|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
371-1208 |
1.63e-167 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 518.96 E-value: 1.63e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 371 GSYPDMHS-------SSASSPVPDRAPEPNST----LVPTPTAAQPAKV--AKPFGYgYPTLQPAYQNAAapPTTAHPSG 437
Cdd:COG5028 7 GVYPQAQSqvhtgaaSSKKSARPHRAYANFSAgqmgMPPYTTPPLQQQSrrQIDQAA-TAMHNTGANNPA--PSVMSPAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 438 PAYSGYPQQYPGvhqlssglgGLSLQSSPQPES-LRPVNL--TQEKNI----LPATPIWAPVPNLSAELSKLNCSPDSFR 510
Cdd:COG5028 84 QSQQKFSSPYGG---------SMADGTAPKPTNpLVPVDLfeDQPPPIsdlfLPPPPIVPPLTTNFVGSEQSNCSPKYVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 511 CTLTSIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVP 585
Cdd:COG5028 155 STMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 586 EEFlYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPG-D 662
Cdd:COG5028 235 EGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 663 SRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFINTRETHSALGP 741
Cdd:COG5028 314 PRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 742 ALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvhHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYS 821
Cdd:COG5028 393 ALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 822 DLASLACMSKYSAGCIFYYPSFHSThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLA 901
Cdd:COG5028 466 DVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFS 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 902 NINPDAGFAVQLSIEESLAdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVS 981
Cdd:COG5028 545 TMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALN 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 982 SSLSDARDALVNAVVDPLSAYSSAVSSVPRSTLTA-PSSLKLLPLYVLALLKQKAFRTGtSTRLDDRVYAMCQMKSQPLV 1060
Cdd:COG5028 624 SSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLK 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1061 HLMKMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWIGKGCDSNFIENVLGYPDFGS 1140
Cdd:COG5028 703 QLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSD 781
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564338714 1141 IPQKMTHLPELDTLPSERTRSFVTWLRDSRP-LSPVLHVVKD--ESPARTDFFQHLVEDRTEAALSYYEFL 1208
Cdd:COG5028 782 IPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
624-867 |
1.44e-130 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 398.95 E-value: 1.44e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 624 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 702
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 703 TPDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 782
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 783 STKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHsTHNPSQAEKLQKDLKRY 862
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239
|
....*
gi 564338714 863 LTRKI 867
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
624-863 |
1.15e-106 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 335.38 E-value: 1.15e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 624 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 703
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 704 PDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 780
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 781 RSSTKVVHHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHnpsQAEKLQKDL 859
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 564338714 860 KRYL 863
Cdd:pfam04811 238 QRYF 241
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
591-1217 |
8.96e-34 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 141.75 E-value: 8.96e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 591 NPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTVLCQSL---LENLdKLPgd 662
Cdd:PTZ00395 921 NLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 663 sRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNM 728
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 729 FINTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVHHLgpatdFYKKLALDCSG 806
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 807 QQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIFYYPSFhsthnpsqaeKLQKDLKR-YL-------TRKIGFEAVMRIR 876
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF----------LWQKDYKEiYMnimdtltSEDIAYCCELKLR 1212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 877 CTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHTLCLPVV 952
Cdd:PTZ00395 1213 YSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLT 1292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 953 SSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDPLSAYSSAVSSVPRST-----LTAPSSLKLLPLYV 1027
Cdd:PTZ00395 1293 SSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSahsgqLILPDTLKLLPLFT 1366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1028 LALLKQKAfrTGTSTRLDDRVYAMCQMKSQPLVHLMKMIHPNLY--RIDRLTDE-GAIHVNDRVVpQPPLQKLSAEKLTR 1104
Cdd:PTZ00395 1367 SSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKIYS 1443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1105 EGAFLMDCGSVFYIWIGKGCDSNFIENVLgypdfGSIP-QKMTHLPELDTLPS----ERTRSFVTWLRDSRPLSPVLhVV 1179
Cdd:PTZ00395 1444 NGIYLLDACTHFYLYFGFHSDANFAKEIV-----GDIPtEKNAHELNLTDTPNaqkvQRIIKNLSRIHHFNKYVPLV-MV 1517
|
650 660 670
....*....|....*....|....*....|....*...
