NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564342414|ref|XP_006234843|]
View 

mitogen-activated protein kinase-binding protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.60e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  291 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIATITEASRLFSGGANARypdtiALTFDPANQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  371 PKKVGKVYSalyHSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWNTESsgvhGSALHrnilsndlikiiyvdg 450
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLAT----GKLLR---------------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  451 ntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHELQSLSELLKVEAHDSEILCLEYSkPDtG 530
Cdd:COG2319   157 ------------------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  531 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQfTRTHHVVR 610
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  611 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFF 686
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 564342414  687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-505 2.00e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 2.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   16 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 94
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   95 TALAFSPDGKYLVTGESGHmpAVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 174
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  175 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgkkadstfci 252
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  253 tssgllceFS-DRRLLdkwvelrttvahcisVSqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiatiteasrlf 331
Cdd:COG2319   254 --------FSpDGRLL---------------AS------GSADGTVRLWDLATGELLRTLTGH----------------- 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  332 SGGANarypdtiALTFDPANQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSNQaclppssFIT 411
Cdd:COG2319   288 SGGVN-------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LAS 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  412 CSSDNTIRLWNTESSGvhgsalhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPNGQHLAS 491
Cdd:COG2319   348 GSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLAS 389

                         490
                  ....*....|....
gi 564342414  492 GDRMGTLRVHELQS 505
Cdd:COG2319   390 GSADGTVRLWDLAT 403
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 837-1207 7.27e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 7.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  837 LGPAPTAN--TGPKRRGRWAQPGVELSVRSMLDLRQLETLAPSPRGPSQDSLAVSPTGPGKHSPQAADLSCAsqnerAPR 914
Cdd:PHA03307   59 AAACDRFEppTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP-----APD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  915 LQASQPCSCPHIIQllSQEEGVFAQDLESAPIEDGIVYPEPSDSPTMDTSAfqvqAPTGGSLGRVYPGSRGSEKHSPDSa 994
Cdd:PHA03307  134 LSEMLRPVGSPGPP--PAASPPAAGASPAAVASDAASSRQAALPLSSPEET----ARAPSSPPAEPPPSTPPAAASPRP- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  995 csvdysssrlsSPEHPNEDSESTEPLSVDGVSSDLEEQAEGEEEEEEEGGTGLCGLQEGSPHTPDQEQFLKQHFETLANG 1074
Cdd:PHA03307  207 -----------PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1075 AAPGgpARALERTESRSISSRfllqvqtSPLREPSLSSSGlALMSRPDQVSQVSGEQLKGSGAT------------PPGA 1142
Cdd:PHA03307  276 NGPS--SRPGPASSSSSPRER-------SPSPSPSSPGSG-PAPSSPRASSSSSSSRESSSSSTssssessrgaavSPGP 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564342414 1143 PPEMEPSSGNsgPKQVAPVLLPRRRTNLDNSWASKKTAATRPLAGLQKAQSVHSLVPQDEVPSRP 1207
Cdd:PHA03307  346 SPSRSPSPSR--PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFP 408
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1138-1402 2.03e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1138 TPPGAPPEMEPSSGNSGPKQVAPVLLPRRRTNLDNSWASKKTAATRPLaglqkaqsvhslvPQDEVPSRPLLFQAEVQGS 1217
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPL-------------PPDTHAPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1218 LGSLPQADGCPSQSHSYWNPTTSSVAKLARSISVGENPGLAAEPQAP----APIRTSPFNKLALPSRahlvldiPKPLPD 1293
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraARPTVGSLTSLADPPP-------PPPTPE 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1294 RPTLTTFSPVSKGLAHSETEQSGPSVSLGKTHTAIEKHSCLGEGTTPKSRTecQAHPGPNHPCAQQLPVSnllqGPESMQ 1373
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAGPPAPAPPAAPAA----GPPRRL 2783

