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Conserved domains on  [gi|530376569|ref|XP_005248113|]
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cytochrome c oxidase subunit 7B2, mitochondrial isoform X1 [Homo sapiens]

Protein Classification

Cyt_c_Oxidase_VIIb domain-containing protein( domain architecture ID 10526782)

Cyt_c_Oxidase_VIIb domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX7B pfam05392
Cytochrome C oxidase chain VIIB;
2-80 2.17e-53

Cytochrome C oxidase chain VIIB;


:

Pssm-ID: 461637  Cd Length: 78  Bit Score: 160.27  E-value: 2.17e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530376569   2 MFPLARNALSsLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWKH 80
Cdd:pfam05392  1 MFPLARAALN-LKARSIQQIAVRQSHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
 
Name Accession Description Interval E-value
COX7B pfam05392
Cytochrome C oxidase chain VIIB;
2-80 2.17e-53

Cytochrome C oxidase chain VIIB;


Pssm-ID: 461637  Cd Length: 78  Bit Score: 160.27  E-value: 2.17e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530376569   2 MFPLARNALSsLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWKH 80
Cdd:pfam05392  1 MFPLARAALN-LKARSIQQIAVRQSHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
Cyt_c_Oxidase_VIIb cd01403
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 30-79 1.48e-31

Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIb subunit is found only in eukaryotes and its specific function remains unclear. A rare polymorphism of the CcO VIIb gene may be associated with the high risk of nasopharyngeal carcinoma in a Cantonese family.


Pssm-ID: 238696  Cd Length: 51  Bit Score: 104.10  E-value: 1.48e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 530376569 30 HSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWK 79
Cdd:cd01403   1 ASPDFHDKYGNAVLISGATFCTAVWTYVMTQTGIEWNLSPVGRVTPKEWR 50
 
Name Accession Description Interval E-value
COX7B pfam05392
Cytochrome C oxidase chain VIIB;
2-80 2.17e-53

Cytochrome C oxidase chain VIIB;


Pssm-ID: 461637  Cd Length: 78  Bit Score: 160.27  E-value: 2.17e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530376569   2 MFPLARNALSsLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWKH 80
Cdd:pfam05392  1 MFPLARAALN-LKARSIQQIAVRQSHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
Cyt_c_Oxidase_VIIb cd01403
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 30-79 1.48e-31

Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIb subunit is found only in eukaryotes and its specific function remains unclear. A rare polymorphism of the CcO VIIb gene may be associated with the high risk of nasopharyngeal carcinoma in a Cantonese family.


Pssm-ID: 238696  Cd Length: 51  Bit Score: 104.10  E-value: 1.48e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 530376569 30 HSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWK 79
Cdd:cd01403   1 ASPDFHDKYGNAVLISGATFCTAVWTYVMTQTGIEWNLSPVGRVTPKEWR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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