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Conserved domains on  [gi|564359076|ref|XP_006241347|]
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decorin isoform X3 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-302 1.07e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  78 TTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNkiskispEAFKPLVKLERLYLSKNHLKELPEKLP--KTLQELRLHDN 155
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 156 EITKLKKSvfnglnrmivielggnplknsgiengaLQGMKGLGYIRISDTNITAIPQGLP--TSISELHLDGNKIAKVdA 233
Cdd:COG4886  147 QLTDLPEP---------------------------LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-P 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 234 ASLKGMSNLSKLGLSFNSITVVENgSLANVPHLRELHLDNNKLLRVPAgLAQHKYVQVVYLHNNNISEV 302
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDL 265
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 6.75e-12

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.75e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564359076    48 MCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-302 1.07e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  78 TTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNkiskispEAFKPLVKLERLYLSKNHLKELPEKLP--KTLQELRLHDN 155
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 156 EITKLKKSvfnglnrmivielggnplknsgiengaLQGMKGLGYIRISDTNITAIPQGLP--TSISELHLDGNKIAKVdA 233
Cdd:COG4886  147 QLTDLPEP---------------------------LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-P 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 234 ASLKGMSNLSKLGLSFNSITVVENgSLANVPHLRELHLDNNKLLRVPAgLAQHKYVQVVYLHNNNISEV 302
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDL 265
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-329 1.01e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.44  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  65 LGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPLVklERLYLSKNHLKELPEKLP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIK---TLYANSNQLTSI-PATLPDTI--QEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 145 KTLQELRLHDNEITKLKKSVFNGLNRMIVIElggNPLKnsgiengALQGM--KGLGYIRISDTNITAIPQGLPTSISELH 222
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIR-------TLPAHlpSGITHLNVQSNSLTALPETLPPGLKTLE 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 223 LDGNKIAKVDAASLKGMSNLSklgLSFNSITVVENgSLAnvPHLRELHLDNNKLLRVPAGL-AQHKYVQVVYlhnNNISE 301
Cdd:PRK15370 332 AGENALTSLPASLPPELQVLD---VSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAALQIMQASR---NNLVR 402

                        250       260
                 ....*....|....*....|....*...
gi 564359076 302 VGQhdfCLPSYQTRKTSYTAVSLYSNPV 329
Cdd:PRK15370 403 LPE---SLPHFRGEGPQPTRIIVEYNPF 427
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 6.75e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.75e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564359076    48 MCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
79-136 8.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 8.46e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 564359076   79 TLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-276 8.67e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 129 LYLSKNHLKELPE-KLPKTLQELRLHDNEITKLKKSVFNglnrmivielggnplknsgiengalqgmkglgyirisdTNI 207
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFL--------------------------------------TNL 48

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 208 TaipqglptsisELHLDGNKIAKVDaaSLKGMSNLSKLGLSFNSITVVENgsLANVPHLRELHLDNNKL 276
Cdd:cd21340   49 T-----------HLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 48-75 6.69e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.40  E-value: 6.69e-10
                          10        20
                  ....*....|....*....|....*...
gi 564359076   48 MCPYRCQCHLRVVQCSDLGLDKVPWEFP 75
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-302 1.07e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  78 TTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNkiskispEAFKPLVKLERLYLSKNHLKELPEKLP--KTLQELRLHDN 155
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 156 EITKLKKSvfnglnrmivielggnplknsgiengaLQGMKGLGYIRISDTNITAIPQGLP--TSISELHLDGNKIAKVdA 233
Cdd:COG4886  147 QLTDLPEP---------------------------LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-P 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 234 ASLKGMSNLSKLGLSFNSITVVENgSLANVPHLRELHLDNNKLLRVPAgLAQHKYVQVVYLHNNNISEV 302
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDL 265
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-329 1.01e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.44  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  65 LGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPLVklERLYLSKNHLKELPEKLP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIK---TLYANSNQLTSI-PATLPDTI--QEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 145 KTLQELRLHDNEITKLKKSVFNGLNRMIVIElggNPLKnsgiengALQGM--KGLGYIRISDTNITAIPQGLPTSISELH 222
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIR-------TLPAHlpSGITHLNVQSNSLTALPETLPPGLKTLE 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 223 LDGNKIAKVDAASLKGMSNLSklgLSFNSITVVENgSLAnvPHLRELHLDNNKLLRVPAGL-AQHKYVQVVYlhnNNISE 301
Cdd:PRK15370 332 AGENALTSLPASLPPELQVLD---VSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAALQIMQASR---NNLVR 402

