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protein furry homolog-like isoform X12 [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
Fry_C
pfam19421 Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044
0e+00
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Pssm-ID: 466072
Cd Length: 633
Bit Score: 1049.74
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1315 V SKELPGKTLDFHFDISETPIIG NK Y GDQ H SA AGR N GKP K VIAVTRSTSSTSSGSNSN A LVPVSWKRPQLSQ R RTREKL M 1394
Cdd:pfam19421 1 S SKELPGKTLDFHFDISETPIIG RR Y DEL H GS AGR D GKP R VIAVTRSTSSTSSGSNSN V LVPVSWKRPQLSQ K RTREKL V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1395 NVLSLCG P E S GL P KNPSV V FSS NE DL EVG DQQTSL I S T t ED INQ EEE V a VE D NS SEQQF G VF K DFDFLDVELED A EGESM 1474
Cdd:pfam19421 81 NVLSLCG Q E V GL T KNPSV I FSS CG DL DLM DQQTSL V S S - ED GIR EEE N - MD D TT SEQQF R VF R DFDFLDVELED G EGESM 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1475 DNFNWGVRRRSLDS I DKGDTPSL Q E Y Q C S S STPSLNLTN Q ED T DESSEEE A a LTASQILS RT Q M LNSDS A T D E ti P D H P D 1554
Cdd:pfam19421 159 DNFNWGVRRRSLDS L DKGDTPSL E E S Q L S G STPSLNLTN H ED S DESSEEE S - LTASQILS HS Q L LNSDS P T E E -- P N H V D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1555 L L L QS E DS TGS it T EE V L qi R D ETP T LE A SL dnansrl PED T tsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421 236 S L S QS Q DS SSA -- D EE S L -- R A ETP S LE V SL ------- PED A -------------------------------------- 266
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdee EQD GFPE V Q T SP L PSPF L SAI I AAFQPV AY DD E 1714
Cdd:pfam19421 267 ----------------------------------------------- SAR GFPE I Q S SP P PSPF F SAI L AAFQPV VC DD A 299
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1715 EEAWRCHVNQ ML SD T DGS S AV F TFHVFS R LFQ T IQRKF GEI T NE AVS F LGDSL QR IG T KF K SS LEVMML CSECPT V FVDA 1794
Cdd:pfam19421 300 EEAWRCHVNQ LV SD S DGS C AV Y TFHVFS S LFQ N IQRKF CSL T CD AVS Y LGDSL RG IG S KF L SS SQMLTS CSECPT L FVDA 379
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1795 ETLMSCGLLE T LKF G VLELQE H LDTYN V K R EAAE Q WLD D CK R TF GAK -- EDMYRINTDA Q QM eil AE LELC R RLYKLHFQ 1872
Cdd:pfam19421 380 ETLMSCGLLE K LKF S VLELQE Y LDTYN N K K EAAE S WLD N CK A TF PRG sg DGVITCQPAD Q EE --- KQ LELC Q RLYKLHFQ 456
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1873 LLLLFQ A YCKLI N QV NT I KNEA E V INMSEELAQLES I LKE ----- AESASEN EE IDI S KAAQTTI E T A IH S LI E T L K NKE 1947
Cdd:pfam19421 457 LLLLFQ S YCKLI G QV HA I SSVP E L INMSEELAQLES S LKE aeasv TSDELAQ EE SAS S EPSFSSS E A A VQ S IL E S L R NKE 536
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1948 F IS A VA Q V K AF RSLWP S DIFGS CED D P VQTLL H IYF H HQTLGQTG S FA VI GSN L D M SE ANY KLMELNLEIR ESL R MV Q S Y 2027
Cdd:pfam19421 537 F ST A IR Q I K EC RSLWP N DIFGS SSE D E VQTLL N IYF R HQTLGQTG T FA LV GSN Q D L SE ICS KLMELNLEIR DMI R RA Q G Y 616
730
....*....|....*..
gi 530376644 2028 QL L AQAK P MGNMVSTGF 2044
Cdd:pfam19421 617 RA L TAFL P DSSVSGSSL 633
MOR2-PAG1_C
pfam14225 Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285
1.65e-75
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.
