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Conserved domains on  [gi|564395377|ref|XP_006255486|]
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protein arginine N-methyltransferase 9 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
148-323 1.56e-39

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 145.95  E-value: 1.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 148 LVERWHFIMLNDTKRNEIYNAAIQKAVRLGSKtVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMED 227
Cdd:COG4076    7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 228 GIRLLHMKSLDLEipkhIPERVSLVVTETVDAGVFGEGIVESLIHAWEHLLlqpqtkgesgswGKYGKVIPASAVISGMA 307
Cdd:COG4076   86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                        170
                 ....*....|....*.
gi 564395377 308 VECAEIRRHHRVSAKD 323
Cdd:COG4076  150 VESPVDAEGFEDWQFD 165
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
40-140 1.47e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG0457   57 RYEEALADYEQALELDPDDAE--------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                         90       100
                 ....*....|....*....|.
gi 564395377 120 AAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG0457  129 AIEAYERALELDPDDADALYN 149
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
148-323 1.56e-39

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 145.95  E-value: 1.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 148 LVERWHFIMLNDTKRNEIYNAAIQKAVRLGSKtVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMED 227
Cdd:COG4076    7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 228 GIRLLHMKSLDLEipkhIPERVSLVVTETVDAGVFGEGIVESLIHAWEHLLlqpqtkgesgswGKYGKVIPASAVISGMA 307
Cdd:COG4076   86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                        170
                 ....*....|....*.
gi 564395377 308 VECAEIRRHHRVSAKD 323
Cdd:COG4076  150 VESPVDAEGFEDWQFD 165
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
40-140 1.47e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG0457   57 RYEEALADYEQALELDPDDAE--------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                         90       100
                 ....*....|....*....|.
gi 564395377 120 AAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG0457  129 AIEAYERALELDPDDADALYN 149
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 180-253 2.39e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 2.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564395377 180 TVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKmEDGIRLLHMKSLDLeiPKHIPERVSLVV 253
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALL-ADNVEVLKGDAEEL--PPEADESFDVII 71
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 181-253 2.39e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.40  E-value: 2.39e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395377  181 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEdgIRLLHMKSLDLEIPkhiPERVSLVV 253
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFP---DGSFDLVV 68
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
169-206 4.41e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 48.99  E-value: 4.41e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564395377 169 AIQKAVRLGsKTVLDIGAGTGILSMFAKKAGAHSVYAC 206
Cdd:PRK00517 112 ALEKLVLPG-KTVLDVGCGSGILAIAAAKLGAKKVLAV 148
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 91-141 5.56e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 39.24  E-value: 5.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564395377   91 EQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKENF 141
Cdd:TIGR02521  55 DKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNNGDVLNNY 105
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
148-323 1.56e-39

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 145.95  E-value: 1.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 148 LVERWHFIMLNDTKRNEIYNAAIQKAVRLGSKtVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMED 227
Cdd:COG4076    7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 228 GIRLLHMKSLDLEipkhIPERVSLVVTETVDAGVFGEGIVESLIHAWEHLLlqpqtkgesgswGKYGKVIPASAVISGMA 307
Cdd:COG4076   86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                        170
                 ....*....|....*.
gi 564395377 308 VECAEIRRHHRVSAKD 323
Cdd:COG4076  150 VESPVDAEGFEDWQFD 165
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 179-254 7.61e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 63.24  E-value: 7.61e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564395377 179 KTVLDIGAGTGILS-MFAKKAGAHSVYACELSKTMYELACDVVAANKMEDGIRLLHMkslDL-EIPKHI-PERVSLVVT 254
Cdd:COG4123   39 GRVLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHG---DLkEFAAELpPGSFDLVVS 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
40-140 1.47e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG0457   57 RYEEALADYEQALELDPDDAE--------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                         90       100
                 ....*....|....*....|.
gi 564395377 120 AAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG0457  129 AIEAYERALELDPDDADALYN 149
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 24-176 3.65e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 3.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  24 LVAQSLQSAEHCLGDQDFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVI 103
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAE--------ALFNLGNLLLALGRLEEALAALRRALALNPDFAEA 148

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395377 104 CNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAkenFYRVANwlverwhfiMLNDTKRNEIYNAAIQKAVRL 176
Cdd:COG3914  149 YLNLGEALRRLGRLEEAIAALRRALELDPDNAEA---LNNLGN---------ALQDLGRLEEAIAAYRRALEL 209
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 36-137 6.16e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.70  E-value: 6.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  36 LGDQDFGTAYAHYLLVLSLAPELKEDVKETFQYTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMG 115
Cdd:COG3914   47 LLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALG 126

