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Conserved domains on  [gi|1387247112|ref|XP_005226197|]
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phospholipid phosphatase 5 isoform X5 [Bos taurus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 42-202 7.14e-33

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03390:

Pssm-ID: 469784 [Multi-domain]  Cd Length: 193  Bit Score: 116.94  E-value: 7.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  42 WLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRC 121
Cdd:cd03390     1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112 122 FPDGQAHGDLM------CTGDKAVVNEGRKSFPSGHASYVFpsssricrSGLRILlpggevTL-----LHTKRPREILEI 190
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAF--------AGLGFL------SLylagkLHIFDPRGSSWR 146

                         170
                  ....*....|..
gi 1387247112 191 LFLSVTPTLCSC 202
Cdd:cd03390   147 LLLALLPLLLAI 158
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 42-202 7.14e-33

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 116.94  E-value: 7.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  42 WLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRC 121
Cdd:cd03390     1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112 122 FPDGQAHGDLM------CTGDKAVVNEGRKSFPSGHASYVFpsssricrSGLRILlpggevTL-----LHTKRPREILEI 190
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAF--------AGLGFL------SLylagkLHIFDPRGSSWR 146

                         170
                  ....*....|..
gi 1387247112 191 LFLSVTPTLCSC 202
Cdd:cd03390   147 LLLALLPLLLAI 158
PLN02250 PLN02250
lipid phosphate phosphatase
 17-156 3.34e-24

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 97.30  E-value: 3.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  17 LALFAVFLVTELLPPFQRLIQPEEMWLYRNPyVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAaDAADSRQACLAASLAL 96
Cdd:PLN02250   30 LLLVVIEVVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSV 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387247112  97 ALNGIFTNTIKLIVGRPRPDFFYRCFPDGQA-----HGDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:PLN02250  108 LITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172
acidPPc smart00014
Acid phosphatase homologues;
99-156 1.39e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.19  E-value: 1.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387247112   99 NGIFTNTIKLIVGRPRPDFFYRCfpdgqahgDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:smart00014   7 SQLFNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAF 56
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 100-156 1.37e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 42.79  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387247112 100 GIFTNTIKLIVGRPRPDFFYRCFPDgqahgdlmcTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGL---------VPAPSTLPGLGYSFPSGHSATAF 57
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 17-156 1.74e-03

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 38.10  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  17 LALFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLAL 96
Cdd:COG0671     3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  97 ALNGIFTNTIKLIVGRPRPdffyrcfpdgqahgDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:COG0671    83 LLLLLLLLLLKYLFGRPRP--------------FVVPDLELLLGTAGGYSFPSGHAAAAF 128
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 42-202 7.14e-33

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 116.94  E-value: 7.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  42 WLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRC 121
Cdd:cd03390     1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112 122 FPDGQAHGDLM------CTGDKAVVNEGRKSFPSGHASYVFpsssricrSGLRILlpggevTL-----LHTKRPREILEI 190
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAF--------AGLGFL------SLylagkLHIFDPRGSSWR 146

                         170
                  ....*....|..
gi 1387247112 191 LFLSVTPTLCSC 202
Cdd:cd03390   147 LLLALLPLLLAI 158
PLN02250 PLN02250
lipid phosphate phosphatase
 17-156 3.34e-24

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 97.30  E-value: 3.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  17 LALFAVFLVTELLPPFQRLIQPEEMWLYRNPyVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAaDAADSRQACLAASLAL 96
Cdd:PLN02250   30 LLLVVIEVVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSV 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387247112  97 ALNGIFTNTIKLIVGRPRPDFFYRCFPDGQA-----HGDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:PLN02250  108 LITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 28-156 1.29e-20

