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Conserved domains on  [gi|568905847|ref|XP_006495791|]
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interleukin-18 receptor 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR super family cl23801
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 375-516 1.16e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


The actual alignment was detected with superfamily member pfam01582:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 114.38  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  375 FVSYLKEchPENKEEYTFAVETLPRVleKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNG-ARREL 453
Cdd:pfam01582   1 YDVFLSF--RGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGwCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  454 ESGLHEALvERKIKIILIEFTP-----ASNITFLPPSLKLLKS----YRVLKWRA-----------DSPSMNSRFWKNLV 513
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRGalnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 568905847  514 YLM 516
Cdd:pfam01582 156 YDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 131-205 7.37e-09

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 53.10  E-value: 7.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 131 VEVNKSLHITC------KNPNYEELIQdtWlYKNCKEISKTPR--------ILKDAEFGDEGYYSCVFSVHHNGTRYNIT 196
Cdd:cd05757    7 LPITKGGKITCpdlddyKNENVLPPIQ--W-YKDCKPLQGDKRfipkgsklLIQNVTEEDAGNYTCKFTYTHNGKQYNVT 83


                 ....*....
gi 568905847 197 KTVNITVIE 205
Cdd:cd05757   84 RTISLTVTE 92
Ig_6 super family cl39786
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 3-98 3.29e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


The actual alignment was detected with superfamily member pfam18452:

Pssm-ID: 465773  Cd Length: 128  Bit Score: 43.56  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847    3 HEELILtLCILIVKSASKSCiHRSQIHVVEGEPfylKPCGISAPVHRnetatMRWFKGSASHEYRELNNRSSPRVTFHDH 82
Cdd:pfam18452   4 EEEFVL-FCDLPEPQKTHFY-HRSQLSPTQGPH---LPCSGSKDLSD-----VQWYWQPKNGDPLEAITESSPHIIQEGN 73

                          90
                  ....*....|....*.
gi 568905847   83 TLEFWPVEMEDEGTYI 98
Cdd:pfam18452  74 ALWFLPVGVNDSGSYI 89
PHA02785 super family cl31505
IL-beta-binding protein; Provisional
 157-257 3.36e-04

IL-beta-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02785:

Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 43.08  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 157 KNCKEISKTPRIL--KDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITViegRSKVTPAILG-PkcEKVGVELGKDVELN 233
Cdd:PHA02785 167 RNKRLKQRTPGIItiEDVRKNDAGYYTCVLKYIYGDKTYNVTRIVKLEV---RDRIIPPTMQlP--EGVVTSIGSNLTIA 241

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568905847 234 CSASLN----KDDLFYWS---IRKEDSSDPN 257
Cdd:PHA02785 242 CRVSLRppttDADVFWISngmYYEEDDEDGD 272
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 212-312 2.09e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20932:

Pssm-ID: 472250  Cd Length: 104  Bit Score: 38.03  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 212 PAILGPKCEKVGVELGKDVELNCSASLNKDDLFYW----SIRKEDssDPNVQEDRKETTTWISEGKLHASKILRFQKITE 287
Cdd:cd20932    1 PVIVSPANETMEVDLGSQIQLICNVTGQLSDLAYWkwngSEIDED--DPVLGEDYYSVENPANKRKSTLITVLNISEIES 78

                         90       100
                 ....*....|....*....|....*
gi 568905847 288 NYLNVLYNCTVANEEAIDTKSFVLV 312
Cdd:cd20932   79 RFYKHPFTCFAKNTHGLDAAYVQLI 103
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 375-516 1.16e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 114.38  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  375 FVSYLKEchPENKEEYTFAVETLPRVleKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNG-ARREL 453
Cdd:pfam01582   1 YDVFLSF--RGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGwCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  454 ESGLHEALvERKIKIILIEFTP-----ASNITFLPPSLKLLKS----YRVLKWRA-----------DSPSMNSRFWKNLV 513
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRGalnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 568905847  514 YLM 516
Cdd:pfam01582 156 YDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
371-519 1.83e-28

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 110.11  E-value: 1.83e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847   371 TYDAFVSYlkechPENKEeytFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGA- 449
Cdd:smart00255   1 EYDVFISY-----SGKED---VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWc 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568905847   450 RRELESGLHEALVERKIKIILIEFTP-ASNITFLPPSLKLLKSYRVLKWRADSPsmnSRFWKNLVYLMPAK 519
Cdd:smart00255  73 LDELVAALENALEEGGLRVIPIFYEViPSDVRKQPGKFRKVFKKNYLKWPEDEK---EQFWKKALYAVPSK 140
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 131-205 7.37e-09

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 53.10  E-value: 7.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 131 VEVNKSLHITC------KNPNYEELIQdtWlYKNCKEISKTPR--------ILKDAEFGDEGYYSCVFSVHHNGTRYNIT 196
Cdd:cd05757    7 LPITKGGKITCpdlddyKNENVLPPIQ--W-YKDCKPLQGDKRfipkgsklLIQNVTEEDAGNYTCKFTYTHNGKQYNVT 83


