|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
783-892 |
1.35e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
:
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 530423356 863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
286-375 |
1.57e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
:
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 530423356 366 CGLGGKLVLP 375
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 super family |
cl27231 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
31-652 |
2.15e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
The actual alignment was detected with superfamily member COG5215:
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 530423356 613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| Importin_rep_5 super family |
cl40106 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1023-1069 |
3.09e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
The actual alignment was detected with superfamily member pfam18816:
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.09e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 530423356 1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
937-984 |
6.39e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
:
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.39e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 530423356 937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
783-892 |
1.35e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 530423356 863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
286-375 |
1.57e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 530423356 366 CGLGGKLVLP 375
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
31-652 |
2.15e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 530423356 613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
390-444 |
4.16e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.52 E-value: 4.16e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 530423356 390 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 444
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1023-1069 |
3.09e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.09e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 530423356 1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
937-984 |
6.39e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.39e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 530423356 937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
783-892 |
1.35e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 530423356 863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
286-375 |
1.57e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 530423356 366 CGLGGKLVLP 375
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
31-652 |
2.15e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 530423356 613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
390-444 |
4.16e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.52 E-value: 4.16e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 530423356 390 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 444
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
370-484 |
9.37e-09 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 55.02 E-value: 9.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 370 GKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfa 449
Cdd:COG1413 41 GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGD--- 107
|
90 100 110
....*....|....*....|....*....|....*
gi 530423356 450 pgfqkkfhEKVIAALLQTMEDQgNQRVQAHAAAAL 484
Cdd:COG1413 108 --------PAAVPALLEALKDP-DWEVRRAAARAL 133
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
379-502 |
5.58e-08 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 52.71 E-value: 5.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 379 EHIMQMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhE 458
Cdd:COG1413 19 PALIAALADEDPDVRAAAARALGRLGDP----------RAVPALLEALKDPDPEVRAAAAEALGRIGD-----------P 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 530423356 459 KVIAALLQTMEDQgNQRVQAHAAAALINFTEDCPKSLLIPYLDN 502
Cdd:COG1413 78 EAVPALIAALKDE-DPEVRRAAAEALGRLGDPAAVPALLEALKD 120
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
383-484 |
1.34e-07 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 50.41 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 383 QMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIA 462
Cdd:pfam13646 7 ALLRDPDPEVRAAAIRALGRIGDP----------EAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65
|
90 100
....*....|....*....|..
gi 530423356 463 ALLQTMEDQGNQRVQAHAAAAL 484
Cdd:pfam13646 66 ALLELLRDDDDDVVRAAAAEAL 87
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1023-1069 |
3.09e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.09e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 530423356 1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| Vac14_Fab1_bd |
pfam12755 |
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ... |
392-440 |
1.42e-05 |
|
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
Pssm-ID: 403838 Cd Length: 97 Bit Score: 44.89 E-value: 1.42e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 530423356 392 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNA 440
Cdd:pfam12755 2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
393-502 |
9.01e-05 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 43.46 E-value: 9.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423356 393 RHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMAtdfapgfqkkfHEKVIAALLQTMEDQg 472
Cdd:COG1413 2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDP- 59
|
90 100 110
....*....|....*....|....*....|
gi 530423356 473 NQRVQAHAAAALINFTEDCPKSLLIPYLDN 502
Cdd:COG1413 60 DPEVRAAAAEALGRIGDPEAVPALIAALKD 89
|
|
| HEAT |
pfam02985 |
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ... |
418-445 |
5.56e-04 |
|
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).
Pssm-ID: 460773 Cd Length: 31 Bit Score: 38.28 E-value: 5.56e-04
10 20
....*....|....*....|....*...
gi 530423356 418 IVNFVLLFLQDPHPRVRYAACNAVGQMA 445
Cdd:pfam02985 1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
937-984 |
6.39e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.39e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 530423356 937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
431-487 |
1.18e-03 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.12 E-value: 1.18e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 530423356 431 PRVRYAACNAVGQMAtDFAPGFQKKFHEKVIAALLQTMEDqGNQRVQAHAAAALINF 487
Cdd:pfam13513 1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
379-445 |
1.43e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 40.00 E-value: 1.43e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530423356 379 EHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMA 445
Cdd:COG1413 81 PALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
|
|
| IBN_N |
pfam03810 |
Importin-beta N-terminal domain; |
62-112 |
2.69e-03 |
|
Importin-beta N-terminal domain;
Pssm-ID: 397745 [Multi-domain] Cd Length: 72 Bit Score: 37.60 E-value: 2.69e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 530423356 62 FLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELL 112
Cdd:pfam03810 17 KLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKNSLPPEEKEQIKNNLL 67
|
|
| HEAT |
pfam02985 |
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ... |
924-953 |
5.44e-03 |
|
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).
Pssm-ID: 460773 Cd Length: 31 Bit Score: 35.58 E-value: 5.44e-03
10 20 30
....*....|....*....|....*....|
gi 530423356 924 FLRPMLQYVCDNSPEVRQAAAYGLGVMAQY 953
Cdd:pfam02985 1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
|
|
| |
