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Conserved domains on  [gi|1207190182|ref|XP_005155896|]
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scm-like with four MBT domains protein 1 isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 276-372 2.34e-59

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


:

Pssm-ID: 439105  Cd Length: 94  Bit Score: 196.63  E-value: 2.34e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEaqkEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPE---EAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPP 77

                          90
                  ....*....|....*..
gi 1207190182 356 GFQGQDFDWADYLKQCE 372
Cdd:cd20115    78 GYPGQDFDWADYLKQCG 94
MBT super family cl45897
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 46-140 7.45e-55

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


The actual alignment was detected with superfamily member cd20111:

Pssm-ID: 459242  Cd Length: 94  Bit Score: 184.26  E-value: 7.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTESEsVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20111     1 QNGFSPGMKLEVAVRTDPN-TYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRD 79

                          90
                  ....*....|....*
gi 1207190182 126 KHQDWEALLEKALAE 140
Cdd:cd20111    80 KLSDWEEFLAQTLTG 94
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 159-259 7.11e-52

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


:

Pssm-ID: 439103  Cd Length: 99  Bit Score: 176.15  E-value: 7.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 159 IDLLSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDGlpENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALL 238
Cdd:cd20113     1 LDLIGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEG--SDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIR 78

                          90       100
                  ....*....|....*....|.
gi 1207190182 239 PLRTEAEWEEVKKSISSQEQD 259
Cdd:cd20113    79 HLKSEAEWQEILKKVKEEEEE 99
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 388-477 8.23e-52

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


:

Pssm-ID: 439107  Cd Length: 90  Bit Score: 175.46  E-value: 8.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 388 QCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHPCKPRVEKQ 467
Cdd:cd20117     1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQ 80

                          90
                  ....*....|
gi 1207190182 468 RKVAVVQPEK 477
Cdd:cd20117    81 RKIAVVQPEK 90
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 511-626 4.40e-50

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


:

Pssm-ID: 463469  Cd Length: 112  Bit Score: 171.62  E-value: 4.40e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 511 CPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLKEVLTLLINSAYKPSRVLRELQLDQEgrwqGHGETLKAKYKGK 590
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNG----GREEIITAKYEGK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207190182 591 SYRATVEIVRTADQVADFCRKTCIKLECCPNLFGPR 626
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSPQ 112
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 784-868 1.86e-47

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


:

Pssm-ID: 188980  Cd Length: 85  Bit Score: 163.39  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 784 EVPQKLCLESSPLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVKLAFY 863
Cdd:cd09581     1 EEEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFY 80


                  ....*
gi 1207190182 864 QQFAS 868
Cdd:cd09581    81 EQFAN 85
 
Name Accession Description Interval E-value
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 276-372 2.34e-59

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 196.63  E-value: 2.34e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEaqkEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPE---EAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPP 77

                          90
                  ....*....|....*..
gi 1207190182 356 GFQGQDFDWADYLKQCE 372
Cdd:cd20115    78 GYPGQDFDWADYLKQCG 94
MBT_SFMBT1_rpt1 cd20111
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 46-140 7.45e-55

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439101  Cd Length: 94  Bit Score: 184.26  E-value: 7.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTESEsVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20111     1 QNGFSPGMKLEVAVRTDPN-TYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRD 79

                          90
                  ....*....|....*
gi 1207190182 126 KHQDWEALLEKALAE 140
Cdd:cd20111    80 KLSDWEEFLAQTLTG 94
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 159-259 7.11e-52

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439103  Cd Length: 99  Bit Score: 176.15  E-value: 7.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 159 IDLLSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDGlpENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALL 238
Cdd:cd20113     1 LDLIGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEG--SDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIR 78

                          90       100
                  ....*....|....*....|.
gi 1207190182 239 PLRTEAEWEEVKKSISSQEQD 259
Cdd:cd20113    79 HLKSEAEWQEILKKVKEEEEE 99
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 388-477 8.23e-52

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 175.46  E-value: 8.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 388 QCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHPCKPRVEKQ 467
Cdd:cd20117     1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQ 80

                          90
                  ....*....|
gi 1207190182 468 RKVAVVQPEK 477
Cdd:cd20117    81 RKIAVVQPEK 90
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 511-626 4.40e-50

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 171.62  E-value: 4.40e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 511 CPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLKEVLTLLINSAYKPSRVLRELQLDQEgrwqGHGETLKAKYKGK 590
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNG----GREEIITAKYEGK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207190182 591 SYRATVEIVRTADQVADFCRKTCIKLECCPNLFGPR 626
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSPQ 112
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 784-868 1.86e-47

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


Pssm-ID: 188980  Cd Length: 85  Bit Score: 163.39  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 784 EVPQKLCLESSPLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVKLAFY 863
Cdd:cd09581     1 EEEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFY 80


                  ....*
gi 1207190182 864 QQFAS 868
Cdd:cd09581    81 EQFAN 85
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 22-120 1.38e-28

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 110.03  E-value: 1.38e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182   22 DDYLEESGALSVPHHAFKHVDQGLETGLTPGMKLEVCVRTESeSVYWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMT 101
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNP-SLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHADS 77

                           90
                   ....*....|....*....
gi 1207190182  102 ADLHPIGWSKQQGRMMKPP 120
Cdd:smart00561  78 PDIFPVGWCEKNGHPLQPP 96
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 366-456 5.23e-26

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 102.71  E-value: 5.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  366 DYLKQCEAEAAPQQCF--PPDPSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLkQAMPEIIVHTDSMDI 443
Cdd:smart00561   2 DYLEETGARAAPVELFkqPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGW-DDKYDFWCHADSPDI 80

                           90
                   ....*....|...
gi 1207190182  444 FPVSWCETNGYPL 456
Cdd:smart00561  81 FPVGWCEKNGHPL 93
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 255-354 1.75e-22

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 92.70  E-value: 1.75e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  255 SQEQDPSISEEFYRDRSAITPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEqFFLVLMDDMRDEaqkeggaHSFLCHRD 334
Cdd:smart00561   5 EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGY-RLLLHFDGWDDK-------YDFWCHAD 76

                           90       100
                   ....*....|....*....|
gi 1207190182  335 SPGIFPTQWSLKNGVKLSPP 354
Cdd:smart00561  77 SPDIFPVGWCEKNGHPLQPP 96
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 394-459 1.09e-21

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 89.11  E-value: 1.09e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAmPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDS-YDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 282-355 3.65e-21

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 87.57  E-value: 3.65e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 282 MKLEAVDPAAPFTISPATVAKVFnEQFFLVLMDDMRDeaqkeggAHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGWDD-------SYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 53-121 2.74e-20

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 85.26  E-value: 2.74e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  53 MKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPE 121
Cdd:pfam02820   1 MKLEA-VDPLNPSLICVATVVKVLGGRLRLRFDGWDDSY--DFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 168-234 8.83e-12

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 60.99  E-value: 8.83e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 168 VELVDHQDAGVVWSAVIEENIGGRLRLRYagtDGLPENQSItWVFYLDPLLHLSGWAQEHNCTLRPP 234
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRF---DGWDDSYDF-WCHADSPDIHPVGWCEKNGHPLQPP 65
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 797-859 4.19e-08

