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Conserved domains on  [gi|564378281|ref|XP_006248957|]
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zinc finger protein 655 isoform X3 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-527 1.38e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 237 PTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKC--KECEKSFSQSSSLSRHKRIHTREKSYRCEA----------- 303
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 304 ---------SDKSCDASDKSCSQSSDVLQHKKVHAKAKSYKCgTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTS 374
Cdd:COG5048  108 sslsssssnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 375 YLveHQRLHHQEKSYEYDECGlayvkqqgiRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEKLHECNergkafSQTSCL 454
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPL---------SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ------SPSSLS 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564378281 455 SQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVFDCDAWEENFSQRAHLIPHERA--HTKE--KPYECNE 527
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPY 326
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-527 1.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 237 PTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKC--KECEKSFSQSSSLSRHKRIHTREKSYRCEA----------- 303
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 304 ---------SDKSCDASDKSCSQSSDVLQHKKVHAKAKSYKCgTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTS 374
Cdd:COG5048  108 sslsssssnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 375 YLveHQRLHHQEKSYEYDECGlayvkqqgiRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEKLHECNergkafSQTSCL 454
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPL---------SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ------SPSSLS 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564378281 455 SQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVFDCDAWEENFSQRAHLIPHERA--HTKE--KPYECNE 527
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPY 326
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 243-265 1.24e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|...
gi 564378281  243 YKCDTCGKTFHQASALTRHQRIH 265
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-527 1.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 237 PTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKC--KECEKSFSQSSSLSRHKRIHTREKSYRCEA----------- 303
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 304 ---------SDKSCDASDKSCSQSSDVLQHKKVHAKAKSYKCgTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTS 374
Cdd:COG5048  108 sslsssssnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564378281 375 YLveHQRLHHQEKSYEYDECGlayvkqqgiRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEKLHECNergkafSQTSCL 454
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPL---------SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ------SPSSLS 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564378281 455 SQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVFDCDAWEENFSQRAHLIPHERA--HTKE--KPYECNE 527
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPY 326
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 243-265 1.24e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|...
gi 564378281  243 YKCDTCGKTFHQASALTRHQRIH 265
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-278 2.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.38e-03
                          10        20
                  ....*....|....*....|..
gi 564378281  257 ALTRHQRIHTREKPYKCKECEK 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 334-356 3.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|...
gi 564378281  334 YKCGTCERVFSRSVHLTQHQRTH 356
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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