                         250       260
                  ....*....|....*....|....*....
gi 564342414 1374 PLSPEKTRNPVESSRPGAALSQDSELALS 1402
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVL 2812
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.60e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  291 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIATITEASRLFSGGANARypdtiALTFDPANQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  371 PKKVGKVYSalyHSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWNTESsgvhGSALHrnilsndlikiiyvdg 450
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLAT----GKLLR---------------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  451 ntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHELQSLSELLKVEAHDSEILCLEYSkPDtG 530
Cdd:COG2319   157 ------------------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  531 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQfTRTHHVVR 610
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  611 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFF 686
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 564342414  687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-505 2.00e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 2.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   16 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 94
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   95 TALAFSPDGKYLVTGESGHmpAVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 174
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  175 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgkkadstfci 252
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  253 tssgllceFS-DRRLLdkwvelrttvahcisVSqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiatiteasrlf 331
Cdd:COG2319   254 --------FSpDGRLL---------------AS------GSADGTVRLWDLATGELLRTLTGH----------------- 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  332 SGGANarypdtiALTFDPANQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSNQaclppssFIT 411
Cdd:COG2319   288 SGGVN-------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LAS 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  412 CSSDNTIRLWNTESSGvhgsalhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPNGQHLAS 491
Cdd:COG2319   348 GSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLAS 389

                         490
                  ....*....|....
gi 564342414  492 GDRMGTLRVHELQS 505
Cdd:COG2319   390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-726 8.62e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 8.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  344 ALTFDPANQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWN 422
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  423 TESSGVhgsalhrnilsndlikIIYVDGNTQAlldtelpggdkadgslmdprvgIRSVCISPNGQHLASGDRMGTLRVHE 502
Cdd:cd00200    80 LETGEC----------------VRTLTGHTSY----------------------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  503 LQSLSELLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 582
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  583 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 662
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564342414  663 QTDPSGiYIATSCS-DKNLSIFDFFSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 726
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-422 1.21e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  242 RGKKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-----CISVS--QEYIFCGCADGTVRLFNPSNLHFLST 310
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  311 LpRPHalgTDIATiteasrlfsgganarypdtiALTFDPANQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 390
Cdd:cd00200   215 L-RGH---ENGVN--------------------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 564342414  391 EVYPEIKDsnqaclppssFITCSSDNTIRLWN 422
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 687-725 2.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.50e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564342414    687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
688-725 7.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 7.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564342414   688 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 837-1207 7.27e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 7.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  837 LGPAPTAN--TGPKRRGRWAQPGVELSVRSMLDLRQLETLAPSPRGPSQDSLAVSPTGPGKHSPQAADLSCAsqnerAPR 914
Cdd:PHA03307   59 AAACDRFEppTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP-----APD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  915 LQASQPCSCPHIIQllSQEEGVFAQDLESAPIEDGIVYPEPSDSPTMDTSAfqvqAPTGGSLGRVYPGSRGSEKHSPDSa 994
Cdd:PHA03307  134 LSEMLRPVGSPGPP--PAASPPAAGASPAAVASDAASSRQAALPLSSPEET----ARAPSSPPAEPPPSTPPAAASPRP- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  995 csvdysssrlsSPEHPNEDSESTEPLSVDGVSSDLEEQAEGEEEEEEEGGTGLCGLQEGSPHTPDQEQFLKQHFETLANG 1074
Cdd:PHA03307  207 -----------PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1075 AAPGgpARALERTESRSISSRfllqvqtSPLREPSLSSSGlALMSRPDQVSQVSGEQLKGSGAT------------PPGA 1142
Cdd:PHA03307  276 NGPS--SRPGPASSSSSPRER-------SPSPSPSSPGSG-PAPSSPRASSSSSSSRESSSSSTssssessrgaavSPGP 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564342414 1143 PPEMEPSSGNsgPKQVAPVLLPRRRTNLDNSWASKKTAATRPLAGLQKAQSVHSLVPQDEVPSRP 1207
Cdd:PHA03307  346 SPSRSPSPSR--PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFP 408
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-207 3.53e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  117 VRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 564342414  197 GNRHIKFWYLD 207
Cdd:PLN00181  636 GSADHKVYYYD 646
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564342414     80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 5.38e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.65  E-value: 5.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414    73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERNQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1138-1402 2.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1138 TPPGAPPEMEPSSGNSGPKQVAPVLLPRRRTNLDNSWASKKTAATRPLaglqkaqsvhslvPQDEVPSRPLLFQAEVQGS 1217
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPL-------------PPDTHAPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1218 LGSLPQADGCPSQSHSYWNPTTSSVAKLARSISVGENPGLAAEPQAP----APIRTSPFNKLALPSRahlvldiPKPLPD 1293
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraARPTVGSLTSLADPPP-------PPPTPE 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1294 RPTLTTFSPVSKGLAHSETEQSGPSVSLGKTHTAIEKHSCLGEGTTPKSRTecQAHPGPNHPCAQQLPVSnllqGPESMQ 1373
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAGPPAPAPPAAPAA----GPPRRL 2783