                 ....*....
gi 568905847 197 KTVNITVIE 205
Cdd:cd05757   84 RTISLTVTE 92
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 3-98 3.29e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 43.56  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847    3 HEELILtLCILIVKSASKSCiHRSQIHVVEGEPfylKPCGISAPVHRnetatMRWFKGSASHEYRELNNRSSPRVTFHDH 82
Cdd:pfam18452   4 EEEFVL-FCDLPEPQKTHFY-HRSQLSPTQGPH---LPCSGSKDLSD-----VQWYWQPKNGDPLEAITESSPHIIQEGN 73

                          90
                  ....*....|....*.
gi 568905847   83 TLEFWPVEMEDEGTYI 98
Cdd:pfam18452  74 ALWFLPVGVNDSGSYI 89
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 157-257 3.36e-04

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 43.08  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 157 KNCKEISKTPRIL--KDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITViegRSKVTPAILG-PkcEKVGVELGKDVELN 233
Cdd:PHA02785 167 RNKRLKQRTPGIItiEDVRKNDAGYYTCVLKYIYGDKTYNVTRIVKLEV---RDRIIPPTMQlP--EGVVTSIGSNLTIA 241

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568905847 234 CSASLN----KDDLFYWS---IRKEDSSDPN 257
Cdd:PHA02785 242 CRVSLRppttDADVFWISngmYYEEDDEDGD 272
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-112 1.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847    26 SQIHVVEGEPFYLkPCgisaPVHRNETATMRWFKGSasHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYI----SQV 101
Cdd:smart00410   2 PSVTVKEGESVTL-SC----EASGSPPPEVTWYKQG--GKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTcaatNSS 74

                           90
                   ....*....|.
gi 568905847   102 GNDRRNWTLNV 112
Cdd:smart00410  75 GSASSGTTLTV 85
Ig3_IL1R_like cd20932
Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 212-312 2.09e-03

Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins. Members of this family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1R (TIR) domain. Three naturally occurring ligands for the IL-1 receptor (IL1R) are known: the agonists IL-1alpha and IL-1beta and the IL-1-receptor antagonist IL1RA. IL-1Rs are involved in immune host defense and hematopoiesis. After binding to interleukin-1, IL1R associates with the coreceptor IL1RAP (interleukin 1 receptor accessory protein, also known as IL-1R3) to form the high affinity interleukin-1 receptor complex, which induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. IL1R binds ligands with comparable affinity to its antagonist IL1RA, and binding of IL1RA to IL1R, prevents association of the latter with IL1RAP to form a signaling complex.


Pssm-ID: 409526  Cd Length: 104  Bit Score: 38.03  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 212 PAILGPKCEKVGVELGKDVELNCSASLNKDDLFYW----SIRKEDssDPNVQEDRKETTTWISEGKLHASKILRFQKITE 287
Cdd:cd20932    1 PVIVSPANETMEVDLGSQIQLICNVTGQLSDLAYWkwngSEIDED--DPVLGEDYYSVENPANKRKSTLITVLNISEIES 78

                         90       100
                 ....*....|....*....|....*
gi 568905847 288 NYLNVLYNCTVANEEAIDTKSFVLV 312
Cdd:cd20932   79 RFYKHPFTCFAKNTHGLDAAYVQLI 103
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 375-516 1.16e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 114.38  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  375 FVSYLKEchPENKEEYTFAVETLPRVleKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNG-ARREL 453
Cdd:pfam01582   1 YDVFLSF--RGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGwCLDEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  454 ESGLHEALvERKIKIILIEFTP-----ASNITFLPPSLKLLKS----YRVLKWRA-----------DSPSMNSRFWKNLV 513
Cdd:pfam01582  77 VKILECAL-DLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRGalnevaniwhsKSVSDESKFWKKIA 155


                  ...
gi 568905847  514 YLM 516
Cdd:pfam01582 156 YDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
371-519 1.83e-28

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 110.11  E-value: 1.83e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847   371 TYDAFVSYlkechPENKEeytFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGA- 449
Cdd:smart00255   1 EYDVFISY-----SGKED---VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWc 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568905847   450 RRELESGLHEALVERKIKIILIEFTP-ASNITFLPPSLKLLKSYRVLKWRADSPsmnSRFWKNLVYLMPAK 519
Cdd:smart00255  73 LDELVAALENALEEGGLRVIPIFYEViPSDVRKQPGKFRKVFKKNYLKWPEDEK---EQFWKKALYAVPSK 140
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 375-472 1.56e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 55.78  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847  375 FVSYlkecHPENKEEytfaVETLPRVLEKQfGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTN-GARREL 453
Cdd:pfam13676   2 FISY----AGEDRAW----AEWLADALEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESpWCRAEW 72

