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Conserved domains on  [gi|528472087|ref|XP_005168479|]
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WD repeat-containing protein 48 isoform X1 [Danio rerio]

Protein Classification

WD repeat WDR48 family protein( domain architecture ID 10078073)

WD repeat WDR48 family protein similar to WD repeat-containing protein 48, a regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-299 3.09e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 3.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSG 269
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 528472087 270 GRDRKIYCTDLRNPDMRVLICEEKAPVLRM 299
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 508-672 2.49e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


:

Pssm-ID: 463358  Cd Length: 171  Bit Score: 191.74  E-value: 2.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  508 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 579
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  580 ------KKDRLSASDMLQVRKVMEHVYEKIINLDTESQATSSSANDKPGEQEKeedvsvmAEEKIELMCLDQVLDPNMDL 653
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 528472087  654 RTVKHFIWKSGGDLTIHYR 672
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-299 3.09e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 3.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSG 269
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 528472087 270 GRDRKIYCTDLRNPDMRVLICEEKAPVLRM 299
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 508-672 2.49e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 191.74  E-value: 2.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  508 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 579
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  580 ------KKDRLSASDMLQVRKVMEHVYEKIINLDTESQATSSSANDKPGEQEKeedvsvmAEEKIELMCLDQVLDPNMDL 653
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 528472087  654 RTVKHFIWKSGGDLTIHYR 672
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 COG2319
WD40 repeat [General function prediction only];
30-275 3.05e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 3.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAFT----H 265
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrT 386

                        250
                 ....*....|
gi 528472087 266 IYSGGRDRKI 275
Cdd:COG2319  387 LASGSADGTV 396
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 560-672 6.90e-47

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 160.53  E-value: 6.90e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 560 KFNKIPFYLQPHSSSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDTESQAtsssandkpgeqekeedvSVMAEEK 637
Cdd:cd17041    1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 528472087 638 IELMCLDQVLDPNMDLRTVKHFIWKSGGDLTIHYR 672
Cdd:cd17041   63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 112-285 2.70e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 112 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-TGTVIISGSTEKV 190
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 191 LRVWDPRTCAKLMKLKGHTDNVKSL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NEAFTHIYS 268
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 528472087 269 GGRDRKIYCTDLRNPDM 285
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 198-237 3.26e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528472087   198 TCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 237
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
202-237 8.89e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.89e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528472087  202 LMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 237
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-299 3.09e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 3.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSG 269
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 528472087 270 GRDRKIYCTDLRNPDMRVLICEEKAPVLRM 299
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 508-672 2.49e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 191.74  E-value: 2.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  508 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 579
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  580 ------KKDRLSASDMLQVRKVMEHVYEKIINLDTESQATSSSANDKPGEQEKeedvsvmAEEKIELMCLDQVLDPNMDL 653
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 528472087  654 RTVKHFIWKSGGDLTIHYR 672
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 COG2319
WD40 repeat [General function prediction only];
30-275 3.05e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 3.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAFT----H 265
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrT 386

                        250
                 ....*....|
gi 528472087 266 IYSGGRDRKI 275
Cdd:COG2319  387 LASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
30-275 2.67e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKDPyiASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 109
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 110 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 189
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKLLASGSADG 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 190 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAFT----H 265
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV----AFSpdgkL 302

                        250
                 ....*....|
gi 528472087 266 IYSGGRDRKI 275
Cdd:COG2319  303 LASGSDDGTV 312
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 560-672 6.90e-47

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 160.53  E-value: 6.90e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 560 KFNKIPFYLQPHSSSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDTESQAtsssandkpgeqekeedvSVMAEEK 637
Cdd:cd17041    1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 528472087 638 IELMCLDQVLDPNMDLRTVKHFIWKSGGDLTIHYR 672
Cdd:cd17041   63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
WD40 COG2319
WD40 repeat [General function prediction only];
31-238 9.53e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 9.53e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMS 110
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 111 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKV 190
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 528472087 191 LRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSL 238
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
33-299 8.18e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 8.18e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKDpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTL 112
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGAL--LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 113 RTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKVLR 192
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 193 VWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAF----THIYS 268
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV----AFspdgRLLAS 263

                        250       260       270
                 ....*....|....*....|....*....|.
gi 528472087 269 GGRDRKIYCTDLRNPDMRVLICEEKAPVLRM 299
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-237 3.58e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.42  E-value: 3.58e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMS 110
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 111 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKV 190
Cdd:cd00200  172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---------TLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528472087 191 LRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 237
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-275 3.91e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  37 QLDPALNRLFTAGRDSIIRIWSVNQhkDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHK 116
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAAL--GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 117 DYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttssLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWDP 196
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 197 RTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAF----THIYSGGRD 272
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV----AFspdgKLLASGSAD 225


