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Conserved domains on  [gi|530408016|ref|XP_005255355|]
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uncharacterized protein C16orf96 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 709-899 1.69e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


:

Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.81  E-value: 1.69e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   709 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 788
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   789 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 868
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 530408016   869 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 899
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 286-436 6.91e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247 2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                  ....*.
gi 530408016  431 GSLWPR 436
Cdd:PHA03247 2998 GHSLSR 3003
penta_MxKDx super family cl11830
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 481-532 3.32e-04

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


The actual alignment was detected with superfamily member TIGR02953:

Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 40.21  E-value: 3.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530408016   481 DRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 532
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
RRM_SF super family cl17169
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ...
 248-284 5.66e-04

RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).


The actual alignment was detected with superfamily member cd12517:

Pssm-ID: 473069 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530408016  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517    40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
 
Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 709-899 1.69e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.81  E-value: 1.69e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   709 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 788
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   789 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 868
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 530408016   869 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 899
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 PHA03247
large tegument protein UL36; Provisional
 286-436 6.91e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247 2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                  ....*.
gi 530408016  431 GSLWPR 436
Cdd:PHA03247 2998 GHSLSR 3003
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 283-427 3.53e-07

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 52.68  E-value: 3.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   283 YEVPELLPEGSSAQ--AVSLSRAQEPAQ-----PPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLeLEPVPALGPVPG 355
Cdd:pfam15822    1 FSLADALPEQSPAKtsAVSNPKPGQPPQgwpgsNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGM-YPSIPLTGPSPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   356 P---------SVTPGSLPAPWPVL-GPVPaPGAQPPPLGDWPALPRRW--------PLPQG-WPRVGSWPlWDLGV---- 412
Cdd:pfam15822   80 PpapfppsgpSCPPPGGPYPAPTVpGPGP-IGPYPTPNMPFPELPRPYgaptdpaaAAPSGpWGSMSSGP-WAPGMggqy 157

                          170
                   ....*....|....*
gi 530408016   413 LRPTQPQPSRAPPPA 427
Cdd:pfam15822  158 PAPNMPYPSPGPYPA 172
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 326-538 1.06e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 46.05  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  326 PGPA----PGTEPVPGLELGLELEPVPALGPVP----GPSVTPGSLPAPWPV--LGPVPAPGAQPPPLGDWPALPRRWPL 395
Cdd:NF038329  122 PGPAgpagPAGEQGPRGDRGETGPAGPAGPPGPqgerGEKGPAGPQGEAGPQgpAGKDGEAGAKGPAGEKGPQGPRGETG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  396 PQGwPRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGE--ENDVPSLRGLRERA 473
Cdd:NF038329  202 PAG-EQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDrgEAGPDGPDGKDGER 280

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408016  474 RKDGAP-KDRTR-KDGVPkdrgGKDvDPKDRAHKDDVPKDRGgKDGDP-KD----RVGKDGAPKEAQPKAPQ 538
Cdd:NF038329  281 GPVGPAgKDGQNgKDGLP----GKD-GKDGQNGKDGLPGKDG-KDGQPgKDglpgKDGKDGQPGKPAPKTPE 346
penta_MxKDx TIGR02953
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 481-532 3.32e-04

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 40.21  E-value: 3.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530408016   481 DRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 532
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 245-541 4.61e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 44.28  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  245 EQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGctTEF 324
Cdd:COG5180   212 EEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPGLPVLEAG--SEP 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  325 APGPAPGTEPVPGLELGLELEPvPALGPV-PGPSVTPGSLPAPwpvLGPVPAPGAQPPPLGDWPALPRRWPLPQGwprvg 403
Cdd:COG5180   290 QSDAPEAETARPIDVKGVASAP-PATRPVrPPGGARDPGTPRP---GQPTERPAGVPEAASDAGQPPSAYPPAEE----- 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  404 swplwdlgvLRPTQPQPSRAPPPATEFGSlwPRPLQPY----QSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAP 479
Cdd:COG5180   361 ---------AVPGKPLEQGAPRPGSSGGD--GAPFQPPngapQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAA 429

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408016  480 KDRTRkdgVPKDRGGKDVdpkdrAHKDDVPKDRGGKDGDPKdrvgkdgAPKEAQPKAPQSAL 541
Cdd:COG5180   430 GGAGQ---GPKADFVPGD-----AESVSGPAGLADQAGAAA-------STAMADFVAPVTDA 476
RRM_RBM27 cd12517
RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup ...
 248-284 5.66e-04

RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup corresponds to the RRM of RBM27 which contains a single RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although the specific function of the RRM in RBM27 remains unclear, it shows high sequence similarity with RRM1of RBM26, which functions as a cutaneous lymphoma (CL)-associated antigen.