                         250       260
                  ....*....|....*....|....*....
gi 564342414 1374 PLSPEKTRNPVESSRPGAALSQDSELALS 1402
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVL 2812
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.60e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  291 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIATITEASRLFSGGANARypdtiALTFDPANQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  371 PKKVGKVYSalyHSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWNTESsgvhGSALHrnilsndlikiiyvdg 450
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLAT----GKLLR---------------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  451 ntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHELQSLSELLKVEAHDSEILCLEYSkPDtG 530
Cdd:COG2319   157 ------------------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  531 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQfTRTHHVVR 610
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  611 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFF 686
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 564342414  687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
25-548 2.28e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.28e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   25 RRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 104
Cdd:COG2319    12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  105 YLVTGesGHMPAVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYQHdmIVNVWAWKKNIVVAS-NKVSSRVTA 183
Cdd:COG2319    92 LLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  184 VSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftdvacgrgkkadstfcitssgllcefs 262
Cdd:COG2319   168 VAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTGHTG------------------------------------- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  263 drrlldkWVelrTTVAhcISVSQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIAtiteasrlfsgganarypdt 342
Cdd:COG2319   206 -------AV---RSVA--FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-------------------- 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  343 ialtFDPANQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWN 422
Cdd:COG2319   254 ----FSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSP---DGKL-------LASGSDDGTVRLWD 316

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  423 TESsgvhGSALHrnilsndlikiiyvdgntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHE 502
Cdd:COG2319   317 LAT----GKLLR----------------------------------TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 564342414  503 LQSLSELLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDA 548
Cdd:COG2319   359 LATGELLRTLTGHTGAVTSVAFS-PDG--RTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
16-505 2.00e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 2.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   16 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 94
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   95 TALAFSPDGKYLVTGESGHmpAVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 174
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  175 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgkkadstfci 252
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  253 tssgllceFS-DRRLLdkwvelrttvahcisVSqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiatiteasrlf 331
Cdd:COG2319   254 --------FSpDGRLL---------------AS------GSADGTVRLWDLATGELLRTLTGH----------------- 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  332 SGGANarypdtiALTFDPANQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSNQaclppssFIT 411
Cdd:COG2319   288 SGGVN-------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LAS 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  412 CSSDNTIRLWNTESSGvhgsalhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPNGQHLAS 491
Cdd:COG2319   348 GSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLAS 389

