHA02874    82 DIIKLLIDNGVD----TSIL---PIPCIEK-----DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1017 VDHLDKNGqCALVHAALRGhlevvkfliqcdwsmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeever 1096
Cdd:PHA02874   150 VNIEDDNG-CYPIHIAIKH------------------------------------------------------------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1097 aqiNSFdslwgetaltaaagrgklDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTP 1176
Cdd:PHA02874   168 ---NFF------------------DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1177 LMMAASegHLGTVEFLLAQGASISLMDKEGLTALSWA----CLKGhlaVVRALVENGAATDHADKNGRTPLDLAAFY-GD 1251
Cdd:PHA02874   227 LHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppCDID---IIDILLYHKADISIKDNKGENPIDTAFKYiNK 301

                          330
                   ....*....|....*...
gi 2024386781 1252 AEVVQFLVDHGAMIEHVD 1269
Cdd:PHA02874   302 DPVIKDIIANAVLIKEAD 319
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1119-1298 2.65e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 2.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1119 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVE-------- 1190
Cdd:PHA02876   157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsn 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1191 ---------------------FLLAQGASISLMDKEGLTALSWACLKGHLA-VVRALVENGAATDHADKNGRTPLDLAAF 1248
Cdd:PHA02876   237 inkndlsllkairnedletslLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAK 316

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024386781 1249 YG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC-RNTSVVVTLLKKGAKI 1298
Cdd:PHA02876   317 NGyDTENIRTLIMLGADVNAADRLYITPLHQASTLdRNKDIVITLLELGANV 368
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1148-1303 2.69e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 2.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1148 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVE 1227
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024386781 1228 NGAatdHADKNGRTPLDlAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS-VVVTLLKKGAKIGCQTL 1303
Cdd:PHA02876   233 NRS---NINKNDLSLLK-AIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNI 305
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1345-1448 3.49e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.63  E-value: 3.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1345 EAAQRYQYALKKFPREGFGedlktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1424
Cdd:COG4235      1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100
                   ....*....|....*....|....
gi 2024386781 1425 AAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLL 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1097-1261 3.74e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.52  E-value: 3.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1097 AQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTP 1176
Cdd:PHA02878   158 ADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1177 LMMAASE-GHLGTVEFLLAQGASISLMDK-EGLTALswaclkgHLA-----VVRALVENGAATDHADKNGRTPLDLAAF- 1248
Cdd:PHA02878   238 LHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTAL-------HSSikserKLKLLLEYGADINSLNSYKLTPLSSAVKq 310

                          170
                   ....*....|...
gi 2024386781 1249 YGDAEVVQFLVDH 1261
Cdd:PHA02878   311 YLCINIGRILISN 323
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1334-1447 4.58e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 4.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRL 1447
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL 124
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1119-1271 4.81e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 64.47  E-value: 4.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1119 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVR-----QGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1193
Cdd:PHA02798    50 STDIVKLFINLGANVNGLDNEYSTPLCTILSnikdyKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILL 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1194 ---AQGASISLMDKEGLTALSWACLKGH---LAVVRALVENGAATD-HADKNGRTPLDLAAFYG----DAEVVQFLVDHG 1262
Cdd:PHA02798   130 fmiENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTLHCYFKYNidriDADILKLFVDNG 209


                   ....*....
gi 2024386781 1263 AMIEHVDYS 1271
Cdd:PHA02798   210 FIINKENKS 218
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1179-1261 5.53e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 64.53  E-value: 5.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1179 MAASEGHLGtVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1258
Cdd:PTZ00322    89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                   ...
gi 2024386781 1259 VDH 1261
Cdd:PTZ00322   168 SRH 170
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1345-1451 8.18e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.59  E-value: 8.18e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1345 EAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1424
Cdd:COG5010     25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDK 104

