NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|529002528|ref|XP_005223276|]
View 

protein CutA isoform X2 [Bos taurus]

Protein Classification

divalent-cation tolerance protein CutA( domain architecture ID 10503769)

divalent-cation tolerance protein CutA is a cytoplasmic protein implicated in regulating intracellular metal homeostasis

CATH:  3.30.70.120
Gene Symbol:  cutA
Gene Ontology:  GO:0010038
SCOP:  4002632

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 47-141 1.60e-54

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


:

Pssm-ID: 460800  Cd Length: 98  Bit Score: 166.86  E-value: 1.60e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528   47 FVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 529002528  127 PVEQGNSPYLQWVRQ 141
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 47-141 1.60e-54

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 166.86  E-value: 1.60e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528   47 FVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 529002528  127 PVEQGNSPYLQWVRQ 141
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
47-143 6.75e-53

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 162.66  E-value: 6.75e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  47 FVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:COG1324    7 LTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVPEIIAL 86

                         90
                 ....*....|....*..
gi 529002528 127 PVEQGNSPYLQWVRQVT 143
Cdd:COG1324   87 PIEAGNPAYLDWIREET 103
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
47-143 2.04e-41

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 133.54  E-value: 2.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  47 FVTCPNEKVAKEIARAVVEKRLAACVNLVpQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:NF041095   5 YTTFPDEESAKEIARKLLEERLIACVNLR-EIRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAILVI 83

                         90
                 ....*....|....*..
gi 529002528 127 PVEQGNSPYLQWVRQVT 143
Cdd:NF041095  84 EVEDVNKEYLSWLDEST 100
PRK10645 PRK10645
divalent cation tolerance protein CutA;
49-139 1.03e-27

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 99.08  E-value: 1.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  49 TCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPV 128
Cdd:PRK10645  17 TAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELLVLPV 96

                         90
                 ....*....|.
gi 529002528 129 EQGNSPYLQWV 139
Cdd:PRK10645  97 THGDTDYLSWL 107
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 47-141 1.60e-54

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 166.86  E-value: 1.60e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528   47 FVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 529002528  127 PVEQGNSPYLQWVRQ 141
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
47-143 6.75e-53

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 162.66  E-value: 6.75e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  47 FVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:COG1324    7 LTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVPEIIAL 86

                         90
                 ....*....|....*..
gi 529002528 127 PVEQGNSPYLQWVRQVT 143
Cdd:COG1324   87 PIEAGNPAYLDWIREET 103
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
47-143 2.04e-41

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 133.54  E-value: 2.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  47 FVTCPNEKVAKEIARAVVEKRLAACVNLVpQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 126
Cdd:NF041095   5 YTTFPDEESAKEIARKLLEERLIACVNLR-EIRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAILVI 83

                         90
                 ....*....|....*..
gi 529002528 127 PVEQGNSPYLQWVRQVT 143
Cdd:NF041095  84 EVEDVNKEYLSWLDEST 100
PRK10645 PRK10645
divalent cation tolerance protein CutA;
49-139 1.03e-27

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 99.08  E-value: 1.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529002528  49 TCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPV 128
Cdd:PRK10645  17 TAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELLVLPV 96

                         90
                 ....*....|.
gi 529002528 129 EQGNSPYLQWV 139
Cdd:PRK10645  97 THGDTDYLSWL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH