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Conserved domains on  [gi|530392191|ref|XP_005252523|]
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ATP-dependent 6-phosphofructokinase, platelet type isoform X2 [Homo sapiens]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1431.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 502 ALLIIGGFEAYKSACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764  481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|..
gi 530392191 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1431.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 502 ALLIIGGFEAYKSACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764  481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|..
gi 530392191 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
25-766 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1298.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  345 VSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNC---NVAVINVGAP 421
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  502 ALLIIGGFEAYKSACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVFIIE 581
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVA-ELKKQTD 740
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720
                         730       740
                  ....*....|....*....|....*.
gi 530392191  741 FEHRIPKEQWWLKLRPLMKILAKYKA 766
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGRDS 746
PFK pfam00365
Phosphofructokinase;
27-330 1.01e-145

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 428.30  E-value: 1.01e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLsENRARKKRL 266
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRF 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530392191  267 NIIIVAEGAIDTqnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 330
Cdd:pfam00365 214 SIIVVAEGASDG-------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
25-373 1.02e-124

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.96  E-value: 1.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDTQNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTpacV 344
Cdd:PRK03202 214 KHAIIVVAEGVMPAEEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283
                        330       340       350
                 ....*....|....*....|....*....|
gi 530392191 345 VSLNGNHAVRLPLMECV-QMTQDVQKAMDE 373
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPFDKDLYE 313
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
25-382 8.21e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 369.40  E-value: 8.21e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:COG0205   80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:COG0205  138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDTQNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEA 329
Cdd:COG0205  215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530392191 330 VIALLEatpDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 382
Cdd:COG0205  295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1431.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 502 ALLIIGGFEAYKSACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764  481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|..
gi 530392191 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
25-766 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1298.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  345 VSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNC---NVAVINVGAP 421
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  502 ALLIIGGFEAYKSACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVFIIE 581
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVA-ELKKQTD 740
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720
                         730       740
                  ....*....|....*....|....*.
gi 530392191  741 FEHRIPKEQWWLKLRPLMKILAKYKA 766
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGRDS 746
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
25-392 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 546.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGlleelarngqidkeavqKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:cd00363   79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:cd00363  142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:cd00363  222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 530392191 345 VSLNGNHAVRLPLMECVQMTQDVQkamderrfqdaVRLRGRSFAGNLN 392
Cdd:cd00363  302 QNLNENQVVRHPLTEAVNMTKRVG-----------VDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
27-330 1.01e-145

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 428.30  E-value: 1.01e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLsENRARKKRL 266
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRF 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530392191  267 NIIIVAEGAIDTqnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 330
Cdd:pfam00365 214 SIIVVAEGASDG-------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
25-373 1.02e-124

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.96  E-value: 1.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDTQNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTpacV 344
Cdd:PRK03202 214 KHAIIVVAEGVMPAEEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283
                        330       340       350
                 ....*....|....*....|....*....|
gi 530392191 345 VSLNGNHAVRLPLMECV-QMTQDVQKAMDE 373
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPFDKDLYE 313
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
25-382 8.21e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 369.40  E-value: 8.21e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:COG0205   80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:COG0205  138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDTQNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEA 329
Cdd:COG0205  215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530392191 330 VIALLEatpDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 382
Cdd:COG0205  295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
27-359 3.05e-110

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 337.78  E-value: 3.05e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEwsglleelarnGQIdkeavqkyaylNVVGMVGSIDNDFCGTDMTIG 186
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVIGLPGTIDNDIPGTDYTIG 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRL 266
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD---IDELIQRLKEQHEAGKKH 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  267 NIIIVAEGAIDTQNKPItSEKIKELVvtqlGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpDTPACVVS 346
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIG 286
                         330
                  ....*....|...
gi 530392191  347 LNGNHAVRLPLME 359
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
PFK pfam00365
Phosphofructokinase;
412-695 8.49e-104

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 320.06  E-value: 8.49e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 488
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  489 EEIATQMRTHSINALLIIGGFEAYKSACDMAEARGrhqelcIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQ 568
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  569 SASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIqrglVLRNESCSenyTTD 648
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGE 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 530392191  649 FIYQLYsEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 695
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
25-371 1.00e-98

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 308.57  E-value: 1.00e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:cd00763    1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:cd00763   79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-----------LTEHG------------FPCVGLPGTIDNDIPGTDYT 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:cd00763  136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGAIDtqnkpitSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEAtpdTPACV 344
Cdd:cd00763  213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282
                        330       340
                 ....*....|....*....|....*..
gi 530392191 345 VSLNGNHAVRLPLMECVQMTQDVQKAM 371
Cdd:cd00763  283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
27-361 6.46e-81

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 261.85  E-value: 6.46e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   27 IGVLTSGGDAQGMNAAVRAVVRMGIYV-GAKVYFIYEGYQGMVDGGSnIAEADWESVSSILQVGGTIIGSARCQAFRT-R 104
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleELARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYT 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD---IDSVCEKVRERFARGK 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  265 RLNIIIVAEGA--------IDTQNKPI--------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 328
Cdd:TIGR02483 215 RFAIVVVAEGAkpkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294
                         330       340       350
                  ....*....|....*....|....*....|...
gi 530392191  329 AVIALLEATPDTpacVVSLNGNHAVRLPLMECV 361
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
22-330 2.45e-59

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 205.30  E-value: 2.45e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  22 GAGKAIGVLTSGGDAQGMNAAVRAVVR--MGIYvGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQ 99
Cdd:PRK14071   2 GEKKRIGILTSGGDCAGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 100 ---AFRTREGRLKAACN-----LLQRGITNLCVIGGDGSLtganlfrkewsGLLEELARNGQIdkeavqkyaylNVVGMV 171
Cdd:PRK14071  81 dpfAFPMPDGSLRDRSQeiidgYHSLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIP 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 172 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPpeegWE-E 250
Cdd:PRK14071 139 KTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTlE 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 251 QMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEK-------------IKELVVTQLGYDTRVTILGHVQRGGTPSAF 317
Cdd:PRK14071 215 NVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPR 294
                        330
                 ....*....|...
gi 530392191 318 DRILASRMGVEAV 330
Cdd:PRK14071 295 DRLLASAFGVAAV 307
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
15-349 2.24e-51

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 191.78  E-value: 2.24e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   15 KFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGsnIAEADWESVSSILQVGGTIIG 94
Cdd:TIGR02478 380 KKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELG 457
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   95 SARcqafRTREGRLKA-ACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKeAVQKYAYLNV--VGMV 171
Cdd:TIGR02478 458 TNR----SLPGDDLGTiAYYFQQHKIDGLIIIGGFEAFEALY-----------------QLDA-AREKYPAFRIpmVVIP 515
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  172 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQ-SHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEE 250
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  251 QMCVKLSENRARKKRLNIIIVAEGAIDTqnkpITSEKIKELV--VTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 328
Cdd:TIGR02478 596 EDIEHLKETFAEGRAGKLILRNEKASKV----YTTDFIARIIseEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIR 671
                         330       340       350
                  ....*....|....*....|....*....|..
gi 530392191  329 AVIALLEATP-----------DTPACVVSLNG 349
Cdd:TIGR02478 672 AVDFIEEKIKankhadklsadDTSAVVIGIRG 703
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
412-735 2.99e-49

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 176.72  E-value: 2.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI 491
Cdd:cd00363    2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSAR-CKEFRTEEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 492 ----ATQMRTHSINALLIIGGFEAYKSACDMAEaRGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIK 567
Cdd:cd00363   81 rakaAENLKKHGIDALVVIGGDGSYTGADLLTE-EWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 568 QSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDlqsnVEHLTEKMKTTIQRG----LVLRNEScse 643
Cdd:cd00363  160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 644 nyTTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKlkeargrgkkfTTDDS 716
Cdd:cd00363  232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEG-----------TGGTP 298
                        330
                 ....*....|....*....
gi 530392191 717 ICVLGISKRNVIFQPVAEL 735
Cdd:cd00363  299 VGIQNLNENQVVRHPLTEA 317
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
412-697 2.04e-48