                           90       100
                   ....*....|....*....|....*..
gi 2024386781 1425 AAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:COG5010    105 DEAKEYYEKALALSPDNPNAYSNLAAL 131
Ank_4 pfam13637
Ankyrin repeats (many copies);
1143-1193 1.02e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 1.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024386781 1143 PLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1193
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1377-1441 1.15e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.18  E-value: 1.15e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024386781 1377 LLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 933-1172 1.34e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 1.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  933 TPNIKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGF--LSIVVLL 1010
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1011 CKKRAKVDHLDKngqcalvhaalrghlevVKFLIqcdwsmagqqqgvfkkshaiqqaliaaasmgyteivSYLLDLPEKD 1090
Cdd:PHA03100   163 IDKGVDINAKNR-----------------VNYLL------------------------------------SYGVPINIKD 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1091 EeeveraqinsfdslWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMAD 1170
Cdd:PHA03100   190 V--------------YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                   ..
gi 2024386781 1171 KQ 1172
Cdd:PHA03100   256 ET 257
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1156-1276 2.05e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.61  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1156 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVenGAATDHA 1235
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS--RHSQCHF 175

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024386781 1236 DKNGRTPLDlaAFYGdaeVVQFLVDHGAMIEHVDYSGM-RPL 1276
Cdd:PTZ00322   176 ELGANAKPD--SFTG---KPPSLEDSPISSHHPDFSAVpQPM 212
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1336-1439 2.49e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 2.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1336 MFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARA 1415
Cdd:COG5010     63 LYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129

                           90       100
                   ....*....|....*....|....
gi 2024386781 1416 RAKRSSRQFAAALEDLNEAIKLCP 1439
Cdd:COG5010    130 ALLLSLGQDDEAKAALQRALGTSP 153
Ank_4 pfam13637
Ankyrin repeats (many copies);
1173-1226 2.78e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024386781 1173 GRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALV 1226
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1334-1502 5.62e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 5.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQVQQQQQQQQQQPPPLPAEPEPEAQHEELYSVQDIFE 1493
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229


                   ....*....
gi 2024386781 1494 EEYLEQDVE 1502
Cdd:COG0457    230 LLALRLAAL 238
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1330-1443 1.00e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.00  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1330 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1409
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024386781 1410 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNRE 1443
Cdd:COG4785    143 AYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
1239-1292 3.54e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.54e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024386781 1239 GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1292
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1303-1441 3.80e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 3.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1303 LPSRPRGPATWAMATSKPDIMiillSKLMEEGDMFYKkgkVKEAAQRYQYALKKFPREGFGEDLKTFRELK----VSLLL 1378
Cdd:COG4785      5 ALALLLALALAAAAASKAAIL----LAALLFAAVLAL---AIALADLALALAAAALAAAALAAERIDRALAlpdlAQLYY 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1379 NLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:COG4785     78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDY 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1334-1448 4.04e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 4.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG2956     49 GNLYRRRGEYDRAIRIHQKLLERDPD-------------RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG2956    116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCEL 150
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1322-1451 4.93e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 4.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1322 IMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKAL 1401
Cdd:COG2956      3 LPVAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-------------VEAHLALGNLYRRRGEYDRAIRIHQKLL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1402 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:COG2956     70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1334-1419 5.66e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 53.07  E-value: 5.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 2024386781 1414 RARAKR 1419
Cdd:COG1729    107 RARLAR 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1373-1448 7.50e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 7.50e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1373 KVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
Ank_5 pfam13857
Ankyrin repeats (many copies);
1159-1210 8.83e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 8.83e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1159 LLTHG-ADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTAL 1210
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 935-1170 1.76e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 1.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  935 NIKVSRLLilgGANVNYRTEVLNNAPILCVQShLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKR 1014
Cdd:PLN03192   506 DLNVGDLL---GDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1015 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCdwsmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeev 1094
Cdd:PLN03192   582 CNVHIRDANGNTALWNAISAKHHKIFRILYHF------------------------------------------------ 613

