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Conserved domains on  [gi|530414522|ref|XP_005259807|]
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zinc finger protein 563 isoform X4 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 9.52e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 9.52e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530414522    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
47-238 1.44e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  47 WEEQNTEDQYKNPRRNLSSYRRHERMHTG-EKPYECKQCSKALPDSSSYIRHERT--HTGE--KPYTC--KQCGKAFSVS 119
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 120 SSLRRHETTHSAEKPYECK--QCGKTFHHLG-----SFQIHMKRHTGDRPHKC--KICGKGFDRPSLVRYHERIHTGEKP 190
Cdd:COG5048  337 DALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530414522 191 YECK--QCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHE 238
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 9.52e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 9.52e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530414522    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 1.31e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 1.31e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530414522   4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 1.40e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 1.40e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530414522     4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
47-238 1.44e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  47 WEEQNTEDQYKNPRRNLSSYRRHERMHTG-EKPYECKQCSKALPDSSSYIRHERT--HTGE--KPYTC--KQCGKAFSVS 119
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 120 SSLRRHETTHSAEKPYECK--QCGKTFHHLG-----SFQIHMKRHTGDRPHKC--KICGKGFDRPSLVRYHERIHTGEKP 190
Cdd:COG5048  337 DALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530414522 191 YECK--QCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHE 238
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-117 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|..
gi 530414522   96 RHERTHTGEKPYTCKQCGKAFS 117
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 9.52e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 9.52e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530414522    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 1.31e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 1.31e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530414522   4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 1.40e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 1.40e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530414522     4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
47-238 1.44e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  47 WEEQNTEDQYKNPRRNLSSYRRHERMHTG-EKPYECKQCSKALPDSSSYIRHERT--HTGE--KPYTC--KQCGKAFSVS 119
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 120 SSLRRHETTHSAEKPYECK--QCGKTFHHLG-----SFQIHMKRHTGDRPHKC--KICGKGFDRPSLVRYHERIHTGEKP 190
Cdd:COG5048  337 DALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530414522 191 YECK--QCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHE 238
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
55-270 1.61e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  55 QYKNPRRNLSSYRRHERMHTGEKPYECKQCSKALPDSSSyirherTHTGEKPYTCKQcGKAFSVSSSLRRHETTHSA-EK 133
Cdd:COG5048  216 SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS------SSASESPRSSLP-TASSQSSSPNESDSSSEKGfSL 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 134 PYECKQCGKTFHHLGSFQIHM--KRHTG--DRPHKCKI--CGKGFDRPSLVRYHERIHTGEKPYECK--QCGKTLSHSSS 205
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530414522 206 FRRHMIMHTGGGPHKCKI-------CGKAFVYPSVCQRHEKSHSGEKPYECK--QCGKALSHSSSFRRHMVMHT 270
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-285 2.35e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 160 DRPHKCKICGKGFDRPSLVRYHERIHTGEKPYEC--KQCGKTLSHSSSFRRHMIMHTGGGPHKC-KICGKAFVYPSVCQR 236
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530414522 237 HEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFV 285
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
57-297 2.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  57 KNPRRNLSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTH-TGEKPYTCKQCGKAFSVSSSLRRHE----TTHSA 131
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLsssdSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 132 EKPYECKQCGKTFHHLGSFQIHMKRHTG-DRPHKCKICGKGFDRPSLVRYHER--IHTGE--KPYEC--KQCGKTLSHSS 204
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 205 SFRRHMIMHTGGGPHKCKIC-------GKAFVYPSVCQRHEKSHSGEKPYEC--KQCGKALSHSSSFRRHMVMHTGDGP- 274
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPy 417

                        250       260
                 ....*....|....*....|....
gi 530414522 275 -NKCKVCGKAFVYPSVCQRHEKTH 297
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-117 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|..
gi 530414522   96 RHERTHTGEKPYTCKQCGKAFS 117
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 3.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 3.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 530414522  205 SFRRHMIMHTGGGPHKCKICGKAFVY 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
65-87 3.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|...
gi 530414522   65 SYRRHERMHTGEKPYECKQCSKA 87
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-150 4.57e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 4.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  50 QNTEDQYKNPRRNLSSYRRhermhtgekPYECKQCSKALPDSSSYIRHERTHTGEKPYTC--KQCGKAFSVSSSLRRHET 127
Cdd:COG5048   14 SVLSSTPKSTLKSLSNAPR---------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLR 84

                         90       100
                 ....*....|....*....|...
gi 530414522 128 THSAEKPYECKQCGKTFHHLGSF 150
Cdd:COG5048   85 THHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-144 5.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.85e-03
                          10        20
                  ....*....|....*....|....
gi 530414522  121 SLRRHETTHSAEKPYECKQCGKTF 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-174 6.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 530414522  149 SFQIHMKRHTGDRPHKCKICGKGFDR 174
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
49-298 6.74e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 6.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  49 EQNTEDQYKNPRRNLSSYR-----RHERMHTGEKPYEC--KQCSKALPDSSSYIRHERTHTGEKPYTCKQCGK--AFSVS 119
Cdd:COG5048   27 LSNAPRPDSCPNCTDSFSRlehltRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKAS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 120 SSLRRHETTHSAEKPYECkQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGF----------------------DRPSL 177
Cdd:COG5048  107 SSSLSSSSSNSNDNNLLS-SHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 178 VRYHERIHTGEKPYECKQCGKTLSHSSSFRRHM----------IMHTGGGPHK------------------CKICGKAFV 229
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQnlensssslpLTTNSQLSPKsllsqspsslsssdssssASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 230 YPSVCQRHEKSHSGE-------KPYECKQCGKALSHSSSFRRHM--VMHTGDG--PNKCKV--CGKAFVYPSVCQRHEKT 296
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRHILL 345


                 ..
gi 530414522 297 HW 298
Cdd:COG5048  346 HT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-278 8.33e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522  85 SKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPHK 164
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414522 165 CKICG------KGFDRPSLVRYHERIHTG-EKPYECKQCGKTLSHSSSFRRHmimhtgggphkckicgkafvYPSVcqrh 237
Cdd:COG5048  257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRH--------------------LRSV---- 312

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 530414522 238 ekSHSGE--KPYEC--KQCGKALSHSSSFRRHMVMHTGDGPNKCK 278
Cdd:COG5048  313 --NHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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