|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1788-2120 |
3.94e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
:
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.94e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1788 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1867
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1868 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1939
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1940 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2014
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2015 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2092
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 564358051 2093 RPETVKRYASLPHISVSRRPDSAVSVPT 2120
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
380-453 |
5.55e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
:
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.55e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564358051 380 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 453
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
7.00e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
:
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 7.00e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 564358051 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-229 |
6.99e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
:
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 6.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 227
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 564358051 228 TS 229
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 super family |
cl25003 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
719-965 |
4.93e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
The actual alignment was detected with superfamily member pfam16629:
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 719 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 798
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 799 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 861
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 862 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 937
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 564358051 938 AAHTSLSNDSLNSGSTSDGYCTREHMTP 965
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
637-676 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564358051 637 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 676
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1622-1643 |
7.35e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.35e-05
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1528-1953 |
8.02e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1528 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1604
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1605 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1673
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1674 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1753
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1754 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1833
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1834 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1912
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 1913 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1953
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| DUF5585 super family |
cl39316 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2065-2304 |
2.60e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
The actual alignment was detected with superfamily member pfam17823:
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2065 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2143
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2144 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2192
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2193 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2268
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 564358051 2269 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2304
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1401-1423 |
6.53e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.53e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
678-718 |
3.15e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564358051 678 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 718
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1277-1298 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1165-1188 |
5.76e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.76e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1788-2120 |
3.94e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.94e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1788 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1867
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1868 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1939
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1940 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2014
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2015 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2092
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 564358051 2093 RPETVKRYASLPHISVSRRPDSAVSVPT 2120
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
380-453 |
5.55e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.55e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564358051 380 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 453
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
7.00e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 7.00e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 564358051 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-229 |
6.99e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 6.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 227
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 564358051 228 TS 229
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
719-965 |
4.93e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 719 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 798
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 799 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 861
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 862 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 937
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 564358051 938 AAHTSLSNDSLNSGSTSDGYCTREHMTP 965
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1799-2305 |
1.42e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1799 ASPASRAQSKGISGPCSAPKKMGTSGTTQpETATKTPsPEQQRSRSlhrPGKISELAALSHPPrSATPPArlTKTPSSSS 1878
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRA---PVDDRGDPRGPAPP-SPLPPD--THAPDPPP 2628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1879 SQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPvripfMQRPARRVPPP-------LARPSP 1951
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-----PQRPRRRAARPtvgsltsLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1952 EPGSrgragAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCR 2031
Cdd:PHA03247 2704 PPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2032 GRPALPAVFLCSSrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETvkryaslphisvsrr 2111
Cdd:PHA03247 2779 PPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--------------- 2841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2112 PDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRrikdedvPHILRSTLPATALPlRGSSPEDSPAGTPHRKtsdav 2191
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-------ARPPVRRLARPAVS-RSTESFALPPDQPERP----- 2908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2192 vQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGlSVVTGGFPTSRHGSPSRAARV 2271
Cdd:PHA03247 2909 -PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPAPSR 2986
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 564358051 2272 PPFNYVPSPMV------VATMTSDSAVEKAPVTSPASLLE 2305
Cdd:PHA03247 2987 EAPASSTPPLTghslsrVSSWASSLALHEETDPPPVSLKQ 3026
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
637-676 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564358051 637 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 676
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
636-676 |
2.31e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.31e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564358051 636 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 676
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1622-1643 |
7.35e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.35e-05
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1528-1953 |
8.02e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1528 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1604
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1605 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1673
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1674 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1753
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1754 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1833
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1834 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1912
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 1913 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1953
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
15-286 |
1.87e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 46.43 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 15 FGNQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSG 92
Cdd:COG4372 16 FGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 93 QTEVLEQLKALQTDISSLynlkfhapalgpepaaqtpegspvhgpapskdsfgelsRATIrllEELDQERCFLlseieke 172
Cdd:COG4372 96 LAQAQEELESLQEEAEEL--------------------------------------QEEL---EELQKERQDL------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 173 ekeklwyYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLE 252
Cdd:COG4372 128 -------EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKE 191
|
250 260 270
....*....|....*....|....*....|....