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1095 erAQINsfDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMAD 1170
Cdd:PLN03192   614 --ASIS--DPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
991-1044 1.93e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 1.93e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024386781  991 GLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1044
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
940-1021 3.15e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 3.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  940 RLLILGGANVNYRTEVLNNAPILCVQShlGYTEMVALLLEFgANVDAaSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDH 1019
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNL-KDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 2024386781 1020 LD 1021
Cdd:pfam12796   90 KD 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1383-1451 4.57e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 4.57e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024386781 1383 CRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEdLNEAIKLCPNNREIQRLLLRV 1451
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAEL 68
Ank_4 pfam13637
Ankyrin repeats (many copies);
960-1010 4.75e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 4.75e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024386781  960 PILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLL 1010
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1330-1447 1.01e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1330 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1409
Cdd:COG2956    147 YCELAELYLEQGDYDEAIEALEKALKLDPD-------------CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024386781 1410 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRL 1447
Cdd:COG2956    214 ALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
Ank_5 pfam13857
Ankyrin repeats (many copies);
1203-1246 1.05e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024386781 1203 DKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLA 1246
Cdd:pfam13857   13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1337-1446 2.67e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.06  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1337 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY---EAYYA 1413
Cdd:COG1729      3 LLKAGDYDEAIAAFKAFLKRYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLK 72

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQR 1446
Cdd:COG1729     73 LGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1107-1228 2.76e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVV--------------PLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1172
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1173 GRTPLMMAASEGHLGTV----EFLLAQGASISLM------DKEGLTALSWACLKGHLAVVRALVEN 1228
Cdd:cd22192    169 GNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1142-1298 2.81e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 2.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1142 VPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISL-------------------- 1201
Cdd:PHA02878    39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVfytlvaikdafnnrnveifk 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1202 ------MDKEGLTALSWACLKGH-----LAVVRALVENGAATDHADKN-GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1269
Cdd:PHA02878   119 iiltnrYKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPD 198

                          170       180
                   ....*....|....*....|....*....
gi 2024386781 1270 YSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1298
Cdd:PHA02878   199 KTNNSPLHHAVKHYNKPIVHILLENGAST 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 933-1166 6.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 6.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  933 TPNIkvsRLLILGGANVNyRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCK 1012
Cdd:PHA02876   321 TENI---RTLIMLGADVN-AADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1013 KRAKVDHLDKNGQCALvHAALRGhlevvkfliqcdwsmagqqqgvfkkshaiqqaliaaaSMGYTEiVSYLLDlpekdee 1092
Cdd:PHA02876   397 YGADIEALSQKIGTAL-HFALCG-------------------------------------TNPYMS-VKTLID------- 430

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024386781 1093 evERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVrqGHWQIVDLLLTHGADV 1166
Cdd:PHA02876   431 --RGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
Ank_5 pfam13857
Ankyrin repeats (many copies);
1126-1180 8.11e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 8.11e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1126 LLEQG-AAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1180
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1565-1864 9.47e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 9.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1565 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1627
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1628 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1704
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1705 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1782
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1783 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1862
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024386781 1863 VG 1864
Cdd:pfam05109  710 SG 711
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1124-1193 9.70e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 9.70e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1124 RLLLEQGAavaQPNRR---GVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1193
Cdd:PTZ00322    99 RILLTGGA---DPNCRdydGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02946 PHA02946
ankyin-like protein; Provisional
 1126-1276 2.21e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1126 LLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPL--MMAASEGHLGTVEFLLAQGASI-SLM 1202
Cdd:PHA02946    58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInNSV 137

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1203 DKEGLTALsWACLKGHLAVVRALVENGAATDHADKNGRTPL--DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1276
Cdd:PHA02946   138 DEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1581-1738 2.32e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1581 PSPPHTSPAHQGSSyRFSPPPVgSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvyrsQSGSPVRYQQEPSAVSPLPGRPK 1660
Cdd:PHA03247  2871 PAAKPAAPARPPVR-RLARPAV-SRSTESFALPPDQPERPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQ 2940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1661 SPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSSA---------VHSSTVIPTGAYSQVAHSMASKYQAAAG 1731
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPP 3020


