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Conserved domains on  [gi|551502350|ref|XP_005802719|]
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selenoprotein S [Xiphophorus maculatus]

Protein Classification

DUF814 domain-containing protein( domain architecture ID 10536524)

DUF814 domain-containing protein similar to vertebrates coiled-coil domain-containing protein 25 and yeast protein JLP2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 5-190 1.78e-86

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


:

Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 252.45  E-value: 1.78e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350    5 VEILDVDDDNSPRQVPLKNQDLSQLSFTVGEFLSLYGWYLLAVTVTVLLLIQHLRKRRTgQSRQDSVPHNL--QDVSLVT 82
Cdd:pfam06936   1 MELEEEPGVQLPARPALENEGLRFLQVTVGSLLSSYGWYLLFGCVLVYLLIQKLRKRRT-ALRQRSSDHSAatVDPDLVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350   83 KRQEAMEAARRRMQAELDAKAAAFKEKQREQEEEKRRQKIEEWESMKQGKSSKGH-KLSENTEEA---SAAAAGVKPKTD 158
Cdd:pfam06936  80 KRQEALEASRLRMQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNaKLAQEETEEtgpSASSAIPKPKPD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 551502350  159 KKPLRSNDYNPLMGQ-GGSCTWRPGRRGPSAGG 190
Cdd:pfam06936 160 KKPLRGSGYNPLTGDgGGSCSWRPGRRGPSSGG 192
 
Name Accession Description Interval E-value
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 5-190 1.78e-86

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 252.45  E-value: 1.78e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350    5 VEILDVDDDNSPRQVPLKNQDLSQLSFTVGEFLSLYGWYLLAVTVTVLLLIQHLRKRRTgQSRQDSVPHNL--QDVSLVT 82
Cdd:pfam06936   1 MELEEEPGVQLPARPALENEGLRFLQVTVGSLLSSYGWYLLFGCVLVYLLIQKLRKRRT-ALRQRSSDHSAatVDPDLVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350   83 KRQEAMEAARRRMQAELDAKAAAFKEKQREQEEEKRRQKIEEWESMKQGKSSKGH-KLSENTEEA---SAAAAGVKPKTD 158
Cdd:pfam06936  80 KRQEALEASRLRMQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNaKLAQEETEEtgpSASSAIPKPKPD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 551502350  159 KKPLRSNDYNPLMGQ-GGSCTWRPGRRGPSAGG 190
Cdd:pfam06936 160 KKPLRGSGYNPLTGDgGGSCSWRPGRRGPSSGG 192
 
Name Accession Description Interval E-value
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 5-190 1.78e-86

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 252.45  E-value: 1.78e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350    5 VEILDVDDDNSPRQVPLKNQDLSQLSFTVGEFLSLYGWYLLAVTVTVLLLIQHLRKRRTgQSRQDSVPHNL--QDVSLVT 82
Cdd:pfam06936   1 MELEEEPGVQLPARPALENEGLRFLQVTVGSLLSSYGWYLLFGCVLVYLLIQKLRKRRT-ALRQRSSDHSAatVDPDLVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502350   83 KRQEAMEAARRRMQAELDAKAAAFKEKQREQEEEKRRQKIEEWESMKQGKSSKGH-KLSENTEEA---SAAAAGVKPKTD 158
Cdd:pfam06936  80 KRQEALEASRLRMQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNaKLAQEETEEtgpSASSAIPKPKPD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 551502350  159 KKPLRSNDYNPLMGQ-GGSCTWRPGRRGPSAGG 190
Cdd:pfam06936 160 KKPLRGSGYNPLTGDgGGSCSWRPGRRGPSSGG 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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