Pssm-ID: 464109
Cd Length: 252
Bit Score: 251.63
E-value: 1.65e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1032 ATI FW IAASL LE SDY E Y E Y L L ALRLL N KLL IH L P LD KSESR EK IENV Q SK l KW TN - F P GLQ Q L F LKG FT S AS T Q E M T VH L 1110
Cdd:pfam14225 1 PQL FW TTVAC LE TIH E H E F L E ALRLL E KLL DK L D LD DPDVV EK LLSS Q PQ - KW EG k F E GLQ P L L LKG LR S SV T L E P T LK L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1111 L SK L ISVSKHT LV D PS Q l S GFPLNI L CL LP HLIQHF D S P -- TQF C K ETA SRI A KVCA E EKC P tlv N LA HMMSL Y STHTY s 1188
Cdd:pfam14225 80 L DR L TKLPDDR LV G PS D - S RLLFLV L AN LP RFLHAL D D P di DPD C I ETA ENL A ELAE E QGL P --- S LA RVLTS Y AKGRF - 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1189 R DCSNWINV V CR YL HDSFS - D TT F NLV T Y L AE LL EK G LSSMQQSL LQI IYS LL SH ID LSAAPAKQFNLEI I KIIGKYV Q S 1267
Cdd:pfam14225 155 R TSDDFLKQ V VS YL REAYF p D YE F QML T F L LG LL TN G PPWVKVKT LQI LKV LL PE ID MRRPEIAGHGADL I SPLLRLL Q T 234
250
....*....|....*...
gi 530376644 1268 PYWKE AL NI L KLV V SR S A 1285
Cdd:pfam14225 235 DLCMQ AL EV L DEI V TI S G 252
MOR2-PAG1_mid super family
cl20509 Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890
2.32e-30
Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.
pfam14228 :Pssm-ID: 433790 [Multi-domain]
Cd Length: 1113
Bit Score: 131.68
E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 127 DR N M Q INRH Q YC A LK AM S A V L C c GP VA D NVGLSSD G YLYK W LDNILD ------------------------------ SLD 176
Cdd:pfam14228 396 EV N E Q VEAI Q WI A MN AM A A L L Y - GP CF D DNARKMS G RVIA W INGLFL epaprapfgyspadprtpsyskfagegvrg LGG 474
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 177 K KV H QL G CEA V T L ------- LL EL N P D qsn L MYWAV D R CY TGSGRV A A G C F KAI A N V FQNRDY - Q CD TVM LL N LIL F K AA 248
Cdd:pfam14228 475 K DR H RG G PLR V H L akvalkn LL QT N L D --- L FPACI D Q CY SSDASI A D G Y F SVL A E V YMRQEI p R CD IQR LL S LIL Y K VV 551
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 249 D S SR S I YEV A M Q L L QI L EPK mf RY A HKL E VQRTDGVLSQLSP LP HL Y SVSY Y Q LS EE LA RAY PEL TLAIFS EI S QR IQT A 328
Cdd:pfam14228 552 D P SR R I RDD A L Q M L ET L SVR -- EW A EDG E EGTGRYRAAVVGN LP DS Y QQFQ Y K LS AK LA KDH PEL SELLCE EI M QR QLD A 629
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 329 -- HP A GR QV m L HYLL PW MN N IELVD L K plptarrhdeded D S lkdrelmvtsrrwlrge GW gspqa TAMV L NN L M Y M T AK 406
Cdd:pfam14228 630 vd II A QH QV - L TCMA PW IE N LNFLK L W ------------- E S ----------------- GW ----- SERL L KS L Y Y V T WR 673
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 407 Y GD ELA w S E V E NV W T T L A DG w P K N LKII L H FLIS -- I CGVN S EP S --------- LLPYV K K V IV YL G R DKTM Q LLEE LV S 475
Cdd:pfam14228 674 H GD QFP - D E I E KL W R T I A SK - P R N ISPV L D FLIS kg I EDCD S NA S aeitgafat YFSVA K R V SL YL A R ICPQ Q TIDH LV Y 751
