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Conserved domains on  [gi|530423457|ref|XP_005254154|]
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testis-expressed protein 30 isoform X1 [Homo sapiens]

Protein Classification

COG3571 superfamily protein( domain architecture ID 1903980)

COG3571 superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3571 super family cl43903
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 2.07e-32

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


The actual alignment was detected with superfamily member COG3571:

Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 116.52  E-value: 2.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571   11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  96 VFLGGRSMGSRAAasvmCHIEPDDGDdfVRGLICISYPLHHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571   82 LVIGGKSMGGRVA----SMLAAEGGG--AAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530423457 176 qkMQAPHKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571  156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 2.07e-32

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 116.52  E-value: 2.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571   11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  96 VFLGGRSMGSRAAasvmCHIEPDDGDdfVRGLICISYPLHHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571   82 LVIGGKSMGGRVA----SMLAAEGGG--AAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530423457 176 qkMQAPHKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571  156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 1.36e-25

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 98.43  E-value: 1.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKSVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   97 FLGGRSMGSRAAAsvmcHIEPDDGddfVRGLICISYPLHHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVAS----LLADDSG---VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 530423457  177 KMQAPHKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 2.07e-32

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 116.52  E-value: 2.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571   11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  96 VFLGGRSMGSRAAasvmCHIEPDDGDdfVRGLICISYPLHHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571   82 LVIGGKSMGGRVA----SMLAAEGGG--AAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530423457 176 qkMQAPHKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571  156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 1.36e-25

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 98.43  E-value: 1.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKSVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   97 FLGGRSMGSRAAAsvmcHIEPDDGddfVRGLICISYPLHHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVAS----LLADDSG---VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 530423457  177 KMQAPHKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
35-192 1.48e-10

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 58.64  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  35 THGasGDMNLPHLMSLASHLASHGFFCLRF----TCK--GlnivhrikAY----------KSVLNYLKTSGeykLAGVFL 98
Cdd:COG2945   34 LFG--GTMDNKVVYTLARALVAAGFAVLRFnfrgVGRseG--------EFdegrgelddaAAALDWLRAQN---PLPLWL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  99 GGRSMGSRAAASVMCHIEPddgddfVRGLICISYPLHHpkqqhkLRDEDLFRLKEPVLFVSGSADEMCEKNLLEKVAQKM 178
Cdd:COG2945  101 AGFSFGAYVALQLAMRLPE------VEGLILVAPPVNR------YDFSFLAPCPAPTLVIHGEQDEVVPPAEVLDWARPL 168