                         490
                  ....*....|....
gi 564342414  492 GDRMGTLRVHELQS 505
Cdd:COG2319   390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-726 8.62e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 8.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  344 ALTFDPANQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWN 422
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  423 TESSGVhgsalhrnilsndlikIIYVDGNTQAlldtelpggdkadgslmdprvgIRSVCISPNGQHLASGDRMGTLRVHE 502
Cdd:cd00200    80 LETGEC----------------VRTLTGHTSY----------------------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  503 LQSLSELLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 582
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  583 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 662
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564342414  663 QTDPSGiYIATSCS-DKNLSIFDFFSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 726
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-422 1.21e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  242 RGKKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-----CISVS--QEYIFCGCADGTVRLFNPSNLHFLST 310
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  311 LpRPHalgTDIATiteasrlfsgganarypdtiALTFDPANQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 390
Cdd:cd00200   215 L-RGH---ENGVN--------------------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 564342414  391 EVYPEIKDsnqaclppssFITCSSDNTIRLWN 422
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
275-588 6.28e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 6.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  275 TTVAhcISVSQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIAtiteasrlfsgganarypdtialtFDPANQWL 354
Cdd:COG2319   124 RSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA------------------------FSPDGKLL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  355 SCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSVEVYPeikDSNQaclppssFITCSSDNTIRLWNTE---------- 424
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTG---HTGAVRSVAFSP---DGKL-------LASGSADGTVRLWDLAtgkllrtltg 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  425 -SSGVHGSALHRN---ILSNDLIKIIYV-DGNTQALLDTelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRMGTLR 499
Cdd:COG2319   245 hSGSVRSVAFSPDgrlLASGSADGTVRLwDLATGELLRT-----------LTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  500 VHELQSLSELLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGQvRM 579
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS-PDG--KTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSP-DGR-TL 387


                  ....*....
gi 564342414  580 ISCGADKSI 588
Cdd:COG2319   388 ASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 476-730 1.19e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  476 GIRSVCISPNGQHLASGDRMGTLRVHELQSLSELLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREYSLQ 555
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADG--TYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  556 qTLDEHSSSITAVKFAASDgqvRMI-SCGADKSIYFRTAQkSGEGVQFTRTHhvvrKTTLYDMDVEPSWKYTAIGCQDRN 634
Cdd:cd00200    88 -TLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKVWDVE-TGKCLTTLRGH----TDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  635 IRIFNISSGKQKKLFKGSQGEdgtLIKVQTDPSGIYIATSCSDKNLSIFDFFSGECVATMFGHSEIVTGMKFSNDCKHLI 714
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                         250
                  ....*....|....*.
gi 564342414  715 SVSGDSCIFVWRLSSE 730
Cdd:cd00200   236 SGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 280-588 1.45e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 1.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  280 CISVSQEYIFCGCADGTVRLFNPSNLHFLSTLpRPHALG-TDIATITEASRLFSGGANarypDTI--------------- 343
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPvRDVAASADGTYLASGSSD----KTIrlwdletgecvrtlt 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  344 -------ALTFDPANQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVypeikdsnqacLPPSSFITCSS-D 415
Cdd:cd00200    91 ghtsyvsSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAF-----------SPDGTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  416 NTIRLWNTESsgvhgsalhrnilsndlIKIIYVdgntqalldtelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRM 495
Cdd:cd00200   157 GTIKLWDLRT-----------------GKCVAT---------------------LTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  496 GTLRVHELQSLSELLKVEAHDSEILCLEYSKPDtglKLLASASRDRLIHVLDaGREYSLQQTLDEHSSSITAVKFAAsDG 575
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG---YLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSP-DG 273

