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Conserved domains on  [gi|568913577|ref|XP_006498049|]
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rab9 effector protein with kelch motifs isoform X3 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
18-234 6.46e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 6.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  18 PRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGG---GERG 94
Cdd:COG3055   12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGftgANPS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  95 AQPVEDVklHVFDANTLTWSQpetHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP------ 168
Cdd:COG3055   86 STPLNDV--YVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPlptprd 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 169 --TGAV---------------------------PVGCAAHAAVAVGHHVYMFGGMtaTGALNMMYKYHTEKQHWTVLqfd 219
Cdd:COG3055  161 hlAAAVlpdgkilviggrngsgfsntwttlaplPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTAL--- 235

                        250
                 ....*....|....*
gi 568913577 220 TSLPAGRLDHSMCVI 234
Cdd:COG3055  236 GELPTPRHGHAAVLT 250
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
18-234 6.46e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 6.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  18 PRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGG---GERG 94
Cdd:COG3055   12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGftgANPS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  95 AQPVEDVklHVFDANTLTWSQpetHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP------ 168
Cdd:COG3055   86 STPLNDV--YVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPlptprd 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 169 --TGAV---------------------------PVGCAAHAAVAVGHHVYMFGGMtaTGALNMMYKYHTEKQHWTVLqfd 219
Cdd:COG3055  161 hlAAAVlpdgkilviggrngsgfsntwttlaplPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTAL--- 235

                        250
                 ....*....|....*
gi 568913577 220 TSLPAGRLDHSMCVI 234
Cdd:COG3055  236 GELPTPRHGHAAVLT 250
PLN02193 PLN02193
nitrile-specifier protein
 59-227 7.55e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.69  E-value: 7.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  59 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 137
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 138 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 217
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                        170
                 ....*....|
gi 568913577 218 FDTSLPAGRL 227
Cdd:PLN02193 307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
82-134 3.40e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 3.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568913577   82 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 134
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
189-234 2.22e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 2.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568913577   189 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 234
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
18-234 6.46e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 6.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  18 PRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGG---GERG 94
Cdd:COG3055   12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGftgANPS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  95 AQPVEDVklHVFDANTLTWSQpetHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP------ 168
Cdd:COG3055   86 STPLNDV--YVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPlptprd 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 169 --TGAV---------------------------PVGCAAHAAVAVGHHVYMFGGMtaTGALNMMYKYHTEKQHWTVLqfd 219
Cdd:COG3055  161 hlAAAVlpdgkilviggrngsgfsntwttlaplPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTAL--- 235

                        250
                 ....*....|....*
gi 568913577 220 TSLPAGRLDHSMCVI 234
Cdd:COG3055  236 GELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-199 7.11e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 78.66  E-value: 7.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577   2 DLGTHQWdTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAAI 81
Cdd:COG3055   96 DPATNTW-TKLAPMPTPRGGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLP 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  82 GNQLYVFGGGErgaqpvedvklhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTKLFIHGGLAGdkFFDDLHCIDIGDM 161
Cdd:COG3055  169 DGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATN 230

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568913577 162 SWQKLGPtgaVPVGCAAHAAVAVGHHVYMFGGMTATGA 199
Cdd:COG3055  231 TWTALGE---LPTPRHGHAAVLTDGKVYVIGGETKPGV 265
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-297 2.16e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 2.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  58 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 135
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 136 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 211
Cdd:COG3055   71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 212 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 287
Cdd:COG3055  148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                        250
                 ....*....|...
gi 568913577 288 GM---NTEGEVYD 297
Cdd:COG3055  214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 59-227 7.55e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.69  E-value: 7.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  59 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 137
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 138 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 217
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                        170
                 ....*....|
gi 568913577 218 FDTSLPAGRL 227
Cdd:PLN02193 307 FHCSTPGDSF 316
PLN02153 PLN02153
epithiospecifier protein
 66-208 3.50e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.94  E-value: 3.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  66 GSPPSPRTFHtSSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTLTWSQPETHGSPPS-PRHGHVMVAAGTKLFIHGGL 144
Cdd:PLN02153  17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568913577 145 AGDKFFDDLHCIDIGDMSWQ---KLGPTGAvPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHT 208
Cdd:PLN02153  95 DEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
PLN02193 PLN02193
nitrile-specifier protein
 34-163 1.51e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.35  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  34 IWVFGG---ADQSGNRNcLQVMSPEDRTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERGAQPvedVKLHVFDANT 110
Cdd:PLN02193 178 IYSFGGeftPNQPIDKH-LYVFDLETRTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDASRQY---NGFYSFDTTT 253

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568913577 111 LTWS--QPETHGspPSPRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSW 163
Cdd:PLN02193 254 NEWKllTPVEEG--PTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
PLN02193 PLN02193
nitrile-specifier protein
 2-196 2.00e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 54.96  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577   2 DLGTHQWDTATREGLLPryeHASFLPSCS---PHSIWVFGGADQSGNRNCLQVMSPEDRTWS--TPEVTGspPSPRTFHt 76
Cdd:PLN02193 199 DLETRTWSISPATGDVP---HLSCLGVRMvsiGSTLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEG--PTPRSFH- 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  77 SSAAIGNQLYVFGGgeRGAQpvedVKLHVFDANTL---TWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFfDDL 153
Cdd:PLN02193 273 SMAADEENVYVFGG--VSAT----ARLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDV 345