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 50.73  E-value: 4.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 797 EWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLnlpTVQECMDL---KLGPAIKLCHHIERVK 859
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQL---TEDDLLKLgvtLLGHRKKILYAIQRLK 64
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 795-859 2.83e-06

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 45.36  E-value: 2.83e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  795 PLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLnlpTVQECMD----LKLGPAIKLCHHIERVK 859
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLL---TSEEDLKelgiTKLGHRKKILKAIQKLK 66
 
Name Accession Description Interval E-value
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 276-372 2.34e-59

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 196.63  E-value: 2.34e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEaqkEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPE---EAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPP 77

                          90
                  ....*....|....*..
gi 1207190182 356 GFQGQDFDWADYLKQCE 372
Cdd:cd20115    78 GYPGQDFDWADYLKQCG 94
MBT_SFMBT1_rpt1 cd20111
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 46-140 7.45e-55

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439101  Cd Length: 94  Bit Score: 184.26  E-value: 7.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTESEsVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20111     1 QNGFSPGMKLEVAVRTDPN-TYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRD 79

                          90
                  ....*....|....*
gi 1207190182 126 KHQDWEALLEKALAE 140
Cdd:cd20111    80 KLSDWEEFLAQTLTG 94
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 159-259 7.11e-52

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439103  Cd Length: 99  Bit Score: 176.15  E-value: 7.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 159 IDLLSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDGlpENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALL 238
Cdd:cd20113     1 LDLIGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEG--SDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIR 78

                          90       100
                  ....*....|....*....|.
gi 1207190182 239 PLRTEAEWEEVKKSISSQEQD 259
Cdd:cd20113    79 HLKSEAEWQEILKKVKEEEEE 99
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 388-477 8.23e-52

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 175.46  E-value: 8.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 388 QCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHPCKPRVEKQ 467
Cdd:cd20117     1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQ 80

                          90
                  ....*....|
gi 1207190182 468 RKVAVVQPEK 477
Cdd:cd20117    81 RKIAVVQPEK 90
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 511-626 4.40e-50

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 171.62  E-value: 4.40e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 511 CPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLKEVLTLLINSAYKPSRVLRELQLDQEgrwqGHGETLKAKYKGK 590
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNG----GREEIITAKYEGK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207190182 591 SYRATVEIVRTADQVADFCRKTCIKLECCPNLFGPR 626
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSPQ 112
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 784-868 1.86e-47

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


Pssm-ID: 188980  Cd Length: 85  Bit Score: 163.39  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 784 EVPQKLCLESSPLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVKLAFY 863
Cdd:cd09581     1 EEEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFY 80


                  ....*
gi 1207190182 864 QQFAS 868
Cdd:cd09581    81 EQFAN 85
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 276-372 5.28e-43

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439106  Cd Length: 93  Bit Score: 151.11  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEAQKeggaHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:cd20116     1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPEASE----NSMLCHADSLGILPVQWCLKNGVNLTPPK 76

                          90
                  ....*....|....*..
gi 1207190182 356 GFQGQDFDWADYLKQCE 372
Cdd:cd20116    77 GYSGQDFDWADYQKQCG 93
MBT_SFMBT_rpt1 cd20093
first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 46-140 7.19e-43

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439083  Cd Length: 94  Bit Score: 150.50  E-value: 7.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRtESESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20093     1 QSGFKPGMKLEVPNK-NNPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKE 79

                          90
                  ....*....|....*
gi 1207190182 126 KHQDWEALLEKALAE 140
Cdd:cd20093    80 KELDWAEFLIKELTG 94
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 46-138 2.18e-41

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439102  Cd Length: 94  Bit Score: 146.28  E-value: 2.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTESESvYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20112     1 QSSFQPGMKLEVANKSNPDT-YWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKE 79

                          90
                  ....*....|...
gi 1207190182 126 KHQDWEALLEKAL 138
Cdd:cd20112    80 KYTDWTEFLIHDL 92
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 278-371 1.92e-39

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 140.85  E-value: 1.92e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEAQKEggaHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVEIDDLRPEESEK---ITFVCHANSPGIFPVGWCAKNGLRLTPPPGY 77

                          90
                  ....*....|....
gi 1207190182 358 QGQDFDWADYLKQC 371
Cdd:cd20095    78 PKSEFDWDSYLKLC 91
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 392-477 3.62e-37

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 134.18  E-value: 3.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 392 ESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHPCKPRVEKQRKVA 471
Cdd:cd20118     4 KNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEYIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKKRKIA 83


                  ....*.
gi 1207190182 472 VVQPEK 477
Cdd:cd20118    84 VVQPEK 89
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 22-120 1.38e-28

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 110.03  E-value: 1.38e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182   22 DDYLEESGALSVPHHAFKHVDQGLETGLTPGMKLEVCVRTESeSVYWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMT 101
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNP-SLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHADS 77

                           90
                   ....*....|....*....
gi 1207190182  102 ADLHPIGWSKQQGRMMKPP 120
Cdd:smart00561  78 PDIFPVGWCEKNGHPLQPP 96
SAM_Polycomb cd09509
SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a ...
 795-857 2.53e-28

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.


Pssm-ID: 188908  Cd Length: 64  Bit Score: 107.95  E-value: 2.53e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 795 PLEWSVTDVVRFIRTTD-CAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIER 857
Cdd:cd09509     1 PSKWSVDDVAQFIKSLDgCAEYAEVFREQEIDGQALLLLTEDDLLKGMGLKLGPALKIYNHIVK 64
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 390-459 5.48e-28

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 107.32  E-value: 5.48e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 390 IKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNIIVDVESTDIFPVGWCESNGYPLVTP 70
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 366-456 5.23e-26

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 102.71  E-value: 5.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  366 DYLKQCEAEAAPQQCF--PPDPSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLkQAMPEIIVHTDSMDI 443
Cdd:smart00561   2 DYLEETGARAAPVELFkqPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGW-DDKYDFWCHADSPDI 80

                           90
                   ....*....|...
gi 1207190182  444 FPVSWCETNGYPL 456
Cdd:smart00561  81 FPVGWCEKNGHPL 93
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 49-145 6.37e-25

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 99.69  E-value: 6.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  49 LTPGMKLEVCVRTE-----SESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGV 123
Cdd:cd20097     4 VKIGVKVEVANRDDdkptdNVKVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPPKSI 83

                          90       100
                  ....*....|....*....|..
gi 1207190182 124 REKHQDWEALLEKALAESCSVP 145
Cdd:cd20097    84 EDKENDWKEYIMKRLHGKRTIP 105
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 278-372 7.47e-24

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 96.21  E-value: 7.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDdmrdEAQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGID----GPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGY 76

                          90
                  ....*....|....*
gi 1207190182 358 QGQDFDWADYLKQCE 372
Cdd:cd20099    77 ESKPFDWEEYLEETG 91
MBT_SFMBT2_rpt2 cd20114
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 159-248 4.08e-23

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439104  Cd Length: 98  Bit Score: 94.41  E-value: 4.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 159 IDLLSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGtdgLPENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALL 238
Cdd:cd20114     1 VDLITVGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVG---LEDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEIC 77

                          90
                  ....*....|
gi 1207190182 239 PLRTEAEWEE 248
Cdd:cd20114    78 DLKSASEWKE 87
MBT_MBTD1_rpt1 cd20120
first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 52-145 4.28e-23