                   ....*..
gi 2024386781 1732 EMGVNQS 1738
Cdd:PHA03247  3021 PVSLKQT 3027
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1089-1266 3.46e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.92  E-value: 3.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1089 KDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQgaavaqpNRRGVV--PLFSAVRQGHWQIVDLLLTHGADV 1166
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1167 nmADKQGRTPLMMAASeghlgTVEFllaqgasislmdKEGLTALSWACLKGHLAVVRALVENGAA------------TDH 1234
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024386781 1235 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1266
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1553-1732 4.48e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1553 SSVGSPTRQGYQSTSPtlsPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPLRRGPQYRASPPAdgm 1632
Cdd:pfam03154  156 SDSDSSAQQQILQTQP---PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT--- 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1633 svyRSQSGSPVRYQQEPSAVSPLPGRPK-SPLSKMSQRSFQMPQLPVAVPQQGLRLQ--PAKAQIVRSNQP--SSAVHSS 1707
Cdd:pfam03154  230 ---LIQQTPTLHPQRLPSPHPPLQPMTQpPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPQPfpLTPQSSQ 306

                          170       180
                   ....*....|....*....|....*
gi 2024386781 1708 TVIPTGAYSQVAHSMASKYQAAAGE 1732
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTPPSQ 331
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1173-1265 5.61e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.34  E-value: 5.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1173 GRTPLMMAASEGHLGTVE--FLLAQGASISLMDKE------------GLTALSWACLKGHLAVVRALVENGAATdHADKN 1238
Cdd:cd21882     26 GKTCLHKAALNLNDGVNEaiMLLLEAAPDSGNPKElvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADV-SARAT 104

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2024386781 1239 GRT--------------PLDLAAFYGDAEVVQFLVDHGAMI 1265
Cdd:cd21882    105 GRFfrkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1335-1450 6.46e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 6.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1335 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1414
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024386781 1415 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1450
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1172-1204 6.75e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 6.75e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024386781 1172 QGRTPLMMAA-SEGHLGTVEFLLAQGASISLMDK 1204
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1402-1450 1.20e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 1.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024386781 1402 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP------NNREIQRLLLR 1450
Cdd:COG4785     67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPdlaeayNNRGLAYLLLG 121
TPR_14 pfam13428
Tetratricopeptide repeat;
1409-1451 1.41e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024386781 1409 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1238-1266 1.46e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.46e-04
                            10        20
                    ....*....|....*....|....*....
gi 2024386781  1238 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1266
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1371-1451 2.17e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 45.67  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1371 ELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA-YYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1449
Cdd:COG3071     47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAvLLTRAELLLDQGQAEQALATLEALRAGAPRHPQVLRLLL 126


                   ..
gi 2024386781 1450 RV 1451
Cdd:COG3071    127 QA 128
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1238-1269 2.33e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2024386781 1238 NGRTPLDLAA-FYGDAEVVQFLVDHGAMIEHVD 1269
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1222-1292 2.76e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.76e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024386781 1222 VRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGcRNTSVVVTLL 1292
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE-NGFREVVQLL 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1401-1448 3.03e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 3.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2024386781 1401 LELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1107-1259 5.63e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 5.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEQGAAV-AQPN-------------RRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1172
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVpARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1173 GRTPLMMAASEGhlgtvEFllaqgasislmdKEGLTALSWAC---LKGHLAVVRALVENGAATDHadkNGRTPLDLAAFY 1249
Cdd:TIGR00870  208 GNTLLHLLVMEN-----EF------------KAEYEELSCQMynfALSLLDKLRDSKELEVILNH---QGLTPLKLAAKE 267

                          170
                   ....*....|
gi 2024386781 1250 GDAEVVQFLV 1259
Cdd:TIGR00870  268 GRIVLFRLKL 277
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1172-1201 6.30e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 6.30e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2024386781  1172 QGRTPLMMAASEGHLGTVEFLLAQGASISL 1201
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 940-1024 6.68e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 6.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  940 RLLILGGANVNYRTevLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDH 1019
Cdd:PTZ00322    99 RILLTGGADPNCRD--YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176