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 476 EL ------ QLTD P VSSGVTHM D nppyyr IT SS YKIPSVTSGTTSSSNTMVA P tdg N P DNK P ikenieesyvh L DIY S G L N 549
Cdd:pfam14228 752 EL aqrmle ESVE P SRPSDGAF D ------ LE SS AVLEFSQGPAPVQVAQLLD P --- Q P HMS P ----------- L LVR S S L E 811
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 550 SH L NRQHHR L esryssss GGSYEEEK S D S M PL YSNWRLKVMEHNQ G E ------- PL P F P PAG G cws PL V ----------- 611
Cdd:pfam14228 812 GP L RNASGS L -------- SWRTVTGR S M S G PL NTMPEVVAVDTHT G R sgqlftg SG P L P NMS G --- PL M gvrsstgslrs 880
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 612 -------- DY VPE T SSPG ----------------- L PL H ----- R CN IA V ILL TD li I DHSVKVEWG S Y L H LL L H AI F IG 661
Cdd:pfam14228 881 hhvsrdsg DY FID T PNSV eeiritpvvnaselqsa L QG H qhwls R AD IA L ILL AE -- I AYENDEDFR S H L P LL F H VT F VS 958
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 662 F D HCHPE V YE HC KR LL LH LL IVMG pnsnirtvasvllrnkefne P R V L TVKQ V A H L D Y nftagindfipdyqpspmtdsg 741
Cdd:pfam14228 959 M D SSEDI V LK HC QH LL VN LL YSLA -------------------- G R H L ELYD V E H G D G ---------------------- 996
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 742 lsssstsssislgnnsaaishlhttilnevdisv E QDGK V KT L MEFIT S RKRGPL W NH ED VSAKNPSIK SA EQ L TTFLKH 821
Cdd:pfam14228 997 ---------------------------------- E YKQQ V VS L IKYVQ S KRGSRM W EN ED MTLTRTELP SA AL L SALVLS 1042
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 822 V V - SV F K Q SS segih L EHHLS E V AL QT A LS C S SRH Y A G RS F QI F RAL KQPL T AT T LSDV L SR L VETV G D P 890
Cdd:pfam14228 1043 M V d AI F F Q GD ----- L REKWG E E AL KW A ME C T SRH L A C RS H QI Y RAL RPSV T SD T CVSL L RC L HRCL G N P 1107
Name
Accession
Description
Interval
E-value
Fry_C
pfam19421 Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044
0e+00
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Pssm-ID: 466072
Cd Length: 633
Bit Score: 1049.74
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1315 V SKELPGKTLDFHFDISETPIIG NK Y GDQ H SA AGR N GKP K VIAVTRSTSSTSSGSNSN A LVPVSWKRPQLSQ R RTREKL M 1394
Cdd:pfam19421 1 S SKELPGKTLDFHFDISETPIIG RR Y DEL H GS AGR D GKP R VIAVTRSTSSTSSGSNSN V LVPVSWKRPQLSQ K RTREKL V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1395 NVLSLCG P E S GL P KNPSV V FSS NE DL EVG DQQTSL I S T t ED INQ EEE V a VE D NS SEQQF G VF K DFDFLDVELED A EGESM 1474
Cdd:pfam19421 81 NVLSLCG Q E V GL T KNPSV I FSS CG DL DLM DQQTSL V S S - ED GIR EEE N - MD D TT SEQQF R VF R DFDFLDVELED G EGESM 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1475 DNFNWGVRRRSLDS I DKGDTPSL Q E Y Q C S S STPSLNLTN Q ED T DESSEEE A a LTASQILS RT Q M LNSDS A T D E ti P D H P D 1554
Cdd:pfam19421 159 DNFNWGVRRRSLDS L DKGDTPSL E E S Q L S G STPSLNLTN H ED S DESSEEE S - LTASQILS HS Q L LNSDS P T E E -- P N H V D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1555 L L L QS E DS TGS it T EE V L qi R D ETP T LE A SL dnansrl PED T tsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421 236 S L S QS Q DS SSA -- D EE S L -- R A ETP S LE V SL ------- PED A -------------------------------------- 266