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439110  Cd Length: 103  Bit Score: 94.53  E-value: 4.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVcVRTESE---SVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKHQ 128
Cdd:cd20120     7 GVRVEV-PNTDCNlptKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQHKYT 85

                          90
                  ....*....|....*..
gi 1207190182 129 DWEALLEKALAESCSVP 145
Cdd:cd20120    86 NWKAFLVKRLTGAKTLP 102
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 255-354 1.75e-22

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 92.70  E-value: 1.75e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  255 SQEQDPSISEEFYRDRSAITPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEqFFLVLMDDMRDEaqkeggaHSFLCHRD 334
Cdd:smart00561   5 EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGY-RLLLHFDGWDDK-------YDFWCHAD 76

                           90       100
                   ....*....|....*....|
gi 1207190182  335 SPGIFPTQWSLKNGVKLSPP 354
Cdd:smart00561  77 SPDIFPVGWCEKNGHPLQPP 96
MBT_L3MBTL2_rpt1 cd20121
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 52-145 2.83e-22

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439111  Cd Length: 102  Bit Score: 92.22  E-value: 2.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVcVRTES---ESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKHQ 128
Cdd:cd20121     7 GMKVEV-LNTDAvlpSRVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTIHAKFT 85

                          90
                  ....*....|....*..
gi 1207190182 129 DWEALLEKALAESCSVP 145
Cdd:cd20121    86 DWRGYLMKRLVGSRTIP 102
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 278-381 3.88e-22

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 91.84  E-value: 3.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEAqkeGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVLRFGYLMIRIDSYEPDA---SGSDWFCYHESSPCIFPAGFCEVNNITLTPPNGY 77

                          90       100
                  ....*....|....*....|....
gi 1207190182 358 QGQDFDWADYLKQCEAEAAPQQCF 381
Cdd:cd20125    78 DGRTFTWEGYLRQTGATAAPQHLF 101
MBT_dSfmbt_rpt1 cd20119
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 49-145 4.73e-22

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439109  Cd Length: 104  Bit Score: 91.74  E-value: 4.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  49 LTPGMKLEV----CVRTESESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVR 124
Cdd:cd20119     4 ITVGMKVEVentdTDLIEDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIE 83

                          90       100
                  ....*....|....*....|.
gi 1207190182 125 EKHQDWEALLEKALAESCSVP 145
Cdd:cd20119    84 HKYSDWKEFLVKRLTGARTLP 104
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 394-459 1.09e-21

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 89.11  E-value: 1.09e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAmPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDS-YDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT_SFMBT_rpt2 cd20094
second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 159-246 1.73e-21

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439084  Cd Length: 91  Bit Score: 89.60  E-value: 1.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 159 IDLLSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDglPENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAALL 238
Cdd:cd20094     1 ADRIKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPE--DSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLE 78


                  ....*...
gi 1207190182 239 PLRTEAEW 246
Cdd:cd20094    79 KLHATEEW 86
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 282-355 3.65e-21

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 87.57  E-value: 3.65e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 282 MKLEAVDPAAPFTISPATVAKVFnEQFFLVLMDDMRDeaqkeggAHSFLCHRDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGWDD-------SYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
SAM_Scm cd09578
SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...
 793-859 1.47e-20

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.


Pssm-ID: 188977  Cd Length: 72  Bit Score: 86.32  E-value: 1.47e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 793 SSPLEWSVTDVVRFIRTTD---CAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVK 859
Cdd:cd09578     2 KDPSTWSVEDVVQFIKEADpqaLAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLK 71
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 53-121 2.74e-20

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 85.26  E-value: 2.74e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  53 MKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPE 121
Cdd:pfam02820   1 MKLEA-VDPLNPSLICVATVVKVLGGRLRLRFDGWDDSY--DFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 274-381 3.04e-20

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 86.17  E-value: 3.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 274 TPHCFTEGMKLEAVDPAAPFTISPATVAKVfnEQFFLVLMDDMRDEAqkeggaHSFLCHRDSPGIFPTQWSLKNGVKLSP 353
Cdd:cd20101     2 NKNGFKVGMKLEGIDPKHPSLFCVLSVAEV--RGYRLRLHFDGYSEC------YDFWVNADSPDIFPVGWCEKTGHKLQP 73

                          90       100
                  ....*....|....*....|....*...
gi 1207190182 354 PPGFQGQDFDWADYLKQCEAEAAPQQCF 381
Cdd:cd20101    74 PKGYTSETFSWSAYLKLTKAQAAPKHLF 101
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 50-111 8.18e-18

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 78.07  E-value: 8.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207190182  50 TPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYqDDRRADFWCDIMTADLHPIGWSK 111
Cdd:cd20088     2 KVGMKLE-AVDPLNPSEICVATVVKVVGGRLLLHFDGW-DPSRYDFWCDVDSPDIHPVGWCE 61
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 275-372 2.22e-17

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 77.67  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVfNEQFFLVLMD---DMRDeaqkeggahsFLCHRDSPGIFPTQWSLKNGVKL 351
Cdd:cd20102     1 PHGFRVGMKLEAVDRKNPSLICVATVTDV-IGNRFLVHFDgwdDSYD----------YWCDPDSPYIHPVGWCEENGKTL 69

                          90       100
                  ....*....|....*....|.
gi 1207190182 352 SPPPGFQGQDFDWADYLKQCE 372
Cdd:cd20102    70 QPPKGYSPGNFSWDKYLEETN 90
MBT_MBTD1_rpt3 cd20126
third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 278-370 5.23e-17

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439116  Cd Length: 90  Bit Score: 76.75  E-value: 5.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMrdeaQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVLANGYLMIGIDGS----EAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGY 76

                          90
                  ....*....|...
gi 1207190182 358 QGQdFDWADYLKQ 370
Cdd:cd20126    77 KKP-FKWFDYLRE 88
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 278-381 1.46e-16

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 75.73  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQfflvlmddMRDEAQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20132     6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYR--------IRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGY 77

                          90       100
                  ....*....|....*....|....
gi 1207190182 358 QGQDFDWADYLKQCEAEAAPQQCF 381
Cdd:cd20132    78 KEEEFNWQSYLKTCKAQAAPKSLF 101
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 390-450 1.75e-16

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 74.21  E-value: 1.75e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182 390 IKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCE 450
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61
SAM_Ph1,2,3 cd09577
SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain ...
 793-859 2.12e-16

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.