Pssm-ID: 409939 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530408016  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517    40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
PRK01156 PRK01156
chromosome segregation protein; Provisional
 715-867 4.14e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.43  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  715 QKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMN-------------KVNK- 780
Cdd:PRK01156  196 NLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEiktaesdlsmeleKNNYy 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  781 STMEEELREKADRSALAGKASRVDLETVA---LELNEMIQGILFKVTIHEDSWKKAmEELSKDvntklvHSDLDPLKKEM 857
Cdd:PRK01156  276 KELEERHMKIINDPVYKNRNYINDYFKYKndiENKKQILSNIDAEINKYHAIIKKL-SVLQKD------YNDYIKKKSRY 348

                         170
                  ....*....|
gi 530408016  858 EEVWKIVRKL 867
Cdd:PRK01156  349 DDLNNQILEL 358
 
Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 709-899 1.69e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.81  E-value: 1.69e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   709 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 788
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   789 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 868
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 530408016   869 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 899
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 PHA03247
large tegument protein UL36; Provisional
 286-436 6.91e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247 2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                  ....*.
gi 530408016  431 GSLWPR 436
Cdd:PHA03247 2998 GHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
 290-444 6.45e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  290 PEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPV 369
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  370 LGPVPAPGAQPPPLGDW------------PALP-----RRWPLPQGWPRVGSWPLWDLGVLRPTQPQ-PSRAPPPATEFG 431
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVrrrppsrspaakPAAParppvRRLARPAVSRSTESFALPPDQPERPPQPQaPPPPQPQPQPPP 2925

                         170
                  ....*....|...
gi 530408016  432 SLWPRPLQPYQSR 444
Cdd:PHA03247 2926 PPQPQPPPPPPPR 2938
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 293-467 1.28e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 56.15  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  293 SSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPgslPAPWPVLGP 372
Cdd:PRK07764  617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA---PAPAAPAAP 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  373 VPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWdlgvlrPTQPQPSRAPPPATE-----FGSLWPRPLQPYQSRQGE 447
Cdd:PRK07764  694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGAS------APSPAADDPVPLPPEpddppDPAGAPAQPPPPPAPAPA 767

                         170       180
                  ....*....|....*....|
gi 530408016  448 ALQLAAVQVKGEENDVPSLR 467
Cdd:PRK07764  768 AAPAAAPPPSPPSEEEEMAE 787
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 301-399 2.54e-07

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 53.74  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  301 SRAQEPAQ---PPALTPESAPGCTTEFAPG--PAPGTEPVPGLELGlelEPVPALGPVPGPS-VTPGSLPAPWPVLGPVP 374
Cdd:PHA03201    6 SRSPSPPRrpsPPRPTPPRSPDASPEETPPspPGPGAEPPPGRAAG---PAAPRRRPRGCPAgVTFSSSAPPRPPLGLDD 82

                          90       100
                  ....*....|....*....|....*
gi 530408016  375 APGAQPPPLgDWPALPRRWPLPQGW 399
Cdd:PHA03201   83 APAATPPPL-DWTEFRRRFLVGDAW 106
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
285-487 2.76e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 54.88  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  285 VPELLPEGSSAQAVSLSRAQ---EPAQPPALTPESAPGCTTEFAPGPAPgtEPVPGLELGLELEPVPALGPVPGPSVTPG 361
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAppaAPAAAPAAAAAARAVAAAPARRSPAP--EALAAARQASARGPGGAPAPAPAPAAAPA 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  362 SLPAPwpvlgpvPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSR-APPPATEFGSLWPRPLQP 440
Cdd:PRK12323  460 AAARP-------AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQpDAAPAGWVAESIPDPATA 532

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 530408016  441 YQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDG 487
Cdd:PRK12323  533 DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 283-427 3.53e-07

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 52.68  E-value: 3.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   283 YEVPELLPEGSSAQ--AVSLSRAQEPAQ-----PPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLeLEPVPALGPVPG 355
Cdd:pfam15822    1 FSLADALPEQSPAKtsAVSNPKPGQPPQgwpgsNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGM-YPSIPLTGPSPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   356 P---------SVTPGSLPAPWPVL-GPVPaPGAQPPPLGDWPALPRRW--------PLPQG-WPRVGSWPlWDLGV---- 412
Cdd:pfam15822   80 PpapfppsgpSCPPPGGPYPAPTVpGPGP-IGPYPTPNMPFPELPRPYgaptdpaaAAPSGpWGSMSSGP-WAPGMggqy 157