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdee EQD GFPE V Q T SP L PSPF L SAI I AAFQPV AY DD E 1714
Cdd:pfam19421 267 ----------------------------------------------- SAR GFPE I Q S SP P PSPF F SAI L AAFQPV VC DD A 299
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1715 EEAWRCHVNQ ML SD T DGS S AV F TFHVFS R LFQ T IQRKF GEI T NE AVS F LGDSL QR IG T KF K SS LEVMML CSECPT V FVDA 1794
Cdd:pfam19421 300 EEAWRCHVNQ LV SD S DGS C AV Y TFHVFS S LFQ N IQRKF CSL T CD AVS Y LGDSL RG IG S KF L SS SQMLTS CSECPT L FVDA 379
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1795 ETLMSCGLLE T LKF G VLELQE H LDTYN V K R EAAE Q WLD D CK R TF GAK -- EDMYRINTDA Q QM eil AE LELC R RLYKLHFQ 1872
Cdd:pfam19421 380 ETLMSCGLLE K LKF S VLELQE Y LDTYN N K K EAAE S WLD N CK A TF PRG sg DGVITCQPAD Q EE --- KQ LELC Q RLYKLHFQ 456
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1873 LLLLFQ A YCKLI N QV NT I KNEA E V INMSEELAQLES I LKE ----- AESASEN EE IDI S KAAQTTI E T A IH S LI E T L K NKE 1947
Cdd:pfam19421 457 LLLLFQ S YCKLI G QV HA I SSVP E L INMSEELAQLES S LKE aeasv TSDELAQ EE SAS S EPSFSSS E A A VQ S IL E S L R NKE 536
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1948 F IS A VA Q V K AF RSLWP S DIFGS CED D P VQTLL H IYF H HQTLGQTG S FA VI GSN L D M SE ANY KLMELNLEIR ESL R MV Q S Y 2027
Cdd:pfam19421 537 F ST A IR Q I K EC RSLWP N DIFGS SSE D E VQTLL N IYF R HQTLGQTG T FA LV GSN Q D L SE ICS KLMELNLEIR DMI R RA Q G Y 616
730
....*....|....*..
gi 530376644 2028 QL L AQAK P MGNMVSTGF 2044
Cdd:pfam19421 617 RA L TAFL P DSSVSGSSL 633
MOR2-PAG1_C
pfam14225 Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285
1.65e-75
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.
Pssm-ID: 464109
Cd Length: 252
Bit Score: 251.63
E-value: 1.65e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1032 ATI FW IAASL LE SDY E Y E Y L L ALRLL N KLL IH L P LD KSESR EK IENV Q SK l KW TN - F P GLQ Q L F LKG FT S AS T Q E M T VH L 1110
Cdd:pfam14225 1 PQL FW TTVAC LE TIH E H E F L E ALRLL E KLL DK L D LD DPDVV EK LLSS Q PQ - KW EG k F E GLQ P L L LKG LR S SV T L E P T LK L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1111 L SK L ISVSKHT LV D PS Q l S GFPLNI L CL LP HLIQHF D S P -- TQF C K ETA SRI A KVCA E EKC P tlv N LA HMMSL Y STHTY s 1188
Cdd:pfam14225 80 L DR L TKLPDDR LV G PS D - S RLLFLV L AN LP RFLHAL D D P di DPD C I ETA ENL A ELAE E QGL P --- S LA RVLTS Y AKGRF - 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1189 R DCSNWINV V CR YL HDSFS - D TT F NLV T Y L AE LL EK G LSSMQQSL LQI IYS LL SH ID LSAAPAKQFNLEI I KIIGKYV Q S 1267
Cdd:pfam14225 155 R TSDDFLKQ V VS YL REAYF p D YE F QML T F L LG LL TN G PPWVKVKT LQI LKV LL PE ID MRRPEIAGHGADL I SPLLRLL Q T 234
250
....*....|....*...