                   ....*
gi 2024386781 1020 LDKNG 1024
Cdd:PTZ00322   177 LGANA 181
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 934-998 7.42e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.42e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024386781  934 PNIKVSRLLILGGANVNYrTEVLNNAPILCVQSHLGyTEMVALLLEFGANVDAASESGLTPLGYA 998
Cdd:PHA02878   179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKHYN-KPIVHILLENGASTDARDKCGNTPLHIS 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1334-1449 8.35e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 8.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:COG3914    153 GEALRRLGRLEEAIAALRRALELDPDN-------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1449
Cdd:COG3914    220 LLFALRQACDWEVYDRFEELLAALARGPSELSPFAL 255
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1385-1451 8.64e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 8.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024386781 1385 RKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1451
Cdd:COG3914     89 QALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEA 155
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1581-1685 8.76e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 8.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1581 PSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSP-PPSPLRRGPQYRASPPADGMSVYRSQSGSPVRYQ-QEPSAVSPLPGR 1658
Cdd:PRK10263   740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPvAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpQQPVAPQPQYQQ 819

                           90       100
                   ....*....|....*....|....*...
gi 2024386781 1659 PKSPLSkmSQRSFQMPQLPVA-VPQQGL 1685
Cdd:PRK10263   820 PQQPVA--PQPQYQQPQQPVApQPQDTL 845
Ank_5 pfam13857
Ankyrin repeats (many copies);
1225-1279 8.90e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 8.90e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1225 LVENG-AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1279
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1334-1451 1.20e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1413
Cdd:TIGR02917  132 GLAYLGLGQLELAQKSYEQALAIDPRSL-------------YAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLL 198

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024386781 1414 RARAKRSSRQFAAALEDLNEAIKLCPNNreIQRLLLRV 1451
Cdd:TIGR02917  199 KGDLLLSLGNIELALAAYRKAIALRPNN--IAVLLALA 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1107-1294 1.22e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEqgAA---VAQPNR----RGVVPLFSAVRQGHWQIVDLLLTHGADVNMAdkqgRTplmm 1179
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLME--AApelVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSP----RA---- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1180 aaseghLGTVeFLLAQGASISLmdkeGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDA----EVV 1255
Cdd:cd22192    121 ------TGTF-FRPGPKNLIYY----GEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKtfacQMY 189

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2024386781 1256 QFLV-----DHGAMIEHV-DYSGMRPLDRAVGCRNTSVVVTLLKK 1294
Cdd:cd22192    190 DLILsydkeDDLQPLDLVpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
TPR_1 pfam00515
Tetratricopeptide repeat;
1408-1441 1.26e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024386781 1408 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1075-1259 1.72e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.59  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1075 GYTEIVSYLLDLPEKDEEEVEraqinsfdslwgeTALTAAAGRGKLDvcRLLleqGAAVAQPNRRGVVPLFSAVRQGHWQ 1154
Cdd:cd22194     94 GKTCLMKALLNINENTKEIVR-------------ILLAFAEENGILD--RFI---NAEYTEEAYEGQTALNIAIERRQGD 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1155 IVDLLLTHGADVNMADKQ--------------GRTPLMMAASEGHLGTVEFLLAQGAS-ISLMDKEG---LTALSWAC-- 1214
Cdd:cd22194    156 IVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAed 235

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1215 LKGHLAVVRALVENgAATDHADKN--------GRTPLDLAAFYGDAEVVQFLV 1259
Cdd:cd22194    236 SKTQNDFVKRMYDM-ILLKSENKNletirnneGLTPLQLAAKMGKAEILKYIL 287
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1238-1263 1.99e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....*.
gi 2024386781 1238 NGRTPLDLAAFYGDAEVVQFLVDHGA 1263
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGA 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1558-1912 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1558 PTRQGYQSTSPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPlrrGPQYRASPPADGMSVYRS 1637
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP---TPEPAPHALVSATPLPPG 2724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1638 QSGSPVRYQQEPSAVSPlPGRPKSPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQP--SSAVHSSTVIPTgAY 1715
Cdd:PHA03247  2725 PAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavASLSESRESLPS-PW 2802