                         90       100
                 ....*....|....*....|..
gi 564395377 116 FRDEAAGYFHKAVKLNPDFNDA 137
Cdd:COG3914  127 RLEEALAALRRALALNPDFAEA 148
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 39-137 7.90e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.32  E-value: 7.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  39 QDFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRD 118
Cdd:COG3914  126 GRLEEALAALRRALALNPDFAE--------AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLE 197

                         90
                 ....*....|....*....
gi 564395377 119 EAAGYFHKAVKLNPDFNDA 137
Cdd:COG3914  198 EAIAAYRRALELDPDNADA 216
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 21-140 5.66e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  21 RDRLVAQSLQSAEHCLGDQDFGTAYAHYLLVLSLAPELKEDVKETFQYTLFKWAEELHALNRIQDLLG-------CYEQA 93
Cdd:COG5010    1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGdfeeslaLLEQA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564395377  94 LELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSN 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
40-140 8.85e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG0457   23 RYEEAIEDYEKALELDPDDAE--------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                         90       100
                 ....*....|....*....|.
gi 564395377 120 AAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG0457   95 ALEDYDKALELDPDDAEALYN 115
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
169-233 1.40e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 57.11  E-value: 1.40e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564395377 169 AIQKAVRLGsKTVLDIGAGTGILSMFAKKAGAHSVYACELSktmyELACDV----VAANKMEDGIRLLH 233
Cdd:COG2264  141 ALEKLLKPG-KTVLDVGCGSGILAIAAAKLGAKRVLAVDID----PVAVEAarenAELNGVEDRIEVVL 204
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 180-253 2.39e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 2.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564395377 180 TVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKmEDGIRLLHMKSLDLeiPKHIPERVSLVV 253
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALL-ADNVEVLKGDAEEL--PPEADESFDVII 71
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-137 1.61e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.47  E-value: 1.61e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564395377  69 TLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDA 137
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 158-253 1.88e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.79  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 158 NDTKRNEIYNAAIQKAVR---LGSKTVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELAcdvvAANKMEDGIRLLHM 234
Cdd:COG2227    2 SDPDARDFWDRRLAALLArllPAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIA----RERAAELNVDFVQG 76

                         90
                 ....*....|....*....
gi 564395377 235 KSLDLEIPkhiPERVSLVV 253
Cdd:COG2227   77 DLEDLPLE---DGSFDLVI 92
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 22-176 2.27e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  22 DRLVAQSLQSAEHCLGDQDFGTAYAHYLLVLSLAPElkedvketFQYTLFKWAEELHALNRIQDLLGCYEQALELFPDDE 101
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPD--------NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395377 102 VICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAkenFYRVANwlverwhfiMLNDTKRNEIYNAAIQKAVRL 176
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA---YLRLAR---------AYRALGRPDEAIAALEKALEL 135
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 164-242 1.83e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.07  E-value: 1.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564395377 164 EIYNAAIQKAVRLGSKTVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELACDvvAANKMEDGIRLLHMKSLDLEIP 242
Cdd:COG2226    9 DGREALLAALGLRPGARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARE--RAAEAGLNVEFVVGDAEDLPFP 84
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
77-145 2.00e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.70  E-value: 2.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564395377  77 LHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGyFHKAVKLNPDFNDAKENFYRVA 145
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELL 69
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 181-253 2.39e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.40  E-value: 2.39e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395377  181 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEdgIRLLHMKSLDLEIPkhiPERVSLVV 253
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFP---DGSFDLVV 68
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 74-137 2.48e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.69  E-value: 2.48e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564395377  74 AEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDA 137
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEA 87
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
169-206 4.41e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 48.99  E-value: 4.41e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564395377 169 AIQKAVRLGsKTVLDIGAGTGILSMFAKKAGAHSVYAC 206
Cdd:PRK00517 112 ALEKLVLPG-KTVLDVGCGSGILAIAAAKLGAKKVLAV 148
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
40-133 7.76e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 7.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPElkedvketFQYTLFKWAEELHALNRIQDLLGcYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG3063    7 DLEEAEEYYEKALELDPD--------NADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|....
gi 564395377 120 AAGYFHKAVKLNPD 133
Cdd:COG3063   78 ALAYLERALELDPS 91
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 168-234 1.82e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 45.69  E-value: 1.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564395377 168 AAIQKAVRLGSK-------TVLDIGAGTGILSMF-AKKAGAHsVYACELSKTMYELACDVVAANKMEDGIRLLHM 234
Cdd:COG2230   35 AQEAKLDLILRKlglkpgmRVLDIGCGWGGLALYlARRYGVR-VTGVTLSPEQLEYARERAAEAGLADRVEVRLA 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
40-148 2.76e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPElkedvketFQYTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG0457   91 RYEEALEDYDKALELDPD--------DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEE 162