gi 530376644 1268 PYWKE AL NI L KLV V SR S A 1285
Cdd:pfam14225 235 DLCMQ AL EV L DEI V TI S G 252
MOR2-PAG1_mid
pfam14228 Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890
2.32e-30
Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.
Pssm-ID: 433790 [Multi-domain]
Cd Length: 1113
Bit Score: 131.68
E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 127 DR N M Q INRH Q YC A LK AM S A V L C c GP VA D NVGLSSD G YLYK W LDNILD ------------------------------ SLD 176
Cdd:pfam14228 396 EV N E Q VEAI Q WI A MN AM A A L L Y - GP CF D DNARKMS G RVIA W INGLFL epaprapfgyspadprtpsyskfagegvrg LGG 474
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 177 K KV H QL G CEA V T L ------- LL EL N P D qsn L MYWAV D R CY TGSGRV A A G C F KAI A N V FQNRDY - Q CD TVM LL N LIL F K AA 248
Cdd:pfam14228 475 K DR H RG G PLR V H L akvalkn LL QT N L D --- L FPACI D Q CY SSDASI A D G Y F SVL A E V YMRQEI p R CD IQR LL S LIL Y K VV 551
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 249 D S SR S I YEV A M Q L L QI L EPK mf RY A HKL E VQRTDGVLSQLSP LP HL Y SVSY Y Q LS EE LA RAY PEL TLAIFS EI S QR IQT A 328
Cdd:pfam14228 552 D P SR R I RDD A L Q M L ET L SVR -- EW A EDG E EGTGRYRAAVVGN LP DS Y QQFQ Y K LS AK LA KDH PEL SELLCE EI M QR QLD A 629
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 329 -- HP A GR QV m L HYLL PW MN N IELVD L K plptarrhdeded D S lkdrelmvtsrrwlrge GW gspqa TAMV L NN L M Y M T AK 406
Cdd:pfam14228 630 vd II A QH QV - L TCMA PW IE N LNFLK L W ------------- E S ----------------- GW ----- SERL L KS L Y Y V T WR 673
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 407 Y GD ELA w S E V E NV W T T L A DG w P K N LKII L H FLIS -- I CGVN S EP S --------- LLPYV K K V IV YL G R DKTM Q LLEE LV S 475
Cdd:pfam14228 674 H GD QFP - D E I E KL W R T I A SK - P R N ISPV L D FLIS kg I EDCD S NA S aeitgafat YFSVA K R V SL YL A R ICPQ Q TIDH LV Y 751
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 476 EL ------ QLTD P VSSGVTHM D nppyyr IT SS YKIPSVTSGTTSSSNTMVA P tdg N P DNK P ikenieesyvh L DIY S G L N 549
Cdd:pfam14228 752 EL aqrmle ESVE P SRPSDGAF D ------ LE SS AVLEFSQGPAPVQVAQLLD P --- Q P HMS P ----------- L LVR S S L E 811
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 550 SH L NRQHHR L esryssss GGSYEEEK S D S M PL YSNWRLKVMEHNQ G E ------- PL P F P PAG G cws PL V ----------- 611
Cdd:pfam14228 812 GP L RNASGS L -------- SWRTVTGR S M S G PL NTMPEVVAVDTHT G R sgqlftg SG P L P NMS G --- PL M gvrsstgslrs 880
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 612 -------- DY VPE T SSPG ----------------- L PL H ----- R CN IA V ILL TD li I DHSVKVEWG S Y L H LL L H AI F IG 661