                         330
                  ....*....|...
gi 564342414  576 QvRMISCGADKSI 588
Cdd:cd00200   274 K-RLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-733 4.42e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 4.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  515 HDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAASDGQvrMISCGADKSIYFRTAQ 594
Cdd:cd00200     8 HTGGVTCVAFS-PDG--KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  595 KSGEGVQFTrtHHvvrKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGedgTLIKVQTDPSGIYIATS 674
Cdd:cd00200    82 TGECVRTLT--GH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVASS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564342414  675 CSDKNLSIFDFFSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTI 733
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-165 6.46e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 6.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   75 LFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSV 153
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGsEDGT---IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                          90
                  ....*....|..
gi 564342414  154 GyqHDMIVNVWA 165
Cdd:cd00200   280 S--ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-219 5.80e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414   73 VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVS 152
Cdd:cd00200   117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  153 VGyqHDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDcSYFVTAG--NRHIKFWyldDSKTSKVNATVP 219
Cdd:cd00200   195 SS--SDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLASGseDGTIRVW---DLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 687-725 2.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.50e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 564342414    687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
688-725 7.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 7.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564342414   688 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 837-1207 7.27e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 7.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  837 LGPAPTAN--TGPKRRGRWAQPGVELSVRSMLDLRQLETLAPSPRGPSQDSLAVSPTGPGKHSPQAADLSCAsqnerAPR 914
Cdd:PHA03307   59 AAACDRFEppTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP-----APD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  915 LQASQPCSCPHIIQllSQEEGVFAQDLESAPIEDGIVYPEPSDSPTMDTSAfqvqAPTGGSLGRVYPGSRGSEKHSPDSa 994
Cdd:PHA03307  134 LSEMLRPVGSPGPP--PAASPPAAGASPAAVASDAASSRQAALPLSSPEET----ARAPSSPPAEPPPSTPPAAASPRP- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  995 csvdysssrlsSPEHPNEDSESTEPLSVDGVSSDLEEQAEGEEEEEEEGGTGLCGLQEGSPHTPDQEQFLKQHFETLANG 1074
Cdd:PHA03307  207 -----------PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1075 AAPGgpARALERTESRSISSRfllqvqtSPLREPSLSSSGlALMSRPDQVSQVSGEQLKGSGAT------------PPGA 1142
Cdd:PHA03307  276 NGPS--SRPGPASSSSSPRER-------SPSPSPSSPGSG-PAPSSPRASSSSSSSRESSSSSTssssessrgaavSPGP 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564342414 1143 PPEMEPSSGNsgPKQVAPVLLPRRRTNLDNSWASKKTAATRPLAGLQKAQSVHSLVPQDEVPSRP 1207
Cdd:PHA03307  346 SPSRSPSPSR--PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFP 408
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.62e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564342414   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200   222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-207 3.53e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414  117 VRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 564342414  197 GNRHIKFWYLD 207
Cdd:PLN00181  636 GSADHKVYYYD 646
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564342414     80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 94-150 5.03e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.64  E-value: 5.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564342414   94 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAErNQVAELQEHKYGVACVAFSPSAKYI 150
Cdd:COG4946   434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVET-GKTVQLTDGRYDDGSPAFSPDGKYL 491
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 5.38e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.65  E-value: 5.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414    73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERNQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-164 6.71e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 6.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 564342414    125 RNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 690-730 9.98e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 9.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564342414  690 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 730
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1138-1402 2.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1138 TPPGAPPEMEPSSGNSGPKQVAPVLLPRRRTNLDNSWASKKTAATRPLaglqkaqsvhslvPQDEVPSRPLLFQAEVQGS 1217
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPL-------------PPDTHAPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1218 LGSLPQADGCPSQSHSYWNPTTSSVAKLARSISVGENPGLAAEPQAP----APIRTSPFNKLALPSRahlvldiPKPLPD 1293
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraARPTVGSLTSLADPPP-------PPPTPE 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342414 1294 RPTLTTFSPVSKGLAHSETEQSGPSVSLGKTHTAIEKHSCLGEGTTPKSRTecQAHPGPNHPCAQQLPVSnllqGPESMQ 1373
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAGPPAPAPPAAPAA----GPPRRL 2783

                         250       260
                  ....*....|....*....|....*....
gi 564342414 1374 PLSPEKTRNPVESSRPGAALSQDSELALS 1402
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVL 2812
WD40 pfam00400
WD domain, G-beta repeat;
82-121 2.09e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 2.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564342414    82 KQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
125-164 6.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 6.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564342414   125 RNQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH