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Conserved domains on  [gi|528944708|ref|XP_005204750|]
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metal regulatory transcription factor 1 isoform X2 [Bos taurus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 3.07e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528944708 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 428-674 1.44e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  428 PPQPLLPASAPSAPLPAPSLGTGSQQA--AFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAPQ--------PIVPGL 497
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAArqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPapappaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  498 SVVAGALASAAAVASAMAAPPQPQSTTEPLPAMVQTLPLDANSVLTSNPTITITPTPSA---AILQPSLVMGeqnlQWLL 574
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPpppGPPPPSLPLG----GSVA 2857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  575 NGAtstPQAQEQIQASKVEKVFFTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAasrrkgcPSPP 654
Cdd:PHA03247 2858 PGG---DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP-------PPPP 2927

                         250       260
                  ....*....|....*....|
gi 528944708  655 PPTLSAQPPDGPSLKLPPQT 674
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTT 2947
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-362 3.77e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 225 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 304
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528944708 305 SLKSHMKGHDNKGNSYSALLNHNGSEDTNHSlclRNLSLLSTDSEFQENSNTGQNLST 362
Cdd:COG5048  104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSRD---PQLPDLLSISNLRNNPLPGNNSSS 158
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 3.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528944708 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
PHA03247 PHA03247
large tegument protein UL36; Provisional
 428-674 1.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  428 PPQPLLPASAPSAPLPAPSLGTGSQQA--AFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAPQ--------PIVPGL 497
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAArqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPapappaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  498 SVVAGALASAAAVASAMAAPPQPQSTTEPLPAMVQTLPLDANSVLTSNPTITITPTPSA---AILQPSLVMGeqnlQWLL 574
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPpppGPPPPSLPLG----GSVA 2857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  575 NGAtstPQAQEQIQASKVEKVFFTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAasrrkgcPSPP 654
Cdd:PHA03247 2858 PGG---DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP-------PPPP 2927

                         250       260
                  ....*....|....*....|
gi 528944708  655 PPTLSAQPPDGPSLKLPPQT 674
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTT 2947
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 4.78e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.78e-06
                          10        20
                  ....*....|....*....|....*..
gi 528944708  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-362 3.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 225 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 304
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528944708 305 SLKSHMKGHDNKGNSYSALLNHNGSEDTNHSlclRNLSLLSTDSEFQENSNTGQNLST 362
Cdd:COG5048  104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSRD---PQLPDLLSISNLRNNPLPGNNSSS 158
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 344-533 1.48e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  344 LSTDSEFQENSNTG--------QNLSTLSPAIIFGPMFQ-KSDDPAIQEDPQQTAALIESFNGDAESVSDVPPSTRHSAS 414
Cdd:pfam03154 378 LSGPSPFQMNSNLPpppalkplSSLSTHHPPSAHPPPLQlMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVP 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  415 LSLPLILQPGISEPPQPLLPASAPsaPLPAPSLGTGSQqaafgnppallQPPEVPVAHSTQFAANHQEFLPHLQAPQpiv 494
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPITPPSGP--PTSTSSAMPGIQ-----------PPSSASVSSSGPVPAAVSCPLPPVQIKE--- 521

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 528944708  495 pglsvvagalaSAAAVASAMAAPPQPQSTTEPLPAMVQT 533
Cdd:pfam03154 522 -----------EALDEAEEPESPPPPPRSPSPEPTVVNT 549
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 289-313 8.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.64e-03
                          10        20
                  ....*....|....*....|....*
gi 528944708  289 FFCPsnGCEKTFSTQYSLKSHMKGH 313
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 3.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528944708 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
PHA03247 PHA03247
large tegument protein UL36; Provisional
 428-674 1.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  428 PPQPLLPASAPSAPLPAPSLGTGSQQA--AFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAPQ--------PIVPGL 497
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAArqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPapappaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  498 SVVAGALASAAAVASAMAAPPQPQSTTEPLPAMVQTLPLDANSVLTSNPTITITPTPSA---AILQPSLVMGeqnlQWLL 574
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPpppGPPPPSLPLG----GSVA 2857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  575 NGAtstPQAQEQIQASKVEKVFFTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAasrrkgcPSPP 654
Cdd:PHA03247 2858 PGG---DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP-------PPPP 2927

                         250       260
                  ....*....|....*....|
gi 528944708  655 PPTLSAQPPDGPSLKLPPQT 674
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTT 2947
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-316 1.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 172 CNQEGCGKAFLTSYSLRIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCE-SEGCSKYFTTLSDL 246
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkLLNSSSKFSPLLNN 369

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528944708 247 RKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNK 316
Cdd:COG5048  370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
PHA03247 PHA03247
large tegument protein UL36; Provisional
 404-674 1.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  404 DVPP-STRHSA----SLSLPLILQPGiSEPPQPLLPASAPSAPLPAPSLGTGSQQAAFGNPPALLQPPEVPVAHSTQFAA 478
Cdd:PHA03247 2590 DAPPqSARPRApvddRGDPRGPAPPS-PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR 2668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  479 NHQeflphlQAPQPIVPGLSVVAGALASAAAVASAMAAPPQPQSTTEPLPAMVQT---LPLDANSVLTSNPTITITPTPS 555
Cdd:PHA03247 2669 RLG------RAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSatpLPPGPAAARQASPALPAAPAPP 2742