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 174.49  E-value: 2.04e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 488
Cdd:COG0205    3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 489 EEIATQMRTHSINALLIIGGFEAYKSACDMAEARGrhqelcIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQ 568
Cdd:COG0205   83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 569 SASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLqsnVEHLTEKMKTTIQRGLVL--------RNES 640
Cdd:COG0205  157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530392191 641 CSENYTTDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 697
Cdd:COG0205  233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
413-754 2.04e-47

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 171.05  E-value: 2.04e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI- 491
Cdd:cd00763    3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGq 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 492 ---ATQMRTHSINALLIIGGFEAYKSACdmaeargRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQ 568
Cdd:cd00763   82 akaIEQLKKHGIDALVVIGGDGSYMGAM-------RLTEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 569 SASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNESCsenYTTD 648
Cdd:cd00763  155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 649 FIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAklkearGRGkkfttddSICVlGISKRNVI 728
Cdd:cd00763  228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA------GKG-------GLAV-GIQNEQLV 291
                        330       340
                 ....*....|....*....|....*.
gi 530392191 729 FQPVAELkkqtdFEHRIPKEQWWLKL 754
Cdd:cd00763  292 HHDIIDA-----IENMKPFKKDWLAL 312
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
422-695 1.39e-45

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 166.02  E-value: 1.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE---EIATQMRTH 498
Cdd:PRK03202  13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 499 SINALLIIGGFEAYKSACDMAEARgrhqelcIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASgTKRRVF 578
Cdd:PRK03202  93 GIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS-SHERVF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 579 IIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNES-CSENYTTDFIyqlyseE 657
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAKEI------E 235
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530392191 658 GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 695
Cdd:PRK03202 236 ERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
27-279 3.14e-27

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 115.91  E-value: 3.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  27 IGVLTSGGDAQGMNAAVRAVVRMGIYV-GAK-VYFIYEGYQGMVDGGSniAEADWESVSSILQVGGTIIGSARcqafrTR 104
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDW--IKLDPKDVKTIHRLGGTILGSSR-----GG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:PTZ00286 163 FDPKVMVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 185 IGTDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPpeegWEEQMCVKLSENRAR 262
Cdd:PTZ00286 226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFD----IPLEGVLEYIEQRLQ 301
                        250
                 ....*....|....*..
gi 530392191 263 KKRLNIIIVAEGAIDTQ 279
Cdd:PTZ00286 302 KKGHCVIVVAEGAGQSL 318
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
28-275 9.04e-20

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 93.01  E-value: 9.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  28 GVLTSGGDAQGMNAAVRAVVR--MGIYVGAKVYFIYEGYQGMV-DGGSNIAEADWESVSSILQVGGTIIGSARcqafrtr 104
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIVLelHHHYGVRRILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR------- 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 105 eGRLKAAC---NLLQRGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGT 181
Cdd:PRK06830 157 -GPQDPEEivdTLERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS---VIGIPKTIDNDINFI 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsEN 259
Cdd:PRK06830 219 QKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPNGLLAAL-EK 297
                        250
                 ....*....|....*.
gi 530392191 260 RARKKRLNIIIVAEGA 275
Cdd:PRK06830 298 RLAERGHAVIVVAEGA 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
413-699 9.85e-19

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 88.59  E-value: 9.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 413 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGT-KRVLPGKY- 487
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTtNKGDPFAFp 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 488 ---------LEEIATQMRTHSINALLIIGGfeayksacD--MAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGL 556
Cdd:PRK14071  87 mpdgslrdrSQEIIDGYHSLGLDALIGIGG--------DgsLAILRRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 557 NAVVETCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIrdlqsnvEHLTEKMKTTIQRG--- 633
Cdd:PRK14071 159 NIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknf 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 634 -LVLRNESC----SENYTTDF---------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 697
Cdd:PRK14071 231 cLVVVSEAVrteeGEQVTKTQalgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLI 310

                 ..
gi 530392191 698 TA 699
Cdd:PRK14071 311 AQ 312
PLN02564 PLN02564
6-phosphofructokinase
29-275 3.99e-16

