TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564332490   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564332490    741 DINECSEGSPCSPG-WCENLPGSYRCTCAQGYEpalDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  657 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKT 692
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564332490   1079 DMDECQDPAACRPG-RCVNLPGSYRCECHPPWvpgSSGRDCQ 1119
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 564332490    863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|
gi 564332490   1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 564332490    700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 564332490   1251 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1289
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564332490   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564332490    741 DINECSEGSPCSPG-WCENLPGSYRCTCAQGYEpalDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  657 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKT 692
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564332490    657 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKTS 693
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 564332490  741 DINECSEGSPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564332490  1143 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 564332490    823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564332490 1079 DMDECQDPAACRP-GRCVNLPGSYRCECHPPWvpgsSGRDCQ 1119
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   782 DMDECETG-NICHD-GICTNTPGSFQCQCLSG 811
Cdd:pfam07645    1 DVDECATGtHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|
gi 564332490 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   352 DINECVMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  613 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 647
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564332490   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564332490    741 DINECSEGSPCSPG-WCENLPGSYRCTCAQGYEpalDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  657 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKT 692
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 564332490    657 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKTS 693
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 564332490  741 DINECSEGSPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564332490  1143 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564332490  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 564332490    823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564332490 1079 DMDECQDPAACRP-GRCVNLPGSYRCECHPPWvpgsSGRDCQ 1119
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32

large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332490  484 PPKPQQLPESPSRAPALEDTEEERGVTLDP--PVSEeRSVQQSHPTTTTSPARPYPELISRP--SPPTFHRFLPDLPPSR 559
Cdd:PHA03247 2829 PPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRR-RPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPER 2907

                          90
                  ....*....|....*
gi 564332490  560 SAVEIAPTQVTETDE 574
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQ 2922

Epidermal growth factor-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 564332490    785 ECETGNICHDGICTNTPGSFQCQCLSGYHLSRD 817
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|
gi 564332490 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 564332490   352 DINECVMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 564332490  660 ECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKTS 693
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 564332490   1251 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1289
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564332490  780 CIDMDECETGNICHDGICTNTPGSFQCQCLSGYHLSRD 817
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLED 221