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Conserved domains on  [gi|564390725|ref|XP_006253757|]
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asporin isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-320 5.13e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  84 SDLGLTSVPSNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 162
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 163 NLPR--SLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 238
Cdd:COG4886  154 PLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 239 LELHLDFNKISTVElEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHNNS 318
Cdd:COG4886  208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                 ..
gi 564390725 319 IT 320
Cdd:COG4886  284 LT 285
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 70-96 1.26e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 47.24  E-value: 1.26e-07
                          10        20
                  ....*....|....*....|....*..
gi 564390725   70 CPFGCQCYSRVVHCSDLGLTSVPSNIP 96
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-320 5.13e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  84 SDLGLTSVPSNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 162
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 163 NLPR--SLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 238
Cdd:COG4886  154 PLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 239 LELHLDFNKISTVElEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHNNS 318
Cdd:COG4886  208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                 ..
gi 564390725 319 IT 320
Cdd:COG4886  284 LT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-310 1.72e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.28  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  86 LGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYAlilNNNKLTKIhPKTFLTT-------------------KK 146
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 147 LRRLYLSHNQLSEIPLNLPRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNNgIEPGafegvtvfhIRIAEA- 225
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET-LPPG---------LKTLEAg 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 226 --KLTSIPKGLPPtllelhldfnkistveledfkrykELQRLGLGNNKITDIENgTFAniPRVREIHLEHNKLKKIPSGL 303
Cdd:PRK15370 334 enALTSLPASLPP------------------------ELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENL 386


                 ....*...
gi 564390725 304 -QELKYLQ 310
Cdd:PRK15370 387 pAALQIMQ 394
LRR_8 pfam13855
Leucine rich repeat;
236-296 1.70e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.70e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564390725  236 PTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKL 296
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 242-322 2.53e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 2.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 242 HLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKKIPsGLQELKYLQIIFLHNNSITK 321
Cdd:cd21340    6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISV 82


                 .
gi 564390725 322 V 322
Cdd:cd21340   83 V 83
LRRNT smart00013
Leucine rich repeat N-terminal domain;
70-99 3.24e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.24e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 564390725    70 CPFGCQCYSRVVHCSDLGLTSVPSNIPFDT 99
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 70-96 1.26e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 47.24  E-value: 1.26e-07
                          10        20
                  ....*....|....*....|....*..
gi 564390725   70 CPFGCQCYSRVVHCSDLGLTSVPSNIP 96
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-320 5.13e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  84 SDLGLTSVPSNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 162
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 163 NLPR--SLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 238
Cdd:COG4886  154 PLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 239 LELHLDFNKISTVElEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHNNS 318
Cdd:COG4886  208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                 ..
gi 564390725 319 IT 320
Cdd:COG4886  284 LT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-322 1.89e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 104 LQNNKIKEIKENDFKGLTSLYALILNNNKltkihpkTFLTTKKLRRLYLSHNQLSEIPLNLPR--SLAELRIHDNKVKKI 181
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 182 QKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIPKGLP--PTLLELHLDFNKISTVELEdFKRY 259
Cdd:COG4886  152 PEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNL 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564390725 260 KELQRLGLGNNKITDIENGtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHNNSITKV 322
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDL 265
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-321 1.69e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  79 RVVHCSDLGLTSVPSNIPFDT--RMVDLQNNKIKEIKEnDFKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQ 156
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 157 LSEIPLNL--PRSLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIP--K 232
Cdd:COG4886  194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-------------------------QLTDLPelG 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 233 GLPpTLLELHLDFNKISTveLEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQII 312
Cdd:COG4886  248 NLT-NLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324


                 ....*....
gi 564390725 313 FLHNNSITK 321
Cdd:COG4886  325 LLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-347 1.31e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  79 RVVHCSDLGLTSVPSNIPFDT--RMVDLQNNKIKEIKENdFKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQ 156
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 157 LSEIPLNLPR--SLAELRIHDNKVKKIqkDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSIPKGL 234
Cdd:COG4886  217 LTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN-------------------------QLTDLPPLA 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 235 P-PTLLELHLDFNKISTVELEDFKRYKEL---QRLGLGNNKITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQ 310
Cdd:COG4886  270 NlTNLKTLDLSNNQLTDLKLKELELLLGLnslLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 564390725 311 IIFLHNNSITKVGVNDFCPTVPKMKKSLYSAISLFNN 347
Cdd:COG4886  350 LTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-310 1.72e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.28  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  86 LGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYAlilNNNKLTKIhPKTFLTT-------------------KK 146
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 147 LRRLYLSHNQLSEIPLNLPRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNNgIEPGafegvtvfhIRIAEA- 225
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET-LPPG---------LKTLEAg 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 226 --KLTSIPKGLPPtllelhldfnkistveledfkrykELQRLGLGNNKITDIENgTFAniPRVREIHLEHNKLKKIPSGL 303
Cdd:PRK15370 334 enALTSLPASLPP------------------------ELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENL 386


