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Conserved domains on  [gi|567200168|ref|XP_006407347|]
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retinoblastoma-related protein 1 isoform X3 [Eutrema salsugineum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RB_A pfam01858
Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.
 409-610 4.05e-86

Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.


:

Pssm-ID: 460364  Cd Length: 195  Bit Score: 275.23  E-value: 4.05e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   409 TPVSTAMTTAKWLRTVICPLLPKPSPGLEHFLKSCDRDITSDVIRRAhVILEAIFPNSSlgdrcaSGSLQPVNLMDDIWA 488
Cdd:pfam01858    1 TPVSSAMQTVSWLQTLLSGLSDEPSEKLLRIFKSCSRDPTETILKRV-KELGEIFCQKY------TEASGEHPSFCIEIA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   489 EQRRLEAVKLYYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSKV 568
Cdd:pfam01858   74 EQRFRLAEKLYYKVLESILKSEKKRLPGNDLSSLLSNDIFHRSLLACCLEIVLFAYNSERLSFPWILEVFGLPPFDFYKV 153

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 567200168   569 IESFIRHEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSL 610
Cdd:pfam01858  154 IESFIRAEDGLPRELVKHLNSIEEQILESLAWKSDSPLWELL 195
CYCLIN_AtRBR_like cd20601
cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar ...
 733-864 1.22e-75

cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar proteins; AtRBR1 is a key regulator of entry into cell division. It acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. AtRBR1 plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis. AtRBR1 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410304  Cd Length: 129  Bit Score: 244.22  E-value: 1.22e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  733 INIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYN 812
Cdd:cd20601     1 INVFFQKVLKLAAIRIADLCERLQQPQLVVEQVYRLIEHVLYEQTGLFFNRHIDQIILCCLYGVCKVHKLNVTFREIIYQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 567200168  813 YRKQPQCKPLVFRSVYVDSLQCRRQgrvGPDHVDIITFYNEVFIPAVKPLLV 864
Cdd:cd20601    81 YRKQPQCKPDVFRNVVIEQRRPTLG---GPDHGDIIAFYNEVFVPATKPFLL 129
DUF3452 pfam11934
Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. ...
 91-218 1.50e-37

Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with pfam01858, pfam01857. This domain has a single completely conserved residue W that may be functionally important.


:

Pssm-ID: 463402  Cd Length: 134  Bit Score: 137.34  E-value: 1.50e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168    91 QSVSGDNGFNLCQILRALKLNIMDFFRELSQFVVKAGPvlcelygeDWENRLQTKELQANLVHLTLLSNFYKRGYREFFL 170
Cdd:pfam11934    1 DGTVEGNCVSLTRLLRACKLSIIDFFKKMKQWADMANL--------DWEFRLEIKELERNFSVTTVLFKKYKRIFNELFL 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 567200168   171 TYDANAEKTSANSA---SYLPDSYRFGWLLFLALRNHAFSRFKDLVTCTNG 218
Cdd:pfam11934   73 SPPPKEPKRSKKSRpapCSYSDLFEFGWLLFLAAKNEFPSISKDLVTSYHL 123
 
Name Accession Description Interval E-value
RB_A pfam01858
Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.
 409-610 4.05e-86

Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.


Pssm-ID: 460364  Cd Length: 195  Bit Score: 275.23  E-value: 4.05e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   409 TPVSTAMTTAKWLRTVICPLLPKPSPGLEHFLKSCDRDITSDVIRRAhVILEAIFPNSSlgdrcaSGSLQPVNLMDDIWA 488
Cdd:pfam01858    1 TPVSSAMQTVSWLQTLLSGLSDEPSEKLLRIFKSCSRDPTETILKRV-KELGEIFCQKY------TEASGEHPSFCIEIA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   489 EQRRLEAVKLYYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSKV 568
Cdd:pfam01858   74 EQRFRLAEKLYYKVLESILKSEKKRLPGNDLSSLLSNDIFHRSLLACCLEIVLFAYNSERLSFPWILEVFGLPPFDFYKV 153