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1716 SQVAHSMASKYQAAAGEMGVNQSRLVYQGSIGGIVGDSRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQ 1795
Cdd:PHA03247  2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1796 TPQIGRSQ-SASYYPMCHSKLDLERSSLPSGQLGSPDVSHLIRRPISVNPSEIKPHP-----PTPRPLLHSQSVGLRFSP 1869
Cdd:PHA03247  2883 VRRLARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqpplaPTTDPAGAGEPSGAVPQP 2962

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2024386781 1870 SSNSISSTSNLTPNFRPSASIQQMEIPLKPAYDRACDELSPVS 1912
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1388-1439 2.24e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024386781 1388 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1439
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 1409-1440 2.53e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 2.53e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024386781 1409 EAYYARARAKRSSRQFAAALEDLNEAIKLCPN 1440
Cdd:pfam07719    2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1143-1171 2.69e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.69e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024386781 1143 PLFSAV-RQGHWQIVDLLLTHGADVNMADK 1171
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 1556-1662 3.08e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 40.41  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1556 GSPTRQGYQStsPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvy 1635
Cdd:pfam15240   75 QPPPQGGKQK--PQGPPPQGGPRPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGNQQGPPPPPP------ 146

                           90       100
                   ....*....|....*....|....*..
gi 2024386781 1636 RSQSGSPVRyqqepsavSPLPGRPKSP 1662
Cdd:pfam15240  147 GNPQGPPQR--------PPQPGNPQGP 165
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 962-1046 3.19e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  962 LCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 1041
Cdd:PTZ00322    86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                   ....*
gi 2024386781 1042 FLIQC 1046
Cdd:PTZ00322   166 LLSRH 170
TPR_12 pfam13424
Tetratricopeptide repeat;
1375-1437 3.63e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 3.63e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024386781 1375 SLLLNLSRCRRKMNDFGMAEEFATKALEL--------KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKL 1437
Cdd:pfam13424    4 TALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 936-1044 4.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 4.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  936 IKVSRLLILGganvNYRTEVL---NNAPiLCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCK 1012
Cdd:PHA02875    82 KAVEELLDLG----KFADDVFykdGMTP-LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2024386781 1013 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1044
Cdd:PHA02875   157 HKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1173-1200 4.60e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 4.60e-03
                           10        20
                   ....*....|....*....|....*...
gi 2024386781 1173 GRTPLMMAASEGHLGTVEFLLAQGASIS 1200
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1537-1719 4.62e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1537 SGSPLGSH----QVFDFRSNSSvgsptrQGYQSTSPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSP 1612
Cdd:pfam03154  284 TGPSHMQHpvppQPFPLTPQSS------QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1613 PPS---PLRRGPQYRASPPadgmsvyrsQSGSPVRYQQePSAVSPLPG-RPKSPLSKMSQRSFQMPqlPVAVPQQGLRLQ 1688
Cdd:pfam03154  358 PPTtpiPQLPNPQSHKHPP---------HLSGPSPFQM-NSNLPPPPAlKPLSSLSTHHPPSAHPP--PLQLMPQSQQLP 425

