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Conserved domains on  [gi|528971425|ref|XP_005213845|]
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zinc finger MYM-type protein 5 isoform X1 [Bos taurus]

Protein Classification

zinc finger and BTB domain-containing protein( domain architecture ID 12219290)

zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Drosophila melanogaster fruitless (fru), which plays a key role in the formation of neural circuits underlying Drosophila male courtship behavior

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
563-638 1.61e-08

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 52.49  E-value: 1.61e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528971425   563 YYTRILANGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCRDWQHLSHILSKHEESEMHINNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 376-416 1.10e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.52  E-value: 1.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528971425  376 LVMNCCEQCGEYLPGKGAGNnVLVIEGQQMRFCCQSCVNEY 416
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-370 2.24e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 2.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528971425  334 LNKSRCTICNKLTEIRHE---VSVNNVTHKLCSNQCFNKY 370
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
245-281 6.19e-05

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.44  E-value: 6.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528971425   245 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 281
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
563-638 1.61e-08

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 52.49  E-value: 1.61e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528971425   563 YYTRILANGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCRDWQHLSHILSKHEESEMHINNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 376-416 1.10e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.52  E-value: 1.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528971425  376 LVMNCCEQCGEYLPGKGAGNnVLVIEGQQMRFCCQSCVNEY 416
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-370 2.24e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 2.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528971425  334 LNKSRCTICNKLTEIRHE---VSVNNVTHKLCSNQCFNKY 370
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
245-281 6.19e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.44  E-value: 6.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528971425   245 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 281
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
381-419 1.31e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.67  E-value: 1.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528971425   381 CEQCGEYLPGKGAGNNVlVIEGQQMRFCCQSCVNEYKQM 419
Cdd:smart00746   1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 242-277 1.40e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 1.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528971425  242 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 277
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
563-638 1.61e-08

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 52.49  E-value: 1.61e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528971425   563 YYTRILANGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCRDWQHLSHILSKHEESEMHINNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 376-416 1.10e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.52  E-value: 1.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528971425  376 LVMNCCEQCGEYLPGKGAGNnVLVIEGQQMRFCCQSCVNEY 416
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-370 2.24e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 2.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 528971425  334 LNKSRCTICNKLTEIRHE---VSVNNVTHKLCSNQCFNKY 370
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
245-281 6.19e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.44  E-value: 6.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528971425   245 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 281
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
381-419 1.31e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.67  E-value: 1.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528971425   381 CEQCGEYLPGKGAGNNVlVIEGQQMRFCCQSCVNEYKQM 419
Cdd:smart00746   1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 242-277 1.40e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 1.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528971425  242 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 277
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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