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Conserved domains on  [gi|564347197|ref|XP_006236694|]
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histone-lysine N-methyltransferase SMYD1 isoform X1 [Rattus norvegicus]

Protein Classification

histone-lysine N-methyltransferase SMYD1( domain architecture ID 14410430)

histone-lysine N-methyltransferase SMYD1 methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation

CATH:  2.170.270.10
EC:  2.1.1.354
Gene Ontology:  GO:0032259|GO:0042054|GO:0046872|GO:1904047
PubMed:  16086857|25580534|25125178|34555372|24710145
SCOP:  4000530

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-268 2.47e-143

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


:

Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 409.11  E-value: 2.47e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFdslinfvchtcfkrqerlhrcgqckfahycdrtcqkdawlnh 86
Cdd:cd10526    1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------ 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  87 knecsaikryGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFS 166
Cdd:cd10526   39 ----------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPYQSQQFS 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 167 MQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHLS 246
Cdd:cd10526  109 MEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFLNTS 188

                        250       260
                 ....*....|....*....|..
gi 564347197 247 EERRQQLKKQYYFDCSCEHCQK 268
Cdd:cd10526  189 EDRKEQLKKQYYFDCTCEHCTK 210
zf-MYND pfam01753
MYND finger;
52-90 2.19e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.19e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564347197   52 CHTCFKRQERLHRCGQCKFAHYCDRTCQKDAWLNHKNEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-268 2.47e-143

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 409.11  E-value: 2.47e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFdslinfvchtcfkrqerlhrcgqckfahycdrtcqkdawlnh 86
Cdd:cd10526    1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------ 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  87 knecsaikryGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFS 166
Cdd:cd10526   39 ----------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPYQSQQFS 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 167 MQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHLS 246
Cdd:cd10526  109 MEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFLNTS 188

                        250       260
                 ....*....|....*....|..
gi 564347197 247 EERRQQLKKQYYFDCSCEHCQK 268
Cdd:cd10526  189 EDRKEQLKKQYYFDCTCEHCTK 210
zf-MYND pfam01753
MYND finger;
52-90 2.19e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.19e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564347197   52 CHTCFKRQERLHRCGQCKFAHYCDRTCQKDAWLNHKNEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
182-266 1.84e-09

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 55.74  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 182 FTLSDQRGLQAVGVGifpNLG-LVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHlsEERrqqlkkqyyFD 260
Cdd:COG2940   60 FELDDDGVIDGALGG---NPArFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGLDYD--EEE---------YP 125


                 ....*.
gi 564347197 261 CSCEHC 266
Cdd:COG2940  126 CRCPNC 131
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 194-244 4.32e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 54.26  E-value: 4.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 564347197   194 GVGIFPNLGLVNHDCWPNCTVIF----NNGKIELRALGKISEGEELTVSYIDFLH 244
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 203-239 2.53e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 2.53e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564347197  203 LVNHDCWPNCTVIF----NNGKIELRALGKISEGEELTVSY 239
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-268 2.47e-143

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 409.11  E-value: 2.47e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFdslinfvchtcfkrqerlhrcgqckfahycdrtcqkdawlnh 86
Cdd:cd10526    1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------ 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  87 knecsaikryGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFS 166
Cdd:cd10526   39 ----------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPYQSQQFS 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 167 MQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHLS 246
Cdd:cd10526  109 MEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFLNTS 188

                        250       260
                 ....*....|....*....|..
gi 564347197 247 EERRQQLKKQYYFDCSCEHCQK 268
Cdd:cd10526  189 EDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 7-268 2.20e-106

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 314.75  E-value: 2.20e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFdslinfvchtcfkrqerlhrcgqckfahycdrtcqkdawlnh 86
Cdd:cd19167    1 GQVERFCSPGKGRGLRALKPFEPGDLIFSERPYAYVLT------------------------------------------ 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  87 knecsaikrygkvPNENIRLAARIMWRVEREGTGlTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFS 166
Cdd:cd19167   39 -------------PPEHVRLTGRILYKQHIRKTR-TSGKLLSVYDLESHVEKLDEEKKDGLRSDVATLHQFMSKDLQLPD 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 167 MQYISHIFGVINCNGFTLSDQrGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHLS 246
Cdd:cd19167  105 AAYLVELFGKVNCNGFTISDE-ELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYIDLLYPT 183

                        250       260
                 ....*....|....*....|..
gi 564347197 247 EERRQQLKKQYYFDCSCEHCQK 268
Cdd:cd19167  184 EERRDQLRDQYFFLCQCADCQT 205
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 8-267 7.65e-51