                         90       100
                 ....*....|....*....|....*....
gi 564395377 120 AAGYFHKAVKLNPDFNDAKENFYRVANWL 148
Cdd:COG0457  163 ALELLEKLEAAALAALLAAALGEAALALA 191
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
179-216 4.45e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 45.28  E-value: 4.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564395377 179 KTVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELA 216
Cdd:COG2263   47 KTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIA 84
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 40-132 6.77e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 6.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  40 DFGTAYAHYLLVLSLAPElkedvketFQYTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDE 119
Cdd:COG5010   69 DFEESLALLEQALQLDPN--------NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140

                         90
                 ....*....|...
gi 564395377 120 AAGYFHKAVKLNP 132
Cdd:COG5010  141 AKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 44-134 1.06e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  44 AYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGY 123
Cdd:COG4783   57 AIVLLHEALELDPDEPE--------ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128

                         90
                 ....*....|.
gi 564395377 124 FHKAVKLNPDF 134
Cdd:COG4783  129 LEKALELDPDD 139
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
164-277 1.55e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.45  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377 164 EIYNAAIQKAVRLGSKTVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELacdvvaANKMEDGIRLLHMkslDLEIPK 243
Cdd:COG4976   33 LLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR-LTGVDLSEEMLAK------AREKGVYDRLLVA---DLADLA 102

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564395377 244 HIPERVSLVVteTVDAGVFGEGIVESLIHAWEHL 277
Cdd:COG4976  103 EPDGRFDLIV--AADVLTYLGDLAAVFAGVARAL 134
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 39-133 2.59e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  39 QDFGTAYAHYLLVLSLAPELKEDvketfqytLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRD 118
Cdd:COG4235   31 GRYDEALAAYEKALRLDPDNADA--------LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYA 102

                         90
                 ....*....|....*
gi 564395377 119 EAAGYFHKAVKLNPD 133
Cdd:COG4235  103 EAIAAWQKLLALLPA 117
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 179-223 3.48e-04

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 42.95  E-value: 3.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564395377 179 KTVLDIGAGTGILSMFAKKAGAHSVYACELSktmyELACDVVAAN 223
Cdd:COG3897   72 KRVLELGCGLGLVGIAAAKAGAADVTATDYD----PEALAALRLN 112
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 176-277 3.67e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.41  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  176 LGSKTVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEDGIRLlhmkSLDLEIPKhipERVSLVVte 255
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEV----YLPGDLPK---EKADVVV-- 230

                          90       100
                  ....*....|....*....|..
gi 564395377  256 tvdAGVFGEGIVESLIHAWEHL 277
Cdd:pfam06325 231 ---ANILADPLIELAPDIYALV 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
90-137 1.19e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 1.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 564395377  90 YEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDA 137
Cdd:COG4785   96 FDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 85-176 1.72e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  85 DLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKENFYRVanwlverwhFIMLNDTKRNE 164
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEA---------LLAAGDTEEAE 71

                         90
                 ....*....|..
gi 564395377 165 iynAAIQKAVRL 176
Cdd:COG4235   72 ---ELLERALAL 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-140 1.79e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  29 LQSAEHCLGDQDFGTAYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMG 108
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVE--------AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564395377 109 EHLFRMGFRDEAAGYFHKAVKLNPDFNDAKEN 140
Cdd:COG2956   84 QDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 90-172 1.99e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.82  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  90 YEQALELFPDDEVICNS---MGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKENFYRVANWLVErwhfimLNDTKR-NEI 165
Cdd:COG1729   16 FKAFLKRYPNSPLAPDAlywLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLE------LGDYDKaRAT 89


                 ....*..
gi 564395377 166 YNAAIQK 172
Cdd:COG1729   90 LEELIKK 96
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-137 4.27e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395377  44 AYAHYLLVLSLAPELKEdvketfqyTLFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGY 123
Cdd:COG2956   95 AEELLEKLLELDPDDAE--------ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166

                         90
                 ....*....|....
gi 564395377 124 FHKAVKLNPDFNDA 137
Cdd:COG2956  167 LEKALKLDPDCARA 180
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 91-141 5.56e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 39.24  E-value: 5.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564395377   91 EQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKENF 141
Cdd:TIGR02521  55 DKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNNGDVLNNY 105
PRK14968 PRK14968
putative methyltransferase; Provisional
 179-215 5.70e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 5.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 564395377 179 KTVLDIGAGTGILSMFAKKAGAHSV------YACELSKTMYEL 215
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKNGKKVVgvdinpYAVECAKCNAKL 67
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 70-139 8.35e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 8.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395377  70 LFKWAEELHALNRIQDLLGCYEQALELFPDDEVICNSM---GEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKE 139
Cdd:COG1729   33 LYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALlklGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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