Pssm-ID: 188976  Cd Length: 69  Bit Score: 74.36  E-value: 2.12e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190182 793 SSPLEWSVTDVVRFIRT-TDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVK 859
Cdd:cd09577     1 SNPSKWSVEDVYEFIRSlPGCSDYAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICAKINSLK 68
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 19-150 4.10e-16

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 75.80  E-value: 4.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  19 FNWDDYLEESGALSVPHHAFKHVDQGLETGLTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGyqDDRRADFWCD 98
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTST-CIATVVGLTGARLRLRLDG--SDNKNDFWRL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207190182  99 IMTADLHPIGWSKQQGRMMKPPEGVREKHQDWEALLEKALAESCSVPASLLE 150
Cdd:cd20105    79 VDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFH 130
MBT_SFMBT_rpt2 cd20094
second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 49-135 6.95e-16

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439084  Cd Length: 91  Bit Score: 73.42  E-value: 6.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  49 LTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKHQ 128
Cdd:cd20094     4 IKVGMYLEVQDELNPYSV-WIAKVLENVGGRLLLRYDGPEDSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLEKLHA 82


                  ....*....
gi 1207190182 129 D--WEALLE 135
Cdd:cd20094    83 TeeWKAILQ 91
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 278-381 1.76e-15

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 72.90  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVfnEQFFLVLMDDMRDEAqkeggaHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20133     6 FKVGMRLEGIDPEHPSLFCVLSVAEV--QGYRLRLHFDGYSEC------YDFWVNADSPDIHPVGWCEKTGHKLLPPKGY 77

                          90       100
                  ....*....|....*....|....
gi 1207190182 358 QGQDFDWADYLKQCEAEAAPQQCF 381
Cdd:cd20133    78 KDGEFNWSSYLKTCKAQAAPKNLF 101
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 278-381 1.83e-15

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 72.99  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNeqFFLVLMDDMRDEAqkeggaHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20131    14 FKLGMKLEGIDPQHPSMYFILTVAEVCG--YRLRLHFDGYSEC------HDFWVNANSPDIHPAGWFEKTGHKLQPPKGY 85

                          90       100
                  ....*....|....*....|....
gi 1207190182 358 QGQDFDWADYLKQCEAEAAPQQCF 381
Cdd:cd20131    86 KEEEFSWSQYLRSTRAQAAPKHLF 109
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 46-149 4.70e-15

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 71.49  E-value: 4.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20132     3 KNGFKVGMKLE-GVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCY--DFWVNADSPDIHPVGWCEKTGHKLHPPKGYKE 79

                          90       100
                  ....*....|....*....|....
gi 1207190182 126 KHQDWEALLEKALAEscSVPASLL 149
Cdd:cd20132    80 EEFNWQSYLKTCKAQ--AAPKSLF 101
MBT_L3MBTL2_rpt3 cd20127
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 278-370 4.85e-15

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439117  Cd Length: 91  Bit Score: 71.01  E-value: 4.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDmrdeAQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPGF 357
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMIGIDG----GPSTDGSDWFCYHASSHAIFPVGFCQKNDIELTPPKGY 76

                          90
                  ....*....|...
gi 1207190182 358 QGQDFDWADYLKQ 370
Cdd:cd20127    77 DAQTFNWENYLEK 89
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 46-149 9.56e-14

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 67.68  E-value: 9.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20101     3 KNGFKVGMKLE-GIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECY--DFWVNADSPDIFPVGWCEKTGHKLQPPKGYTS 79

                          90       100
                  ....*....|....*....|....
gi 1207190182 126 KHQDWEALLEKALAEscSVPASLL 149
Cdd:cd20101    80 ETFSWSAYLKLTKAQ--AAPKHLF 101
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 391-459 1.26e-13

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 67.28  E-value: 1.26e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWI----RLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20095     2 KVGMKLEALHPKNPSTICPATVTKVFNEYYFLveidDLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPP 74
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 278-344 9.09e-13

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 63.81  E-value: 9.09e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFnEQFFLVLMDDMRDEaqkeggAHSFLCHRDSPGIFPTQWS 344
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVV-GGRLLLHFDGWDPS------RYDFWCDVDSPDIHPVGWC 60
SAM_Atherin-like cd09583
SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin ...
 795-858 9.54e-13

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.


Pssm-ID: 188982  Cd Length: 69  Bit Score: 63.83  E-value: 9.54e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 795 PLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERV 858
Cdd:cd09583     1 PSNWSVEDVVQYFKTAGFPEEANAFKEQEIDGKSLLLLTRSDVLTGLSLKLGPALKIYEHVVKL 64
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 46-136 3.10e-12

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 63.03  E-value: 3.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20102     1 PHGFRVGMKLEAVDRKNPSLI-CVATVTDVIGNRFLVHFDGW--DDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSP 77

                          90
                  ....*....|.
gi 1207190182 126 KHQDWEALLEK 136
Cdd:cd20102    78 GNFSWDKYLEE 88
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 168-234 8.83e-12

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 60.99  E-value: 8.83e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 168 VELVDHQDAGVVWSAVIEENIGGRLRLRYagtDGLPENQSItWVFYLDPLLHLSGWAQEHNCTLRPP 234
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRF---DGWDDSYDF-WCHADSPDIHPVGWCEKNGHPLQPP 65
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 49-140 9.00e-12

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439103  Cd Length: 99  Bit Score: 62.13  E-value: 9.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  49 LTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVR--EK 126
Cdd:cd20113     4 IGPGSRLE-LQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRhlKS 82

                          90
                  ....*....|....
gi 1207190182 127 HQDWEALLEKALAE 140
Cdd:cd20113    83 EAEWQEILKKVKEE 96
SAM_Scm-like-3MBT3,4 cd09582
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 795-859 9.40e-12

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.


Pssm-ID: 188981  Cd Length: 66  Bit Score: 61.14  E-value: 9.40e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 795 PLEWSVTDVVRFIRT-TDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVK 859
Cdd:cd09582     1 VLRWSVDEVAEFVQSlPGCEEHAKVFRDEQIDGEAFLLLTQSDLVKILGIKLGPALKIYNSILMLR 66
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 46-135 1.43e-11

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 61.73  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDdrRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20133     3 RNGFKVGMRLE-GIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSE--CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKD 79

                          90
                  ....*....|
gi 1207190182 126 KHQDWEALLE 135
Cdd:cd20133    80 GEFNWSSYLK 89
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 278-354 1.89e-11

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 60.54  E-value: 1.89e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFlVLMDDMRdeaqkegGAHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20110     6 FKVGMKLEAVDRKNPHLICPATVGAVKDDQIF-VTFDGWR-------GAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 48-134 2.87e-11

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 61.05  E-value: 2.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  48 GLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKH 127
Cdd:cd20131    13 GFKLGMKLE-GIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECH--DFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEE 89


                  ....*..
gi 1207190182 128 QDWEALL 134
Cdd:cd20131    90 FSWSQYL 96
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 275-369 3.49e-11

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 60.40  E-value: 3.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVFnEQFFLVLMDDMRDeaqkeggAHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20136     2 PKEFQVGMKLEAVDRKNPSLVCVATIADIV-EDRLLVHFDNWDD-------SYDYWCDVNSPYIQPVGWCQENGRTLVAP 73

                          90
                  ....*....|....*.
gi 1207190182 355 PGFQGQD-FDWADYLK 369
Cdd:cd20136    74 QGYPNPEkFSWTEYLE 89
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 273-370 3.80e-11

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 60.20  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 273 ITPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEQfFLVLMDDMRDeaqkeggAHSFLCHRDSPGIFPTQWSLKNGVKLS 352
Cdd:cd20135     1 VTPSGFRVGMKLEAVDKKNPSFICVATITDMVDNR-LLIHFDNWDE-------SYDYWCDASSPYIHPVGYCQEHGRTLT 72

                          90
                  ....*....|....*....
gi 1207190182 353 PPPGFQ-GQDFDWADYLKQ 370
Cdd:cd20135    73 TPPGYKdPKHFSWEKYLEE 91
SAM_Scm-like-4MBT cd09580
SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 795-859 5.36e-11

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT (Sex comb on midleg like, Malignant Brain Tumor) subfamily proteins of the polycomb group is a putative protein-protein interaction domain. Additionally to the SAM domain, most of the proteins of this subfamily have 4 MBT repeats. In Drosophila SAM-Scm-like-4MBT protein (known as dSfmbt) is a member of Pho repressive complex (PhoRC). Additionally to dSfmbt, the PhoRC complex includes Pho or Pho-like proteins. This complex is responsible for HOX (Homeobox) gene silencing: Pho or Pho-like proteins bind DNA and dSmbt binds methylated histones. dSmbt can interact with mono- and di-methylated histones H3 and H4 (however this activity has been shown for the MBT repeats, while exact function of the SAM domain is unclear). Besides interaction with histones, dSmbt can interact with Scm (a member of PRC complex), but this interaction also seems to be SAM domain independent.


