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Conserved domains on  [gi|568913583|ref|XP_006498052|]
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rab9 effector protein with kelch motifs isoform X9 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-245 1.52e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   6 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 83
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  84 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 159
Cdd:COG3055   71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583 160 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 235
Cdd:COG3055  148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                        250
                 ....*....|...
gi 568913583 236 GM---NTEGEVYD 245
Cdd:COG3055  214 GEsgfSDEVEAYD 226
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-245 1.52e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   6 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 83
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  84 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 159
Cdd:COG3055   71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583 160 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 235
Cdd:COG3055  148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                        250
                 ....*....|...
gi 568913583 236 GM---NTEGEVYD 245
Cdd:COG3055  214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 7-175 4.89e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 76.92  E-value: 4.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   7 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 85
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  86 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 165
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                        170
                 ....*....|
gi 568913583 166 FDTSLPAGRL 175
Cdd:PLN02193 307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
30-82 2.57e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 2.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568913583   30 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 82
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
137-182 1.88e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 1.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568913583   137 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 182
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-245 1.52e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   6 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 83
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  84 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 159
Cdd:COG3055   71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583 160 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 235
Cdd:COG3055  148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                        250
                 ....*....|...
gi 568913583 236 GM---NTEGEVYD 245
Cdd:COG3055  214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 7-175 4.89e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 76.92  E-value: 4.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   7 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 85
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  86 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 165
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                        170
                 ....*....|
gi 568913583 166 FDTSLPAGRL 175
Cdd:PLN02193 307 FHCSTPGDSF 316
PLN02153 PLN02153
epithiospecifier protein
 14-156 2.14e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.56  E-value: 2.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  14 GSPPSPRTFHtSSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTLTWSQPETHGSPPS-PRHGHVMVAAGTKLFIHGGL 92
Cdd:PLN02153  17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568913583  93 AGDKFFDDLHCIDIGDMSWQ---KLGPTGAvPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHT 156
Cdd:PLN02153  95 DEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-147 6.49e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 58.24  E-value: 6.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   6 TWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvedvklhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTK 85
Cdd:COG3055  148 TWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGGK 208

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568913583  86 LFIHGGLAGdkFFDDLHCIDIGDMSWQKLGPtgaVPVGCAAHAAVAVGHHVYMFGGMTATGA 147
Cdd:COG3055  209 ILVFGGESG--FSDEVEAYDPATNTWTALGE---LPTPRHGHAAVLTDGKVYVIGGETKPGV 265
PLN02193 PLN02193
nitrile-specifier protein
 5-111 3.10e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.72  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   5 RTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERGAQPvedVKLHVFDANTLTWS--QPETHGspPSPRHGHVMVAA 82
Cdd:PLN02193 203 RTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDASRQY---NGFYSFDTTTNEWKllTPVEEG--PTPRSFHSMAAD 277

