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Conserved domains on  [gi|545833264|ref|XP_005656040|]
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MORN repeat-containing protein 1 isoform X2 [Sus scrofa]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.15e-43

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.80  E-value: 2.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  24 QDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCRHWAlSGNTYTGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 104 KAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 545833264 184 RGVFSGLGNMAHCSGVVYRGIWIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.15e-43

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.80  E-value: 2.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  24 QDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCRHWAlSGNTYTGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 104 KAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 545833264 184 RGVFSGLGNMAHCSGVVYRGIWIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 58-208 2.23e-26

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 111.46  E-value: 2.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  58 DGSYYEGEFAEGEITGEGCRHWAlSGNTYTGQFVLGEPQGHGVMKYKAGGRYEGELSHGMREGHGHLVDADGQVYWGSFH 137
Cdd:PLN03185   7 NGDFYSGSLLGNVPEGPGKYLWS-DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWR 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545833264 138 KNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWHRGVFSGLGNMAHCSGVVYRGIWING 208
Cdd:PLN03185  86 LNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 155-177 6.46e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.62  E-value: 6.46e-04
                          10        20
                  ....*....|....*....|...
gi 545833264  155 YEGDWVQGQRQGHGVLRRADGST 177
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
153-174 1.96e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.39  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|..
gi 545833264   153 DEYEGDWVQGQRQGHGVLRRAD 174
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.15e-43

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.80  E-value: 2.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  24 QDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCRHWAlSGNTYTGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 104 KAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 545833264 184 RGVFSGLGNMAHCSGVVYRGIWIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
20-210 5.78e-35

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 130.08  E-value: 5.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  20 GRPPQDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCRHWALSGNTYTGQFVLGEPQGHG 99
Cdd:COG4642   61 GVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 100 VMKYKAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYE 179
Cdd:COG4642  141 IYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYE 220

                        170       180       190
                 ....*....|....*....|....*....|.
gi 545833264 180 GQWHRGVFSGLGNMAHCSGVVYRGIWINGHP 210
Cdd:COG4642  221 GEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
20-208 3.06e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 109.28  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  20 GRPPQDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEIT-----------GEGCRHWALSGNTYTG 88
Cdd:COG4642   27 AAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGgggggkgdggdGGGGEGGFGGGGGGGG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  89 QFVLGEPQGHGVMKYKAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHG 168
Cdd:COG4642  107 GKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQG 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 545833264 169 VLRRADGSTYEGQWHRGVFSGLGNMAHCSGVVYRGIWING 208
Cdd:COG4642  187 TLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNG 226
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 58-208 2.23e-26

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 111.46  E-value: 2.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  58 DGSYYEGEFAEGEITGEGCRHWAlSGNTYTGQFVLGEPQGHGVMKYKAGGRYEGELSHGMREGHGHLVDADGQVYWGSFH 137
Cdd:PLN03185   7 NGDFYSGSLLGNVPEGPGKYLWS-DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWR 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545833264 138 KNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWHRGVFSGLGNMAHCSGVVYRGIWING 208
Cdd:PLN03185  86 LNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 25-191 2.50e-25

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 108.38  E-value: 2.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  25 DGYGVYVYPNSFFrYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCrHWALSGNTYTGQFVLGEPQGHGVMKYK 104
Cdd:PLN03185  21 EGPGKYLWSDGCM-YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDGTTYKGRWRLNLKHGLGYQRYP 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 105 AGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWHR 184
Cdd:PLN03185  99 NGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTR 178


                 ....*..
gi 545833264 185 GVFSGLG 191
Cdd:PLN03185 179 GLKDGKG 185
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
22-210 1.72e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 84.62  E-value: 1.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264  22 PPQDGYGVYVYPNSFFRYEGEWKGGKKHGRGKLLFKDGSYYEGEFAEGEITGEGCRHWALSGNTYTGQFVLGEPQGHGVM 101
Cdd:COG4642   17 ALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 102 KYKAGGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQ 181
Cdd:COG4642   97 GFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGE 176

                        170       180
                 ....*....|....*....|....*....
gi 545833264 182 WHRGVFSGLGNMAHCSGVVYRGIWINGHP 210
Cdd:COG4642  177 FKNGKRHGQGTLTYANGDVYEGEFKNGQR 205
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 106-210 3.48e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 77.57  E-value: 3.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545833264 106 GGRYEGELSHGMREGHGHLVDADGQVYWGSFHKNKQHGQGRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWHRG 185
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                         90       100
                 ....*....|....*....|....*
gi 545833264 186 VFSGLGNMAHCSGVVYRGIWINGHP 210
Cdd:PLN03185  88 LKHGLGYQRYPNGDVFEGSWIQGLQ 112
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 145-209 9.33e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 54.07  E-value: 9.33e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545833264 145 GRMVFRNGDEYEGDWVQGQRQGHGVLRRADGSTYEGQWHRGVFSGLGNMAHCSGVVYRGIWINGH 209
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGY 65
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 155-177 6.46e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.62  E-value: 6.46e-04
                          10        20
                  ....*....|....*....|...
gi 545833264  155 YEGDWVQGQRQGHGVLRRADGST 177
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
153-174 1.96e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.39  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|..
gi 545833264   153 DEYEGDWVQGQRQGHGVLRRAD 174
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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