                        250       260
                 ....*....|....*....|....*...
gi 564359076 302 VGQhdfCLPSYQTRKTSYTAVSLYSNPV 329
Cdd:PRK15370 403 LPE---SLPHFRGEGPQPTRIIVEYNPF 427
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-290 2.58e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  56 HLRVVQCSDLGLDKVPWEFPPDTTL--LDLQNNKITEIKEgAFKNLKDLHTLILVNNKISKIsPEAFKPLVKLERLYLSK 133
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 134 NHLKELPE--KLPKtLQELRLHDNEITKLKKSVfnGLNRMIVIELGGNPLKNSGIEN-GALQGMKGLGYIRISDTNITAI 210
Cdd:COG4886  238 NQLTDLPElgNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKElELLLGLNSLLLLLLLLNLLELL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 211 PQGLPTSISELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLLRVPAGLAQHKYVQ 290
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-301 1.09e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  83 LQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKLKK 162
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 163 SVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLP--TSISELHLDGNKIAKVDAaSLKGMS 240
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGNLT 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564359076 241 NLSKLGLSFNSITVVENgSLANVPHLRELHLDNNKLLRVPAGLAQHKYVQVVYLHNNNISE 301
Cdd:COG4886  160 NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-245 3.91e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 3.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  42 DNPLISMcPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEgafKNLKDLHTLILVNNKISKIsPEAFK 121
Cdd:PRK15370 208 NNELKSL-PENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 122 PlvKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKLKKSVFNGLNrmiVIELGGNPLknSGIENGALQGMKGLGyir 201
Cdd:PRK15370 283 E--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENAL--TSLPASLPPELQVLD--- 352

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564359076 202 ISDTNITAIPQGLPTSISELHLDGNKIAKVD---AASLKGM----SNLSKL 245
Cdd:PRK15370 353 VSKNQITVLPETLPPTITTLDVSRNALTNLPenlPAALQIMqasrNNLVRL 403
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 6.75e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.75e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564359076    48 MCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
79-136 8.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 8.46e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 564359076   79 TLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-276 8.67e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 129 LYLSKNHLKELPE-KLPKTLQELRLHDNEITKLKKSVFNglnrmivielggnplknsgiengalqgmkglgyirisdTNI 207
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFL--------------------------------------TNL 48

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 208 TaipqglptsisELHLDGNKIAKVDaaSLKGMSNLSKLGLSFNSITVVENgsLANVPHLRELHLDNNKL 276
Cdd:cd21340   49 T-----------HLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-288 1.46e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  79 TLLDLQNNKITEIkeGAFKNLKDLHTLILVNNKISKIspEAFKPLVKLERLYLSKNHLKELP--EKLPKtLQELRLHDNE 156
Cdd:cd21340    5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 157 ITKlkksvfnglnrmivielggnplknsgIENgaLQGMKGLGYIRISDTNItaiPQGLP--------TSISE----LHLD 224
Cdd:cd21340   80 ISV--------------------------VEG--LENLTNLEELHIENQRL---PPGEKltfdprslAALSNslrvLNIS 128

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564359076 225 GNKIAkvDAASLKGMSNLSKLGLSFNSITVVEN--GSLANVPHLRELHLDNNKLLRvpaglaQHKY 288
Cdd:cd21340  129 GNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK------KPKY 186
LRR_8 pfam13855
Leucine rich repeat;
216-276 2.96e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 2.96e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564359076  216 TSISELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKL 276
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 48-75 6.69e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.40  E-value: 6.69e-10
                          10        20
                  ....*....|....*....|....*...
gi 564359076   48 MCPYRCQCHLRVVQCSDLGLDKVPWEFP 75
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-285 1.00e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  79 TLLDLQNNKITEIKEGAFKNL---KDLHTLILVNNKIS----KISPEAFKPLV-KLERLYLSKNHLK-ELPEKLPKTLQE 149
Cdd:cd00116   84 QELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEgASCEALAKALRA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 150 LRlhdneitKLKKsvfnglnrmivIELGGNPLKNSGIENGAlQGMK---GLGYIRISDTNIT-----AIPQGLPT--SIS 219
Cdd:cd00116  164 NR-------DLKE-----------LNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGLTdegasALAETLASlkSLE 224

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564359076 220 ELHLDGNKIAKVDAASL-----KGMSNLSKLGLSFNSITVVENGSLANV----PHLRELHLDNNKLLRVPAGLAQ 285
Cdd:cd00116  225 VLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGAQLLA 299
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-276 5.14e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  75 PPDTTLLDLQNNKITEikEGA------FKNLKDLHTLILVNNKISKISPEAFKPLVK----LERLYLSKNHLKElpeklp 144
Cdd:COG5238  207 NTTVTTLWLKRNPIGD--EGAeilaeaLKGNKSLTTLDLSNNQIGDEGVIALAEALKnnttVETLYLSGNQIGA------ 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 145 KTLQELRLHDNEITKLKKsvfnglnrmivIELGGNPLKNSGIENGA--LQGMK-----GLGYIRISDTNITAIPQGLP-- 215
Cdd:COG5238  279 EGAIALAKALQGNTTLTS-----------LDLSVNRIGDEGAIALAegLQGNKtlhtlNLAYNGIGAQGAIALAKALQen 347

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564359076 216 TSISELHLDGNKI----AKVDAASLKGMSNLSKLGLSFNSITVVENGSLA---NVPHLRELHLDNNKL 276
Cdd:COG5238  348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNLI 415
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-188 2.20e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  34 SGIIPYDPDNPLISMCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITeikegafknlkdlhtlilvnnkis 113
Cdd:PRK15370 304 SGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQIT------------------------ 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 114 kISPEAFKPlvKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKLKKSVFNGLNR-----MIVIELggNPLKNSGIEN 188
Cdd:PRK15370 360 -VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFRGEgpqptRIIVEY--NPFSERTIQN 434
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-300 2.59e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  70 VPWEFPPDTTL--LDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLK-ELPEKLP-- 144
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIql 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 145 KTLQELRLHDNEITKLKKSVFNGLNRMIVIELGGNPL-----KNSGIENgalqgmkGLGYIRISDTNITA-IPQGLPTSi 218
Cdd:PLN00113 308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHN-------NLTVLDLSTNNLTGeIPEGLCSS- 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 219 selhldgnkiakvdaaslkgmSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLL-RVPAGLAQHKYVQVVYLHNN 297
Cdd:PLN00113 380 ---------------------GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNN 438


                 ...
gi 564359076 298 NIS 300
Cdd:PLN00113 439 NLQ 441
LRR_8 pfam13855
Leucine rich repeat;
102-157 2.72e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  102 LHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEK----LPKtLQELRLHDNEI 157
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-302 1.88e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 155 NEITKLKKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLPTSISELHLDGNKiakvdaa 234
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564359076 235 SLKGMSNLSKLGLSFNSITVVENgSLANVPHLRELHLDNNKLLRVPAGLAQHKYVQVVYLHNNNISEV 302
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL 174
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
59-301 2.86e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  59 VVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEGAfknlKDLHTLILVNNKISKIS--PEAF-------KPLVKLE-- 127
Cdd:PRK15387 205 VLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPvlPPGLlelsifsNPLTHLPal 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 128 -----RLYLSKNHLKELPeKLPKTLQELRLHDNEITKLKK---------SVFNGLNRMIVIELGGNPLKNSGIENGALQG 193
Cdd:PRK15387 281 psglcKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPAlpselcklwAYNNQLTSLPTLPSGLQELSVSDNQLASLPT 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 194 MKGLGY-IRISDTNITAIPqGLPTSISELHLDGNKIAKVDAASlkgmSNLSKLGLSFNSITvvengSLANVPH-LRELHL 271
Cdd:PRK15387 360 LPSELYkLWAYNNRLTSLP-ALPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLT-----SLPMLPSgLLSLSV 429

                        250       260       270
                 ....*....|....*....|....*....|
gi 564359076 272 DNNKLLRVPAGLAQHKYVQVVYLHNNNISE 301
Cdd:PRK15387 430 YRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-302 6.03e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 216 TSISELHLDGNKIAKVDAasLKGMSNLSKLGLSFNSITVVENgsLANVPHLRELHLDNNKLLRVPaGLAQHKYVQVVYLH 295
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76


                 ....*..
gi 564359076 296 NNNISEV 302
Cdd:cd21340   77 GNRISVV 83
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-300 1.06e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  80 LLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYL-----------------SKNHLK----- 137
Cdd:PLN00113 168 VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgynnlsgeipyeiggltSLNHLDlvynn 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 138 ---ELPEKLP--KTLQELRLHDNEIT-KLKKSVFnGLNRMIVIELGGNPLknSGIENGALQGMKGLGYIRISDTNITA-I 210
Cdd:PLN00113 248 ltgPIPSSLGnlKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSL--SGEIPELVIQLQNLEILHLFSNNFTGkI 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 211 PQGLPT--SISELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLL-RVPAGLAQHK 287
Cdd:PLN00113 325 PVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACR 404