                          90
                  ....*....|....*....
gi 568905847  454 ESGLHEALVERKIKIILIE 472
Cdd:pfam13676  73 EAALADPEGRKRLIPVRLE 91
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 131-205 7.37e-09

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 53.10  E-value: 7.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 131 VEVNKSLHITC------KNPNYEELIQdtWlYKNCKEISKTPR--------ILKDAEFGDEGYYSCVFSVHHNGTRYNIT 196
Cdd:cd05757    7 LPITKGGKITCpdlddyKNENVLPPIQ--W-YKDCKPLQGDKRfipkgsklLIQNVTEEDAGNYTCKFTYTHNGKQYNVT 83


                 ....*....
gi 568905847 197 KTVNITVIE 205
Cdd:cd05757   84 RTISLTVTE 92
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 142-205 2.87e-05

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 42.84  E-value: 2.87e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568905847 142 KNPNyEELIQDTWlYKNCKEISKTPR---------ILKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIE 205
Cdd:cd20994   24 KDEN-NNLPKVQW-YKDCKPLLLDDKrfaglesdlLIFNVTVQDQGNYTCHTSYTYMGKQYNISRTISLIVLE 94
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 3-98 3.29e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 43.56  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847    3 HEELILtLCILIVKSASKSCiHRSQIHVVEGEPfylKPCGISAPVHRnetatMRWFKGSASHEYRELNNRSSPRVTFHDH 82
Cdd:pfam18452   4 EEEFVL-FCDLPEPQKTHFY-HRSQLSPTQGPH---LPCSGSKDLSD-----VQWYWQPKNGDPLEAITESSPHIIQEGN 73

                          90
                  ....*....|....*.
gi 568905847   83 TLEFWPVEMEDEGTYI 98
Cdd:pfam18452  74 ALWFLPVGVNDSGSYI 89
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 157-257 3.36e-04

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 43.08  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 157 KNCKEISKTPRIL--KDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITViegRSKVTPAILG-PkcEKVGVELGKDVELN 233
Cdd:PHA02785 167 RNKRLKQRTPGIItiEDVRKNDAGYYTCVLKYIYGDKTYNVTRIVKLEV---RDRIIPPTMQlP--EGVVTSIGSNLTIA 241

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568905847 234 CSASLN----KDDLFYWS---IRKEDSSDPN 257
Cdd:PHA02785 242 CRVSLRppttDADVFWISngmYYEEDDEDGD 272
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-112 1.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847    26 SQIHVVEGEPFYLkPCgisaPVHRNETATMRWFKGSasHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYI----SQV 101
Cdd:smart00410   2 PSVTVKEGESVTL-SC----EASGSPPPEVTWYKQG--GKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTcaatNSS 74

                           90
                   ....*....|.
gi 568905847   102 GNDRRNWTLNV 112
Cdd:smart00410  75 GSASSGTTLTV 85
Ig3_IL1R_like cd20932
Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 212-312 2.09e-03

Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins. Members of this family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1R (TIR) domain. Three naturally occurring ligands for the IL-1 receptor (IL1R) are known: the agonists IL-1alpha and IL-1beta and the IL-1-receptor antagonist IL1RA. IL-1Rs are involved in immune host defense and hematopoiesis. After binding to interleukin-1, IL1R associates with the coreceptor IL1RAP (interleukin 1 receptor accessory protein, also known as IL-1R3) to form the high affinity interleukin-1 receptor complex, which induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. IL1R binds ligands with comparable affinity to its antagonist IL1RA, and binding of IL1RA to IL1R, prevents association of the latter with IL1RAP to form a signaling complex.


Pssm-ID: 409526  Cd Length: 104  Bit Score: 38.03  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905847 212 PAILGPKCEKVGVELGKDVELNCSASLNKDDLFYW----SIRKEDssDPNVQEDRKETTTWISEGKLHASKILRFQKITE 287
Cdd:cd20932    1 PVIVSPANETMEVDLGSQIQLICNVTGQLSDLAYWkwngSEIDED--DPVLGEDYYSVENPANKRKSTLITVLNISEIES 78

                         90       100
                 ....*....|....*....|....*
gi 568905847 288 NYLNVLYNCTVANEEAIDTKSFVLV 312
Cdd:cd20932   79 RFYKHPFTCFAKNTHGLDAAYVQLI 103
Ig2_IL1R2_like cd05897
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2), and similar ...
 169-205 4.97e-03

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds the IL-1 receptor, type II (IL1R2) represented in this group. Mature IL1R2 consists of three IG-like domains, a transmembrane domain, and a short cytoplasmic domain. It lacks the large cytoplasmic domain of mature IL1R1 and does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409478  Cd Length: 95  Bit Score: 36.66  E-value: 4.97e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568905847 169 LKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIE 205
Cdd:cd05897   59 IHDVSLNDSGYYTCKLTFTHEGKKYNITRSIELRIVK 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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