gi 564338714 1180 KDESPARTDFFQHLVEDRTEAALSYYEFLIHVQQQVCK 1217
Cdd:PTZ00395 1518 APKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1-418 |
8.81e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.62 E-value: 8.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1 MSAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPS-GYGLPHQnymapSGHYSQGPGKMTSLPLDNQceny 79
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPqPFPLTPQ-----SSQSQVPPGPSPAAPGQSQ---- 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 80 ySRPYTAPTQNvgTPSSANQPGAQLMYGRGPSAPHMGASMPGPFQGAPASASHSYPSasqpysslgnRYSSPATYSATAS 159
Cdd:pfam03154 323 -QRIHTPPSQS--QLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP----------HLSGPSPFQMNSN 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 160 VasqgyPSTCSHYPISTVSNVVYPNVSYPSLPASePYGQmftsQSAPPPARP--LKESYSGPSTAVAYPsrpppppsqhq 237
Cdd:pfam03154 390 L-----PPPPALKPLSSLSTHHPPSAHPPPLQLM-PQSQ----QLPPPPAQPpvLTQSQSLPPPAASHP----------- 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 238 qqqqqqqqqqqqshsgysslPWSGPGLPPAQDSLIRNQMGSLAIPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPG 317
Cdd:pfam03154 449 --------------------PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 318 PSSTRMPPapshpvgpvpsappppeqMQTKgvdsssttssasplpnsYDALEGGSYPDmhsssaSSPVPDRAPEPNSTLV 397
Cdd:pfam03154 509 AVSCPLPP------------------VQIK-----------------EEALDEAEEPE------SPPPPPRSPSPEPTVV 547
|
410 420
....*....|....*....|..
gi 564338714 398 PTPT-AAQPAKVAKPFGYGYPT 418
Cdd:pfam03154 548 NTPShASQSARFYKHLDRGYNS 569
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4-411 |
1.28e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 4 PAGSPHPAAGaRMPPKLGGAVSGLAPPQQNGPAQSQMQVPSGYGLPHQNymapsghySQGPGKMTSLPLDNQCENYYSRP 83
Cdd:PHA03247 2589 PDAPPQSARP-RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN--------EPDPHPPPTVPPPERPRDDPAPG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 84 YTAPTQNVGTPSSANQPGAQLMYGRGPSAPHMGASM-----PGPFQGAPASASHSYPSASQ-PYSSLGNRYSSPATYSAT 157
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLtsladPPPPPPTPEPAPHALVSATPlPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 158 ASVASQGYPSTcshyPISTVSNVVYPNVSYPSLPASePYGQMftsqSAPPPARPLKESYSGPSTAVAYPSRPPPPPSQHQ 237
Cdd:PHA03247 2740 APPAVPAGPAT----PGGPARPARPPTTAGPPAPAP-PAAPA----AGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 238 QQQQQQQQQQQQSHSGYSSLPWS----GPGLPPAQDSLIRNQMGSLA--------IPNSHPAINVADSLSCPITENVQPP 305
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSaqptAPPPPPGPPPPSLPLGGSVApggdvrrrPPSRSPAAKPAAPARPPVRRLARPA 2890
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 306 KPSSVVATVLPGPSSTRMPPAPShpvgpvpsAPPPPEQMQTKGVDSSSTTSSASPLPNSYDAleggsyPDMHSSSASSPV 385
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQPQA--------PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA------PTTDPAGAGEPS 2956
|
410 420
....*....|....*....|....*.
gi 564338714 386 PDRAPEPNSTLVPTPTAAQPAKVAKP 411
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQP 2982
|
|
| GEL |
smart00262 |
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ... |
1083-1124 |
8.85e-03 |
|
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.