gi 564358051 253 AQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPED 286
Cdd:COG4372 192 ANRNAEKEEELAEAEKLIESLPRELAEELLEAKD 225
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2065-2304 |
2.60e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2065 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2143
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2144 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2192
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2193 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2268
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 564358051 2269 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2304
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1401-1423 |
6.53e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.53e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
678-718 |
3.15e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564358051 678 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 718
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1277-1298 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1165-1188 |
5.76e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.76e-03
|
| ZapB |
COG3074 |
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ... |
17-82 |
6.78e-03 |
|
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442308 [Multi-domain] Cd Length: 79 Bit Score: 37.64 E-value: 6.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564358051 17 NQALQEL--KMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLE 82
Cdd:COG3074 3 LELLEELeaKVQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIR 70
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
30-263 |
7.02e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.58 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQ--EARVLVSSGQTEVLEQLKALQTDI 107
Cdd:TIGR02168 267 EKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEEleAQLEELESKLDELAEELAELEEKL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 108 SSLYNLKFHAPALGPEPAAQTPEGSpvHGPAPSKDSFGELSRATIRLLEELDQERcfllseiekeekeklwyySQLQGLS 187
Cdd:TIGR02168 347 EELKEELESLEAELEELEAELEELE--SRLEELEEQLETLRSKVAQLELQIASLN------------------NEIERLE 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 188 KRLDELPH-VDTQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQ 263
Cdd:TIGR02168 407 ARLERLEDrRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE 483
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1788-2120 |
3.94e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.94e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1788 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1867
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1868 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1939
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1940 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2014
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2015 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2092
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 564358051 2093 RPETVKRYASLPHISVSRRPDSAVSVPT 2120
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
380-453 |
5.55e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.55e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564358051 380 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 453
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
7.00e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 7.00e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 564358051 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-229 |
6.99e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 6.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 227
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 564358051 228 TS 229
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
719-965 |
4.93e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 719 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 798
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 799 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 861
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 862 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 937
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 564358051 938 AAHTSLSNDSLNSGSTSDGYCTREHMTP 965
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1799-2305 |
1.42e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1799 ASPASRAQSKGISGPCSAPKKMGTSGTTQpETATKTPsPEQQRSRSlhrPGKISELAALSHPPrSATPPArlTKTPSSSS 1878
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRA---PVDDRGDPRGPAPP-SPLPPD--THAPDPPP 2628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1879 SQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPvripfMQRPARRVPPP-------LARPSP 1951
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-----PQRPRRRAARPtvgsltsLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1952 EPGSrgragAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCR 2031
Cdd:PHA03247 2704 PPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2032 GRPALPAVFLCSSrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETvkryaslphisvsrr 2111
Cdd:PHA03247 2779 PPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--------------- 2841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2112 PDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRrikdedvPHILRSTLPATALPlRGSSPEDSPAGTPHRKtsdav 2191
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-------ARPPVRRLARPAVS-RSTESFALPPDQPERP----- 2908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2192 vQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGlSVVTGGFPTSRHGSPSRAARV 2271
Cdd:PHA03247 2909 -PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPAPSR 2986
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 564358051 2272 PPFNYVPSPMV------VATMTSDSAVEKAPVTSPASLLE 2305
Cdd:PHA03247 2987 EAPASSTPPLTghslsrVSSWASSLALHEETDPPPVSLKQ 3026
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
637-676 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564358051 637 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 676
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
636-676 |
2.31e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.31e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564358051 636 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 676
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1936-2270 |
6.35e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.71 E-value: 6.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1936 QRPARRVPPPLARPSPEPGSRGRAGAeGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTfikESPGLLRRRRSELS 2015
Cdd:PHA03307 80 PANESRSTPTWSLSTLAPASPAREGS-PTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV---GSPGPPPAASPPAA 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2016 SADSTVSTSQTASPCRGRPALPAVflcssrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPE 2095