Pssm-ID: 188979  Cd Length: 67  Bit Score: 58.92  E-value: 5.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190182 795 PLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLnlpTVQECMDL---KLGPAIKLCHHIERVK 859
Cdd:cd09580     1 PSTWGVKDVSQFLRENDCGAYCECFCRQNIDGKRLLSL---TKEQIMTLtgmKVGPSLKIYDLIQQLK 65
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 391-459 7.42e-11

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 59.24  E-value: 7.42e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKV-KGQHMWIRLEGLKQAMPE--IIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20099     2 KVGMKLEAVDPLNLSSICVATVRKVlRFGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPP 73
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
 52-139 7.58e-11

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 59.62  E-value: 7.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVCVRTESESVYwVATIITTCGQLLLLRYEGyqDDRRADFW--CDimTADLHPIGWSKQQGRMMKPPEGVREKHQD 129
Cdd:cd20091    13 GMKLEAQDPRNLTSTC-IATVVGIQGPRLRLRLDG--SDNKNDFWrlVD--SSDIHPVGWCEKNGGLLQPPLGFRMNPSS 87

                          90
                  ....*....|
gi 1207190182 130 WEALLEKALA 139
Cdd:cd20091    88 WPMFLQKTLN 97
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
 385-459 9.08e-11

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 58.52  E-value: 9.08e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190182 385 PSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20092     1 PEKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAF-DYWCRYDSRDIFPVGWCKKTGHPLQPP 74
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
 275-354 1.33e-10

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 57.97  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFlVLMDDMRdeaqkegGAHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20109     3 LNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVF-ITFDGWR-------GAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
 278-354 1.40e-10

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 58.14  E-value: 1.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFlVLMDDMRdeaqkegGAHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIH-ISFDGWR-------GAFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 274-370 1.40e-10

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 58.69  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 274 TPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEQfFLVLMDDMRDeaqkeggAHSFLCHRDSPGIFPTQWSLKNGVKLSP 353
Cdd:cd20134     2 PPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSR-FLVHFDNWDD-------TYDYWCDPSSPYIHPVGWCQKQGKPLTP 73

                          90
                  ....*....|....*...
gi 1207190182 354 PPGFQGQD-FDWADYLKQ 370
Cdd:cd20134    74 PQDYPDPDnFSWEKYLEE 91
MBT_SCML2_rpt1 cd20106
first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...
 52-138 2.05e-10

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439096  Cd Length: 98  Bit Score: 58.40  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGyqDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKHQDWE 131
Cdd:cd20106    13 GMKLEARDPRNATSV-CIATVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNASSWP 89


                  ....*..
gi 1207190182 132 ALLEKAL 138
Cdd:cd20106    90 MFLLRTL 96
SAM_Samd7,11 cd09579
SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a ...
 796-857 3.00e-10

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.


Pssm-ID: 188978  Cd Length: 68  Bit Score: 56.69  E-value: 3.00e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 796 LEWSVTDVVRFIRTTD-CAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIER 857
Cdd:cd09579     2 RKWTVDDVCSFIGSLPgCAEYAQVFREHSIDGETLPLLTEEHLLNTMGLKLGPALKIRSQVAK 64
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 390-459 3.33e-10

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 56.90  E-value: 3.33e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 390 IKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGlkqaMPEII---VHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20103     5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDG----WPDIYdfwVDDDSPDIHPPGWCSKTGHPLEPP 73
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 47-137 3.48e-10

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 57.51  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  47 TGLTPGMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE- 125
Cdd:cd20135     4 SGFRVGMKLEA-VDKKNPSFICVATITDMVDNRLLIHFDNW--DESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDp 80

                          90
                  ....*....|..
gi 1207190182 126 KHQDWEALLEKA 137
Cdd:cd20135    81 KHFSWEKYLEET 92
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 391-459 5.97e-10

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 56.14  E-value: 5.97e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHtDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20100     4 KVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDC-DSPDIYPVGWCELVGYPLQPP 71
MBT_dScm_rpt1 cd20107
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...
 47-138 1.52e-09

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439097  Cd Length: 99  Bit Score: 55.70  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  47 TGLTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGyqDDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREK 126
Cdd:cd20107     8 NEFKIGMKLEALDPRNVTST-CIATVVGVLGPRLRLRLDG--SDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMN 84

                          90
                  ....*....|..
gi 1207190182 127 HQDWEALLEKAL 138
Cdd:cd20107    85 ASSWPMFLLKTL 96
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 52-122 1.74e-09

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 55.39  E-value: 1.74e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182  52 GMKLEVCVRtESESVYWVATIITTCGQLLLLRYEGYQDDrrADFWCDIMTADLHPIGWSKQQGRMMKPPEG 122
Cdd:cd20136     8 GMKLEAVDR-KNPSLVCVATIADIVEDRLLVHFDNWDDS--YDYWCDVNSPYIQPVGWCQENGRTLVAPQG 75
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 48-120 2.57e-09

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 54.21  E-value: 2.57e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182  48 GLTPGMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20103     4 GFEVGMKLEA-VDKRNPRLIRVATVADVEDYRVKLHFDGWPDIY--DFWVDDDSPDIHPPGWCSKTGHPLEPP 73
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 275-354 3.38e-09

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 53.82  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVfNEQFFLVLMDDMRDEaqkeggaHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20103     2 PHGFEVGMKLEAVDKRNPRLIRVATVADV-EDYRVKLHFDGWPDI-------YDFWVDDDSPDIHPPGWCSKTGHPLEPP 73
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 46-135 3.53e-09

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 54.46  E-value: 3.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  46 ETGLTPGMKLEVCVRTeSESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPPEGVRE 125
Cdd:cd20134     3 PLGFQVGMKLEAVDRM-NPSLVCVASVTDVVDSRFLVHFDNWDDTY--DYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPD 79

                          90
                  ....*....|.
gi 1207190182 126 -KHQDWEALLE 135
Cdd:cd20134    80 pDNFSWEKYLE 90
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 163-225 3.62e-09

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 53.41  E-value: 3.62e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 163 SPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYagtDGLPENQSITWVFYLDPLLHLSGWAQ 225
Cdd:cd20088     2 KVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHF---DGWDPSRYDFWCDVDSPDIHPVGWCE 61
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 278-354 4.11e-09

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 53.79  E-value: 4.11e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQfFLVLMDDMRdeaqkegGAHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20108     6 FKTGMKLEAVDRKNPHFICPATIGEVRGSE-VLVTFDGWR-------GAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 38-120 5.78e-09

