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Conserved domains on  [gi|564355918|ref|XP_006240139|]
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striatin-3 isoform X3 [Rattus norvegicus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 388-709 4.78e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 4.78e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 388 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 467
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 468 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 547
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 548 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 626
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 627 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 706
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355918 707 KVF 709
Cdd:cd00200  286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 1.26e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.89  E-value: 1.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355918  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 388-709 4.78e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 4.78e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 388 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 467
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 468 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 547
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 548 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 626
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 627 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 706
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355918 707 KVF 709
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
348-708 7.58e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.68  E-value: 7.58e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 348 LLSVLGLGDLADLTVTNDADYSYDLPANKDALRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 422
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 423 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAV 502
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 503 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCICTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSL 580
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 581 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 660
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 564355918 661 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 708
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 1.26e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.89  E-value: 1.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355918  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 625-664 4.97e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 4.97e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355918   625 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 664
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
626-664 9.25e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355918  626 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 664
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 388-709 4.78e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 4.78e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 388 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 467
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 468 ATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCICTYNGdKEHGIp 547
Cdd:cd00200   73 KTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 548 TSVDFIGCDpaHMVTSF-NTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 626
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 627 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 706
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 564355918 707 KVF 709
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
348-708 7.58e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.68  E-value: 7.58e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 348 LLSVLGLGDLADLTVTNDADYSYDLPANKDALRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 422
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 423 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAV 502
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 503 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCICTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSL 580
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 581 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 660
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 564355918 661 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 708
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 1.26e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.89  E-value: 1.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918   64 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 564355918  144 dlkmptfeseetkdaeappaqnsqlTWKQGRQLLRQYLQEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
381-667 1.67e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 1.67e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 381 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQ 460
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 461 CFSGGIDATIQWWNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKlPCICTYNG 540
Cdd:COG2319  219 LASGSADGTVRLWDLATGK-----------LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTG 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 541 DkeHGIPTSVDFIGcDPAHMVTSFNTGSAIIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKF 620
Cdd:COG2319  287 H--SGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-------VRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 564355918 621 FDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 667
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
313-709 7.52e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 7.52e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 313 GAGEARSSGDGTEWAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADysydlpANKDALRKTWNPKYTLRSH 392
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDL------TLLLLDAAAGALLATLLGH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 393 FDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQW 472
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATG-----------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 473 WNMPSPNvdpydtyeshvLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKlPCICTYNGDKehGIPTSVDF 552
Cdd:COG2319  147 WDLATGK-----------LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAVRSVAF 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 553 igcdpahmvtsfntgsaiiydletsqslvmlssqvdsglqSSNHiNRVVShptlpvtitAHEDRHIKFFDNKTGKMIHSM 632
Cdd:COG2319  213 ----------------------------------------SPDG-KLLAS---------GSADGTVRLWDLATGKLLRTL 242

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564355918 633 VAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 709
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 491-709 7.67e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 7.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 491 LAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNpQEKLPCICTYngdKEHGIP-TSVDFIGCDPAhMVTSFNTGSA 569
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTL---KGHTGPvRDVAASADGTY-LASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564355918 570 IIYDLETSQSLVMLSSqvdsglqssnHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDP 646
Cdd:cd00200   76 RLWDLETGECVRTLTG----------HTSYVSSvafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564355918 647 NGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 709
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 625-664 4.97e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 4.97e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355918   625 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 664
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
626-664 9.25e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355918  626 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 664
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 382-421 1.42e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.42e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564355918   382 TWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 421
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
383-421 6.75e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.75e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564355918  383 WNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 421
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 494-527 1.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 564355918   494 TLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 527
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
493-527 7.60e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564355918  493 GTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 527
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
380-423 1.14e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.14e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 564355918 380 RKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 423
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 437-474 1.18e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.18e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564355918   437 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 474
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
437-474 1.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564355918  437 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 474
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 667-709 7.33e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 7.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 564355918   667 SKTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 709
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 626-691 4.77e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 4.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564355918  626 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL--------DSKTCVQEItaHRKklDESIYDVAFH 691
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEF--PRK--DHVIAETPFH 183
WD40 pfam00400
WD domain, G-beta repeat;
668-709 5.02e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564355918  668 KTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 709
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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