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 87.78  E-value: 1.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  28 LLPPFQRLIQPEEMWLYRNPyVEAEYLPTKPMFVIAFLAPLApVLLARCLKAADAADSRQACLAASLALALNGIFTNTIK 107
Cdd:PLN02731   60 IIHPFYRFVGKDMMTDLSYP-LKSNTVPIWSVPVYAMLLPLV-IFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIK 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1387247112 108 LIVGRPRPDFFYRCFPDGQA----HGDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:PLN02731  138 NAVGRPRPDFFWRCFPDGKAlydsLGDVICHGDKSVIREGHKSFPSGHTSWSF 190
PLN02715 PLN02715
lipid phosphate phosphatase
 19-156 1.68e-20

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 87.42  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  19 LFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAeylpTKPMFVIAFLAPLAPVLLARC--LKAADAADSRQACLAASLAL 96
Cdd:PLN02715   57 LIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDN----TVPIWSVPVYAVLLPIILFVCfyLKRRCVYDLHHSILGLLFAV 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387247112  97 ALNGIFTNTIKLIVGRPRPDFFYRCFPDGQ----AHGDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:PLN02715  133 LITGVITDSIKVATGRPRPNFYWRCFPDGKelydALGGVICHGKAAEVKEGHKSFPSGHTSWSF 196
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 101-172 7.49e-14

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 66.11  E-value: 7.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112 101 IFTNTIKLIVGRPRPDFFYRCFPDG----------QAHGDLMCTGDKAVVNEGRKSFPSGHASYVFPSS--------SRI 162
Cdd:cd03384    18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAvflalylqARL 97

                          90
                  ....*....|
gi 1387247112 163 CRSGLRILLP 172
Cdd:cd03384    98 KLRGSRLLRP 107
acidPPc smart00014
Acid phosphatase homologues;
99-156 1.39e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.19  E-value: 1.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387247112   99 NGIFTNTIKLIVGRPRPDFFYRCfpdgqahgDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:smart00014   7 SQLFNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAF 56
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 99-156 4.46e-08

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 49.77  E-value: 4.46e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387247112  99 NGIFTNTIKLIVGRPRPDFFYRCFPDGQAHgdlmctgdkaVVNEGRKSFPSGHASYVF 156
Cdd:cd01610    15 GLLLTGVLKYLFGRPRPYFLLRCGPDGDPL----------LLTEGGYSFPSGHAAFAF 62
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 100-156 1.37e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 42.79  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387247112 100 GIFTNTIKLIVGRPRPDFFYRCFPDgqahgdlmcTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGL---------VPAPSTLPGLGYSFPSGHSATAF 57
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 100-156 1.47e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 38.07  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387247112 100 GIFTNTIKLIVGRPRPDFFYrcfpDGQAHGDLMCTGDKAVvnegrKSFPSGHASYVF 156
Cdd:cd03389    82 GILVNLLKFIIGRARPKLLF----DDGLYGFDPFHADYAF-----TSFPSGHSATAG 129
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 17-156 1.74e-03

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 38.10  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  17 LALFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLAL 96
Cdd:COG0671     3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387247112  97 ALNGIFTNTIKLIVGRPRPdffyrcfpdgqahgDLMCTGDKAVVNEGRKSFPSGHASYVF 156
Cdd:COG0671    83 LLLLLLLLLLKYLFGRPRP--------------FVVPDLELLLGTAGGYSFPSGHAAAAF 128
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 99-162 4.18e-03

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 35.77  E-value: 4.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387247112  99 NGIFTNTIKLIVGRPRPDffyrcfpdgqahgdlmctGDkavvNEGRKSFPSGHASYVFPSSSRI 162
Cdd:cd03394    15 TAAVTEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFL 56
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 100-156 6.91e-03

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 36.05  E-value: 6.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387247112 100 GIFTNTIKLIVGRPRPDFFYRCFPDGqahgdlmctgdkavvnegrKSFPSGHASYVF 156
Cdd:cd03392    75 GALNTLLKLLVQRPRPPLHLLVPEGG-------------------YSFPSGHAMGAT 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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