                         90       100
                 ....*....|....*....|....*....
gi 568913583  83 GTKLFIHGGLAGDKFFDDLHCIDIGDMSW 111
Cdd:PLN02193 278 EENVYVFGGVSATARLKTLDSYNIVDKKW 306
Kelch_3 pfam13415
Galactose oxidase, central domain;
30-82 2.57e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 2.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568913583   30 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 82
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
26-105 1.24e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.78  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  26 SAAIGNQLYVFGGGERGA-----QPVEDVklHVFDANTLTWSQPETHgsppSPRH--GHVMVAA-GTKLFIHGGLAG--- 94
Cdd:PRK14131  80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                         90
                 ....*....|.
gi 568913583  95 DKFFDDLHCID 105
Cdd:PRK14131 154 DGYFEDLAAAG 164
Kelch_6 pfam13964
Kelch motif;
19-74 1.80e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 1.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568913583   19 PRTFHtSSAAIGNQLYVFGGGERGAQPVEdvKLHVFDANTLTWsqpETHGSPPSPR 74
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 5-118 2.13e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.90  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   5 RTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERgAQPVEDvkLHVFDANTLTW---SQPETHGSPPSpRHGHVMVA 81
Cdd:PLN02153  60 HTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE-KREFSD--FYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMAS 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568913583  82 AGTKLFIHGGLAGD------KFFDDLHCIDIGDMSWQKLGPTG 118
Cdd:PLN02153 136 DENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQLPDPG 178
PLN02193 PLN02193
nitrile-specifier protein
 17-144 2.57e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.86  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  17 PSPRTFHtSSAAIGNQLYVFGGgeRGAQpvedVKLHVFDANTL---TWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLA 93
Cdd:PLN02193 266 PTPRSFH-SMAADEENVYVFGG--VSAT----ARLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFN 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568913583  94 GDKFfDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTA 144
Cdd:PLN02193 339 GCEV-DDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIA 388
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 71-102 2.58e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 2.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568913583   71 PSPRHGHVMVAAGTKLFIHGG--LAGDKFFDDLH 102
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
73-116 4.71e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 4.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568913583   73 PRHGHVMVA-AGTKLFIHGGLAGD-KFFDDLHCIDIGDMSWQKLGP 116
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
PLN02772 PLN02772
guanylate kinase
 25-96 5.52e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.59  E-value: 5.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568913583  25 SSAAIGNQLYVFGGGERGAQPVEDVKLhvFDANTLTWSQPETHGSPPSPRHGH--VMVAAGTKLFIHGGLAGDK 96
Cdd:PLN02772  29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPDD 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 73-116 6.88e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 6.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568913583   73 PRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP 116
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch smart00612
Kelch domain;
137-182 1.88e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 1.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568913583   137 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 182
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
19-63 2.65e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568913583   19 PRTFHTSSAAIGNQLYVFGGGERGAQPVEDvkLHVFDANTLTWSQ 63
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD--LWVFDLSTNEWTR 43
PLN02153 PLN02153
epithiospecifier protein
 7-102 4.91e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 37.66  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583   7 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGG-------GERGAQPVEDvKLHVFDANTLTWSQPETHGSPPSPRHGHVM 79
Cdd:PLN02153 229 WTEVETTGAKPSARSVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSN-EGYALDTETLVWEKLGECGEPAMPRGWTAY 306

                         90       100
                 ....*....|....*....|....*...
gi 568913583  80 VAA---GTK-LFIHGG-LAGDKFFDDLH 102
Cdd:PLN02153 307 TTAtvyGKNgLLMHGGkLPTNERTDDLY 334
PRK14131 PRK14131
N-acetylneuraminate epimerase;
26-123 5.75e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 37.69  E-value: 5.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  26 SAAIGNQLYVfGGGERGaqpvedVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLaGDK-------FF 98
Cdd:PRK14131  34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGI-GKTnsegspqVF 105

                         90       100
                 ....*....|....*....|....*
gi 568913583  99 DDLHCIDIGDMSWQKLgPTGAvPVG 123
Cdd:PRK14131 106 DDVYKYDPKTNSWQKL-DTRS-PVG 128
PHA03098 PHA03098
kelch-like protein; Provisional
 25-182 5.91e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.82  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583  25 SSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTltWSQpethgSPP--SPRHGHVMVAAGTKLFIHGGLA-GDKFFDDL 101
Cdd:PHA03098 337 GVTVFNNRIYVIGG-IYNSISLNTVESWKPGESK--WRE-----EPPliFPRYNPCVVNVNNLIYVIGGISkNDELLKTV 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913583 102 HCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMT---ATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHS 178
Cdd:PHA03098 409 ECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGISyidNIKVYNIVESYNPVTNKWTEL---SSLNFPRINAS 482


                 ....
gi 568913583 179 MCVI 182
Cdd:PHA03098 483 LCIF 486
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 19-63 6.66e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 33.74  E-value: 6.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568913583   19 PRTFHtSSAAIGNQLYVFGGGeRGAQPVEDVklHVFDANTLTWSQ 63
Cdd:pfam01344   1 RRSGA-GVVVVGGKIYVIGGF-DGNQSLNSV--EVYDPETNTWSK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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