Cdd:PHA03307 156 GASPAAVASDAASSRQAALPLSSP-------EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2096 TVKRYASLPHISVSRRPDSAVSVPttqanatrrgsdgEARPLPRvAAPGTTWRRIkDEDVPHILRSTLPATALP------ 2169
Cdd:PHA03307 229 ADDAGASSSDSSSSESSGCGWGPE-------------NECPLPR-PAPITLPTRI-WEASGWNGPSSRPGPASSssspre 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2170 LRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTnSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPP----ASAPF 2245
Cdd:PHA03307 294 RSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS-SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSsprkRPRPS 372
|
330 340
....*....|....*....|....*
gi 564358051 2246 THEGLSVVTGGFPTSRHGSPSRAAR 2270
Cdd:PHA03307 373 RAPSSPAASAGRPTRRRARAAVAGR 397
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1933-2292 |
2.52e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 2.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1933 PFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRVASTRSSGSEssdrsgfrRQLTFIKespGLlrrrrS 2012
Cdd:PHA03247 2478 PVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHP--------RMLTWIR---GL-----E 2541
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2013 ELSSADS--------------TVSTSQTASPCRGRPALPAVFLCSSRCD------------ELRASPRQPLAAQRVPQAK 2066
Cdd:PHA03247 2542 ELASDDAgdpppplppaappaAPDRSVPPPRPAPRPSEPAVTSRARRPDappqsarprapvDDRGDPRGPAPPSPLPPDT 2621
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2067 PGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPdSAVSVPTTQANATRRGSDGEARP-------LPR 2139
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-RRLGRAAQASSPPQRPRRRAARPtvgsltsLAD 2700
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2140 VAAPGTTwrrikDEDVPHILRSTLPATALPL--RGSSPEDSPAGTPHRKTSDAVVQTEDV------ATSKTNSSTSPSLE 2211
Cdd:PHA03247 2701 PPPPPPT-----PEPAPHALVSATPLPPGPAaaRQASPALPAAPAPPAVPAGPATPGGPArparppTTAGPPAPAPPAAP 2775
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2212 SRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGLSVVTGGFPTSRHGSPSRAARVPPFNYVPSPMVVATMTSDSA 2291
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
|
.
gi 564358051 2292 V 2292
Cdd:PHA03247 2856 V 2856
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1622-1643 |
7.35e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.35e-05
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1528-1953 |
8.02e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1528 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1604
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1605 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1673
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1674 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1753
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1754 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1833
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1834 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1912
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 1913 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1953
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
15-286 |
1.87e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 46.43 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 15 FGNQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSG 92
Cdd:COG4372 16 FGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 93 QTEVLEQLKALQTDISSLynlkfhapalgpepaaqtpegspvhgpapskdsfgelsRATIrllEELDQERCFLlseieke 172
Cdd:COG4372 96 LAQAQEELESLQEEAEEL--------------------------------------QEEL---EELQKERQDL------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 173 ekeklwyYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLE 252
Cdd:COG4372 128 -------EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKE 191
|
250 260 270
....*....|....*....|....*....|....
gi 564358051 253 AQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPED 286
Cdd:COG4372 192 ANRNAEKEEELAEAEKLIESLPRELAEELLEAKD 225
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1752-2226 |
2.57e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1752 RPEKRGTTSTKGSGSPRFPSGPEKAKGtqKTMAGESAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGT-TQPET 1830
Cdd:PHA03247 2572 RPAPRPSEPAVTSRARRPDAPPQSARP--RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPpTVPPP 2649
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1831 ATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPV 1910
Cdd:PHA03247 2650 ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1911 PKSPARALLAKQHKTQKSPVrIPFMQRPARRVPPPLARPSPEPGsrgrAGAEGTPGARGSRLGLVRVASTRSSGSESsdr 1990
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTAGPPAPAPP----AAPAAGPPRRLTRPAVASLSESRESLPSP--- 2801
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1991 sgfrrqltfikespgllrrrrSELSSADSTVSTSQTASPCRGRPALPAVFLCSSrcdeLRASPRQPLAAQRVPQAKPG-L 2069
Cdd:PHA03247 2802 ---------------------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSA----QPTAPPPPPGPPPPSLPLGGsV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2070 APRAPRRTSSESPSRLPVRATPGRPetvkRYASLPHISVSRRPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRR 2149
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 2150 IKDEDVPhilrstlPATALPLRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAP 2226
Cdd:PHA03247 2933 PPPPPRP-------QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2065-2304 |
2.60e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2065 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2143
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2144 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2192
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2193 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2268
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 564358051 2269 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2304
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2003-2235 |
3.88e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2003 SPGLLRRRRSELSSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASP-RQPLAAQRVPQAKPGLAPRAPR------ 2075
Cdd:PHA03247 256 APPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPlALPAPPDPPPPAPAGDAEEEDDedgame 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2076 ------RTSSESPSRLPVRATPgrpeTVKRYASLPHISVSRRPDSAVSVPTTQANATR-------RGSDGEARPLPRVAA 2142
Cdd:PHA03247 336 vvsplpRPRQHYPLGFPKRRRP----TWTPPSSLEDLSAGRHHPKRASLPTRKRRSARhaatpfaRGPGGDDQTRPAAPV 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 2143 PGTTwrriKDEDVPHILRSTLPATALPLRGSSP--EDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPI 2220
Cdd:PHA03247 412 PASV----PTPAPTPVPASAPPPPATPLPSAEPgsDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEPPG 487
|
250
....*....|....*..
gi 564358051 2221 SGPVAPLGS--DVDGPV 2235
Cdd:PHA03247 488 ADLAELLGRhpDTAGTV 504
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1401-1423 |
6.53e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.53e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
678-718 |
3.15e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564358051 678 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 718
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1277-1298 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| ZapB |
pfam06005 |
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ... |
22-83 |
5.02e-03 |
|
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.
Pssm-ID: 428718 [Multi-domain] Cd Length: 71 Bit Score: 37.63 E-value: 5.02e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564358051 22 ELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQ 83
Cdd:pfam06005 10 ETKIQAAVDTIALLQMENEELKEENEELKEEANELEEENQQLKQERNQWQERIRGLLGKLDE 71
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1165-1188 |
5.76e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.76e-03
|
| ZapB |
COG3074 |
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ... |
17-82 |
6.78e-03 |
|
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442308 [Multi-domain] Cd Length: 79 Bit Score: 37.64 E-value: 6.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564358051 17 NQALQEL--KMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLE 82
Cdd:COG3074 3 LELLEELeaKVQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIR 70
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
30-263 |
7.02e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.58 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQ--EARVLVSSGQTEVLEQLKALQTDI 107
Cdd:TIGR02168 267 EKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEEleAQLEELESKLDELAEELAELEEKL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 108 SSLYNLKFHAPALGPEPAAQTPEGSpvHGPAPSKDSFGELSRATIRLLEELDQERcfllseiekeekeklwyySQLQGLS 187
Cdd:TIGR02168 347 EELKEELESLEAELEELEAELEELE--SRLEELEEQLETLRSKVAQLELQIASLN------------------NEIERLE 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564358051 188 KRLDELPH-VDTQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQ 263
Cdd:TIGR02168 407 ARLERLEDrRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE 483
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1460-1898 |
9.91e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.31 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1460 AAGAGAGKSTEHTRGANRNRAGLELPLSRPQSARSNRDGSCQTRTRGDGALQSLCLTT-PTEEAVYCFYDSDEEPPATAP 1538
Cdd:PHA03307 12 EAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgPPPGPGTEAPANESRSTPTWS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1539 PTRRASAIPRALKREKPAGR--KETPTRATQPATLPVRAQPRLIvdETPPCYSLTSSASSLSEPEASEQPACHPRVEEqG 1616
Cdd:PHA03307 92 LSTLAPASPAREGSPTPPGPssPDPPPPTPPPASPPPSPAPDLS--EMLRPVGSPGPPPAASPPAAGASPAAVASDAA-S 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1617 SKQDSSPRAEEELLQRCISLAMPRRRTQVPSSRRRKPRAVRSdiRPTELPQKCREEVPGSDPASDLDSVEWQAIQEGAnS 1696
Cdd:PHA03307 169 SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRS--SPISASASSPAPAPGRSAADDAGASSSDSSSSES-S 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1697 IVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSklRKGRKPVAEAGGAWRPEKRGTTSTKGSGSPRFPSGPEKA 1776
Cdd:PHA03307 246 GCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP--ASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564358051 1777 KGTQKTMAGeSAMLRGRTVIYTASPASRAQSKGISGP--CSAPKKMGTSGTTQPETATKTPSPEQQRSRSlhrpgkisel 1854
Cdd:PHA03307 324 SSSSSTSSS-SESSRGAAVSPGPSPSRSPSPSRPPPPadPSSPRKRPRPSRAPSSPAASAGRPTRRRARA---------- 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 564358051 1855 AALSHPPRSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPT 1898
Cdd:PHA03307 393 AVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPS 436
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2232-2280 |
9.95e-03 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 39.21 E-value: 9.95e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 564358051 2232 DGPVLAKPPASAPFTHEGLSVVTGGFPT---SRHGSPSR--AARVPPFNYVPSP 2280
Cdd:pfam05937 68 ETKPLQNNPVPTPETNENPVSERTPFSSsssSKHSSPSGavAARVTPFNYNPSP 121
|
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