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 53.69  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  38 FKHVDQGLETGLTPGMKLEVCVRTESESVYwVATIITTCGQLLLLRYEGYQDDRrADFWCDIMTADLHPIGWSKQQGRMM 117
Cdd:cd20122     3 HNKVNESLRSRFRLGLNLECVDKNRISQVR-VATVTKIVGKRLHLRYEGSEPDD-DGFWCHEDSPLIHPVGWAQTVGHNL 80


                  ...
gi 1207190182 118 KPP 120
Cdd:cd20122    81 AAS 83
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 362-459 1.59e-08

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 53.84  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 362 FDWADYLKQCEAEAAPQQCFPPD--PSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGL--KQAMPEIIvh 437
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSytPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSdnKNDFWRLV-- 79

                          90       100
                  ....*....|....*....|..
gi 1207190182 438 tDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20105    80 -DSSEIQPIGNCEKNGGMLQPP 100
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
 385-459 2.68e-08

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 51.42  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 385 PSDQCIKESMMLEAV---NP--ICPenihvATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20109     1 PPLNNFKVGMKLEAIdkkNPylICP-----ATIGDVKGDEVFITFDGWRGAF-DYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 164-226 3.26e-08

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 51.38  E-value: 3.26e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 164 PGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYagtDGLPENQSITWVFYLDPLLHLSGWAQE 226
Cdd:cd20122    16 LGLNLECVDKNRISQVRVATVTKIVGKRLHLRY---EGSEPDDDGFWCHEDSPLIHPVGWAQT 75
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 797-859 4.19e-08

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 50.73  E-value: 4.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 797 EWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLnlpTVQECMDL---KLGPAIKLCHHIERVK 859
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQL---TEDDLLKLgvtLLGHRKKILYAIQRLK 64
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 51-114 5.88e-08

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 50.71  E-value: 5.88e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  51 PGMKLEV-----CVRTEsesvywVATIITTCGQLLLLRYEGyQDDRRADFWCDIMTADLHPIGWSKQQG 114
Cdd:cd20098    17 VGMRLEVvdkmcISRTR------VAVVEEVVGGRLRLQYVD-SEDDDDDFWCHMKSPLIHPVGWSQAVG 78
MBT_SFMBT2_rpt2 cd20114
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 65-141 9.08e-08

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439104  Cd Length: 98  Bit Score: 50.88  E-value: 9.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  65 SVYWVATIITTCGQLLLLRYEGYQDDRRaDFWCDIMTADLHPIGWSKQQGRMMKPPEGVR--EKHQDWEALLEKALAES 141
Cdd:cd20114    19 FQYWIVRVIENVGGRLRLRYVGLEDESH-DQWLFYLDTRLRPVGWCQENNLRMEPPTEICdlKSASEWKEALEKSLAEA 96
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 385-459 9.13e-08

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 50.14  E-value: 9.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 385 PSDQCIKESMMLEAV---NP--ICPenihvATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20110     1 PESNLFKVGMKLEAVdrkNPhlICP-----ATVGAVKDDQIFVTFDGWRGAF-DYWCRYDSRDIFPVGWCARSGHPLQPP 74
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 48-120 1.29e-07

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 49.54  E-value: 1.29e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182  48 GLTPGMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20138     8 GFQKNMKLEV-VDKRNPMLIRVATVADTDDHRVKVHFDGWNNCY--DYWIDADSPDIHPAGWCAKTGHPLQPP 77
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 389-459 1.41e-07

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 50.35  E-value: 1.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182 389 CIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQaMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20101     5 GFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSE-CYDFWVNADSPDIFPVGWCEKTGHKLQPP 74
MBT_L3MBTL2_rpt2 cd20124
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 52-122 1.75e-07

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439114  Cd Length: 84  Bit Score: 49.45  E-value: 1.75e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182  52 GMKLEVCVRTESeSVYWVATIITTCGQLLLLRYEGYQDDrrADFWCDIMTADLHPIGWSKQQGRMMKPPEG 122
Cdd:cd20124    17 GMRVEVVDKSQV-SRTRMAVVDTVIGGRLRLLYEDGDSD--DDFWCHMWSPLIHPVGWSRRVGHSIKMSDR 84
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 162-226 2.14e-07

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 49.17  E-value: 2.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190182 162 LSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDglpENQSITWVFYLDPLLHLSGWAQE 226
Cdd:cd20098    15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSE---DDDDDFWCHMKSPLIHPVGWSQA 76
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
 382-459 3.24e-07

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 49.22  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 382 PPDPSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGL--KQAMPEIIvhtDSMDIFPVSWCETNGyPLLHP 459
Cdd:cd20091     2 SPIPPVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSdnKNDFWRLV---DSSDIHPVGWCEKNG-GLLQP 77
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 394-460 3.62e-07

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 48.78  E-value: 3.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHPC 460
Cdd:cd20102     8 MKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSY-DYWCDPDSPYIHPVGWCEENGKTLQPPK 73
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 391-462 4.03e-07

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 49.02  E-value: 4.03e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP--CKP 462
Cdd:cd20133     7 KVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECY-DFWVNADSPDIHPVGWCEKTGHKLLPPkgYKD 79
MBT_MBTD1_rpt3 cd20126
third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 391-459 5.84e-07

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439116  Cd Length: 90  Bit Score: 48.25  E-value: 5.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKV-KGQHMWIRLEGLKQAMPE--IIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20126     2 KEGMKLEAIDPLNLSTICVATVRKVlANGYLMIGIDGSEAADGSdwFCYHATSPSIFPVGFCEINMIELTPP 73
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 48-120 6.40e-07

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 47.28  E-value: 6.40e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182  48 GLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDrrADFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20100     2 GFKVGMKLE-AVDLMEPRLICVATVTRVVGRLLRVHFDGWDDE--FDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 48-120 6.85e-07

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 47.28  E-value: 6.85e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182  48 GLTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20129     2 GFRVGMKLEAVDLMEPRLV-CVATVTRIIHRLLRIHFDGWEDEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 71
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 802-857 7.77e-07

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 46.85  E-value: 7.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 802 DVVRFIRTTDCAPLARIFMDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIER 857
Cdd:cd09487     1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 385-459 7.95e-07

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 47.24  E-value: 7.95e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190182 385 PSDQCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20108     1 PSQNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAF-DYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 394-459 8.05e-07

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 47.51  E-value: 8.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQaMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20137     9 MKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSH-GYDFWIDADHPDIHPAGWCSKTGHPLQPP 73
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 50-120 8.25e-07

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 47.23  E-value: 8.25e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182  50 TPGMKLEVCVRTESESVYwVATIITTCGQLLLLRYEGYQDDRRaDFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20096     2 ERGMKLEAVNPENPNQIC-VATITKVVGPLLWLHLDSEKKLSP-NIIVDVESTDIFPVGWCESNGYPLVTP 70
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 48-122 1.07e-06

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 47.17  E-value: 1.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190182  48 GLTPGMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEG 122
Cdd:cd20139     8 GFQVNMKLEA-VDKRNPILIRVATIVDKDDHRIKLHFDGW--DHNYDFWVDADSPDIHPVGWCDKTGHALQVPLG 79
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 276-354 1.08e-06