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 171.78  E-value: 7.65e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   8 NVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVfdslinfvchtcfkrqerlhrcgqCKfahycdrtcqkdAWLNHK 87
Cdd:cd19203    2 KVEKFETAEKGRGLRAVTPLKPGELVLKADPFAYTV------------------------CN------------PPDSVR 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  88 NECSAIKRYGKVPNEnirlaarimwrveregtgLTEGcLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFSm 167
Cdd:cd19203   46 LEGRIIFKLLDKAPS------------------ESEK-LYSFYDLQSNINKLSEDRKEGLRQLAMVLQHYLREEIQDAS- 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 168 QYIS-----HIFGVINCNGFTLSDQRgLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDF 242
Cdd:cd19203  106 QLPPafdifELFAKVTCNSFTICDAE-MQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISYIDM 184

                        250       260
                 ....*....|....*....|....*
gi 564347197 243 LHLSEERRQQLKKQYYFDCSCEHCQ 267
Cdd:cd19203  185 LMPSEERRKQLRDQYCFECDCFRCQ 209
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-266 1.40e-32

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 123.01  E-value: 1.40e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVfdslinfvchtcfkrqerlhrcgqckfahycdrtcqkdawlnh 86
Cdd:cd19202    1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVL------------------------------------------- 37

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  87 knecsaikrygkVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFS 166
Cdd:cd19202   38 ------------TPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPD 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 167 MQYISHIFGVINCNGFTLSDQRgLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHLS 246
Cdd:cd19202  106 NDSLVVLFAQVNCNGFTIEDEE-LSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPT 184

                        250       260
                 ....*....|....*....|
gi 564347197 247 EERRQQLKKQYYFDCSCEHC 266
Cdd:cd19202  185 EDRNDRLRDSYFFTCECQEC 204
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 180-266 1.26e-29

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 112.09  E-value: 1.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 180 NGFTLSDQRGlqAVGVGIFPNLGLVNHDCWPNCTVIFN-NGKIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYY 258
Cdd:cd20071   37 NSFSLTDGLN--EIGVGLFPLASLLNHSCDPNAVVVFDgNGTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYG 114


                 ....*...
gi 564347197 259 FDCSCEHC 266
Cdd:cd20071  115 FTCSCPRC 122
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 193-266 4.29e-24

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 100.07  E-value: 4.29e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564347197 193 VGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSY-IDFLHLS-EERRQQLKKQYYFDCSCEHC 266
Cdd:cd10536  143 IATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYgPHFSRMKrSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
52-90 2.19e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.19e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564347197   52 CHTCFKRQERLHRCGQCKFAHYCDRTCQKDAWLNHKNEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 8-267 3.41e-12

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 66.95  E-value: 3.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   8 NVEV-FTSEGKGRGLKATKEFWAADVIFAERAYSAVVFdsLINfVCHTCFKRQErlhrcgqckfahycdrtcqkdAWLN- 85
Cdd:cd10521    1 HVEVrFIDAAKGRGLFATRDFKKGDIIFEEKPLVCAQF--LWN-ELHPLNKLQE---------------------AWRNm 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  86 HknecsaikrYgkvPNE--NIRLAARIMWRV------EREGTGLTEGCLVSVDDlQNHVEH--FGEEEQKELRVDVDTFL 155
Cdd:cd10521   57 H---------Y---PPEtaSIMLIARMIATVkqakdkDEWLKLFSQFCSATANE-EEHIAHklLGKQFQGQLELLRQLFT 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 156 Q--YWPPQSQQFSMQYISHIFGVI-----------------NCNGFTLSDQRG---------------------LQAVGV 195
Cdd:cd10521  124 EalYEERLSQWFTPEGFRSLFALVgtngqgigtsslsvwvhNCDALELPEQEReeldafidqlyvdiekesgefLNCEGS 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564347197 196 GIFPNLGLVNHDCWPNCTVIF--NNGKIELRALGKISEGEELTVSYID--FLHLSEERRQQ-LKKQYYFDCSCEHCQ 267
Cdd:cd10521  204 GLYLLQSCCNHSCVPNAEITFpeNNFTLSLKALRDIQEGEEICISYLDecQRERSRHSRQKiLRENYLFICNCPKCE 280
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
182-266 1.84e-09

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 55.74  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 182 FTLSDQRGLQAVGVGifpNLG-LVNHDCWPNCTVIFNNGKIELRALGKISEGEELTVSYIDFLHlsEERrqqlkkqyyFD 260
Cdd:COG2940   60 FELDDDGVIDGALGG---NPArFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGLDYD--EEE---------YP 125