                        250
                 ....*....|...
gi 564359076 288 YVQVVYLHNNNIS 300
Cdd:PLN00113 405 SLRRVRLQDNSFS 417
LRR_8 pfam13855
Leucine rich repeat;
240-299 1.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564359076  240 SNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLLRVPAGLAQH-KYVQVVYLHNNNI 299
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
81-159 1.29e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.14  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076   81 LDLQNNKITEIKegAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLP----KTLQELRLHDNE 156
Cdd:pfam14580  47 IDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPlaslKKLTFLSLLRNP 124


                  ...
gi 564359076  157 ITK 159
Cdd:pfam14580 125 VTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 163-304 1.09e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 163 SVFNGLNRMIVIELGGNPLkNSGIENGALQGMKGLGYIRISDTNIT-AIPQGLPTSISELHLDGNKIAKVDAASLKGMSN 241
Cdd:PLN00113  87 SAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSS 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564359076 242 LSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLL-RVPAGLAQHKYVQVVYLHNNNIS-----EVGQ 304
Cdd:PLN00113 166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgeipyEIGG 234
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 174-329 1.30e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 174 IELGGNPLKNSGIEN--GALQGMKGLGYIRISDTNIT-----AIPQGL--PTSISELHLDGNKI----AKVDAASLKGMS 240
Cdd:COG5238  213 LWLKRNPIGDEGAEIlaEALKGNKSLTTLDLSNNQIGdegviALAEALknNTTVETLYLSGNQIgaegAIALAKALQGNT 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 241 NLSKLGLSFNSITvvENGSLANVPHLRelhldNNKLLRVpaglaqhkyvqvVYLHNNNISEVGqhdfCLPSYQTRKTSYT 320
Cdd:COG5238  293 TLTSLDLSVNRIG--DEGAIALAEGLQ-----GNKTLHT------------LNLAYNGIGAQG----AIALAKALQENTT 349

                        170
                 ....*....|.
gi 564359076 321 AVS--LYSNPV 329
Cdd:COG5238  350 LHSldLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-300 2.68e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  76 PDTTLLDLQNNKIT-EIKEGAFKNlKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNHLK-ELPEKLP--KTLQELR 151
Cdd:PLN00113 332 PRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVR 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 152 LHDNEITKLKKSVFNGLNRMIVIELGGNPLknSGIENGALQGMKGLGYIRISDTNITAipqGLPTS-----ISELHLDGN 226
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNL--QGRINSRKWDMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRN 485

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564359076 227 KIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLL-RVPAGLAQHKYVQVVYLHNNNIS 300
Cdd:PLN00113 486 QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS 560
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-303 3.81e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 202 ISDTNITAIPQGLPTSISELHLDGNKIAKVDAASLKGMSNLSKLGLSfnsitvvENGSLANVPHLRELHLDNNKLLRVPA 281
Cdd:COG4886   58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPE 130

                         90       100
                 ....*....|....*....|..
gi 564359076 282 GLAQHKYVQVVYLHNNNISEVG 303
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLP 152
PLN03150 PLN03150
hypothetical protein; Provisional
 212-283 6.03e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 6.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 212 QGL----PTSISELH------LDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKLL-RVP 280
Cdd:PLN03150 428 QGLrgfiPNDISKLRhlqsinLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVP 507


                 ...
gi 564359076 281 AGL 283
Cdd:PLN03150 508 AAL 510
LRR_8 pfam13855
Leucine rich repeat;
125-181 5.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076  125 KLERLYLSKNHLKELPEKLPKTLQELR---LHDNEITKLKKSVFNGLNRMIVIELGGNPL 181
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKvldLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 81-117 6.40e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 6.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564359076   81 LDLQNNKITEIkeGAFKNLKDLHTLILV-NNKISKISP 117
Cdd:pfam12799   6 LDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLSD 41
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 114-327 8.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 8.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 114 KISPEAFKPLVKLERLYLSKNHLKE-------LPEKLPKT--LQELRLHDNEITKLKKSVFNGLNRmivielgGNPLKNS 184
Cdd:cd00116   41 KALASALRPQPSLKELCLSLNETGRiprglqsLLQGLTKGcgLQELDLSDNALGPDGCGVLESLLR-------SSSLQEL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564359076 185 GIENGALQGMKGlgyiRIsdtnITAIPQGLPTSISELHLDGNKIAKVDAASLKG----MSNLSKLGLSFNSITvvENG-- 258
Cdd:cd00116  114 KLNNNGLGDRGL----RL----LAKGLKDLPPALEKLVLGRNRLEGASCEALAKalraNRDLKELNLANNGIG--DAGir 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564359076 259 ----SLANVPHLRELHLDNNKLLR-----VPAGLAQHKYVQVVYLHNNNISEVGQHDFClPSYQTRKTSYTAVSLYSN 327
Cdd:cd00116  184 alaeGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALA-SALLSPNISLLTLSLSCN 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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