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Conserved domains on  [gi|530390393|ref|XP_005251699|]
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rab9 effector protein with kelch motifs isoform X4 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-237 3.06e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 91.37  E-value: 3.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPDTLTWSQpetLGNPPSPRHGH-VMVAAGTKLFIHGGLAGDRFYDd 173
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSN- 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530390393 174 lhcidisdmKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTpaGALDTMYQYHTEEQHWTLL 237
Cdd:COG3055  186 ---------TWTTLAP---LPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL 235
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-237 3.06e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 91.37  E-value: 3.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPDTLTWSQpetLGNPPSPRHGH-VMVAAGTKLFIHGGLAGDRFYDd 173
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSN- 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530390393 174 lhcidisdmKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTpaGALDTMYQYHTEEQHWTLL 237
Cdd:COG3055  186 ---------TWTTLAP---LPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 58-237 1.14e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.14  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  58 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTC--KGLLPRYEHASfipSCTPDRIWVFGGANQSGNRNCLQVLNPDTLTWS 135
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPveEGPTPRSFHSM---AADEENVYVFGGVSATARLKTLDSYNIVDKKWF 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 136 QPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFyDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG- 214
Cdd:PLN02193 308 HCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGe 386

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530390393 215 --------MTPAGALDTMYQYHTEEQHWTLL 237
Cdd:PLN02193 387 iamdplahVGPGQLTDGTFALDTETLQWERL 417
Kelch_3 pfam13415
Galactose oxidase, central domain;
107-155 4.55e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.13  E-value: 4.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530390393  107 DRIWVFGGANQSGNR--NCLQVLNPDTLTWsqpETLGNPPSPRHGHVMVAA 155
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-237 3.06e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 91.37  E-value: 3.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPDTLTWSQpetLGNPPSPRHGH-VMVAAGTKLFIHGGLAGDRFYDd 173
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSN- 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530390393 174 lhcidisdmKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTpaGALDTMYQYHTEEQHWTLL 237
Cdd:COG3055  186 ---------TWTTLAP---LPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL 235
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-224 6.56e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.13  E-value: 6.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  21 PRKATWYTLtvpGDSPCARVGHSCSYLppvgnakRGKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTckgllPRYE 96
Cdd:COG3055   97 PATNTWTKL---APMPTPRGGATALLL-------DGKIYVVGGWDDGGNVAWVEVYDPATGTWtqlaPLPT-----PRDH 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  97 HAS-FIPSctpDRIWVFGGANQSGNRNclqvlnpdtlTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLH 175
Cdd:COG3055  162 LAAaVLPD---GKILVIGGRNGSGFSN----------TWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVE 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530390393 176 CIDISDMKWQKLNPTgaaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTM 224
Cdd:COG3055  224 AYDPATNTWTALGEL---PTPRHGHAAVLTDGKVYVIGGETKPGVRTPL 269
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
93-237 3.66e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.81  E-value: 3.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  93 PRYEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPDTLTWSQpetLGNPP-SPRHGHVMVAAGTKLFIHGGLAGD--- 168
Cdd:COG3055   12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPgPPRHHAAAVAQDGKLYVFGGFTGAnps 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 169 -RFYDDLHCIDISDMKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 237
Cdd:COG3055   86 sTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL 152
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
56-223 7.01e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 73.65  E-value: 7.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  56 GKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTckglLPRYEHASFIPSctpDRIWVFGGANQSGNRNCLQ----VL 127
Cdd:COG3055   23 GKVYVAGGLSGGSASNSFEVYDPATNTWselaPLPG----PPRHHAAAVAQD---GKLYVFGGFTGANPSSTPLndvyVY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 128 NPDTLTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGK 207
Cdd:COG3055   96 DPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA--AVLPDG 170

                        170
                 ....*....|....*.
gi 530390393 208 HVYIFGGMTPAGALDT 223
Cdd:COG3055  171 KILVIGGRNGSGFSNT 186
PLN02193 PLN02193
nitrile-specifier protein
 58-237 1.14e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.14  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  58 VFIVGGANPNRSFSDVHTMDLGKHQWDLDTC--KGLLPRYEHASfipSCTPDRIWVFGGANQSGNRNCLQVLNPDTLTWS 135
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPveEGPTPRSFHSM---AADEENVYVFGGVSATARLKTLDSYNIVDKKWF 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 136 QPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFyDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG- 214
Cdd:PLN02193 308 HCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGe 386