                 ...
gi 528472087 273 RKI 275
Cdd:COG2319  226 GTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
31-198 9.26e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 9.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMS 110
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 111 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKV 190
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR---------TLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 528472087 191 LRVWDPRT 198
Cdd:COG2319  396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-281 7.20e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 7.20e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 108 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT------------------------ASNNTV----- 158
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgSSDKTIrlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 159 ----TTSSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIR 234
Cdd:cd00200   81 etgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528472087 235 LWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSGGRDRKIYCTDLR 281
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
29-103 2.34e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 2.34e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528472087  29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKDpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNA 103
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL--LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 112-285 2.70e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 112 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-TGTVIISGSTEKV 190
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 191 LRVWDPRTCAKLMKLKGHTDNVKSL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NEAFTHIYS 268
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 528472087 269 GGRDRKIYCTDLRNPDM 285
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-285 1.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 205 LKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSGGRDRKIYCTDLRNPD 284
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84


                 .
gi 528472087 285 M 285
Cdd:cd00200   85 C 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 198-237 3.26e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528472087   198 TCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 237
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
202-237 8.89e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.89e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528472087  202 LMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 237
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 67-102 2.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 528472087    67 IASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWN 102
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
67-102 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528472087   67 IASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWN 102
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-144 1.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528472087   105 KGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 144
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 44-201 1.70e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  44 RLFTAGRDSIIRIWSV-----NQHKDPYIASMEHHTDWVNDIILCCNGK-TLISASSDTTVKVWNAHKGFCMSTLRTHKD 117
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIpeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 118 YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSlsgnKDSIYSLAMNQTGTVIISGSTEKVLRVWDPR 197
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS----QRCLWAKRKDLIITLGCSKSQQRQIMLWDTR 245


                 ....
gi 528472087 198 TCAK 201
Cdd:PTZ00421 246 KMAS 249
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-216 1.91e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  10 AGRRKVQV----SYvIRDEVEKYNRNGVnaLQL-DPALNRLFTAGRDSIIRIWSVN-QHKDPYIasmehhtdwvndiilc 83
Cdd:PLN00181 530 ASRSKLSGicwnSY-IKSQVASSNFEGV--VQVwDVARSQLVTEMKEHEKRVWSIDySSADPTL---------------- 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  84 cngktLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNtltaltasNNTVTTSSL 163
Cdd:PLN00181 591 -----LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR--------NPKLPLCTM 657

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528472087 164 SGNKDSIYSLAMNQTGTvIISGSTEKVLRVWDPRTCAK------LMKLKGHTdNVKSLL 216
Cdd:PLN00181 658 IGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISginetpLHSFMGHT-NVKNFV 714
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-238 4.81e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 4.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  82 LCCNG--KTLISASS-DTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQIFLWDVNTLTALTASNNT 157
Cdd:PLN00181 538 ICWNSyiKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 158 VTTSSLSGNKDSIYSLAMnqtgtviisGSTEKVLRVWDPRTCA-KLMKLKGHTDNVkSLLLNRDGTQCLSGSSDGTIRLW 236
Cdd:PLN00181 618 ANICCVQFPSESGRSLAF---------GSADHKVYYYDLRNPKlPLCTMIGHSKTV-SYVRFVDSSTLVSSSTDNTLKLW 687


                 ..
gi 528472087 237 SL 238
Cdd:PLN00181 688 DL 689
WD40 pfam00400
WD domain, G-beta repeat;
106-144 4.83e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528472087  106 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 144
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 41-150 2.48e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087  41 ALNRLFTAGRDSIIRIWSVNQHKdpYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD-YV 119
Cdd:PTZ00421 137 AMNVLASAGADMVVNVWDVERGK--AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaKS 214

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 528472087 120 KALAYAKDKELVASAGLD----RQIFLWDVNTLTA 150
Cdd:PTZ00421 215 QRCLWAKRKDLIITLGCSksqqRQIMLWDTRKMAS 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-195 4.18e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 528472087   161 SSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWD 195
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
160-195 7.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528472087  160 TSSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWD 195
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 133-305 2.37e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 133 SAGLDRQIFLWDVNT--LTALTASNntvtTSSLSGNKD-----SIYSLAMNqtgtVIISGSTEKVLRVWDPRTCAKLMKL 205
Cdd:PTZ00421  93 TASEDGTIMGWGIPEegLTQNISDP----IVHLQGHTKkvgivSFHPSAMN----VLASAGADMVVNVWDVERGKAVEVI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528472087 206 KGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEG-----VWALQVNEAFTHIYSGGRDRKIYCTDL 280
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrcLWAKRKDLIITLGCSKSQQRQIMLWDT 244

                        170       180
                 ....*....|....*....|....*
gi 528472087 281 RnpDMrvliceeKAPVLRMELDRSA 305
Cdd:PTZ00421 245 R--KM-------ASPYSTVDLDQSS 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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