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Conserved domains on  [gi|564367090|ref|XP_006244485|]
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UNC5C-like protein isoform X2 [Rattus norvegicus]

Protein Classification

protein kinase family protein( domain architecture ID 12010081)

protein kinase family protein, may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 108-185 9.18e-30

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


:

Pssm-ID: 459941  Cd Length: 97  Bit Score: 111.47  E-value: 9.18e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564367090  108 VDHRGGCLMLQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHKQGLVSPVVACGPHGASFLKPCILTFKHCA 185
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHCA 82
UPA super family cl25437
UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich ...
 243-355 2.82e-07

UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich structure.


The actual alignment was detected with superfamily member pfam17217:

Pssm-ID: 465384  Cd Length: 140  Bit Score: 49.67  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367090  243 ARKWLQLAMFcSPLAPGQTHLQLRVYFLNNTPCALQWAITNEQPHGGR-MRGPCQLFdFTGARADQCLKLKYISEG-WEN 320
Cdd:pfam17217   1 AIKRLRLAVF-APAACTSLEYSLRVYCLDDTPDALKEVVQLEKQLGGQlLEEPKTLH-FKDSTHNLRLSIHDIPPSlWKS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564367090  321 VDDSSSQLVPHLHIWHGKCPFRSFCF--RRKSANGNE 355
Cdd:pfam17217  79 KLFAKYQEIPFYHVWSGNQNPLHCTFtlERYSLATTE 115
DD super family cl14633
Death Domain Superfamily of protein-protein interaction domains; The Death Domain (DD) ...
 408-445 3.90e-07

Death Domain Superfamily of protein-protein interaction domains; The Death Domain (DD) superfamily includes the DD, Pyrin, CARD (Caspase activation and recruitment domain) and DED (Death Effector Domain) families. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. They are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways including those that impact innate immunity, inflammation, differentiation, and cancer.


The actual alignment was detected with superfamily member cd08781:

Pssm-ID: 472698  Cd Length: 83  Bit Score: 47.66  E-value: 3.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564367090 408 LPPELFEQLQMLLEPSSVTGNDWRKLASHLgLCGMKIR 445
Cdd:cd08781    1 LPYSIRQKLCSLLDPPNARGNDWRLLAQKL-SVDRYIN 37
 
Name Accession Description Interval E-value
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 108-185 9.18e-30

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 111.47  E-value: 9.18e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564367090  108 VDHRGGCLMLQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHKQGLVSPVVACGPHGASFLKPCILTFKHCA 185
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHCA 82
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 108-185 1.25e-20

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 86.64  E-value: 1.25e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564367090   108 VDHRGGCLMLQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHKQGLVSPVVACGPHGASFLKPCILTFKHCA 185
Cdd:smart00218   9 FDARGGRLRGPRTGVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHGALFLRPVILEVPHCA 86
UPA pfam17217
UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich ...
 243-355 2.82e-07

UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich structure.


Pssm-ID: 465384  Cd Length: 140  Bit Score: 49.67  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367090  243 ARKWLQLAMFcSPLAPGQTHLQLRVYFLNNTPCALQWAITNEQPHGGR-MRGPCQLFdFTGARADQCLKLKYISEG-WEN 320
Cdd:pfam17217   1 AIKRLRLAVF-APAACTSLEYSLRVYCLDDTPDALKEVVQLEKQLGGQlLEEPKTLH-FKDSTHNLRLSIHDIPPSlWKS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564367090  321 VDDSSSQLVPHLHIWHGKCPFRSFCF--RRKSANGNE 355
Cdd:pfam17217  79 KLFAKYQEIPFYHVWSGNQNPLHCTFtlERYSLATTE 115
Death_UNC5-like cd08781
Death domain found in Uncoordinated-5 homolog family; Death Domain (DD) found in ...
 408-445 3.90e-07

Death domain found in Uncoordinated-5 homolog family; Death Domain (DD) found in Uncoordinated-5 (UNC-5) homolog family, which includes Unc5A, B, C and D in vertebrates. UNC5 proteins are receptors for secreted netrins (netrin-1, -3 and -4) that are involved in diverse processes like axonal guidance, neuronal migration, blood vessel patterning, and apoptosis. They are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260051  Cd Length: 83  Bit Score: 47.66  E-value: 3.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564367090 408 LPPELFEQLQMLLEPSSVTGNDWRKLASHLgLCGMKIR 445
Cdd:cd08781    1 LPYSIRQKLCSLLDPPNARGNDWRLLAQKL-SVDRYIN 37
Death pfam00531
Death domain;
414-447 6.21e-06

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 44.28  E-value: 6.21e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564367090  414 EQLQMLLEPSSVTGNDWRKLASHLGLCGMKIRQV 447
Cdd:pfam00531   2 KQLDRLLDPPPPLGKDWRELARKLGLSENEIDEI 35
 
Name Accession Description Interval E-value
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 108-185 9.18e-30

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 111.47  E-value: 9.18e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564367090  108 VDHRGGCLMLQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHKQGLVSPVVACGPHGASFLKPCILTFKHCA 185
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHCA 82
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 108-185 1.25e-20

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 86.64  E-value: 1.25e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564367090   108 VDHRGGCLMLQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHKQGLVSPVVACGPHGASFLKPCILTFKHCA 185
Cdd:smart00218   9 FDARGGRLRGPRTGVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHGALFLRPVILEVPHCA 86
UPA pfam17217
UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich ...
 243-355 2.82e-07

UPA domain; The UPA domain is conserved in UNC5, PIDD, and Ankyrins. It has a beta sandwich structure.


Pssm-ID: 465384  Cd Length: 140  Bit Score: 49.67  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564367090  243 ARKWLQLAMFcSPLAPGQTHLQLRVYFLNNTPCALQWAITNEQPHGGR-MRGPCQLFdFTGARADQCLKLKYISEG-WEN 320
Cdd:pfam17217   1 AIKRLRLAVF-APAACTSLEYSLRVYCLDDTPDALKEVVQLEKQLGGQlLEEPKTLH-FKDSTHNLRLSIHDIPPSlWKS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564367090  321 VDDSSSQLVPHLHIWHGKCPFRSFCF--RRKSANGNE 355
Cdd:pfam17217  79 KLFAKYQEIPFYHVWSGNQNPLHCTFtlERYSLATTE 115
Death_UNC5-like cd08781
Death domain found in Uncoordinated-5 homolog family; Death Domain (DD) found in ...
 408-445 3.90e-07

Death domain found in Uncoordinated-5 homolog family; Death Domain (DD) found in Uncoordinated-5 (UNC-5) homolog family, which includes Unc5A, B, C and D in vertebrates. UNC5 proteins are receptors for secreted netrins (netrin-1, -3 and -4) that are involved in diverse processes like axonal guidance, neuronal migration, blood vessel patterning, and apoptosis. They are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260051  Cd Length: 83  Bit Score: 47.66  E-value: 3.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564367090 408 LPPELFEQLQMLLEPSSVTGNDWRKLASHLgLCGMKIR 445
Cdd:cd08781    1 LPYSIRQKLCSLLDPPNARGNDWRLLAQKL-SVDRYIN 37
Death pfam00531
Death domain;
414-447 6.21e-06

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 44.28  E-value: 6.21e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564367090  414 EQLQMLLEPSSVTGNDWRKLASHLGLCGMKIRQV 447
Cdd:pfam00531   2 KQLDRLLDPPPPLGKDWRELARKLGLSENEIDEI 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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