                          170
                   ....*....|....*
gi 530408016   413 LRPTQPQPSRAPPPA 427
Cdd:pfam15822  158 PAPNMPYPSPGPYPA 172
PHA03378 PHA03378
EBNA-3B; Provisional
 286-422 5.00e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.30  E-value: 5.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGS-LP 364
Cdd:PHA03378  697 PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGApTP 776

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408016  365 APWPVLGPVP------APGAQPPPLGDWPAL---PRRWPLPQGWPRVGSWPLWDLGVL--RPTQPQPSR 422
Cdd:PHA03378  777 QPPPQAPPAPqqrprgAPTPQPPPQAGPTSMqlmPRAAPGQQGPTKQILRQLLTGGVKrgRPSLKKPAA 845
PHA03378 PHA03378
EBNA-3B; Provisional
 288-467 5.87e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.92  E-value: 5.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  288 LLPEGSSAQAVSLSRAQEPAQPPALTPESAPgcttefAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPW 367
Cdd:PHA03378  685 LPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQ------RPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  368 PVLGPVPAPGAQPPPLGDWPAlPRRWPLPQGWPRVGswplwdlgvlrPTQPQPSRAPPPATEFGslwprPLQPYQSRQGE 447
Cdd:PHA03378  759 AAPGRARPPAAAPGAPTPQPP-PQAPPAPQQRPRGA-----------PTPQPPPQAGPTSMQLM-----PRAAPGQQGPT 821

                         170       180
                  ....*....|....*....|
gi 530408016  448 ALQLAAVQVKGEENDVPSLR 467
Cdd:PHA03378  822 KQILRQLLTGGVKRGRPSLK 841
PHA03378 PHA03378
EBNA-3B; Provisional
 306-442 7.44e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 7.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  306 PAQPPALTPESAPGCTTEFAPGPA------PGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQ 379
Cdd:PHA03378  651 PHQPPQVEITPYKPTWTQIGHIPYqpsptgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAA 730

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530408016  380 PPPLGDWPALPRRWPLPQGWPrvgswplwdlGVLRPTQPQPSRAPPPATEFGSlwPRPLQPYQ 442
Cdd:PHA03378  731 PGRARPPAAAPGRARPPAAAP----------GRARPPAAAPGRARPPAAAPGA--PTPQPPPQ 781
PHA03378 PHA03378
EBNA-3B; Provisional
 307-482 1.31e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 52.76  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  307 AQPPALTPESAP-GCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGD 385
Cdd:PHA03378  667 TQIGHIPYQPSPtGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  386 WPALPRRWPLPQGWPRVGSWPLWDLGvlRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGeALQLAAVQVKGEENDVPS 465
Cdd:PHA03378  747 PAAAPGRARPPAAAPGRARPPAAAPG--APTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPT-SMQLMPRAAPGQQGPTKQ 823

                         170
                  ....*....|....*...
gi 530408016  466 -LRGLRERARKDGAPKDR 482
Cdd:PHA03378  824 iLRQLLTGGVKRGRPSLK 841
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 249-463 3.60e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  249 EAALAQTTKYLEatRAIQVSEPVQNPQllqtvwhyevpellPEGSSAQAVSLSRAQEPAQP-PALTPESAPGCTTEFAPG 327
Cdd:PRK07764  371 ERGLLARLERLE--RRLGVAGGAGAPA--------------AAAPSAAAAAPAAAPAPAAAaPAAAAAPAPAAAPQPAPA 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  328 PAPGTEPvPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPpplgdwpalprrWPLPQGWPRVgswpl 407
Cdd:PRK07764  435 PAPAPAP-PSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPA------------APAPAAAPAA----- 496

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530408016  408 wdlgvlrPTQPQPSRAPPPATEFGSLWPRPLQ--PYQSRQGEALQLAAVQVKGEENDV 463
Cdd:PRK07764  497 -------PAAPAAPAGADDAATLRERWPEILAavPKRSRKTWAILLPEATVLGVRGDT 547
PHA03247 PHA03247
large tegument protein UL36; Provisional
 301-445 4.29e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  301 SRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSLPAPWPVLGP-------V 373
Cdd:PHA03247 2584 SRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPP--------DTHAPDPPPPSPSPAANEPDPHPPPTVPpperprdD 2655