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 567200168   569 IESFIRHEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSL 610
Cdd:pfam01858  154 IESFIRAEDGLPRELVKHLNSIEEQILESLAWKSDSPLWELL 195
CYCLIN_AtRBR_like cd20601
cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar ...
 733-864 1.22e-75

cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar proteins; AtRBR1 is a key regulator of entry into cell division. It acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. AtRBR1 plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis. AtRBR1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410304  Cd Length: 129  Bit Score: 244.22  E-value: 1.22e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  733 INIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYN 812
Cdd:cd20601     1 INVFFQKVLKLAAIRIADLCERLQQPQLVVEQVYRLIEHVLYEQTGLFFNRHIDQIILCCLYGVCKVHKLNVTFREIIYQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 567200168  813 YRKQPQCKPLVFRSVYVDSLQCRRQgrvGPDHVDIITFYNEVFIPAVKPLLV 864
Cdd:cd20601    81 YRKQPQCKPDVFRNVVIEQRRPTLG---GPDHGDIIAFYNEVFVPATKPFLL 129
RB_B pfam01857
Retinoblastoma-associated protein B domain; The crystal structure of the Rb pocket bound to a ...
 732-860 1.46e-60

Retinoblastoma-associated protein B domain; The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.


Pssm-ID: 460363  Cd Length: 131  Bit Score: 202.41  E-value: 1.46e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   732 GINIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIY 811
Cdd:pfam01857    1 SLNLFFRKVYHLAAVRLQDLCSRLDLSSDLREKIWTCFEHSLVHQTDLMKDRHLDQILLCAIYVICKVTKEELTFKEIMK 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 567200168   812 NYRKQPQCKPLVFRSVYVDSLQCRRQGRV--GPDHVDIITFYNEVFIPAVK 860
Cdd:pfam01857   81 CYRKQPQASSHVYRSVLIRRRERERNGKNneEEERGDIIKFYNKVFVPAMK 131
DUF3452 pfam11934
Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. ...
 91-218 1.50e-37

Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with pfam01858, pfam01857. This domain has a single completely conserved residue W that may be functionally important.


Pssm-ID: 463402  Cd Length: 134  Bit Score: 137.34  E-value: 1.50e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168    91 QSVSGDNGFNLCQILRALKLNIMDFFRELSQFVVKAGPvlcelygeDWENRLQTKELQANLVHLTLLSNFYKRGYREFFL 170
Cdd:pfam11934    1 DGTVEGNCVSLTRLLRACKLSIIDFFKKMKQWADMANL--------DWEFRLEIKELERNFSVTTVLFKKYKRIFNELFL 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 567200168   171 TYDANAEKTSANSA---SYLPDSYRFGWLLFLALRNHAFSRFKDLVTCTNG 218
Cdd:pfam11934   73 SPPPKEPKRSKKSRpapCSYSDLFEFGWLLFLAAKNEFPSISKDLVTSYHL 123
 
Name Accession Description Interval E-value
RB_A pfam01858
Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.
 409-610 4.05e-86

Retinoblastoma-associated protein A domain; This domain has the cyclin fold as predicted.


Pssm-ID: 460364  Cd Length: 195  Bit Score: 275.23  E-value: 4.05e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   409 TPVSTAMTTAKWLRTVICPLLPKPSPGLEHFLKSCDRDITSDVIRRAhVILEAIFPNSSlgdrcaSGSLQPVNLMDDIWA 488
Cdd:pfam01858    1 TPVSSAMQTVSWLQTLLSGLSDEPSEKLLRIFKSCSRDPTETILKRV-KELGEIFCQKY------TEASGEHPSFCIEIA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   489 EQRRLEAVKLYYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSKV 568
Cdd:pfam01858   74 EQRFRLAEKLYYKVLESILKSEKKRLPGNDLSSLLSNDIFHRSLLACCLEIVLFAYNSERLSFPWILEVFGLPPFDFYKV 153