Pssm-ID: 214590 [Multi-domain] Cd Length: 90 Bit Score: 36.89 E-value: 8.85e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 564338714 1083 HVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGC 1124
Cdd:smart00262 4 RVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
371-1208 |
1.63e-167 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 518.96 E-value: 1.63e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 371 GSYPDMHS-------SSASSPVPDRAPEPNST----LVPTPTAAQPAKV--AKPFGYgYPTLQPAYQNAAapPTTAHPSG 437
Cdd:COG5028 7 GVYPQAQSqvhtgaaSSKKSARPHRAYANFSAgqmgMPPYTTPPLQQQSrrQIDQAA-TAMHNTGANNPA--PSVMSPAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 438 PAYSGYPQQYPGvhqlssglgGLSLQSSPQPES-LRPVNL--TQEKNI----LPATPIWAPVPNLSAELSKLNCSPDSFR 510
Cdd:COG5028 84 QSQQKFSSPYGG---------SMADGTAPKPTNpLVPVDLfeDQPPPIsdlfLPPPPIVPPLTTNFVGSEQSNCSPKYVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 511 CTLTSIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVP 585
Cdd:COG5028 155 STMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 586 EEFlYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPG-D 662
Cdd:COG5028 235 EGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 663 SRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFINTRETHSALGP 741
Cdd:COG5028 314 PRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 742 ALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvhHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYS 821
Cdd:COG5028 393 ALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 822 DLASLACMSKYSAGCIFYYPSFHSThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLA 901
Cdd:COG5028 466 DVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFS 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 902 NINPDAGFAVQLSIEESLAdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVS 981
Cdd:COG5028 545 TMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALN 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 982 SSLSDARDALVNAVVDPLSAYSSAVSSVPRSTLTA-PSSLKLLPLYVLALLKQKAFRTGtSTRLDDRVYAMCQMKSQPLV 1060
Cdd:COG5028 624 SSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLK 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1061 HLMKMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWIGKGCDSNFIENVLGYPDFGS 1140
Cdd:COG5028 703 QLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSD 781
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564338714 1141 IPQKMTHLPELDTLPSERTRSFVTWLRDSRP-LSPVLHVVKD--ESPARTDFFQHLVEDRTEAALSYYEFL 1208
Cdd:COG5028 782 IPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
624-867 |
1.44e-130 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 398.95 E-value: 1.44e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 624 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 702
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 703 TPDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 782
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 783 STKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHsTHNPSQAEKLQKDLKRY 862
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239
|
....*
gi 564338714 863 LTRKI 867
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
624-863 |
1.15e-106 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 335.38 E-value: 1.15e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 624 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 703
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 704 PDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 780
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 781 RSSTKVVHHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHnpsQAEKLQKDL 859
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 564338714 860 KRYL 863
Cdd:pfam04811 238 QRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
624-861 |
1.28e-103 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 326.89 E-value: 1.28e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 624 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 703
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 704 PDSLLVNLYESKELIKDLLNALPNMF--INTRETHSALGPALQAAFKLMSPT--GGRVSVFQTQLPSLGAGLLQSREDPN 779
Cdd:cd01468 81 PDRFLVPLSECKKVIHDLLEQLPPMFwpVPTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 780 QRSSTKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSthnPSQAEKLQKDL 859
Cdd:cd01468 161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237
|
..
gi 564338714 860 KR 861
Cdd:cd01468 238 QR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
591-1217 |
8.96e-34 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 141.75 E-value: 8.96e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 591 NPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTVLCQSL---LENLdKLPgd 662
Cdd:PTZ00395 921 NLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 663 sRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNM 728
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 729 FINTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVHHLgpatdFYKKLALDCSG 806
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 807 QQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIFYYPSFhsthnpsqaeKLQKDLKR-YL-------TRKIGFEAVMRIR 876
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF----------LWQKDYKEiYMnimdtltSEDIAYCCELKLR 1212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 877 CTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHTLCLPVV 952
Cdd:PTZ00395 1213 YSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLT 1292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 953 SSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDPLSAYSSAVSSVPRST-----LTAPSSLKLLPLYV 1027
Cdd:PTZ00395 1293 SSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSahsgqLILPDTLKLLPLFT 1366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1028 LALLKQKAfrTGTSTRLDDRVYAMCQMKSQPLVHLMKMIHPNLY--RIDRLTDE-GAIHVNDRVVpQPPLQKLSAEKLTR 1104
Cdd:PTZ00395 1367 SSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKIYS 1443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1105 EGAFLMDCGSVFYIWIGKGCDSNFIENVLgypdfGSIP-QKMTHLPELDTLPS----ERTRSFVTWLRDSRPLSPVLhVV 1179
Cdd:PTZ00395 1444 NGIYLLDACTHFYLYFGFHSDANFAKEIV-----GDIPtEKNAHELNLTDTPNaqkvQRIIKNLSRIHHFNKYVPLV-MV 1517
|
650 660 670
....*....|....*....|....*....|....*...