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  374 PAPGAQPPP-----LGDWP---ALPRRWPLPQGWPRVGswPLWDLGVLRPTQPQPSRAPPPATefgSLWPRPLQPYQSRQ 445
Cdd:PHA03247 2656 PAPGRVSRPrrarrLGRAAqasSPPQRPRRRAARPTVG--SLTSLADPPPPPPTPEPAPHALV---SATPLPPGPAAARQ 2730
PHA03247 PHA03247
large tegument protein UL36; Provisional
 226-418 4.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  226 DAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLlqtvwHYEV-------PELLPEGSSAQAV 298
Cdd:PHA03247  295 DGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQ-----HYPLgfpkrrrPTWTPPSSLEDLS 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  299 SLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGlelglelEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPG- 377
Cdd:PHA03247  370 AGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPA-------APVPASVPTPAPTPVPASAPPPPATPLPSAEPGs 442

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 530408016  378 --AQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQP 418
Cdd:PHA03247  443 ddGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEP 485
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 292-434 5.30e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  292 GSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPgtePVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLG 371
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAA---APAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530408016  372 PVPAPGAQPPPLGDWPALPRRWPLPQGWPRvgswplwDLGVLRPTQPQPsrAPPPATEFGSLW 434
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVA-------SAAPAPAAAPAA--ARLTPTEEGDVW 497
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 290-447 1.04e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.60  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  290 PEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLElglelEPVPALGPVPGPSVTPGSLPAPWPV 369
Cdd:PRK07764  632 AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP-----PPAPAPAAPAAPAGAAPAQPAPAPA 706

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408016  370 LGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGvLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGE 447
Cdd:PRK07764  707 ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP-PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-446 2.44e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  270 PVQNPQLLQTVWHYEVPeLLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPA 349
Cdd:PHA03247 2704 PPPTPEPAPHALVSATP-LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  350 LGPVPGPSVTPG--SLPAPWpvlGPVPAPGAQPPPLgdwPALPrrwplPQGWPRVGSWPlwdlgvlrPTQPQPSRAPPPa 427
Cdd:PHA03247 2783 LTRPAVASLSESreSLPSPW---DPADPPAAVLAPA---AALP-----PAASPAGPLPP--------PTSAQPTAPPPP- 2842

                         170
                  ....*....|....*....
gi 530408016  428 tefgslwPRPLQPYQSRQG 446
Cdd:PHA03247 2843 -------PGPPPPSLPLGG 2854
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
248-446 2.87e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESApgcttefAPG 327
Cdd:PRK12323  392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA-------ARP 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  328 PAPGTEPVPGLELGLELEPVPALGPVPGPSVTPgslpaPW---PVLGPVPAPGAQPPPLGDWPAlprrwplpQGWPRVGS 404
Cdd:PRK12323  465 AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-----PWeelPPEFASPAPAQPDAAPAGWVA--------ESIPDPAT 531

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 530408016  405 WPLWDLGVLRPTQPQPSRAPPPATEFGSLWPrPLQPYQSRQG 446
Cdd:PRK12323  532 ADPDDAFETLAPAPAAAPAPRAAAATEPVVA-PRPPRASASG 572
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
290-395 3.97e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  290 PEGSSAQAVSLSRAQEPAQPPALTPESAP---GCTTEFA-PGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPA 365
Cdd:PRK12323  469 PRPVAAAAAAAPARAAPAAAPAPADDDPPpweELPPEFAsPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530408016  366 PWPV--LGPVPAPGAQPPPL----------GDWPALPRRWPL 395
Cdd:PRK12323  549 PAPRaaAATEPVVAPRPPRAsasglpdmfdGDWPALAARLPV 590
PHA03247 PHA03247
large tegument protein UL36; Provisional
 296-427 5.33e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  296 QAVSLSRAQEPAQPP-ALTPESAP---GCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVT-PGSLPAPWPVL 370
Cdd:PHA03247 2666 RARRLGRAAQASSPPqRPRRRAARptvGSLTSLADPPPPPPTPEP--------APHALVSATPLPPGPaAARQASPALPA 2737

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530408016  371 GPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvgSWPLWDlgvlrPTQPQPSRAPPPA 427
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPA--PAPPAA-----PAAGPPRRLTRPA 2787
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 306-445 9.60e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 9.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   306 PAQPPALTPESA-----PGCTTEFAPGPAPGTEPVPglelgleLEPVPALGPVP----GPSVTPGSLPAPWPVLGPVPAP 376
Cdd:pfam03154  183 PPSPPPPGTTQAatagpTPSAPSVPPQGSPATSQPP-------NQTQSTAAPHTliqqTPTLHPQRLPSPHPPLQPMTQP 255