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 567200168   569 IESFIRHEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSL 610
Cdd:pfam01858  154 IESFIRAEDGLPRELVKHLNSIEEQILESLAWKSDSPLWELL 195
CYCLIN_AtRBR_like cd20601
cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar ...
 733-864 1.22e-75

cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar proteins; AtRBR1 is a key regulator of entry into cell division. It acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. AtRBR1 plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis. AtRBR1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410304  Cd Length: 129  Bit Score: 244.22  E-value: 1.22e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  733 INIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYN 812
Cdd:cd20601     1 INVFFQKVLKLAAIRIADLCERLQQPQLVVEQVYRLIEHVLYEQTGLFFNRHIDQIILCCLYGVCKVHKLNVTFREIIYQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 567200168  813 YRKQPQCKPLVFRSVYVDSLQCRRQgrvGPDHVDIITFYNEVFIPAVKPLLV 864
Cdd:cd20601    81 YRKQPQCKPDVFRNVVIEQRRPTLG---GPDHGDIIAFYNEVFVPATKPFLL 129
RB_B pfam01857
Retinoblastoma-associated protein B domain; The crystal structure of the Rb pocket bound to a ...
 732-860 1.46e-60

Retinoblastoma-associated protein B domain; The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.


Pssm-ID: 460363  Cd Length: 131  Bit Score: 202.41  E-value: 1.46e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168   732 GINIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIY 811
Cdd:pfam01857    1 SLNLFFRKVYHLAAVRLQDLCSRLDLSSDLREKIWTCFEHSLVHQTDLMKDRHLDQILLCAIYVICKVTKEELTFKEIMK 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 567200168   812 NYRKQPQCKPLVFRSVYVDSLQCRRQGRV--GPDHVDIITFYNEVFIPAVK 860
Cdd:pfam01857   81 CYRKQPQASSHVYRSVLIRRRERERNGKNneEEERGDIIKFYNKVFVPAMK 131
CYCLIN_RB-like cd20548
cyclin box found in retinoblastoma-associated protein (RB) family; The RB family includes ...
 733-855 1.13e-42

cyclin box found in retinoblastoma-associated protein (RB) family; The RB family includes retinoblastoma-associated protein (RB), and two retinoblastoma-like proteins, RBL1 and RBL2. RB, also called p105-Rb, pRb, or pp110, is a key regulator of entry into cell division, and also acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It also acts as a transcription repressor of E2F1 target genes. RB is directly involved in heterochromatin formation by maintaining overall chromatin structure. It recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. RBL1 and RBL2 are also key regulators of entry into cell division. RBL1 and RBL2 recruit and target histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. They control histone H4 'Lys-20' trimethylation and probably act as transcription repressors by recruiting chromatin-modifying enzymes to promoters. They may also act as tumor suppressors. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410251  Cd Length: 122  Bit Score: 151.31  E-value: 1.13e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  733 INIFFTKINKLAAVRINGMVERL-QLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIY 811
Cdd:cd20548     1 LQLFFRKLYRLAAARLQDLCKRLdLLSPPLRERIWTVFKHILSEETELLFDRHLDQIILCSIYAVCKVNNENLTFKEILD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 567200168  812 NYRKQPQCKPLVFRSvyVDSLQCRRQGRVGPDHVDIITFYNEVF 855
Cdd:cd20548    81 AYRKQPQAESEVYRS--VLPLFRSVGSDDEGESGDIIKFYNQVF 122
DUF3452 pfam11934
Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. ...
 91-218 1.50e-37

Domain of unknown function (DUF3452); This presumed domain is functionally uncharacterized. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with pfam01858, pfam01857. This domain has a single completely conserved residue W that may be functionally important.


Pssm-ID: 463402  Cd Length: 134  Bit Score: 137.34  E-value: 1.50e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168    91 QSVSGDNGFNLCQILRALKLNIMDFFRELSQFVVKAGPvlcelygeDWENRLQTKELQANLVHLTLLSNFYKRGYREFFL 170
Cdd:pfam11934    1 DGTVEGNCVSLTRLLRACKLSIIDFFKKMKQWADMANL--------DWEFRLEIKELERNFSVTTVLFKKYKRIFNELFL 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 567200168   171 TYDANAEKTSANSA---SYLPDSYRFGWLLFLALRNHAFSRFKDLVTCTNG 218
Cdd:pfam11934   73 SPPPKEPKRSKKSRpapCSYSDLFEFGWLLFLAAKNEFPSISKDLVTSYHL 123
CYCLIN_RB cd20599
cyclin box found in retinoblastoma-associated protein (RB) and similar proteins; RB, also ...
 731-860 1.25e-27