                 ....*...
gi 564390725 304 -QELKYLQ 310
Cdd:PRK15370 387 pAALQIMQ 394
LRR_8 pfam13855
Leucine rich repeat;
236-296 1.70e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.70e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564390725  236 PTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKL 296
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
100-157 2.52e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 2.52e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 564390725  100 RMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQL 157
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 242-322 2.53e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 2.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 242 HLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKKIPsGLQELKYLQIIFLHNNSITK 321
Cdd:cd21340    6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISV 82


                 .
gi 564390725 322 V 322
Cdd:cd21340   83 V 83
LRRNT smart00013
Leucine rich repeat N-terminal domain;
70-99 3.24e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.24e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 564390725    70 CPFGCQCYSRVVHCSDLGLTSVPSNIPFDT 99
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRR_8 pfam13855
Leucine rich repeat;
121-202 8.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  121 TSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPlnlprslaelrihdnkvkkiqKDTFKGMNALHVLEMSAN 200
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---------------------PGAFSGLPSLRYLDLSGN 59


                  ..
gi 564390725  201 PL 202
Cdd:pfam13855  60 RL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 70-96 1.26e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 47.24  E-value: 1.26e-07
                          10        20
                  ....*....|....*....|....*..
gi 564390725   70 CPFGCQCYSRVVHCSDLGLTSVPSNIP 96
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-300 1.42e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  81 VHCSDLGLTSVPSNIPF-DTRMVDLQNNKIKEIKENDF-KGLTSLYaliLNNNKLTKIhpkTFLTT-KKLRRLYLSHNQL 157
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKI---ENLENlVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 158 SEIP-LNLPRSLAELRIhdnkvkkiqkdtfkgmnalhvlemsanplDNNGIEPG---AFEGVTVFHIRiaeakltsipkg 233
Cdd:cd21340   81 SVVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------ 119

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564390725 234 lpPTLLELHLDFNKISTveLEDFKRYKELQRLGLGNNKITDIEN--GTFANIPRVREIHLEHNKLKKIP 300
Cdd:cd21340  120 --NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-316 1.81e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 123 LYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEiplNLPRSLAELR------IHDNKVKKIQKDTFKGMNALHVLE 196
Cdd:PLN00113 382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG---ELPSEFTKLPlvyfldISNNNLQGRINSRKWDMPSLQMLS 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 197 MSANPLdnNGIEPGAFEGVTVFHIRIAEAKLT-SIPKGLP--PTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKIT 273
Cdd:PLN00113 459 LARNKF--FGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGslSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 564390725 274 DIENGTFANIPRVREIHLEHNKLK-KIPSGLQELKYL-QIIFLHN 316
Cdd:PLN00113 537 GQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLvQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
261-319 4.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  261 ELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLKKI-PSGLQELKYLQIIFLHNNSI 319
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 145-353 3.85e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 145 KKLRRLYLSHNQLSEIP-LNLPRSLAELRIHDNKVKKIQKdtfkgmnalhvlemsanpLDNNgiepgafegvtvfhiria 223
Cdd:cd21340    2 KRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIEN------------------LEFL------------------ 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 224 eakltsipkglpPTLLELHLDFNKIStvELEDFKRYKELQRLGLGNNKITDIENgtFANIPRVREIHLEHNKLKK----- 298
Cdd:cd21340   46 ------------TNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgeklt 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 299 ------------------------IPSGLQELKYLQIIFLHNNSITKvgVNDFCPTVPKMkKSLYSaISLFNNPM----K 350
Cdd:cd21340  110 fdprslaalsnslrvlnisgnnidSLEPLAPLRNLEQLDASNNQISD--LEELLDLLSSW-PSLRE-LDLTGNPVckkpK 185


                 ...
gi 564390725 351 YWE 353
Cdd:cd21340  186 YRD 188
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 100-315 5.67e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 100 RMVDLQNNKI-----KEIKENdFKGLTSLYALILNNNKLTK---IHPKTFLTT-KKLRRLYLSHNQLSEiplNLPRSLAE 170
Cdd:COG5238  211 TTLWLKRNPIgdegaEILAEA-LKGNKSLTTLDLSNNQIGDegvIALAEALKNnTTVETLYLSGNQIGA---EGAIALAK 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 171 lrihdnkvkkiqkdTFKGMNALHVLEMSANPLDnngiepgaFEGVTVFHIRIAEAKltsipkglppTLLELHLDFNKIST 250
Cdd:COG5238  287 --------------ALQGNTTLTSLDLSVNRIG--------DEGAIALAEGLQGNK----------TLHTLNLAYNGIGA 334