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530408016   377 G--------AQPPPLGDWPALPRRWPLPQGwPRVGSWPLWDLGVLRPTQPQPSRAPPPatefgslwPRPLQPYQSRQ 445
Cdd:pfam03154  256 PppsqvspqPLPQPSLHGQMPPMPHSLQTG-PSHMQHPVPPQPFPLTPQSSQSQVPPG--------PSPAAPGQSQQ 323
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 326-538 1.06e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 46.05  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  326 PGPA----PGTEPVPGLELGLELEPVPALGPVP----GPSVTPGSLPAPWPV--LGPVPAPGAQPPPLGDWPALPRRWPL 395
Cdd:NF038329  122 PGPAgpagPAGEQGPRGDRGETGPAGPAGPPGPqgerGEKGPAGPQGEAGPQgpAGKDGEAGAKGPAGEKGPQGPRGETG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  396 PQGwPRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGE--ENDVPSLRGLRERA 473
Cdd:NF038329  202 PAG-EQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDrgEAGPDGPDGKDGER 280

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408016  474 RKDGAP-KDRTR-KDGVPkdrgGKDvDPKDRAHKDDVPKDRGgKDGDP-KD----RVGKDGAPKEAQPKAPQ 538
Cdd:NF038329  281 GPVGPAgKDGQNgKDGLP----GKD-GKDGQNGKDGLPGKDG-KDGQPgKDglpgKDGKDGQPGKPAPKTPE 346
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 291-396 1.91e-04

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 44.75  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   291 EGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEP-VPGLELGlELEPVPALGPVPGPSVTPG--SLPAPW 367
Cdd:pfam16072  153 SAGSGTTVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPAPAPgAPQTPLA-PLNPVAAAPAAAAGAAAAPvvAAAAPA 231

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 530408016   368 PVLGPVPAPGAqPPPLGDWPA------LPRRWPLP 396
Cdd:pfam16072  232 AAAPPPPAPAA-PPADAAPPApggiicVPVRVPEP 265
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 292-399 2.86e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 44.15  E-value: 2.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   292 GSSAQAVSL---SRAQEPAQPPALTPESAPgctteFAPGPAPgtePVPGlelglelEPVPAlgPVPGPSVTPGSLPAPWP 368
Cdd:pfam07174   25 GASAVAVALpavAHADPEPAPPPPSTATAP-----PAPPPPP---PAPA-------APAPP--PPPAAPNAPNAPPPPAD 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 530408016   369 VLGPVPAPG--AQPPPLGDWPALPR-----------RWPLPQGW 399
Cdd:pfam07174   88 PNAPPPPPAdpNAPPPPAVDPNAPEpgridnavggfSYVVPAGW 131
penta_MxKDx TIGR02953
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 481-532 3.32e-04

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 40.21  E-value: 3.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530408016   481 DRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 532
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 301-540 3.58e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  301 SRAQEPAQPPALTPESAPGCTTEFAPGPAP-GTEPVPGLELGLELEPVPALgpvPGPSVTPGSLPAPWPVLGPVPAPGAQ 379
Cdd:PHA03307   75 PGTEAPANESRSTPTWSLSTLAPASPAREGsPTPPGPSSPDPPPPTPPPAS---PPPSPAPDLSEMLRPVGSPGPPPAAS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  380 PPPLGDWPALPRRwplpqgwprvGSWPLWDLGVLRPTQPQPSRAP-PPATEFGSLWPRP-LQPYQSRQGEALQLAAVqvk 457
Cdd:PHA03307  152 PPAAGASPAAVAS----------DAASSRQAALPLSSPEETARAPsSPPAEPPPSTPPAaASPRPPRRSSPISASAS--- 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  458 geenDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVP-KDRGGKDGDPKDR----VGKDGAPKEA 532
Cdd:PHA03307  219 ----SPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtRIWEASGWNGPSSrpgpASSSSSPRER 294


                  ....*...
gi 530408016  533 QPKAPQSA 540
Cdd:PHA03307  295 SPSPSPSS 302
PHA03379 PHA03379
EBNA-3A; Provisional
 321-474 4.28e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 44.66  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  321 TTEFAPGPAPGTE----PVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPV---LGPVPAPGAQPPPLGDWPALP-RR 392
Cdd:PHA03379  404 ALEKASEPTYGTPrppvEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPLhdqHSMAPCPVAQLPPGPLQDLEPgDQ 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  393 WPLPQGWPRVGSWPLWDLG--VLRPTQPQPSRAP--PPATEF-----GSLWPRPLQPYQSRQGEALQLAAVQVKGEENdv 463
Cdd:PHA03379  484 LPGVVQDGRPACAPVPAPAgpIVRPWEASLSQVPgvAFAPVMpqpmpVEPVPVPTVALERPVCPAPPLIAMQGPGETS-- 561