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  556 AAILQPSLVMGEQnlqwllngATSTPQAQEQIQASKVEKVffTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCAC 635
Cdd:PHA03247 2743 AVPAGPATPGGPA--------RPARPPTTAGPPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 528944708  636 RDSAKERAASRRKGcPSPPPPTLSAQPPDGPSLKLPPQT 674
Cdd:PHA03247 2813 APAAALPPAASPAG-PLPPPTSAQPTAPPPPPGPPPPSL 2850
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 4.78e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.78e-06
                          10        20
                  ....*....|....*....|....*..
gi 528944708  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-362 3.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 225 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 304
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528944708 305 SLKSHMKGHDNKGNSYSALLNHNGSEDTNHSlclRNLSLLSTDSEFQENSNTGQNLST 362
Cdd:COG5048  104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSRD---PQLPDLLSISNLRNNPLPGNNSSS 158
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-302 4.93e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.93e-05
                          10        20
                  ....*....|....*....|....*...
gi 528944708  275 HLKTHVRTHTGERPFFCPSngCEKTFST 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-213 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*...
gi 528944708  186 SLRIHVRVHTKEKPFECDVqgCEKAFNT 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-284 1.66e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 197 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfnceseGCSKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 276
Cdd:COG5189  347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                 ....*...
gi 528944708 277 KTHvRTHT 284
Cdd:COG5189  415 KYH-RKHS 421
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 231-310 1.78e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 41.25  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  231 CESEGCSKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNgCEKTFSTQY 304
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN-CLLRFRTHR 80


                  ....*.
gi 528944708  305 SLKSHM 310
Cdd:pfam15909  81 SLFKHL 86
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 429-561 3.59e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  429 PQPLLPASAPSAPLPAPSLGTGSQQAAFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAPQPIVPGLSVVAGALASAA 508
Cdd:PRK10263  731 PMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQP 810

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528944708  509 AVASAMAAPP-----------QPQSTTEPLPAMVQTLPL---DANSVLTSNPTitiTPTPSAAILQP 561
Cdd:PRK10263  811 VAPQPQYQQPqqpvapqpqyqQPQQPVAPQPQDTLLHPLlmrNGDSRPLHKPT---TPLPSLDLLTP 874
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-447 1.00e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 264 DGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGNSYSALLNHNGSEDTNHSLclrNLSL 343
Cdd:COG5048   37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS---LSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708 344 LSTDSEFQENSNTGQNLSTLSPAIIFG---PMFQKSDDPAIQEDPQQTAAlIESFNGDAES-VSDVPPSTRHSASLSLPL 419
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLlsiSNLRNNPLPGNNSSSVNTPQ-SNSLHPPLPAnSLSKDPSSNLSLLISSNV 192

                        170       180
                 ....*....|....*....|....*...
gi 528944708 420 ILQPGISEPPQPLLPASAPSAPLPAPSL 447
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNL 220
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-340 1.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528944708 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKgnsysaLLNHNGSEDTNHSLCLRN 340
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQ------KLHENPSPEKMNIFSAKD 396
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 344-533 1.48e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  344 LSTDSEFQENSNTG--------QNLSTLSPAIIFGPMFQ-KSDDPAIQEDPQQTAALIESFNGDAESVSDVPPSTRHSAS 414
Cdd:pfam03154 378 LSGPSPFQMNSNLPpppalkplSSLSTHHPPSAHPPPLQlMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVP 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  415 LSLPLILQPGISEPPQPLLPASAPsaPLPAPSLGTGSQqaafgnppallQPPEVPVAHSTQFAANHQEFLPHLQAPQpiv 494
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPITPPSGP--PTSTSSAMPGIQ-----------PPSSASVSSSGPVPAAVSCPLPPVQIKE--- 521

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 528944708  495 pglsvvagalaSAAAVASAMAAPPQPQSTTEPLPAMVQT 533
Cdd:pfam03154 522 -----------EALDEAEEPESPPPPPRSPSPEPTVVNT 549
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 376-562 1.71e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  376 SDDPAIQEDPQQTAALIESFNgDAESVSDvpPSTRHSASLSLPLILQPGISEPPQPLLPASAPSA---PLPAPSLGTGSQ 452
Cdd:pfam03154 132 SDPKDIDQDNRSTSPSIPSPQ-DNESDSD--SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQaatAGPTPSAPSVPP 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  453 QA--AFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAP-QPIVPGLSVVAGALASAAAVASAMAAPPQPQSTTEPLPA 529
Cdd:pfam03154 209 QGspATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288

                         170       180       190
                  ....*....|....*....|....*....|...
gi 528944708  530 MVQTLPLDANSVLTSNPTITITPTPSAAILQPS 562
Cdd:pfam03154 289 MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS 321
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 172-250 3.86e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.40  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944708  172 CNQEGCGKAFLTSYSLRIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSD 245
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRS 81


                  ....*
gi 528944708  246 LRKHI 250
Cdd:pfam15909  82 LFKHL 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 259-283 4.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*
gi 528944708  259 FRCDHdgCGKAFAASHHLKTHVRTH 283
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 229-253 8.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.15e-03
                          10        20
                  ....*....|....*....|....*
gi 528944708  229 FNCEseGCSKYFTTLSDLRKHIRTH 253
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 289-313 8.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.64e-03
                          10        20
                  ....*....|....*....|....*
gi 528944708  289 FFCPsnGCEKTFSTQYSLKSHMKGH 313
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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