Cdd:pfam14228 881 hhvsrdsg DY FID T PNSV eeiritpvvnaselqsa L QG H qhwls R AD IA L ILL AE -- I AYENDEDFR S H L P LL F H VT F VS 958
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 662 F D HCHPE V YE HC KR LL LH LL IVMG pnsnirtvasvllrnkefne P R V L TVKQ V A H L D Y nftagindfipdyqpspmtdsg 741
Cdd:pfam14228 959 M D SSEDI V LK HC QH LL VN LL YSLA -------------------- G R H L ELYD V E H G D G ---------------------- 996
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 742 lsssstsssislgnnsaaishlhttilnevdisv E QDGK V KT L MEFIT S RKRGPL W NH ED VSAKNPSIK SA EQ L TTFLKH 821
Cdd:pfam14228 997 ---------------------------------- E YKQQ V VS L IKYVQ S KRGSRM W EN ED MTLTRTELP SA AL L SALVLS 1042
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 822 V V - SV F K Q SS segih L EHHLS E V AL QT A LS C S SRH Y A G RS F QI F RAL KQPL T AT T LSDV L SR L VETV G D P 890
Cdd:pfam14228 1043 M V d AI F F Q GD ----- L REKWG E E AL KW A ME C T SRH L A C RS H QI Y RAL RPSV T SD T CVSL L RC L HRCL G N P 1107
Name
Accession
Description
Interval
E-value
Fry_C
pfam19421 Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044
0e+00
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Pssm-ID: 466072
Cd Length: 633
Bit Score: 1049.74
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1315 V SKELPGKTLDFHFDISETPIIG NK Y GDQ H SA AGR N GKP K VIAVTRSTSSTSSGSNSN A LVPVSWKRPQLSQ R RTREKL M 1394
Cdd:pfam19421 1 S SKELPGKTLDFHFDISETPIIG RR Y DEL H GS AGR D GKP R VIAVTRSTSSTSSGSNSN V LVPVSWKRPQLSQ K RTREKL V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1395 NVLSLCG P E S GL P KNPSV V FSS NE DL EVG DQQTSL I S T t ED INQ EEE V a VE D NS SEQQF G VF K DFDFLDVELED A EGESM 1474
Cdd:pfam19421 81 NVLSLCG Q E V GL T KNPSV I FSS CG DL DLM DQQTSL V S S - ED GIR EEE N - MD D TT SEQQF R VF R DFDFLDVELED G EGESM 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1475 DNFNWGVRRRSLDS I DKGDTPSL Q E Y Q C S S STPSLNLTN Q ED T DESSEEE A a LTASQILS RT Q M LNSDS A T D E ti P D H P D 1554
Cdd:pfam19421 159 DNFNWGVRRRSLDS L DKGDTPSL E E S Q L S G STPSLNLTN H ED S DESSEEE S - LTASQILS HS Q L LNSDS P T E E -- P N H V D 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1555 L L L QS E DS TGS it T EE V L qi R D ETP T LE A SL dnansrl PED T tsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421 236 S L S QS Q DS SSA -- D EE S L -- R A ETP S LE V SL ------- PED A -------------------------------------- 266
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdee EQD GFPE V Q T SP L PSPF L SAI I AAFQPV AY DD E 1714
Cdd:pfam19421 267 ----------------------------------------------- SAR GFPE I Q S SP P PSPF F SAI L AAFQPV VC DD A 299