                         170
                  ....*....|.
gi 530408016  464 pSLRGLRERAR 474
Cdd:PHA03379  562 -GIVRVRERWR 571
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 245-541 4.61e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 44.28  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  245 EQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGctTEF 324
Cdd:COG5180   212 EEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPGLPVLEAG--SEP 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  325 APGPAPGTEPVPGLELGLELEPvPALGPV-PGPSVTPGSLPAPwpvLGPVPAPGAQPPPLGDWPALPRRWPLPQGwprvg 403
Cdd:COG5180   290 QSDAPEAETARPIDVKGVASAP-PATRPVrPPGGARDPGTPRP---GQPTERPAGVPEAASDAGQPPSAYPPAEE----- 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  404 swplwdlgvLRPTQPQPSRAPPPATEFGSlwPRPLQPY----QSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAP 479
Cdd:COG5180   361 ---------AVPGKPLEQGAPRPGSSGGD--GAPFQPPngapQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAA 429

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408016  480 KDRTRkdgVPKDRGGKDVdpkdrAHKDDVPKDRGGKDGDPKdrvgkdgAPKEAQPKAPQSAL 541
Cdd:COG5180   430 GGAGQ---GPKADFVPGD-----AESVSGPAGLADQAGAAA-------STAMADFVAPVTDA 476
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 274-428 5.28e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 5.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   274 PQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPG-------LELGLELEP 346
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPhlsgpspFQMNSNLPP 392

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   347 VPALGPVPGPSV--TPGSLPAP---WPVLGPVPAPGAQPPPLGDWPALP---RRWPLPQGWPRVGSWPLWDLGVLRPTQP 418
Cdd:pfam03154  393 PPALKPLSSLSThhPPSAHPPPlqlMPQSQQLPPPPAQPPVLTQSQSLPppaASHPPTSGLHQVPSQSPFPQHPFVPGGP 472

                          170
                   ....*....|...
gi 530408016   419 Q---PSRAPPPAT 428
Cdd:pfam03154  473 PpitPPSGPPTST 485
RRM_RBM27 cd12517
RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup ...
 248-284 5.66e-04

RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup corresponds to the RRM of RBM27 which contains a single RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although the specific function of the RRM in RBM27 remains unclear, it shows high sequence similarity with RRM1of RBM26, which functions as a cutaneous lymphoma (CL)-associated antigen.


Pssm-ID: 409939 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530408016  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517    40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 293-439 6.37e-04

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 41.95  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   293 SSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLP-APWPVLG 371
Cdd:pfam15240   14 SSAQSSSEDVSQEDSPSLISEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPqGPPPQGG 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530408016   372 PVPAPGAQ---PPPLGDWPALPRRWPLPQGWPRVGSWPLWDLG-VLRPTQPQPSR--APPPATEFGSLWPRPLQ 439
Cdd:pfam15240   94 PRPPPGKPqgpPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGnQQGPPPPPPGNpqGPPQRPPQPGNPQGPPQ 167
RRM1_RBM26 cd12516
RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26); This ...
 248-284 9.73e-04

RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26); This subgroup corresponds to the RRM1 of RBM26, also known as cutaneous T-cell lymphoma (CTCL) tumor antigen se70-2, which represents a cutaneous lymphoma (CL)-associated antigen. It contains two RNA recognition motifs (RRMs), also known as RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The RRMs may play some functional roles in RNA-binding or protein-protein interactions.


Pssm-ID: 409938 [Multi-domain]  Cd Length: 76  Bit Score: 38.84  E-value: 9.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530408016  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12516    40 PEGALIQFATHEEAKRAISSTEAVLNNRFIKVYWHRE 76
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 309-440 1.58e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  309 PPALTPESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVtPGSLPAPWPVLGPVPAPGAQPPPLGDWPA 388
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAP--------VAQAAAAPAPAAAP-AAAASAPAAPPAAAPPAPVAAPAAAAPAA 436

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530408016  389 LPRRWPLPQGWPRVGSWPL--WDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQP 440
Cdd:PRK14951  437 APAAAPAAVALAPAPPAQAapETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
272-423 1.76e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.46  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  272 QNPQLLQTVWHYEVPELLPEGSSAqavslSRAQEPAQP--PALT-PESAPGCTTEFAPGPAPGTEPVPglelglelEPVP 348
Cdd:PRK14971  346 KNKRLLVELTLIQLAQLTQKGDDA-----SGGRGPKQHikPVFTqPAAAPQPSAAAAASPSPSQSSAA--------AQPS 412