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 46.90  E-value: 1.08e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNeQFFLVLMDDMRDEaqkeggaHSFLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20100     1 HGFKVGMKLEAVDLMEPRLICVATVTRVVG-RLLRVHFDGWDDE-------FDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 391-459 1.17e-06

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 46.89  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIiVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20129     4 RVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQW-VDCESPDLYPVGWCQLTGYQLQPP 71
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 275-354 1.46e-06

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 46.84  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVfneqfflvlmDDMRDEAQKEGGAH--SFLCHRDSPGIFPTQWSLKNGVKLS 352
Cdd:cd20138     6 PHGFQKNMKLEVVDKRNPMLIRVATVADT----------DDHRVKVHFDGWNNcyDYWIDADSPDIHPAGWCAKTGHPLQ 75


                  ..
gi 1207190182 353 PP 354
Cdd:cd20138    76 PP 77
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
 278-371 2.03e-06

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 46.91  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVL--MDDMRDeaqkeggaHSFLChrDSPGIFPTQWSLKNGVKLSPPP 355
Cdd:cd20091    10 FKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLdgSDNKND--------FWRLV--DSSDIHPVGWCEKNGGLLQPPL 79

                          90
                  ....*....|....*.
gi 1207190182 356 GFQGQDFDWADYLKQC 371
Cdd:cd20091    80 GFRMNPSSWPMFLQKT 95
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 275-356 2.14e-06

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 45.97  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVfneqfflvlmDDMRDEAQKEGGAH--SFLCHRDSPGIFPTQWSLKNGVKLS 352
Cdd:cd20137     2 PHGFQVNMKLEAVDRRNPALIRVASVEDV----------EDHRIKIHFDGWSHgyDFWIDADHPDIHPAGWCSKTGHPLQ 71


                  ....
gi 1207190182 353 PPPG 356
Cdd:cd20137    72 PPLG 75
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 48-120 2.62e-06

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 45.75  E-value: 2.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182  48 GLTPGMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYqdDRRADFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20130     5 GFKVGMKLEAVDLMEPRLI-CVATVKRVVHRLLSIHFDGW--DSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 795-859 2.83e-06

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 45.36  E-value: 2.83e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  795 PLEWSVTDVVRFIRTTDCAPLARIFMDQEIDGQALLLLnlpTVQECMD----LKLGPAIKLCHHIERVK 859
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLL---TSEEDLKelgiTKLGHRKKILKAIQKLK 66
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 391-461 3.36e-06

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 46.45  E-value: 3.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPlLHPCK 461
Cdd:cd20132     7 KVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCY-DFWVNADSPDIHPVGWCEKTGHK-LHPPK 75
MBT_SFMBT_rpt1 cd20093
first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 388-459 3.58e-06

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439083  Cd Length: 94  Bit Score: 46.11  E-value: 3.58e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190182 388 QCIKESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAmpeiiVHTD------SMDIFPVSWCETNGYPLLHP 459
Cdd:cd20093     2 SGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDD-----RSADfwcdlsSGDVHPIGWCAQNGKPLQPP 74
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 388-459 4.48e-06

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 45.63  E-value: 4.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 388 QCIKESMMLEAVNPICPENIHVATVTKV-KGQHMWIRLEGLK---QAMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVfNEKFFLVEMDDLRpeeAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPP 76
MBT_MBTD1_rpt2 cd20123
second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 41-118 5.48e-06

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439113  Cd Length: 85  Bit Score: 45.33  E-value: 5.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190182  41 VDQGLETGLTPGMKLEVCVRTESESVYwVATIITTCGQLLLLRYEgYQDDRRADFWCDIMTADLHPIGWSKQQGRMMK 118
Cdd:cd20123     6 VSESMQYPFKPCMRVEVVDKTHLCRTR-VAVVESVIGGRLRLVYE-ESEDGTDDFWCHMYSPLIHHIGWSRSIGHRFK 81
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 391-459 6.66e-06

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 44.92  E-value: 6.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20138    10 QKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCY-DYWIDADSPDIHPAGWCAKTGHPLQPP 77
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 391-459 8.56e-06

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 44.60  E-value: 8.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIiVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20130     7 KVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQW-VDCESPDIYPVGWCELTGYQLQPP 74
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 275-356 1.32e-05

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 44.09  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 275 PHCFTEGMKLEAVDPAAPFTISPATVAKVfneqfflvlmDDMRDEAQKEGGAHS--FLCHRDSPGIFPTQWSLKNGVKLS 352
Cdd:cd20139     6 PHGFQVNMKLEAVDKRNPILIRVATIVDK----------DDHRIKLHFDGWDHNydFWVDADSPDIHPVGWCDKTGHALQ 75


                  ....
gi 1207190182 353 PPPG 356
Cdd:cd20139    76 VPLG 79
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 394-453 1.41e-05

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 44.16  E-value: 1.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNG 453
Cdd:cd20098    19 MRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDDFWCHMKSPLIHPVGWSQAVG 78
MBT_dSfmbt_rpt4 cd20128
fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 48-109 3.94e-05

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439118  Cd Length: 72  Bit Score: 42.33  E-value: 3.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207190182  48 GLTPGMKLEvCVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGW 109
Cdd:cd20128     2 GFEVGMSLE-CADLMDPRLVCVATVARVVGRLLKVHFDGWTDEY--DQWLDCESADIYPVGW 60
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 394-459 5.34e-05

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 42.55  E-value: 5.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMpEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20139    13 MKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNY-DFWVDADSPDIHPVGWCDKTGHALQVP 77
MBT_L3MBTL2_rpt2 cd20124
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 165-234 5.72e-05

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439114  Cd Length: 84  Bit Score: 42.52  E-value: 5.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 165 GLNVELVDHQDAGVVWSAVIEENIGGRLRLRYagTDGlpENQSITWVFYLDPLLHLSGWAQEHNCTLRPP 234
Cdd:cd20124    17 GMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLY--EDG--DSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 53-120 6.69e-05

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 41.73  E-value: 6.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190182  53 MKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDDRraDFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20137     9 MKLEA-VDRRNPALIRVASVEDVEDHRIKIHFDGWSHGY--DFWIDADHPDIHPAGWCSKTGHPLQPP 73
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 278-344 7.68e-05

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 42.14  E-value: 7.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190182 278 FTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDMRDEAqkeggahSFLCHRDSPGIFPTQWS 344
Cdd:cd20122    14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDD-------GFWCHEDSPLIHPVGWA 73
MBT_SFMBT_rpt1 cd20093
first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 277-371 8.54e-05

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439083  Cd Length: 94  Bit Score: 42.26  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 277 CFTEGMKLEAVDPAAPFTISPATVAKVFnEQFFLVlmddmRDEAQKEGGAHSFLCHRDSPGIFPTQWSLKNGVKLSPPPG 356
Cdd:cd20093     3 GFKPGMKLEVPNKNNPDTYWVATVVMTC-GPLLRL-----RYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPAD 76

                          90
                  ....*....|....*
gi 1207190182 357 FQGQDFDWADYLKQC 371
Cdd:cd20093    77 IKEKELDWAEFLIKE 91
MBT_SFMBT1_rpt1 cd20111
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 162-234 9.75e-05