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568913577 154 HCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTA 196
Cdd:PLN02193 346 HYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIA 388
Kelch_3 pfam13415
Galactose oxidase, central domain;
82-134 3.40e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 3.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568913577   82 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 134
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
78-157 1.39e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.16  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  78 SAAIGNQLYVFGGGERGA-----QPVEDVklHVFDANTLTWSQPETHgsppSPRH--GHVMVAA-GTKLFIHGGLAG--- 146
Cdd:PRK14131  80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                         90
                 ....*....|.
gi 568913577 147 DKFFDDLHCID 157
Cdd:PRK14131 154 DGYFEDLAAAG 164
Kelch_6 pfam13964
Kelch motif;
71-126 2.43e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 2.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568913577   71 PRTFHtSSAAIGNQLYVFGGGERGAQPVEdvKLHVFDANTLTWsqpETHGSPPSPR 126
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 2-193 7.42e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577   2 DLGTHQWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMSPEDRTW---STPEVTGSPPSpRTFHtSS 78
Cdd:PLN02153  56 DFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWtflTKLDEEGGPEA-RTFH-SM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  79 AAIGNQLYVFGGGERGAQPVEDVKLHVFDANTLT---WSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLA--------GD 147
Cdd:PLN02153 134 ASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIAdgkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpggkSD 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568913577 148 KFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGG 193
Cdd:PLN02153 214 YESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
PLN02153 PLN02153
epithiospecifier protein
 27-170 1.47e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.05  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  27 PSCSpHSIWVFG------GADQSGNRNC---LQVMSPEDRTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERgAQP 97
Cdd:PLN02153  22 PRCS-HGIAVVGdklysfGGELKPNEHIdkdLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE-KRE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  98 VEDvkLHVFDANTLTW---SQPETHGSPPSpRHGHVMVAAGTKLFIHGGLAGD------KFFDDLHCIDIGDMSWQKLGP 168
Cdd:PLN02153 100 FSD--FYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMASDENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQLPD 176


                 ..
gi 568913577 169 TG 170
Cdd:PLN02153 177 PG 178
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-101 2.60e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.68  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577   4 GTHQWDTATREGLLP--RYEHASFLPScspHSIWVFGGadQSGNRNCLQVMSPEDRTWSTpevTGSPPSPRTFHTSsAAI 81
Cdd:COG3055  180 GSGFSNTWTTLAPLPtaRAGHAAAVLG---GKILVFGG--ESGFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLT 250

                         90       100
                 ....*....|....*....|
gi 568913577  82 GNQLYVFGGGERGAQPVEDV 101
Cdd:COG3055  251 DGKVYVIGGETKPGVRTPLV 270
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 123-154 3.04e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 3.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568913577  123 PSPRHGHVMVAAGTKLFIHGG--LAGDKFFDDLH 154
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
125-168 6.73e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 6.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568913577  125 PRHGHVMVA-AGTKLFIHGGLAGD-KFFDDLHCIDIGDMSWQKLGP 168
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
PLN02772 PLN02772
guanylate kinase
 77-148 6.75e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 6.75e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568913577  77 SSAAIGNQLYVFGGGERGAQPVEDVKLhvFDANTLTWSQPETHGSPPSPRHGH--VMVAAGTKLFIHGGLAGDK 148
Cdd:PLN02772  29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPDD 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 125-168 8.44e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 8.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568913577  125 PRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP 168
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_3 pfam13415
Galactose oxidase, central domain;
32-80 2.10e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568913577   32 HSIWVFGGADQSGNR--NCLQVMSPEDRTWSTpevTGSPPSPRTFHTSSAA 80
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
189-234 2.22e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 2.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568913577   189 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 234
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
71-115 3.70e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 3.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568913577   71 PRTFHTSSAAIGNQLYVFGGGERGAQPVEDvkLHVFDANTLTWSQ 115
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD--LWVFDLSTNEWTR 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
78-175 6.12e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.07  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  78 SAAIGNQLYVfGGGERGaqpvedVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLaGDK-------FF 150
Cdd:PRK14131  34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGI-GKTnsegspqVF 105

                         90       100
                 ....*....|....*....|....*
gi 568913577 151 DDLHCIDIGDMSWQKLgPTGAvPVG 175
Cdd:PRK14131 106 DDVYKYDPKTNSWQKL-DTRS-PVG 128
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 71-115 8.15e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 33.74  E-value: 8.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568913577   71 PRTFHtSSAAIGNQLYVFGGGeRGAQPVEDVklHVFDANTLTWSQ 115
Cdd:pfam01344   1 RRSGA-GVVVVGGKIYVIGGF-DGNQSLNSV--EVYDPETNTWSK 41
PHA03098 PHA03098
kelch-like protein; Provisional
 77-234 8.98e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.44  E-value: 8.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577  77 SSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTltWSQpethgSPP--SPRHGHVMVAAGTKLFIHGGLA-GDKFFDDL 153
Cdd:PHA03098 337 GVTVFNNRIYVIGG-IYNSISLNTVESWKPGESK--WRE-----EPPliFPRYNPCVVNVNNLIYVIGGISkNDELLKTV 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913577 154 HCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMT---ATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHS 230
Cdd:PHA03098 409 ECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGISyidNIKVYNIVESYNPVTNKWTEL---SSLNFPRINAS 482


                 ....
gi 568913577 231 MCVI 234
Cdd:PHA03098 483 LCIF 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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