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 82.10  E-value: 3.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  29 VLTSGGDAQGMNAAVRAVVrMGI---YVGAKVYFIYEGYQGMVdgGSNIAEADWESVSSILQVGGTIIGSARcqafrTRE 105
Cdd:PLN02564  92 IVTCGGLCPGLNTVIREIV-CGLsymYGVTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSR-----GGH 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 106 GRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGTDMTI 185
Cdd:PLN02564 164 DTSKIVDSIQDRGINQVYIIGGDGTQKGASV-------IYEEIRRRG-------LKVA---VAGIPKTIDNDIPVIDKSF 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 186 GTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALAC-GADWVFLPESP----PEEGWEEQMCVKLSEN 259
Cdd:PLN02564 227 GFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKEN 306
                        250
                 ....*....|....*.
gi 530392191 260 RARkkrlnIIIVAEGA 275
Cdd:PLN02564 307 GHM-----VIVVAEGA 317
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
157-335 3.42e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 78.36  E-value: 3.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 157 EAVQKYAY-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCGYLALVSA 229
Cdd:PRK14072 124 QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAGWLAAAAA 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 230 LAC-----GADWVFLPESPPEegwEEQMCVKLSENRARKKRLnIIIVAEGAIDTQNKPITSEK----------------- 287
Cdd:PRK14072 201 LAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaqlggvapv 276
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530392191 288 IKELVVTQLGYDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 335
Cdd:PRK14072 277 LANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
PLN02884 PLN02884
6-phosphofructokinase
28-367 7.33e-15

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 77.54  E-value: 7.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  28 GVLTSGGDAQGMNAAVRAVV-RMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAfRTREg 106
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRGGA-KTSD- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 107 rlkAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleelarngqIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:PLN02884 135 ---IVDSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFG 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 187 TDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsENRARKK 264
Cdd:PLN02884 195 FDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHL-EHLIETK 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 265 RLNIIIVAEGA-IDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS-----------------AFDRILASRMG 326
Cdd:PLN02884 274 GSAVVCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLG 353
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 530392191 327 VEAVIAlleATPDTPACVVSLNGNHAVRLPLMECVQMTQDV 367
Cdd:PLN02884 354 QNAVHG---AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
413-591 6.76e-11

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 65.45  E-value: 6.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 413 VAVINVGAPAAGMNAAVRSAVRVGIADGH--RMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEE 490
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR--GGFDPKV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 491 IATQMRTHSINALLIIGGFEAYKSACDMA-EARGRHQElcIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQS 569
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGGDGTHRGALAIYkELRRRKLN--ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVE 245
                        170       180
                 ....*....|....*....|..
gi 530392191 570 ASGTKRRVFIIETMGGYCGYLA 591
Cdd:PTZ00286 246 AKSAKNGVGIVKLMGRDSGFIA 267
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
25-231 1.17e-10

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 64.26  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIY--EGYQGMVDGGS-NIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIERYTEIAPEVEIIAyrSGYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVKLT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 102 RT---------REGR--LKAACNLLQR-GITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavqkYAyLNVVG 169
Cdd:PRK06555  84 NVadcvkrglvKEGEnpLKVAAERLAAdGVDILHTIGGDDTNTTA-------ADLAAYLAENG---------YD-LTVVG 146
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530392191 170 MVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALA 231
Cdd:PRK06555 147 LPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARA 209
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
27-277 5.81e-06

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 50.04  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   27 IGVLTSGGDAQGMNAAVRavvrmGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSIL-----QVGG-TIIGSARCQA 100
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGKV 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  101 fRTREGRLKAACNLLQRGITNLCVIGGDGSLTGAnlfrkewsGLLEELARNGQIDkeavqkyayLNVVGMVGSIDNDFC- 179
Cdd:PTZ00287  255 -RNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKs 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  180 -GTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVK-- 255
Cdd:PTZ00287  317 eAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSLKDIVSni 396
                         250       260
                  ....*....|....*....|....*
gi 530392191  256 ---LSENRARKKRLNIIIVAEGAID 277
Cdd:PTZ00287  397 vntILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
25-305 1.16e-05