gi 564338714 1180 KDESPARTDFFQHLVEDRTEAALSYYEFLIHVQQQVCK 1217
Cdd:PTZ00395 1518 APKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
868-952 |
2.90e-33 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 123.42 E-value: 2.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 868 GFEAVMRIRCTKGLSMHTFHGNFFVRS-TDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHT 946
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 564338714 947 LCLPVV 952
Cdd:pfam08033 81 VALPVT 86
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
507-986 |
2.82e-22 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 103.42 E-value: 2.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 507 DSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfIDQRR--WKCNLCYRVNDV 584
Cdd:COG5047 10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 585 PEEflYNPLTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVEAGYLTVLCQSLLENLDKLPGDS 663
Cdd:COG5047 89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 664 RtrIGFMTFDSTIHF----------------------YNLQE--GLSQPQMLIV--SDIDDVFLPTPDSLLVNLYESKEL 717
Cdd:COG5047 157 L--VGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 718 IKDLLNAL-PNMF--INTRETHSALGPALQAAFKLMSPT----GGRVSVFQTQLPSLGAGLLQSRE--DP---NQRSSTK 785
Cdd:COG5047 235 LLNILEQLqPDPWpvPAGKRPLRCTGSALNIASSLLEQCfpnaGCHIVLFAGGPCTVGPGTVVSTElkEPmrsHHDIESD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 786 VVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHNPSQAEK-LQKDLKRYLt 864
Cdd:COG5047 315 SAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRiFNRDSEGYL- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 865 rKIGFEAVMRIRCTKGLSMHTFHGN---------------FFVRSTDLLSLANINPDAGFAVQLSIEESLADTS------ 923
Cdd:COG5047 394 -KMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGAASGSaqrpae 472
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564338714 924 -LVCFQTalLYTSSKGERRIRVHTLCLPVVSSLADV-YAGVDVQAAICLLANMAVDRSVSSSLSD 986
Cdd:COG5047 473 aYIQFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIID 535
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
963-1064 |
2.14e-18 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 81.40 E-value: 2.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 963 DVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDPLSA-YSSAVSSVPRSTLTAPSSLKLLPLYVLALLKQKAFRTGTS 1041
Cdd:pfam04815 1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAyRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
|
90 100
....*....|....*....|...
gi 564338714 1042 TRLDDRVYAMCQMKSQPLVHLMK 1064
Cdd:pfam04815 81 SPSDERAYARHLLLSLPVEELLL 103
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
551-587 |
8.90e-16 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 72.09 E-value: 8.90e-16
10 20 30
....*....|....*....|....*....|....*...
gi 564338714 551 IVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEE 587
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
507-991 |
4.99e-14 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 76.90 E-value: 4.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 507 DSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFiDQRRWKCNLCYRVNDV 584
Cdd:PLN00162 10 DGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 585 PeeflynpltRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTvlcQSLLENLDKL 659
Cdd:PLN00162 88 P---------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 660 PGDSrtRIGFMTFDSTIHFYNL------------------------QEGLS----QPQMLIVSDIDDVFLPTP-DSLLVN 710
Cdd:PLN00162 155 PENA--LVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 711 LYESKELIKDLLNALPNMFINTRETHSAL---GPALQAAFKLM---SP-TGGRVSVFqTQLPS-LGAGLLQSREDPNQRS 782
Cdd:PLN00162 233 ASECEFTLNSALEELQKDPWPVPPGHRPArctGAALSVAAGLLgacVPgTGARIMAF-VGGPCtEGPGAIVSKDLSEPIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 783 STK-----VVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSthnpsqaEKLQK 857
Cdd:PLN00162 312 SHKdldkdAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGH-------SVFKD 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 858 DLKRYLTR------KIGFEAVMRIRCTKGL----------SMH----------TFHGNffvrsTDLLSLANINPDAGFAV 911
Cdd:PLN00162 385 SLRRVFERdgegslGLSFNGTFEVNCSKDVkvqgaigpcaSLEkkgpsvsdteIGEGG-----TTAWKLCGLDKKTSLAV 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 912 --QLSIEESLADTSL---VCFQTALLYTSSKGERRIRVHTLCLPVV--SSLADVYAGVDVQAAICLLANMAVDRSVSssl 984
Cdd:PLN00162 460 ffEVANSGQSNPQPPgqqFFLQFLTRYQHSNGQTRLRVTTVTRRWVegSSSEELVAGFDQEAAAVVMARLASHKMET--- 536
|
....*..