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1715 EEAWRCHVNQ ML SD T DGS S AV F TFHVFS R LFQ T IQRKF GEI T NE AVS F LGDSL QR IG T KF K SS LEVMML CSECPT V FVDA 1794
Cdd:pfam19421 300 EEAWRCHVNQ LV SD S DGS C AV Y TFHVFS S LFQ N IQRKF CSL T CD AVS Y LGDSL RG IG S KF L SS SQMLTS CSECPT L FVDA 379
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1795 ETLMSCGLLE T LKF G VLELQE H LDTYN V K R EAAE Q WLD D CK R TF GAK -- EDMYRINTDA Q QM eil AE LELC R RLYKLHFQ 1872
Cdd:pfam19421 380 ETLMSCGLLE K LKF S VLELQE Y LDTYN N K K EAAE S WLD N CK A TF PRG sg DGVITCQPAD Q EE --- KQ LELC Q RLYKLHFQ 456
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1873 LLLLFQ A YCKLI N QV NT I KNEA E V INMSEELAQLES I LKE ----- AESASEN EE IDI S KAAQTTI E T A IH S LI E T L K NKE 1947
Cdd:pfam19421 457 LLLLFQ S YCKLI G QV HA I SSVP E L INMSEELAQLES S LKE aeasv TSDELAQ EE SAS S EPSFSSS E A A VQ S IL E S L R NKE 536
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1948 F IS A VA Q V K AF RSLWP S DIFGS CED D P VQTLL H IYF H HQTLGQTG S FA VI GSN L D M SE ANY KLMELNLEIR ESL R MV Q S Y 2027
Cdd:pfam19421 537 F ST A IR Q I K EC RSLWP N DIFGS SSE D E VQTLL N IYF R HQTLGQTG T FA LV GSN Q D L SE ICS KLMELNLEIR DMI R RA Q G Y 616
730
....*....|....*..
gi 530376644 2028 QL L AQAK P MGNMVSTGF 2044
Cdd:pfam19421 617 RA L TAFL P DSSVSGSSL 633
MOR2-PAG1_C
pfam14225 Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285
1.65e-75
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.
Pssm-ID: 464109
Cd Length: 252
Bit Score: 251.63
E-value: 1.65e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1032 ATI FW IAASL LE SDY E Y E Y L L ALRLL N KLL IH L P LD KSESR EK IENV Q SK l KW TN - F P GLQ Q L F LKG FT S AS T Q E M T VH L 1110
Cdd:pfam14225 1 PQL FW TTVAC LE TIH E H E F L E ALRLL E KLL DK L D LD DPDVV EK LLSS Q PQ - KW EG k F E GLQ P L L LKG LR S SV T L E P T LK L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1111 L SK L ISVSKHT LV D PS Q l S GFPLNI L CL LP HLIQHF D S P -- TQF C K ETA SRI A KVCA E EKC P tlv N LA HMMSL Y STHTY s 1188
Cdd:pfam14225 80 L DR L TKLPDDR LV G PS D - S RLLFLV L AN LP RFLHAL D D P di DPD C I ETA ENL A ELAE E QGL P --- S LA RVLTS Y AKGRF - 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 1189 R DCSNWINV V CR YL HDSFS - D TT F NLV T Y L AE LL EK G LSSMQQSL LQI IYS LL SH ID LSAAPAKQFNLEI I KIIGKYV Q S 1267
Cdd:pfam14225 155 R TSDDFLKQ V VS YL REAYF p D YE F QML T F L LG LL TN G PPWVKVKT LQI LKV LL PE ID MRRPEIAGHGADL I SPLLRLL Q T 234
250
....*....|....*...
gi 530376644 1268 PYWKE AL NI L KLV V SR S A 1285
Cdd:pfam14225 235 DLCMQ AL EV L DEI V TI S G 252
MOR2-PAG1_mid
pfam14228 Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890
2.32e-30
Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.