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530408016  349 ALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGswplwdLGVLRPTQPQPSRA 423
Cdd:PRK14971  413 APQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLG------PSTLRPIQEKAEQA 481
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
303-537 2.58e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  303 AQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGlELGLELEPVPALGPVPGPSVTPGSLPAP--------WPVLGPVP 374
Cdd:PRK07003  370 GGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTG-AAGAALAPKAAAAAAATRAEAPPAAPAPpatadrgdDAADGDAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  375 APGAQPPPLGDWPALPRRWPLPQGWPRVGSWPlwdlgvlrptqpqPSRAPPPATEFGSLWPRPLQPYQS-RQGEALQLAA 453
Cdd:PRK07003  449 VPAKANARASADSRCDERDAQPPADSGSASAP-------------ASDAPPDAAFEPAPRAAAPSAATPaAVPDARAPAA 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  454 VQvKGEENDVPSLRGLRERARKDGAPKDRTRKDG------VPKDRGGKdvdpkdrahkddVPKDRGGK-DGDPKDRVGKD 526
Cdd:PRK07003  516 AS-REDAPAAAAPPAPEARPPTPAAAAPAARAGGaaaaldVLRNAGMR------------VSSDRGARaAAAAKPAAAPA 582

                         250
                  ....*....|.
gi 530408016  527 GAPKEAQPKAP 537
Cdd:PRK07003  583 AAPKPAAPRVA 593
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 282-543 2.78e-03

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 41.87  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  282 HYE-VPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSvTP 360
Cdd:PHA03321  417 HYEaSLRLLSSRQPPGAPAPRRDNDPPPPPRARPGSTPACARRARAQRARDAGPEYVDPLGALRRLPAGAAPPPEPA-AA 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  361 GSLPAPWPVLGPVPapgaqppplgdwPALPRRWPLPQgwprvgswplwdlgVLRPTQPQPSRAPPPATEFGSLWPRPLQP 440
Cdd:PHA03321  496 PSPATYYTRMGGGP------------PRLPPRNRATE--------------TLRPDWGPPAAAPPEQMEDPYLEPDDDRF 549

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  441 YQSRQGEALQLAAVQVKGEENDVPSLRGLRERARK--DGAPKDRTRKDGVPKDRGGKDVDPKDRA-------HKDDVPKD 511
Cdd:PHA03321  550 DRRDGAAAAATSHPREAPAPDDDPIYEGVSDSEEPvyEEIPTPRVYQNPLPRPMEGAGEPPDLDAptspwveEENPIYGW 629

                         250       260       270
                  ....*....|....*....|....*....|..
gi 530408016  512 RGGKDGDPKDRVGKDGAPKEAQPKAPQSALHR 543
Cdd:PHA03321  630 GDSPLFSPPPAARFPPPDPALSPEPPALPAHR 661
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 332-385 3.81e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 39.08  E-value: 3.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530408016  332 TEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGaqPPPLGD 385
Cdd:PRK05641   33 TYEVEAKGLGIDLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPA--PASAGE 84
PRK01156 PRK01156
chromosome segregation protein; Provisional
 715-867 4.14e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.43  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  715 QKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMN-------------KVNK- 780
Cdd:PRK01156  196 NLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEiktaesdlsmeleKNNYy 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  781 STMEEELREKADRSALAGKASRVDLETVA---LELNEMIQGILFKVTIHEDSWKKAmEELSKDvntklvHSDLDPLKKEM 857
Cdd:PRK01156  276 KELEERHMKIINDPVYKNRNYINDYFKYKndiENKKQILSNIDAEINKYHAIIKKL-SVLQKD------YNDYIKKKSRY 348

                         170
                  ....*....|
gi 530408016  858 EEVWKIVRKL 867
Cdd:PRK01156  349 DDLNNQILEL 358
PHA03247 PHA03247
large tegument protein UL36; Provisional
 299-543 4.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  299 SLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGpSVTPGSLPAPwPVLGPVPapga 378
Cdd:PHA03247 2465 SLSLLLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGG--------PPDPDAPPAPS-RLAPAILPDE-PVGEPVH---- 2530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  379 qppplgdwpalPRRWPLPQGWPRVGSWPLWDlgvlrPTQPQPSRAPPPATEFG----SLWPRPLQPyqsrqgealqlaAV 454
Cdd:PHA03247 2531 -----------PRMLTWIRGLEELASDDAGD-----PPPPLPPAAPPAAPDRSvpppRPAPRPSEP------------AV 2582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  455 QVKGEENDVPSlRGLRERARKD--GAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 532
Cdd:PHA03247 2583 TSRARRPDAPP-QSARPRAPVDdrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661