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530390393 215 --------MTPAGALDTMYQYHTEEQHWTLL 237
Cdd:PLN02193 387 iamdplahVGPGQLTDGTFALDTETLQWERL 417
PLN02153 PLN02153
epithiospecifier protein
 89-233 6.74e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 68.47  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  89 KGLLPRYEHASfipSCTPDRIWVFGG---ANQSGNRNcLQVLNPDTLTWSQPETLGNPPS-PRHGHVMVAAGTKLFIHGG 164
Cdd:PLN02153  18 KGPGPRCSHGI---AVVGDKLYSFGGelkPNEHIDKD-LYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGG 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530390393 165 LAGDRFYDDLHCIDISDMKWQ---KLNPTGAaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 233
Cdd:PLN02153  94 RDEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAY 164
PLN02193 PLN02193
nitrile-specifier protein
 107-234 1.93e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 67.67  E-value: 1.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 107 DRIWVFGG---ANQSGNRNcLQVLNPDTLTWS-QPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDM 182
Cdd:PLN02193 176 NKIYSFGGeftPNQPIDKH-LYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTN 254

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530390393 183 KWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 234
Cdd:PLN02193 255 EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
PLN02153 PLN02153
epithiospecifier protein
 141-252 2.22e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.85  E-value: 2.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 141 GNPPSPRHGHVMVAAGTKLFIHGG-LAGDRFYD-DLHCIDISDMKWQKLNPTGAAPA-GCAAHSAVAMGKHVYIFGGMTP 217
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDE 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530390393 218 AGALDTMYQYHTEEQHWTLL-KFDTL-LPPGRLDHSM 252
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLtKLDEEgGPEARTFHSM 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
133-252 3.03e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 3.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 133 TWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYIF 212
Cdd:COG3055    2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAA--AVAQDGKLYVF 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530390393 213 GGMTPA----GALDTMYQYHTEEQHWTLLkfdTLLPPGRLDHSM 252
Cdd:COG3055   77 GGFTGAnpssTPLNDVYVYDPATNTWTKL---APMPTPRGGATA 117
PLN02153 PLN02153
epithiospecifier protein
 25-214 5.89e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.70  E-value: 5.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  25 TWYTLTVPGDSPcaRVGHSCSYLPPVGNakrgKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTCKGLLPRYEHASf 100
Cdd:PLN02153  61 TWSIAPANGDVP--RISCLGVRMVAVGT----KLYIFGGRDEKREFSDFYSYDTVKNEWtfltKLDEEGGPEARTFHSM- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 101 ipSCTPDRIWVFGGANQSGNRNC------LQVLNPDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA------GD 168
Cdd:PLN02153 134 --ASDENHVYVFGGVSKGGLMKTperfrtIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpgGK 211

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530390393 169 RFYDD--LHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG 214
Cdd:PLN02153 212 SDYESnaVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
PRK14131 PRK14131
N-acetylneuraminate epimerase;
143-214 2.94e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 54.64  E-value: 2.94e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530390393 143 PPSPRHGHVMVAAGTKLFIHGGL------AGDRFYDDLHCIDISDMKWQKLNPTgaAPAGCAAHSAVAM-GKHVYIFGG 214
Cdd:PRK14131  71 PGGPREQAVAAFIDGKLYVFGGIgktnseGSPQVFDDVYKYDPKTNSWQKLDTR--SPVGLAGHVAVSLhNGKAYITGG 147
Kelch_3 pfam13415
Galactose oxidase, central domain;
107-155 4.55e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.13  E-value: 4.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530390393  107 DRIWVFGGANQSGNR--NCLQVLNPDTLTWsqpETLGNPPSPRHGHVMVAA 155
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 134-252 6.85e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.72  E-value: 6.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 134 WSQPETLGNPPSPRHGHVMVAAGTKLFIHGG-LAGDRFYDD-LHCIDISDMKWQKLNPTGAAPA-GCAAHSAVAMGKHVY 210
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGeFTPNQPIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLY 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530390393 211 IFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSM 252
Cdd:PLN02193 233 VFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSM 274
PHA03098 PHA03098
kelch-like protein; Provisional
 58-255 9.02e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 9.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  58 VFIVGGANPNR-SFSDVHTMDLGKHQWdLDTCKGLLPRYEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPDTLTWSQ 136
Cdd:PHA03098 297 IYFIGGMNKNNlSVNSVVSYDTKTKSW-NKVPELIYPRKNPGVTVFN---NRIYVIGGIYNSISLNTVESWKPGESKWRE 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 137 PETLgnpPSPRHGHVMVAAGTKLFIHGGLA-GDRFYDDLHCIDISDMKWQKLNPTgaaPAGCAAHSAVAMGKHVYIFGGM 215
Cdd:PHA03098 373 EPPL---IFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGI 446

