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Conserved domains on  [gi|530399758|ref|XP_005268701|]
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protein NEDD1 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-306 4.68e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 4.68e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  31 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 110
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 111 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 189
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 190 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 268
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530399758 269 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 306
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-306 4.68e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 4.68e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  31 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 110
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 111 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 189
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 190 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 268
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530399758 269 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 306
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
6-306 3.01e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 3.01e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758   6 AVMQENLRFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAE 83
Cdd:COG2319   85 AFSPDGRLLASASADgtVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  84 GQKQ----------TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILH 153
Cdd:COG2319  152 GKLLrtltghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 154 SVTTNLSSTPFGHGSNqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIG 233
Cdd:COG2319  232 DLATGKLLRTLTGHSG-SVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGS 307

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530399758 234 LDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 306
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 180-316 2.64e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 180 FKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 259
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530399758 260 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 316
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-154 3.81e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530399758   115 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 154
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-306 4.68e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 4.68e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  31 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 110
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 111 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 189
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 190 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 268
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530399758 269 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 306
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
6-306 3.01e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 3.01e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758   6 AVMQENLRFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAE 83
Cdd:COG2319   85 AFSPDGRLLASASADgtVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  84 GQKQ----------TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILH 153
Cdd:COG2319  152 GKLLrtltghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 154 SVTTNLSSTPFGHGSNqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIG 233
Cdd:COG2319  232 DLATGKLLRTLTGHSG-SVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGS 307

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530399758 234 LDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 306
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
13-285 6.51e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 6.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  13 RFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIV----VSSCKCkpvpLLELAEGQK 86
Cdd:COG2319  134 TLASGSADgtVRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGKLLASGSD--DGTVrlwdLATGKL----LRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  87 Q-TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFG 165
Cdd:COG2319  206 AvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 166 HGSNqSVRHLKYSLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSS 245
Cdd:COG2319  286 GHSG-GVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 530399758 246 KKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLR 285
Cdd:COG2319  362 GELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
99-306 1.29e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  99 LVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHGSnqSVRHLKY 177
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtGHTG--AVRSVAF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 178 SLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFdSVHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 256
Cdd:COG2319  129 SPDGKTLA-SGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTg 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530399758 257 PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 306
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF 254
WD40 COG2319
WD40 repeat [General function prediction only];
13-201 2.54e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 2.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  13 RFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLvtASSSGDKIV----VSSCKCkpvplLELAEGQK 86
Cdd:COG2319  218 LLASGSADgtVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL--ASGSADGTVrlwdLATGEL-----LRTLTGHS 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  87 Q--TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTN-LSSTP 163
Cdd:COG2319  289 GgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGeLLRTL 368

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530399758 164 FGHGSnqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNS 201
Cdd:COG2319  369 TGHTG--AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-152 8.18e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 8.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  15 ASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIV--VSSCKCkpvplLELAEGQKQ--T 88
Cdd:cd00200  151 ASSSQDgtIKLWDLRTGKCVATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-----LGTLRGHENgvN 223

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530399758  89 CVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIIL 152
Cdd:cd00200  224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-112 1.22e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758  11 NLRFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGdKIVV-SSCKCKPVplLELAEGQKQ 87
Cdd:cd00200  189 GEKLLSSSSDgtIKLWDLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSEDG-TIRVwDLRTGECV--QTLSGHTNS 263

                         90       100
                 ....*....|....*....|....*.
gi 530399758  88 -TCVNLNSTSMYLVSGGLNNTVNIWD 112
Cdd:cd00200  264 vTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 180-316 2.64e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 180 FKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 259
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530399758 260 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 316
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
132-295 5.26e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 132 VTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDsV 211
Cdd:COG3391   30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-V 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399758 212 HKAPaSGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGK-----IYQYDLRM 286
Cdd:COG3391  109 GGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187


                 ....*....
gi 530399758 287 LKsPVKTIS 295
Cdd:COG3391  188 GK-VVATIP 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-154 3.81e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530399758   115 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 154
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 217-286 9.07e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 9.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530399758 217 SGICF-SPVNELLFVTIGLDKRIILYDTSSKK--LVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRM 286
Cdd:cd22857  182 TDLTFlSKDDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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