                         250
                  ....*....|.
gi 530408016  533 QPKAPQSALHR 543
Cdd:PHA03247 2662 SRPRRARRLGR 2672
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 326-435 4.62e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 40.29  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   326 PGPAPgtePVPglelglelePVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPplgdwPALPRRWPLPQGWPRVGSW 405
Cdd:pfam07174   41 PEPAP---PPP---------STATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPP-----PADPNAPPPPPADPNAPPP 103

                           90       100       110
                   ....*....|....*....|....*....|
gi 530408016   406 PLWDlgvlrPTQPQPSRAPPPATEFGSLWP 435
Cdd:pfam07174  104 PAVD-----PNAPEPGRIDNAVGGFSYVVP 128
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-435 5.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  274 PQLLQTVWHYEVPELLPE---GSSAQAVSLSRAQEPAQP---PALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPV 347
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPErppQPQAPPPPQPQPQPPPPPqpqPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  348 PALGPVPGPSVTPgslPAPwpvlgPVPAPGAQPPPLGDWPAlprrwplpqgwPRVGSWPLwDLGVLRPTqpqpsrAPPPA 427
Cdd:PHA03247 2969 PGRVAVPRFRVPQ---PAP-----SREAPASSTPPLTGHSL-----------SRVSSWAS-SLALHEET------DPPPV 3022


                  ....*...
gi 530408016  428 TEFGSLWP 435
Cdd:PHA03247 3023 SLKQTLWP 3030
PRK11633 PRK11633
cell division protein DedD; Provisional
 286-379 5.57e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPgCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSLPA 365
Cdd:PRK11633   64 PTQPPEGAAEAVRAGDAAAPSLDPATVAPPNTP-VEPEPAPVEPPKPKPVE--------KPKPKPKPQQKVEAPPAPKPE 134

                          90
                  ....*....|....
gi 530408016  366 PWPVLGPVPAPGAQ 379
Cdd:PRK11633  135 PKPVVEEKAAPTGK 148
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 272-440 6.11e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 6.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   272 QNPQLLQTVWHYEVPELLPEGSSAQAVSlsrAQEPAQPPALTPESAPGcTTEFAPGPAPGTEPVPGLELGLELEP----- 346
Cdd:pfam03154  169 TQPPVLQAQSGAASPPSPPPPGTTQAAT---AGPTPSAPSVPPQGSPA-TSQPPNQTQSTAAPHTLIQQTPTLHPqrlps 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   347 -----VPALGPVPGPSVTPGSLPAPW--PVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQpQ 419
Cdd:pfam03154  245 phpplQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ-Q 323

                          170       180
                   ....*....|....*....|.
gi 530408016   420 PSRAPPPATEFGSLWPRPLQP 440
Cdd:pfam03154  324 RIHTPPSQSQLQSQQPPREQP 344
PHA03378 PHA03378
EBNA-3B; Provisional
 286-484 8.15e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPG-PAPGTEPVPGLELG---LELEPVP---ALGPVPG--P 356
Cdd:PHA03378  576 PLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPEtSAPRQWPMPLRPIPmrpLRMQPITfnvLVFPTPHqpP 655

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016  357 SVTPGSLPAPWPVLGPVPApgaQPPPLGDWPALPRRWPLpqgwprvgswplwdlGVLRPTQPQPSRAPPPATEFGSLWPR 436
Cdd:PHA03378  656 QVEITPYKPTWTQIGHIPY---QPSPTGANTMLPIQWAP---------------GTMQPPPRAPTPMRPPAAPPGRAQRP 717

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 530408016  437 PLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTR 484
Cdd:PHA03378  718 AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 765
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 286-431 8.45e-03

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 38.31  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408016   286 PELLPEGSSAQAVSLSRAQEPAQPPALtpesaPGCTTEFAPGPAPGTEPVPglelglELEPVPALGPVPGPSVTPGS--L 363
Cdd:pfam06346   25 PPLPGGGGPPPPPPLPGSAAIPPPPPL-----PGGTSIPPPPPLPGAASIP------PPPPLPGSTGIPPPPPLPGGagI 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408016   364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPrvgswplwdlgvLRPTQPQPSRAPPPATEFG 431
Cdd:pfam06346   94 PPPPPPLPGGAGVPPPPPPLPGGPGIPPPPPFPGGPG------------IPPPPPGMGMPPPPPFGFG 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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