gi 564338714 985 SDARDAL 991
Cdd:PLN00162 537 EEEFDAT 543
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
1088-1163 |
1.18e-09 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 55.78 E-value: 1.18e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564338714 1088 VVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGcdSNFIENVLGYPDFGSIP-QKMTHLPELDTLP-SERTRSFV 1163
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDdDERFPLPEVIRVPqGKEPARFL 76
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1-418 |
8.81e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.62 E-value: 8.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 1 MSAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPS-GYGLPHQnymapSGHYSQGPGKMTSLPLDNQceny 79
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPqPFPLTPQ-----SSQSQVPPGPSPAAPGQSQ---- 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 80 ySRPYTAPTQNvgTPSSANQPGAQLMYGRGPSAPHMGASMPGPFQGAPASASHSYPSasqpysslgnRYSSPATYSATAS 159
Cdd:pfam03154 323 -QRIHTPPSQS--QLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP----------HLSGPSPFQMNSN 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 160 VasqgyPSTCSHYPISTVSNVVYPNVSYPSLPASePYGQmftsQSAPPPARP--LKESYSGPSTAVAYPsrpppppsqhq 237
Cdd:pfam03154 390 L-----PPPPALKPLSSLSTHHPPSAHPPPLQLM-PQSQ----QLPPPPAQPpvLTQSQSLPPPAASHP----------- 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 238 qqqqqqqqqqqqshsgysslPWSGPGLPPAQDSLIRNQMGSLAIPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPG 317
Cdd:pfam03154 449 --------------------PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 318 PSSTRMPPapshpvgpvpsappppeqMQTKgvdsssttssasplpnsYDALEGGSYPDmhsssaSSPVPDRAPEPNSTLV 397
Cdd:pfam03154 509 AVSCPLPP------------------VQIK-----------------EEALDEAEEPE------SPPPPPRSPSPEPTVV 547
|
410 420
....*....|....*....|..
gi 564338714 398 PTPT-AAQPAKVAKPFGYGYPT 418
Cdd:pfam03154 548 NTPShASQSARFYKHLDRGYNS 569
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4-411 |
1.28e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 4 PAGSPHPAAGaRMPPKLGGAVSGLAPPQQNGPAQSQMQVPSGYGLPHQNymapsghySQGPGKMTSLPLDNQCENYYSRP 83
Cdd:PHA03247 2589 PDAPPQSARP-RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN--------EPDPHPPPTVPPPERPRDDPAPG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 84 YTAPTQNVGTPSSANQPGAQLMYGRGPSAPHMGASM-----PGPFQGAPASASHSYPSASQ-PYSSLGNRYSSPATYSAT 157
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLtsladPPPPPPTPEPAPHALVSATPlPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 158 ASVASQGYPSTcshyPISTVSNVVYPNVSYPSLPASePYGQMftsqSAPPPARPLKESYSGPSTAVAYPSRPPPPPSQHQ 237
Cdd:PHA03247 2740 APPAVPAGPAT----PGGPARPARPPTTAGPPAPAP-PAAPA----AGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 238 QQQQQQQQQQQQSHSGYSSLPWS----GPGLPPAQDSLIRNQMGSLA--------IPNSHPAINVADSLSCPITENVQPP 305
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSaqptAPPPPPGPPPPSLPLGGSVApggdvrrrPPSRSPAAKPAAPARPPVRRLARPA 2890
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 306 KPSSVVATVLPGPSSTRMPPAPShpvgpvpsAPPPPEQMQTKGVDSSSTTSSASPLPNSYDAleggsyPDMHSSSASSPV 385
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQPQA--------PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA------PTTDPAGAGEPS 2956
|
410 420
....*....|....*....|....*.