                        170
                 ....*....|....
gi 530423457 179 QAPHKIHWIEKANH 192
Cdd:COG2945  169 SPPLPVVVVPGADH 182
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-194 1.53e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 58.86  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   1 MSHTEVKLKIPFGNKLlDAVCLVPNKSLTYGIILTHGASGDMNlpHLMSLASHLASHGFFCLRF-------TCKGLNIVH 73
Cdd:COG2267    1 MTRRLVTLPTRDGLRL-RGRRWRPAGSPRGTVVLVHGLGEHSG--RYAELAEALAAAGYAVLAFdlrghgrSDGPRGHVD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  74 RIKAY----KSVLNYLKTSGEYKlagVFLGGRSMGSRAAASVMchiepDDGDDFVRGLICIS-----YPLHHPKQQHkLR 144
Cdd:COG2267   78 SFDDYvddlRAALDALRARPGLP---VVLLGHSMGGLIALLYA-----ARYPDRVAGLVLLApayraDPLLGPSARW-LR 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530423457 145 D----EDLFRLKEPVLFVSGSADEMCEKNLLEKVAQKMQAPHKIHWIEKANHSM 194
Cdd:COG2267  149 AlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHEL 202
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-203 8.03e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 51.12  E-value: 8.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  31 GIILTHGASGdMNlPHLMSLASHLASHGFFCL---RFTCKGLN-----------------IVHRIKAyksVLNYLKTSGE 90
Cdd:COG0412   31 GVVVLHEIFG-LN-PHIRDVARRLAAAGYVVLapdLYGRGGPGddpdearalmgaldpelLAADLRA---ALDWLKAQPE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  91 YKLAGVFLGGRSMGSRAAASVMCHiEPDdgddfVRGLICIsyplhHPKQQHKLRDEDLFRLKEPVLFVSGSADEMCEKNL 170
Cdd:COG0412  106 VDAGRVGVVGFCFGGGLALLAAAR-GPD-----LAAAVSF-----YGGLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQ 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530423457 171 LEKVAQKMQA---PHKIHWIEKANHSMAVKGRSTND 203
Cdd:COG0412  175 VAALEAALAAagvDVELHVYPGAGHGFTNPGRPRYD 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
32-208 1.47e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.40  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  32 IILTHGASGDMNlPHLMSLASHLASHGFFCLRF------TCKGLNIVHRIKAYKSVLNYLKTSGEYKLAGVFLGGRSMGS 105
Cdd:COG1506   26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPdyrgygESAGDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457 106 RAAASVMCHiepddGDDFVRGLICIS------------YPLHHPKQQHKLRDEDLF----------RLKEPVLFVSGSAD 163
Cdd:COG1506  105 YMALLAAAR-----HPDRFKAAVALAgvsdlrsyygttREYTERLMGGPWEDPEAYaarsplayadKLKTPLLLIHGEAD 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530423457 164 EMCEKNLLEKVAQKMQA---PHKIHWIEKANHSMAvkGRSTNDVFKEI 208
Cdd:COG1506  180 DRVPPEQAERLYEALKKagkPVELLVYPGEGHGFS--GAGAPDYLERI 225
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
30-221 8.43e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 45.32  E-value: 8.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  30 YGIILTHGASGDMNlpHLMSLASHLASHGFFCLRFTCKG-------LNIVHRIKAYKSV---LNYLKTSGEYklagVFLG 99
Cdd:COG1647   16 KGVLLLHGFTGSPA--EMRPLAEALAKAGYTVYAPRLPGhgtspedLLKTTWEDWLEDVeeaYEILKAGYDK----VIVI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457 100 GRSMGSrAAASVMCHIEPDdgddfVRGLICIS------------------------------------------YPLHHP 137
Cdd:COG1647   90 GLSMGG-LLALLLAARYPD-----VAGLVLLSpalkiddpsapllpllkylarslrgigsdiedpevaeyaydrTPLRAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457 138 KQQHKLRDE---DLFRLKEPVLFVSGSADEMCEKNLLEKVAQKMQAPHK-IHWIEKANHSMAVkGRSTNDVFKEINTqil 213
Cdd:COG1647  164 AELQRLIREvrrDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKeLVWLEDSGHVITL-DKDREEVAEEILD--- 239


                 ....*...
gi 530423457 214 fWIQEITE 221
Cdd:COG1647  240 -FLERLAA 246
DLH pfam01738
Dienelactone hydrolase family;
82-200 3.89e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 40.03  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457   82 LNYLKTSGEYKLAGVFLGGRSMGSRAAASVMCHIEPDDGddfvrgliCISYPLHHPKQQHKLRDedlfRLKEPVLFVSGS 161
Cdd:pfam01738  84 VNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDA--------AVGFYGVGPEPPLIEAP----DIKAPILFHFGE 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530423457  162 ADEMCEKNLLEKVAQKM---QAPHKIHWIEKANHSMAVKGRS 200
Cdd:pfam01738 152 EDHFVPADSRELIEEALkaaNVDHQIHSYPGAGHAFANDSRP 193
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
32-215 9.80e-04

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 39.32  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  32 IILTHGASGDMNLphLMSLASHLASHGFFC-------------------LRFTCKGLNIVHRIKAYKSVLNYLKTSGEYK 92
Cdd:COG4188   65 VVLSHGLGGSREG--YAYLAEHLASHGYVVaapdhpgsnaadlsaaldgLADALDPEELWERPLDLSFVLDQLLALNKSD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457  93 --LAG------VFLGGRSMGSRAAASVM-CHIEPDDGDDF---VRGLICISYPLHHPKQQhkLRD--------------- 145
Cdd:COG4188  143 ppLAGrldldrIGVIGHSLGGYTALALAgARLDFAALRQYcgkNPDLQCRALDLPRLAYD--LRDprikavvalapggsg 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423457 146 ----EDLFRLKEPVLFVSGSADEMcEKNLLE--KVAQKMQAPHK-IHWIEKANHSM---------------AVKGRSTND 203
Cdd:COG4188  221 lfgeEGLAAITIPVLLVAGSADDV-TPAPDEqiRPFDLLPGADKyLLTLEGATHFSfldpctpgaailpepDPPGPDRAA 299

                        250
                 ....*....|...
gi 530423457 204 VFKEINTQIL-FW 215
Cdd:COG4188  300 IHEYLNALSLaFF 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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