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 49.20  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   25 KAIGVLTSGGDAQGMNAAVRAVVRmgiYV-----GAKVYFIYEGYQGMVDggSNIAEADWESVSSILQVGG-TIIGSARc 98
Cdd:PTZ00468  103 RRIGVVLSGGQASGGHNVIAGLMS---YIklcnqSSQLFGFLGGPEGVYS--ERYRELTEDDINGILNQGGfNIICSGR- 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191   99 QAFRTREgRLKAACNLLQR-GITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavqkyAYLNVVGMVGSIDND 177
Cdd:PTZ00468  177 HKIETEE-QMRASLEICEKlKLHGLVVIGGDDSNTNAAV-------LAEYFKRNS----------SSTVVVGCPKTIDGD 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  178 FCG--TDMTIGTDSALHRIIEVVDAIMTTAQSHQ-RTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWE----- 249
Cdd:PTZ00468  239 LKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSlmsiv 318
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530392191  250 EQMCVKLSENRARKKRLNIIIVAEGAIDTqnKPITSEKIKELVVTQLGYDTRVTIL 305
Cdd:PTZ00468  319 DEIVEMILKRDSLGKKHGIVLLPEGLIEF--IPEFETLIKELNLILLKTNDRKQII 372
PLN02564 PLN02564
6-phosphofructokinase
424-591 7.51e-05

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 45.89  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 424 GMNAAVRSAVrVGIADG---HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEEIATQMRTHSI 500
Cdd:PLN02564 101 GLNTVIREIV-CGLSYMygvTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSR--GGHDTSKIVDSIQDRGI 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 501 NALLIIGGFEAYKSACDMAEaRGRHQELCIPLCVVPATISNNVPGTEISLGSDTglnAVVETCDRIKQS---ASGTKRRV 577
Cdd:PLN02564 178 NQVYIIGGDGTQKGASVIYE-EIRRRGLKVAVAGIPKTIDNDIPVIDKSFGFDT---AVEEAQRAINAAhveAESVENGI 253
                        170
                 ....*....|....
gi 530392191 578 FIIETMGGYCGYLA 591
Cdd:PLN02564 254 GLVKLMGRYSGFIA 267
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
27-230 1.48e-03

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 41.83  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  27 IGVLTSGGDAQG-MNaavravVRMGIYVGAKVY--------FIyEGYQGMVDGgsNIAEADWESVSSILQVGG-TIIGSA 96
Cdd:PRK07085  73 VGVILSGGQAPGgHN------VIAGLFDGLKKLnpdsklfgFI-GGPLGLLNG--KYIEITEEVIDEYRNTGGfDMIGSG 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191  97 RCQaFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavqkyAYLNVVGMVGSIDN 176
Cdd:PRK07085 144 RTK-IETEEQKEACLETVKKLKLDGLVIIGGDDSNTNAAI-------LAEYFAKHG----------CKTQVIGVPKTIDG 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530392191 177 DFCGT--DMTIGTDSALHRIIEVVDAIMTTAQSHQRT--FVlEVMGRHCGYLALVSAL 230
Cdd:PRK07085 206 DLKNEfiETSFGFDTATKTYSEMIGNISRDALSAKKYwhFI-KLMGRSASHIALECAL 262
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
488-591 6.43e-03

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 39.61  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392191 488 LEEIATQMRTHSINALLIIGGFEAYKSACDMAEARGRHQelcIPLCVV--PATISNNVPGTEISLGSDTGLNAVVETCDR 565
Cdd:PRK06555 101 LKVAAERLAADGVDILHTIGGDDTNTTAADLAAYLAENG---YDLTVVglPKTIDNDVVPIRQSLGAWTAAEQGARFFDN 177
                         90       100
                 ....*....|....*....|....*.
gi 530392191 566 IKQSASGTKRRVFIIETMGGYCGYLA 591
Cdd:PRK06555 178 VINEHSANPRMLIIHEVMGRNCGWLT 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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