cyclin box found in retinoblastoma-associated protein (RB) and similar proteins; RB, also called p105-Rb, pRb, or pp110, is a key regulator of entry into cell division and also acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It also acts as a transcription repressor of E2F1 target genes. RB is directly involved in heterochromatin formation by maintaining overall chromatin structure, especially that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RB contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410302  Cd Length: 126  Bit Score: 108.53  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  731 TGINIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREII 810
Cdd:cd20599     1 TSLSLFYKKVYRLAYLRLNTLCDLLLLHPDLEHRIWTCFEHCLQNRYELLKDRHLDQIMMCSMYGICKVKNKDLRFKTIV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 567200168  811 YNYRKQPQCKPLVFRSVYVDSLQcrrqgrvgpdHVDIITFYNEVFIPAVK 860
Cdd:cd20599    81 TAYKDLPHASQEVYKRVLIRGEE----------YDSIIGFYNRVFMQALK 120
CYCLIN_RBL1 cd20605
cyclin box found in retinoblastoma-like protein 1 (RBL1) and similar proteins; RBL1, also ...
 735-860 4.81e-23

cyclin box found in retinoblastoma-like protein 1 (RBL1) and similar proteins; RBL1, also called 107 kDa retinoblastoma-associated protein (p107), retinoblastoma-related protein 1 (RBR-1), or pRb1, is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure, especially that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It may also act as a tumor suppressor. RBL1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410308  Cd Length: 130  Bit Score: 95.72  E-value: 4.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  735 IFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYNYR 814
Cdd:cd20605    10 LFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFSLVHCTDLMKDRHLDQLLLCAFYIMAKVTKEERTFQDIMKCYR 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 567200168  815 KQPQCKPLVFRSVyvdslqcrrqgRVGPDHVDIITFYNEVFIPAVK 860
Cdd:cd20605    90 NQPQANSHVYRSV-----------LLKEERGDLIKFYNTIYVGRVK 124
CYCLIN_RBL cd20600
cyclin box found in retinoblastoma-like protein (RBL) subfamily; The RBL subfamily includes ...
 735-860 9.01e-23

cyclin box found in retinoblastoma-like protein (RBL) subfamily; The RBL subfamily includes two retinoblastoma-like proteins, RBL1 and RBL2. They are key regulators of entry into cell division and are directly involved in heterochromatin formation by maintaining overall chromatin structure. RBL1 and RBL2 recruit and target histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. They control histone H4 'Lys-20' trimethylation and probably act as transcription repressors by recruiting chromatin-modifying enzymes to promoters. They may also act as tumor suppressors. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410303  Cd Length: 112  Bit Score: 94.01  E-value: 9.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  735 IFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYNYR 814
Cdd:cd20600     4 LFFRKVYHLASVRLRDLCEKLEISEELRRKIWTCFEHSLVHHIELMRDRHLDQLLMCAVYVIAKVTKQDKSFQEIMKCYR 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 567200168  815 KQPQCKplvfrsvyvdslqcrrQGrvgpdhvDIITFYNEVFIPAVK 860
Cdd:cd20600    84 LQPQAQ----------------SG-------DLIQFYNSVYVKKMK 106
CYCLIN_RBL2 cd20606
cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins; RBL2, also ...
 733-838 2.65e-19

cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins; RBL2, also called 130 kDa retinoblastoma-associated protein (p130), retinoblastoma-related protein 2 (RBR-2), or pRb2, is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure, especially that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It may also act as a tumor suppressor. RBL2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410309  Cd Length: 189  Bit Score: 86.88  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567200168  733 INIFFTKINKLAAVRINGMVERLQLSQQIRESVYCLFQHVLAQRTSLLFNRHIDQIILCCFYGVAKISQMSLTFREIIYN 812
Cdd:cd20606     2 LSLFFRKVYHLASVRLRDLCAKLDISDELRKKIWTCFEYSLVHCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRC 81

                          90       100
                  ....*....|....*....|....*.
gi 567200168  813 YRKQPQCKPLVFRSVYVDSLQCRRQG 838
Cdd:cd20606    82 YRTQPQASSSVYRSVLIKGRRRRRSG 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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