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024386781 1689 PAKAQ-IVRSNQPSSAVHSSTVIPTGAYSQVA 1719
Cdd:pfam03154  426 PPPAQpPVLTQSQSLPPPAASHPPTSGLHQVP 457
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1384-1445 5.01e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 42.21  E-value: 5.01e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024386781 1384 RRKMNDFGMAEEFATKALELKPkSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQ 1445
Cdd:PRK09782   586 RYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNNSNYQ 646
TPR_19 pfam14559
Tetratricopeptide repeat;
1388-1448 5.08e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.18  E-value: 5.08e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024386781 1388 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1448
Cdd:pfam14559    2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1205-1234 5.22e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 5.22e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024386781 1205 EGLTALSWACLKGHLAVVRALVENGAATDH 1234
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TPR_12 pfam13424
Tetratricopeptide repeat;
1334-1406 5.27e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 5.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024386781 1334 GDMFYKKGKVKEAAQRYQYALKKFpREGFGEDlktfRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1406
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1408-1441 5.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2024386781  1408 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1441
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1143-1168 6.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 6.11e-03
                            10        20
                    ....*....|....*....|....*.
gi 2024386781  1143 PLFSAVRQGHWQIVDLLLTHGADVNM 1168
Cdd:smart00248    5 PLHLAAENGNLEVVKLLLDKGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1119-1199 6.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.65  E-value: 6.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1119 KLDVCRLLLEQGAAVaqpNRRGVV--PLFSAVRQGHW------QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVE 1190
Cdd:PHA02989    49 KIKIVKLLIDNGADV---NYKGYIetPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCD 125

                           90
                   ....*....|..
gi 2024386781 1191 ---FLLAQGASI 1199
Cdd:PHA02989   126 mlrFLLSKGINV 137
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1205-1237 7.13e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 7.13e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024386781 1205 EGLTALSWACLK-GHLAVVRALVENGAATDHADK 1237
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1107-1181 7.14e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1107 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGR------------ 1174
Cdd:PTZ00322   115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKpdsftgkppsle 194


                   ....*...
gi 2024386781 1175 -TPLMMAA 1181
Cdd:PTZ00322   195 dSPISSHH 202
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 936-1222 8.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.88  E-value: 8.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781  936 IKVSRLLILGGANVNYR-------TEVLNNAPIlcvqSHLGYTEMVALLLEFGANVDAASESGLTPLG---YAAAAGFLS 1005
Cdd:PHA02989    50 IKIVKLLIDNGADVNYKgyietplCAVLRNREI----TSNKIKKIVKLLLKFGADINLKTFNGVSPIVcfiYNSNINNCD 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1006 IVVLLCKKRAKVDHLDKNGQCALVHAALRG---HLEVVKFLIQcdwsmAGqqQGVFKKSHAiqqaliaaasMGYTEIVSY 1082
Cdd:PHA02989   126 MLRFLLSKGINVNDVKNSRGYNLLHMYLESfsvKKDVIKILLS-----FG--VNLFEKTSL----------YGLTPMNIY 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1083 LldlpekdeeeveRAQINSFDslwgetaltaaagrgkLDVCRLLLEQGAAVAQPNRRGVVPLFSAVR------QGHWQIV 1156
Cdd:PHA02989   189 L------------RNDIDVIS----------------IKVIKYLIKKGVNIETNNNGSESVLESFLDnnkilsKKEFKVL 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024386781 1157 DLLLTHgADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVV 1222
Cdd:PHA02989   241 NFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDML 305
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1075-1259 8.29e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.02  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1075 GYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAAAGRGKLDVCRLLLEQGAAV-AQPNRR------------G 1140
Cdd:cd21882     40 GVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYqGQTALHIAIENRNLNLVRLLVENGADVsARATGRffrkspgnlfyfG 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024386781 1141 VVPLFSAVRQGHWQIVDLLLTHGAD---VNMADKQGRTPL--MMAASEGHLGTVEFLLAQGASISLMDKegltalswacl 1215
Cdd:cd21882    120 ELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLhaLVLQADNTPENSAFVCQMYNLLLSYGA----------- 188

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2024386781 1216 KGHLAVVRALVENgaatdhadKNGRTPLDLAAFYGDAEVVQFLV 1259
Cdd:cd21882    189 HLDPTQQLEEIPN--------HQGLTPLKLAAVEGKIVMFQHIL 224
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1143-1168 9.24e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 9.24e-03
                           10        20
                   ....*....|....*....|....*.
gi 2024386781 1143 PLFSAVRQGHWQIVDLLLTHGADVNM 1168
Cdd:pfam13606    5 PLHLAARNGRLEIVKLLLENGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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