                 ....*.
gi 564347197 261 CSCEHC 266
Cdd:COG2940  126 CRCPNC 131
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 194-244 4.32e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 54.26  E-value: 4.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 564347197   194 GVGIFPNLGLVNHDCWPNCTVIF----NNGKIELRALGKISEGEELTVSYIDFLH 244
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 203-239 2.53e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 2.53e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 564347197  203 LVNHDCWPNCTVIF----NNGKIELRALGKISEGEELTVSY 239
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 203-268 2.62e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 49.59  E-value: 2.62e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564347197 203 LVNHDCWPNCtVIFNNGK--IELRALGKISEGEELTVSYidflhlSEErrqqlkkqyYF-----DCSCEHCQK 268
Cdd:cd10524   79 FINHDCRPNC-KFVPTGKstACVKVLRDIEPGEEITVYY------GDN---------YFgenneECECETCER 135
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 182-239 6.53e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 41.08  E-value: 6.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564347197 182 FTLSD-QRGlQAVGVGIFpnlglVNHDCWPNC----TVIFNNGKIELRALGKISEGEELTVSY 239
Cdd:cd08161   15 FATRDiPKG-EVIGLARF-----INHSCEPNCefeeVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 159-239 3.66e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.93  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 159 PPQSQQFSMQYishifGVINCNGFTLSDQRGLQAVGVGifpnlGLVNHDCWPNCTVI--FNNGKIELRALGKISEGEELT 236
Cdd:cd10540   34 LPKEEYQHLCK-----TVLDHYVFSWGDGCLALALGYG-----SMFNHSYTPNAEYEidFENQTIVFYALRDIEAGEELT 103


                 ...
gi 564347197 237 VSY 239
Cdd:cd10540  104 INY 106
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 203-268 9.15e-04

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 39.58  E-value: 9.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 203 LVNHDCWPNC-TVIFN-NG--KIELRALGKISEGEELTVSYiDFLHLSEERRQQLKkqyyfdCSCEHCQK 268
Cdd:cd19174   75 FVNHSCDPNCeMQKWSvNGvyRIGLFALKDIPAGEELTYDY-NFHSFNVEKQQPCK------CGSPNCRG 137
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 204-239 9.25e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 39.68  E-value: 9.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564347197 204 VNHDCWPNC----TVIFNNGKIELRALGKISEGEELTVSY 239
Cdd:cd19170   90 INHSCEPNCysrvVNIDGKKHIVIFALRRILRGEELTYDY 129
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 211-244 5.79e-03

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 36.94  E-value: 5.79e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 564347197 211 NCTVIFNNGKIELRALGKISEGEELTVSYIDFLH 244
Cdd:cd19201   89 NLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 8-239 5.79e-03

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 38.20  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197   8 NVEVFTSEGKGRGLKATKEFWAADVIFAeraysaVVFDSLINFvchtcfkrqERLHRCGQCKFAHYCDRTCQKDAWLN-- 85
Cdd:cd10527    1 GVELAESPDGGRGLFATRDIAAGEVLLS------VPRSLLLTV---------ETARESPLGGAALALLELDPELSWDVal 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197  86 --------HKNECSAIKRYGKV-PNENIRLAarIMWRVERegtgltegclvsVDDLQN-HVEHFGEEEQKELRVDVDTFL 155
Cdd:cd10527   66 alfllyerARGPDSFWAPYLDSlPRPFEDTP--LFWSEEE------------LDALQGtPLLEAAAAQRRRLREEYEALV 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564347197 156 QYWPPQ-----SQQFSMQYISHIFGVINCNGFTLSDQRGLQavGVGIFPNLGLVNHDCW-PNCTVIF--NNGKIELRALG 227
Cdd:cd10527  132 EALPEAlpaepGEAFTLEEFLWALALVLSRAFSLPVPDGGG--GLALVPLADMLNHSPDaPNVRYEYdeDEGSFVLVATR 209

                        250
                 ....*....|..
gi 564347197 228 KISEGEELTVSY 239
Cdd:cd10527  210 DIAAGEEVFISY 221
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 204-239 8.93e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 37.02  E-value: 8.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564347197 204 VNHDCWPNCT---VIFNNG-KIELRALGKISEGEELTVSY 239
Cdd:cd19171   90 INHSCNPNCVaevVTFDKEkKIIIISNRRIAKGEELTYDY 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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