gi 564338714 386 PDRAPEPNSTLVPTPTAAQPAKVAKP 411
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQP 2982
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
121-493 |
1.21e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.86 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 121 GPFQGAPASASHSYPSASQPYSSLGNRYSSPAtysATASVASQGYPstcshyPISTVSNV-VYPNVSYPSLPASEPYGQM 199
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA---VTSRARRPDAP------PQSARPRApVDDRGDPRGPAPPSPLPPD 2620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 200 FTSQSAPPPA-RPLKESYSGPSTAVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSLP--WSGPGLPPAQDSLI---- 272
Cdd:PHA03247 2621 THAPDPPPPSpSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrPRRRAARPTVGSLTslad 2700
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 273 ----------RNQMGSLAIPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPGPSSTRMPPA--PSHPVGPVPSAPPP 340
Cdd:PHA03247 2701 pppppptpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgpPAPAPPAAPAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 341 peqmqtkgvdSSSTTSSASPLPNSYDALEGGSYPDMHSSSASSPVPDRAPEPN-STLVPTPTAAQPAKVAKPFGYGYPTL 419
Cdd:PHA03247 2781 ----------RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 420 Q---------------PAYQNAAAPPTTAHP-----SGPAYSGYPQQYPgvhqlssgLGGLSLQSSPQPESLRPVnLTQE 479
Cdd:PHA03247 2851 PlggsvapggdvrrrpPSRSPAAKPAAPARPpvrrlARPAVSRSTESFA--------LPPDQPERPPQPQAPPPP-QPQP 2921
|
410
....*....|....
gi 564338714 480 KNILPATPIWAPVP 493
Cdd:PHA03247 2922 QPPPPPQPQPPPPP 2935
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
141-435 |
1.17e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 43.02 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 141 YSSLGNRYSSPATYSATA-SVASQGYPSTCSHYPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPLKESySGP 219
Cdd:pfam17823 90 HTPHGTDLSEPATREGAAdGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAA-SAP 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 220 STAVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSLPWSGPGLPPAQDSLIRNQMGSLA-IPNSHPA---INVADSLS 295
Cdd:pfam17823 169 HAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAaVGNSSPAagtVTAAVGTV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 296 CPITENVQPPKPSSVVATV----LPGPSSTRMPPAPSHPVGPVPSAPPPPEQMQTKG------VDSSSTTSSASPLPNSY 365
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAgtinMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGpiiqvsTDQPVHNTAGEPTPSPS 328
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564338714 366 DALEGGSYPDMHSSSASSPVPD---RAPEPNSTLVPTPTAAQPAKVAKPFGYGYPTLQPAYQNAAAPPTTAHP 435
Cdd:pfam17823 329 NTTLEPNTPKSVASTNLAVVTTtkaQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAP 401
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
3-211 |
6.42e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 6.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 3 APAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPSGyglPHQNYMAPSGHYSQGPGKMTSLPLDNQCENYYSR 82
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAG---AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564338714 83 PYTAPTQNVGTPSSANQPGAQLMYGRGPSAPHMGASMPGPFQGAPASASHSYPSASQpysslgnrySSPATYSATASVAS 162
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPP---------QAAQGASAPSPAAD 736
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 564338714 163 QGYPstcshyPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARP 211
Cdd:PRK07764 737 DPVP------LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| GEL |
smart00262 |
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ... |
1083-1124 |
8.85e-03 |
|
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.
Pssm-ID: 214590 [Multi-domain] Cd Length: 90 Bit Score: 36.89 E-value: 8.85e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 564338714 1083 HVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGC 1124
Cdd:smart00262 4 RVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
|
|
| |