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564390725 251 VE----LEDFKRYKELQRLGLGNNKITDIENGTFA----NIPRVREIHLEHNKLKKipSGLQEL-KYLQIIFLH 315
Cdd:COG5238  335 QGaialAKALQENTTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGK--QGAEALiDALQTNRLH 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-284 1.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  79 RVVHCSDLGLTSVPSNIPFDTRM--VDLQNNKIKEIKEndFKGLTSLYALILNNNKLTKIHPKTFLTtkKLRRLYLSHNQ 156
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 157 LSEIPLNLPRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPP 236
Cdd:COG4886  284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 564390725 237 TLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIP 284
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 141-347 2.52e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 141 FLTTKKLRRLYLSHNQLSE------IPLNLPRSLAELRIHDNKV-----KKIQKDTFKGMNALHVLEMSANPLDNNGIEP 209
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPdgcgvlESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 210 gafegvtvfhirIAEAkLTSIPKglpptLLELHLDFNKIS----TVELEDFKRYKELQRLGLGNNKITDIENGTFANIPR 285
Cdd:cd00116  157 ------------LAKA-LRANRD-----LKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564390725 286 vreihlehnklkkipsglqELKYLQIIFLHNNSITKVGVNDFCPTVPKMKKSLYSaISLFNN 347
Cdd:cd00116  219 -------------------SLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLT-LSLSCN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-181 5.31e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 5.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  79 RVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIK----------EIKENDFKGLTSLYA--------LILNNNKLTkIHPKT 140
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENALTSLPAslppelqvLDVSKNQIT-VLPET 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564390725 141 FLTTkkLRRLYLSHNQLSEIPLNLPRSLAELRIHDNKVKKI 181
Cdd:PRK15370 365 LPPT--ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL 403
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-170 2.20e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.15  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  79 RVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYaliLNNNKLTKIhPKTFltTKKLRRLYLSHNQLS 158
Cdd:PRK15370 328 KTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNL-PENL--PAALQIMQASRNNLV 401

                         90
                 ....*....|..
gi 564390725 159 EIPLNLPRSLAE 170
Cdd:PRK15370 402 RLPESLPHFRGE 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-320 3.00e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  63 PFDLFPTCpfgcqcYS-RVVHCSDLGLT-SVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKT 140
Cdd:PLN00113 110 PDDIFTTS------SSlRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 141 FLTTKKLRRLYLSHNQLS-EIPLNLP--RSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAFEGVTV 217
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVgQIPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL--TGPIPSSLGNLKN 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 218 FH-IRIAEAKLT-SIPKGL--PPTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEH 293
Cdd:PLN00113 262 LQyLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWS 341

                        250       260
                 ....*....|....*....|....*...
gi 564390725 294 NKLK-KIPSGLQELKYLQIIFLHNNSIT 320
Cdd:PLN00113 342 NKFSgEIPKNLGKHNNLTVLDLSTNNLT 369
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-335 3.80e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725  84 SDLGLTSVPSNIPFDTRM--VDLQNNKIKEIKENDFKGLT---SLYALILNNNKLTKIHPKTFLT-----TKKLRRLYLS 153
Cdd:cd00116   66 IPRGLQSLLQGLTKGCGLqeLDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKglkdlPPALEKLVLG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 154 HNQLSEIPLnlpRSLAELRIHDNKvkkiqkdtfkgmnaLHVLEMSANPLDNNGIEpgafegvtvfhiRIAEAkLTSIPKg 233
Cdd:cd00116  146 RNRLEGASC---EALAKALRANRD--------------LKELNLANNGIGDAGIR------------ALAEG-LKANCN- 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 234 lpptLLELHLDFNKISTVEL----EDFKRYKELQRLGLGNNKITDIENGTFANIprvreihlehnklkkIPSGLQELKYL 309
Cdd:cd00116  195 ----LEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGAAALASA---------------LLSPNISLLTL 255

                        250       260
                 ....*....|....*....|....*.
gi 564390725 310 QiifLHNNSITKVGVNDFCPTVPKMK 335
Cdd:cd00116  256 S---LSCNDITDDGAKDLAEVLAEKE 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-320 4.24e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 4.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 237 TLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKitdiengTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHN 316
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSN 145


                 ....
gi 564390725 317 NSIT 320
Cdd:COG4886  146 NQLT 149
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-162 4.39e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 4.39e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564390725 102 VDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLS-EIPL 162
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPA 541
PLN03150 PLN03150
hypothetical protein; Provisional
 255-320 2.35e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 2.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564390725 255 DFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLK-KIPSGLQELKYLQIIFLHNNSIT 320
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-320 6.57e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 106 NNKIKEIKENdFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLS-EIP----------------------- 161
Cdd:PLN00113 246 NNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPelviqlqnleilhlfsnnftgki 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 162 ----LNLPRsLAELRIHDNKVK-KIQKDTFKgMNALHVLEMSANPL---------------------------------- 202
Cdd:PLN00113 325 pvalTSLPR-LQVLQLWSNKFSgEIPKNLGK-HNNLTVLDLSTNNLtgeipeglcssgnlfklilfsnslegeipkslga 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390725 203 ----------DNN--GIEPGAFEGVT-VFHIRIAEAKLT---SIPKGLPPTLLELHLDFNKISTvELEDFKRYKELQRLG 266
Cdd:PLN00113 403 crslrrvrlqDNSfsGELPSEFTKLPlVYFLDISNNNLQgriNSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLD 481

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564390725 267 LGNNKITDIENGTFANIPRVREIHLEHNKLK-KIPSGLQELKYLQIIFLHNNSIT 320
Cdd:PLN00113 482 LSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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