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530390393 216 TPA---GALDTMYQYHTEEQHWTLLKfdTLLPPgRLDHSMCII 255
Cdd:PHA03098 447 SYIdniKVYNIVESYNPVTNKWTELS--SLNFP-RINASLCIF 486
PHA03098 PHA03098
kelch-like protein; Provisional
 49-238 3.71e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 48.23  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  49 PVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTcKGLLPRYEHASFIpscTPDRIWVFGGANQSG-NRNCLQVL 127
Cdd:PHA03098 336 PGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEP-PLIFPRYNPCVVN---VNNLIYVIGGISKNDeLLKTVECF 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 128 NPDTLTWSqpetLGNP-PSPRHGHVMVAAGTKLFIHGGLA---GDRFYDDLHCIDISDMKWQKLNPTGaAPAGCAahSAV 203
Cdd:PHA03098 412 SLNTNKWS----KGSPlPISHYGGCAIYHDGKIYVIGGISyidNIKVYNIVESYNPVTNKWTELSSLN-FPRINA--SLC 484

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530390393 204 AMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLK 238
Cdd:PHA03098 485 IFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFC 519
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 197-237 2.35e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530390393  197 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 237
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 146-189 1.41e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 1.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530390393  146 PRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNP 189
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
PLN02193 PLN02193
nitrile-specifier protein
 25-174 2.97e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 42.25  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393  25 TWYTLTVPGDSPCARVGHSCSYLppvgnakRGKVFIVGGANpNRSFSDVHTMDLGKHQWDLDTCKGLLPRyEHASFIPSC 104
Cdd:PLN02193 305 KWFHCSTPGDSFSIRGGAGLEVV-------QGKVWVVYGFN-GCEVDDVHYYDPVQDKWTQVETFGVRPS-ERSVFASAA 375

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390393 105 TPDRIWVFGG-------ANQSGNR--NCLQVLNPDTLTWSQPETLGNP---PSPRhGHVMVAAGT-----KLFIHGGLA- 166
Cdd:PLN02193 376 VGKHIVIFGGeiamdplAHVGPGQltDGTFALDTETLQWERLDKFGEEeetPSSR-GWTASTTGTidgkkGLVMHGGKAp 454


                 ....*....
gi 530390393 167 -GDRFyDDL 174
Cdd:PLN02193 455 tNDRF-DDL 462
Kelch_4 pfam13418
Galactose oxidase, central domain;
146-187 3.69e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 3.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530390393  146 PRHGHVMVA-AGTKLFIHGGLAGD-RFYDDLHCIDISDMKWQKL 187
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRL 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 144-175 4.33e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 4.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530390393  144 PSPRHGHVMVAAGTKLFIHGGLAGDR--FYDDLH 175
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
93-145 5.74e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 5.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530390393   93 PRYEHASFipSCTPDRIWVFGGANQSGNR-NCLQVLNPDTLTWSQpetLGNPPS 145
Cdd:pfam13418   1 PRAYHTST--SIPDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTR---LGSLPS 49
Kelch_6 pfam13964
Kelch motif;
93-147 1.10e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530390393   93 PRYEHASFIPSctpDRIWVFGGANQSGNR-NCLQVLNPDTLTWsqpETLGNPPSPR 147
Cdd:pfam13964   1 PRTFHSVVSVG---GYIYVFGGYTNASPAlNKLEVYNPLTKSW---EELPPLPTPR 50
PLN02772 PLN02772
guanylate kinase
 107-168 4.24e-03

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 38.67  E-value: 4.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530390393 107 DRIWVFGGANQSGNRNC-LQVLNPDTLTWSQPETLGNPPSPRHGH--VMVAAGTKLFIHGGLAGD 168
Cdd:PLN02772  35 DKTYVIGGNHEGNTLSIgVQILDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPD 99
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 194-230 7.45e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 7.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530390393  194 PAGCAAHSAVAMGKHVYIFGGMTPAG--ALDTMYQYHTE 230
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVYVLSLP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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