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439101  Cd Length: 94  Bit Score: 42.12  E-value: 9.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 162 LSPGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYagtDGLPENQSIT-WVFYLDPLLHLSGWAQEHNCTLRPP 234
Cdd:cd20111     4 FSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRY---DGYGEDRRADfWCDIMTADLHPIGWCEQNGKTLRPP 74
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 391-459 1.05e-04

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 42.15  E-value: 1.05e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKV-KGQHMWIRL---EGLKQAMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20125     2 KEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRIdsyEPDASGSDWFCYHESSPCIFPAGFCEVNNITLTPP 74
MBT_MBTD1_rpt1 cd20120
first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 390-459 1.46e-04

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439110  Cd Length: 103  Bit Score: 41.76  E-value: 1.46e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 390 IKESMMLEAVNPICPENIHV---ATVTKVKGQHMWIRLEGLKQ-AMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20120     4 IAEGVRVEVPNTDCNLPTKVfwiAGIVKLAGYKALLRYEGFENdSSLDFWCNICGSDIHPVGWCATSGKPLVPP 77
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
795-859 1.70e-04

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 40.33  E-value: 1.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 795 PLEWSVTDVVRFIRTTDCAPLARIFMDQEIDG-QALLLLNLPTVQECMDLKLGPAIKLCHHIERVK 859
Cdd:pfam07647   1 VESWSLESVADWLRSIGLEQYTDNFRDQGITGaELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66
MBT_L3MBTL2_rpt3 cd20127
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 391-459 1.87e-04

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439117  Cd Length: 91  Bit Score: 40.97  E-value: 1.87e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 391 KESMMLEAVNPICPENIHVATVTKV--KGQHMwIRLEGLKQA--MPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20127     2 EEGMKLEAIDPLNLGNICVATVCKVllDGYLM-IGIDGGPSTdgSDWFCYHASSHAIFPVGFCQKNDIELTPP 73
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 164-237 1.87e-04

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439102  Cd Length: 94  Bit Score: 41.12  E-value: 1.87e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190182 164 PGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYAGTDglPENQSITWVFYLDPLLHLSGWAQEHNCTLRPPAAL 237
Cdd:cd20112     6 PGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYG--DDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAI 77
MBT_MBTD1_rpt2 cd20123
second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 164-225 1.91e-04

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439113  Cd Length: 85  Bit Score: 41.10  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190182 164 PGLNVELVDHQDAGVVWSAVIEENIGGRLRLRYA----GTDGLpenqsitWVFYLDPLLHLSGWAQ 225
Cdd:cd20123    16 PCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEesedGTDDF-------WCHMYSPLIHHIGWSR 74
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 387-459 2.03e-04

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 41.52  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 387 DQCIKESMMLEAVNPICPENIH------VATVTKVKGQHMWIRLEGL-KQAMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20097     1 WEKVKIGVKVEVANRDDDKPTDnvkvywFARIIKVAGYRVLLRYEGYdEDSSHDFWINLCSNEIHPIGYAAENGKILVPP 80
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 52-120 2.58e-04

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 40.31  E-value: 2.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  52 GMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYQDdrRADFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20108     9 GMKLEAVDRKNPHFI-CPATIGEVRGSEVLVTFDGWRG--AFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 272-352 3.16e-04

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 40.31  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 272 AITPHCFTEGMKLEAVDPAAPFTISPATVAKVFNEQFFLVLMDDmrdeaqkEGGAHSFLCHRDSPGIFPTQWSLKNGVKL 351
Cdd:cd20098     9 SLKSTPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDS-------EDDDDDFWCHMKSPLIHPVGWSQAVGHKI 81


                  .
gi 1207190182 352 S 352
Cdd:cd20098    82 R 82
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
 52-120 3.23e-04

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 40.03  E-value: 3.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYqddRRA-DFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20092     9 GMKLEA-VDRKNPQLICPATVGDVDGDEIHISFDGW---RGAfDYWCRYDSRDIFPVGWCKKTGHPLQPP 74
MBT_dSfmbt_rpt1 cd20119
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 394-459 9.33e-04

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439109  Cd Length: 104  Bit Score: 39.35  E-value: 9.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207190182 394 MMLEAVNPIC-----PENIHVATVTKVKGQHMWIRLEGLKQ-AMPEIIVHTDSMDIFPVSWCETNGYPLLHP 459
Cdd:cd20119     8 MKVEVENTDTdliedPTSFWIATVLKIAGYKALMRYEGFGTdDSKDFWVNLCSEDVHPVGWCATRGKPLIPP 79
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 51-136 1.13e-03

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 38.82  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  51 PGMKLEVcVRTESESVYWVATIITTCGQ-LLLLRYEGYQ-DDRRADFWCDIMTADLHPIGWSKQQGRMMKPPEGVREKHQ 128
Cdd:cd20099     3 VGMKLEA-VDPLNLSSICVATVRKVLRFgYLVIGIDGPSaDDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKPF 81


                  ....*...
gi 1207190182 129 DWEALLEK 136
Cdd:cd20099    82 DWEEYLEE 89
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 276-354 1.16e-03

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 38.42  E-value: 1.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFNeQFFLVLMDDMRDEAQKeggahsfLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20129     1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIH-RLLRIHFDGWEDEYDQ-------WVDCESPDLYPVGWCQLTGYQLQPP 71
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 271-381 1.41e-03

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 39.59  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182 271 SAITPHCFTE-----------GMKLEAVDPAAPFTISPATVAKVFNEQFFLVLmdDMRDEAqkeggaHSFLCHRDSPGIF 339
Cdd:cd20105    14 VPAPVHCFKQsytppvnefkiGMKLEAQDPRNTTSTCIATVVGLTGARLRLRL--DGSDNK------NDFWRLVDSSEIQ 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207190182 340 PTQWSLKNGVKLSPPPGFQGQDFDWADYLKQC--EAEAAPQQCF 381
Cdd:cd20105    86 PIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTlnGAEMAPVRIF 129
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
 52-120 2.89e-03

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 37.17  E-value: 2.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182  52 GMKLEVcVRTESESVYWVATIITTCGQLLLLRYEGYQDdrRADFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20109     9 GMKLEA-IDKKNPYLICPATIGDVKGDEVFITFDGWRG--AFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 394-456 3.54e-03

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 37.13  E-value: 3.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190182 394 MMLEAVNPICPENIHVATVTKVKGQHMWIRLEGLKQAMPEIIVHTDSMDIFPVSWCETNGYPL 456
Cdd:cd20122    18 LNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNL 80
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 276-354 6.26e-03

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 36.51  E-value: 6.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190182 276 HCFTEGMKLEAVDPAAPFTISPATVAKVFnEQFFLVLMDDMRDEAQKeggahsfLCHRDSPGIFPTQWSLKNGVKLSPP 354
Cdd:cd20130     4 HGFKVGMKLEAVDLMEPRLICVATVKRVV-HRLLSIHFDGWDSEYDQ-------WVDCESPDIYPVGWCELTGYQLQPP 74
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 52-120 7.63e-03

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 35.89  E-value: 7.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190182  52 GMKLEVCVRTESESVyWVATIITTCGQLLLLRYEGYqddRRA-DFWCDIMTADLHPIGWSKQQGRMMKPP 120
Cdd:cd20110     9 GMKLEAVDRKNPHLI-CPATVGAVKDDQIFVTFDGW---RGAfDYWCRYDSRDIFPVGWCARSGHPLQPP 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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