Pssm-ID: 433790 [Multi-domain]
Cd Length: 1113
Bit Score: 131.68
E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 127 DR N M Q INRH Q YC A LK AM S A V L C c GP VA D NVGLSSD G YLYK W LDNILD ------------------------------ SLD 176
Cdd:pfam14228 396 EV N E Q VEAI Q WI A MN AM A A L L Y - GP CF D DNARKMS G RVIA W INGLFL epaprapfgyspadprtpsyskfagegvrg LGG 474
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 177 K KV H QL G CEA V T L ------- LL EL N P D qsn L MYWAV D R CY TGSGRV A A G C F KAI A N V FQNRDY - Q CD TVM LL N LIL F K AA 248
Cdd:pfam14228 475 K DR H RG G PLR V H L akvalkn LL QT N L D --- L FPACI D Q CY SSDASI A D G Y F SVL A E V YMRQEI p R CD IQR LL S LIL Y K VV 551
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 249 D S SR S I YEV A M Q L L QI L EPK mf RY A HKL E VQRTDGVLSQLSP LP HL Y SVSY Y Q LS EE LA RAY PEL TLAIFS EI S QR IQT A 328
Cdd:pfam14228 552 D P SR R I RDD A L Q M L ET L SVR -- EW A EDG E EGTGRYRAAVVGN LP DS Y QQFQ Y K LS AK LA KDH PEL SELLCE EI M QR QLD A 629
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 329 -- HP A GR QV m L HYLL PW MN N IELVD L K plptarrhdeded D S lkdrelmvtsrrwlrge GW gspqa TAMV L NN L M Y M T AK 406
Cdd:pfam14228 630 vd II A QH QV - L TCMA PW IE N LNFLK L W ------------- E S ----------------- GW ----- SERL L KS L Y Y V T WR 673
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 407 Y GD ELA w S E V E NV W T T L A DG w P K N LKII L H FLIS -- I CGVN S EP S --------- LLPYV K K V IV YL G R DKTM Q LLEE LV S 475
Cdd:pfam14228 674 H GD QFP - D E I E KL W R T I A SK - P R N ISPV L D FLIS kg I EDCD S NA S aeitgafat YFSVA K R V SL YL A R ICPQ Q TIDH LV Y 751
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 476 EL ------ QLTD P VSSGVTHM D nppyyr IT SS YKIPSVTSGTTSSSNTMVA P tdg N P DNK P ikenieesyvh L DIY S G L N 549
Cdd:pfam14228 752 EL aqrmle ESVE P SRPSDGAF D ------ LE SS AVLEFSQGPAPVQVAQLLD P --- Q P HMS P ----------- L LVR S S L E 811
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 550 SH L NRQHHR L esryssss GGSYEEEK S D S M PL YSNWRLKVMEHNQ G E ------- PL P F P PAG G cws PL V ----------- 611
Cdd:pfam14228 812 GP L RNASGS L -------- SWRTVTGR S M S G PL NTMPEVVAVDTHT G R sgqlftg SG P L P NMS G --- PL M gvrsstgslrs 880
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 612 -------- DY VPE T SSPG ----------------- L PL H ----- R CN IA V ILL TD li I DHSVKVEWG S Y L H LL L H AI F IG 661
Cdd:pfam14228 881 hhvsrdsg DY FID T PNSV eeiritpvvnaselqsa L QG H qhwls R AD IA L ILL AE -- I AYENDEDFR S H L P LL F H VT F VS 958
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 662 F D HCHPE V YE HC KR LL LH LL IVMG pnsnirtvasvllrnkefne P R V L TVKQ V A H L D Y nftagindfipdyqpspmtdsg 741
Cdd:pfam14228 959 M D SSEDI V LK HC QH LL VN LL YSLA -------------------- G R H L ELYD V E H G D G ---------------------- 996
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 742 lsssstsssislgnnsaaishlhttilnevdisv E QDGK V KT L MEFIT S RKRGPL W NH ED VSAKNPSIK SA EQ L TTFLKH 821
Cdd:pfam14228 997 ---------------------------------- E YKQQ V VS L IKYVQ S KRGSRM W EN ED MTLTRTELP SA AL L SALVLS 1042
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644 822 V V - SV F K Q SS segih L EHHLS E V AL QT A LS C S SRH Y A G RS F QI F RAL KQPL T AT T LSDV L SR L VETV G D P 890
Cdd:pfam14228 1043 M V d AI F F Q GD ----- L REKWG E E AL KW A ME C T SRH L A C RS H QI Y RAL RPSV T SD T CVSL L RC L HRCL G N P 1107
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
